MA55390B1 - Dispositif pour découper l'adn à base de la protéine cas9 à partir de la bactérie pasteurella pneumotropica - Google Patents

Dispositif pour découper l'adn à base de la protéine cas9 à partir de la bactérie pasteurella pneumotropica

Info

Publication number
MA55390B1
MA55390B1 MA55390A MA55390A MA55390B1 MA 55390 B1 MA55390 B1 MA 55390B1 MA 55390 A MA55390 A MA 55390A MA 55390 A MA55390 A MA 55390A MA 55390 B1 MA55390 B1 MA 55390B1
Authority
MA
Morocco
Prior art keywords
cas9
cas9 protein
bacterium
dna based
pneumotropica
Prior art date
Application number
MA55390A
Other languages
English (en)
Other versions
MA55390A1 (fr
Inventor
Konstantin Viktorovich Severinov
Daria Nikolaevna Artamonova
Olga Sergeevna Musharova
Tatiana Olegovna Artamonova
Sergey Anatolievich Shmakov
Ignaty Igorevich Goryanin
Julia Valerevna Andreeva
Tatiana Igorevna Zyubko
Yana Vitalievna Fedorova
Mikhail Alekseevich Khodorkovskii
George Evgenevich Pobegalov
Anatoliy Nikolaevich Arseniev
Polina Anatolevna Selkova
Aleksandra Andreevna Vasilieva
Marina Viktorovna Abramova
Original Assignee
Biocad Joint Stock Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocad Joint Stock Co filed Critical Biocad Joint Stock Co
Priority claimed from PCT/RU2020/050137 external-priority patent/WO2020251413A1/fr
Publication of MA55390A1 publication Critical patent/MA55390A1/fr
Publication of MA55390B1 publication Critical patent/MA55390B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une nouvelle nucléase bactérienne du système crispr-cas9 à partir de la bactérie p. Pneumotropica, ainsi que son utilisation pour former des ruptures strictement spécifiques à deux brins dans la molécule d'adn. Cette nucléase possède des propriétés inhabituelles et peut être utilisée en tant qu'instrument pour apporter des modifications dans des endroits strictement déterminés de l'adn génomique d'organismes unicellulaires ou pluricellulaires. Il est ainsi possible d'améliorer l'universalité de systèmes disponibles crispr-cas9, ce qui permet d'utiliser les nucléases cas9 provenant de différents organismes pour découper l'adn génomique ou plasmidique dans une grande quantité de sites spécifiques et dans diverses conditions.
MA55390A 2019-04-23 2020-06-30 Dispositif pour découper l'adn à base de la protéine cas9 à partir de la bactérie pasteurella pneumotropica MA55390B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2019112296A RU2734432C1 (ru) 2019-04-23 2019-04-23 Моноклональное антитело, которое специфически связывается с GITR
PCT/RU2020/050137 WO2020251413A1 (fr) 2019-06-11 2020-06-30 Dispositif pour découper l'adn à base de la protéine cas9 à partir de la bactérie pasteurella pneumotropica

Publications (2)

Publication Number Publication Date
MA55390A1 MA55390A1 (fr) 2022-05-31
MA55390B1 true MA55390B1 (fr) 2022-10-31

Family

ID=69821666

Family Applications (2)

Application Number Title Priority Date Filing Date
MA54969A MA54969A1 (fr) 2019-04-23 2020-04-23 Anticorps monoclonal se liant spécifiquement à gitr
MA55390A MA55390B1 (fr) 2019-04-23 2020-06-30 Dispositif pour découper l'adn à base de la protéine cas9 à partir de la bactérie pasteurella pneumotropica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA54969A MA54969A1 (fr) 2019-04-23 2020-04-23 Anticorps monoclonal se liant spécifiquement à gitr

Country Status (22)

