AU2019315466B2 - Synergistic antitumor effect of Bcl-2 inhibitor combined with rituximab and/or bendamustine or Bcl-2 inhibitor combined with CHOP - Google Patents

Synergistic antitumor effect of Bcl-2 inhibitor combined with rituximab and/or bendamustine or Bcl-2 inhibitor combined with CHOP Download PDF

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AU2019315466B2
AU2019315466B2 AU2019315466A AU2019315466A AU2019315466B2 AU 2019315466 B2 AU2019315466 B2 AU 2019315466B2 AU 2019315466 A AU2019315466 A AU 2019315466A AU 2019315466 A AU2019315466 A AU 2019315466A AU 2019315466 B2 AU2019315466 B2 AU 2019315466B2
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cancer
bcl
inhibitor
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mab
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AU2019315466A1 (en
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Guangfeng Wang
Dajun Yang
Yifan Zhai
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Ascentage Pharma Suzhou Co Ltd
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AU2019315466A 2018-07-31 2019-07-22 Synergistic antitumor effect of Bcl-2 inhibitor combined with rituximab and/or bendamustine or Bcl-2 inhibitor combined with CHOP Active AU2019315466B2 (en)

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CN201810867252.2 2018-07-31
CN201810867252 2018-07-31
PCT/CN2019/097028 WO2020024826A1 (en) 2018-07-31 2019-07-22 Synergistic antitumor effect of bcl-2 inhibitor combined with rituximab and/or bendamustine or bcl-2 inhibitor combined with chop

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AU2019315466B2 true AU2019315466B2 (en) 2022-05-19

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US (1) US11554127B2 (zh)
EP (1) EP3672591B1 (zh)
JP (1) JP2021516262A (zh)
KR (1) KR20200139139A (zh)
CN (1) CN110772640B (zh)
AU (1) AU2019315466B2 (zh)
BR (1) BR112020019134A2 (zh)
CA (1) CA3092753C (zh)
EA (1) EA202091963A1 (zh)
GE (1) GEP20237460B (zh)
IL (1) IL277309A (zh)
MX (1) MX2020009759A (zh)
TW (1) TWI726362B (zh)
UA (1) UA125241C2 (zh)
WO (1) WO2020024826A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110772640B (zh) 2018-07-31 2023-02-03 苏州亚盛药业有限公司 Bcl-2抑制剂与利妥昔单抗和/或苯达莫司汀或与CHOP联合的协同抗肿瘤作用
CN110772521A (zh) 2018-07-31 2020-02-11 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
WO2020024834A1 (en) 2018-07-31 2020-02-06 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
MX2020009757A (es) 2018-07-31 2020-10-08 Ascentage Pharma Suzhou Co Ltd Producto combinado de inhibidor de bcl-2 e inhibidor de mdm2 y uso de este en la prevencion y/o tratamiento de enfermedades.
WO2021110097A1 (en) * 2019-12-03 2021-06-10 Ascentage Pharma (Suzhou) Co., Ltd. N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
US20220323465A1 (en) * 2019-12-04 2022-10-13 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical combination and use thereof
JP2023545498A (ja) * 2020-10-16 2023-10-30 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー Bcl-2阻害剤と化学療法剤との組み合わせ
CN114681458B (zh) * 2020-12-28 2023-07-18 苏州亚盛药业有限公司 治疗多发性硬化症的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018027097A1 (en) * 2016-08-05 2018-02-08 The Regents Of The University Of Michigan N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005049593A2 (en) 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
CA2662320C (en) 2006-09-05 2014-07-22 Abbott Laboratories Bcl inhibitors treating platelet excess
CN101611154A (zh) 2006-12-04 2009-12-23 艾博特公司 用于癌症治疗的成对诊断测定
US20090098118A1 (en) * 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
AR070047A1 (es) 2007-12-27 2010-03-10 Infinity Pharmaceuticals Inc Tratamientos terapeuticos contra el cancer. composicion que comprende un inhibidor de hedgehog.
UA108193C2 (uk) 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
PT2376480T (pt) 2008-12-05 2016-10-26 Abbvie Inc Derivados de sulfonamida como agentes indutores de apoptose seletivos de bcl-2 para o tratamento do cancro e de doenças imunes
WO2010093742A1 (en) 2009-02-11 2010-08-19 Abbott Laboratories Methods and compositions for identifying, classifying and monitoring subject having bcl-2 family inhibitor-resistant tumors and cancers
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
RU2535347C3 (ru) 2009-05-26 2019-05-14 ЭббВи Айэленд Анлимитед Компани Индуцирующие апоптоз средства для лечения злокачественной опухоли и иммунных и аутоиммунных заболеваний
TWI520960B (zh) 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑
JP6068352B2 (ja) 2010-10-29 2017-01-25 アッヴィ・インコーポレイテッド アポトーシス誘発剤を含む固体分散体
BR112013012740A2 (pt) 2010-11-23 2016-09-13 Abbvie Inc sais e formas cristalinas de um agente que induz apoptose
SG190399A1 (en) 2010-11-23 2013-06-28 Abbvie Inc Methods of treatment using selective bcl-2 inhibitors
SG192126A1 (en) 2011-01-25 2013-09-30 Univ Michigan Bcl-2/bcl-xl inhibitors and therapeutic methods using the same
WO2014039855A1 (en) * 2012-09-07 2014-03-13 Genentech, Inc. Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor
SG11201505525UA (en) 2013-01-16 2015-08-28 Univ Michigan Bcl-2bcl-xl inhibitors and therapeutic methods using the same
EP3110509B1 (en) 2014-02-28 2020-08-19 Merck Sharp & Dohme Corp. Treating cancer with a combination comprising dinaciclib
KR102599945B1 (ko) 2014-04-17 2023-11-09 더 리젠츠 오브 더 유니버시티 오브 미시간 Mdm2 저해제 및 이 저해제를 사용하는 치료 방법
EP3179991B1 (en) 2014-08-11 2021-10-06 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor and a bcl-2 inhibitor
UA124617C2 (uk) * 2015-05-26 2021-10-20 Ф. Хоффманн-Ля Рош Аг КОМБІНОВАНА ТЕРАПІЯ РАКУ НА ОСНОВІ ГУМАНІЗОВАНОГО АНТИТІЛА B-Ly1 В ПОЄДНАННІ З ІНГІБІТОРОМ Bcl-2 ТА ІНГІБІТОРОМ MDM2
CN105061315B (zh) 2015-08-06 2017-10-24 大连理工大学 