Country Link
US (1) US20220213209A1 (fr)
EP (1) EP3964525A4 (fr)
JP (1) JP2022532991A (fr)
KR (1) KR20220010501A (fr)
CN (1) CN110903392B (fr)
AR (1) AR118763A1 (fr)
AU (1) AU2020261207A1 (fr)
BR (1) BR112021021281A2 (fr)
CA (1) CA3137822A1 (fr)
CL (1) CL2021002792A1 (fr)
CO (1) CO2021014153A2 (fr)
EA (1) EA202192907A1 (fr)
IL (1) IL287531A (fr)
JO (1) JOP20210286A1 (fr)
MA (2) MA54969A1 (fr)
MX (1) MX2021012962A (fr)
PE (1) PE20220144A1 (fr)
RU (1) RU2734432C1 (fr)
TW (1) TWI803718B (fr)
UY (1) UY38672A (fr)
WO (1) WO2020218951A2 (fr)
ZA (1) ZA202109374B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111732658B (zh) * 2020-06-28 2022-04-26 英诺湖医药(杭州)有限公司 一组gitr单克隆抗体及其医药用途
CN112362876B (zh) * 2020-08-06 2023-12-15 武汉天德生物科技有限公司 一种检测早期老年痴呆症的胶体金试纸条及其制备方法
CN112540179B (zh) * 2020-08-06 2023-07-07 武汉天德生物科技有限公司 一种测试ApoE4蛋白含量的ELISA试剂盒
CN111763257B (zh) * 2020-09-01 2020-12-15 北京百奥赛图基因生物技术有限公司 抗gitr抗体及其用途
CN114891111A (zh) * 2020-12-31 2022-08-12 中元汇吉生物技术股份有限公司 特异性结合人IgG4的蛋白及其应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
CA1319120C (fr) 1985-04-01 1993-06-15 John Henry Kenten Lignee cellulaire myelomateuse transformee et expression d'un gene codant pour un polypeptide d'eucaryote a l'aide de cette lignee
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4959455A (en) 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
DK0814159T3 (da) 1990-08-29 2005-10-24 Genpharm Int Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
LU91067I2 (fr) 1991-06-14 2004-04-02 Genentech Inc Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
CA2372813A1 (fr) 1992-02-06 1993-08-19 L.L. Houston Proteine fixatrice biosynthetique pour marqueur du cancer
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
DE19544393A1 (de) 1995-11-15 1997-05-22 Hoechst Schering Agrevo Gmbh Synergistische herbizide Mischungen
US6517529B1 (en) 1999-11-24 2003-02-11 Radius International Limited Partnership Hemodialysis catheter
WO2004107618A2 (fr) * 2003-05-23 2004-12-09 Wyeth Ligand du gitr et molecules et anticorps lies au ligand du gitr et leurs utilisations
WO2005047327A2 (fr) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. Variants de polypeptide se liant au recepteur fc neonatal (fcrn), proteines de liaison fc dimeres et techniques associees
WO2006104989A2 (fr) 2005-03-29 2006-10-05 Verenium Corporation Anticorps a regions fc modifiees et utilisations
WO2007005612A2 (fr) 2005-07-01 2007-01-11 Medimmune, Inc. Approche integree permettant de generer des applications therapeutiques a base de proteine multidomaine
SG178991A1 (en) * 2009-09-03 2012-04-27 Schering Corp Anti-gitr antibodies
TW201605896A (zh) 2013-08-30 2016-02-16 安美基股份有限公司 Gitr抗原結合蛋白
KR102433464B1 (ko) * 2014-05-28 2022-08-17 아게누스 인코포레이티드 항-gitr 항체 및 이의 사용 방법
CN106459203B (zh) 2014-06-06 2021-08-03 百时美施贵宝公司 抗糖皮质激素诱导肿瘤坏死因子受体(gitr)的抗体及其用途
GB2557389B (en) * 2015-01-14 2020-12-23 Brigham & Womens Hospital Inc Treatment of cancer with anti-lap monoclonal antibodies
CN108473579B (zh) 2015-10-22 2022-03-01 埃博灵克斯股份有限公司 Gitr激动剂
US20200123265A1 (en) 2015-12-02 2020-04-23 Agenus Inc. Anti-gitr antibodies and methods of use thereof
SG11201810525XA (en) 2016-06-10 2018-12-28 Regeneron Pharma Anti-gitr antibodies and uses thereof
JP2019519536A (ja) * 2016-07-01 2019-07-11 ファイブ プライム セラピューティクス， インコーポレイテッド Ｇｉｔｒアゴニストおよびｃｐｇを用いた組み合わせ抗腫瘍療法
CA3033665A1 (fr) * 2016-08-12 2018-02-15 Janssen Biotech, Inc. Anticorps de membres de la superfamille anti-tnfr modifies par fc ayant une activite agoniste amelioree et leurs procedes d'utilisation
CA3042727A1 (fr) * 2016-11-19 2018-05-24 Potenza Therapeutics, Inc. Proteines de liaison a un antigene anti-gitr et leurs procedes d'utilisation
MX2019010458A (es) * 2017-03-03 2020-01-20 Rinat Neuroscience Corp Anticuerpos anti-gitr y metodos de uso de los mismos.
TWI788340B (zh) * 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 抗icos促效劑抗體及其用途

Also Published As

Publication number Publication date
CA3137822A1 (fr) 2020-10-29
UY38672A (es) 2020-10-30
JOP20210286A1 (ar) 2023-01-30
MX2021012962A (es) 2021-12-15
CN110903392A (zh) 2020-03-24
TW202100554A (zh) 2021-01-01
KR20220010501A (ko) 2022-01-25
MA55390A1 (fr) 2022-05-31
EA202192907A1 (ru) 2022-01-25
PE20220144A1 (es) 2022-01-27
AU2020261207A1 (en) 2021-12-23
MA54969A1 (fr) 2022-08-31
AR118763A1 (es) 2021-10-27
RU2734432C1 (ru) 2020-10-16
EP3964525A4 (fr) 2022-12-28
IL287531A (en) 2021-12-01
WO2020218951A3 (fr) 2020-12-24
BR112021021281A2 (pt) 2022-03-08
EP3964525A2 (fr) 2022-03-09
TWI803718B (zh) 2023-06-01
WO2020218951A2 (fr) 2020-10-29
ZA202109374B (en) 2022-12-21
US20220213209A1 (en) 2022-07-07
JP2022532991A (ja) 2022-07-21
CL2021002792A1 (es) 2022-06-24
CO2021014153A2 (es) 2021-10-29
CN110903392B (zh) 2024-02-13

Similar Documents

Publication Publication Date Title
MA55390B1 (fr) Dispositif pour découper l'adn à base de la protéine cas9 à partir de la bactérie pasteurella pneumotropica
Neueder et al. The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients
Dı́ez et al. Study of genetic diversity of eukaryotic picoplankton in different oceanic regions by small-subunit rRNA gene cloning and sequencing
MA41667A1 (fr) Procede de diagnostic et de traitement du cancer
Carvalho et al. IL-17A and IL-17F polymorphisms in rheumatoid arthritis and Sjögren’s syndrome
FR3034430A1 (fr) Lignee cellulaire surexprimant l'antigene cd303 humain
FR2981354B1 (fr) Copolymere dienique a au moins deux blocs, son procede de synthese et composition de caoutchouc le contenant
MA53578B1 (fr) Dispositif pour découper l'adn à base de la protéine cas9 à partir de defluviimonas sp.
Yassai et al. A molecular marker for thymocyte-positive selection: selection of CD4 single-positive thymocytes with shorter TCRB CDR3 during T cell development
Sevillano et al. Spatial-temporal targeted and non-targeted surveys to assess microbiological composition of drinking water in Puerto Rico following Hurricane Maria
Barragán-Ruiz et al. Molecular sexing of Xenarthra: a tool for genetic and ecological studies
MA57032A1 (fr) Utilisation de beige cas9 issu de bactérie pasteurella pneumotropica
Mavropoulou et al. High-throughput double quantitative competitive polymerase chain reaction for determination of genetically modified organisms
Sakamoto et al. Tissue-specific imprinting of the G protein G s α is associated with tissue-specific differences in histone methylation
Pérez-Espona et al. First assessment of MHC diversity in wild Scottish red deer populations
MA53577B1 (fr) Moyen de découpage d'adn à base de la protéine cas9 sur la base d'une bactérie à valeur biotechnologique clostridium cellulolyticum
Salvi et al. Detection and quantification of genetically modified organisms using very short, locked nucleic acid TaqMan probes
Ribas et al. Major histocompatibility complex class I chain‐related gene A polymorphism and linkage disequilibrium with HLA‐B alleles in Euro‐Brazilians
Postovoitova et al. Molecular genetic evaluation of Ukrainian flax cultivar homogeneity based on intron length polymorphism of actin genes and microsatellite loci
Almeida et al. Rheological study of polymers used as viscosity index improvers for automotive lubricant oils
FR3096373B1 (fr) Outil genetique optimisé pour modifier les bacteries
FR2771422B1 (fr) Reactifs et methodes pour la detection de genes lies au complexe majeur d'histocompatibilite d'oiseaux d'elevage, tels que le poulet
Katz et al. Genetic follow-up of male offspring born by ICSI, using a multiplex fluorescent PCR-based test for Yq deletions
Birch et al. Genomic location and characterisation of MIC genes in cattle
Ferreira et al. Identification and characterization of microsatellite markers for population genetic studies of Panstrongylus megistus (Burmeister, 1835)(Triatominae: Reduviidae)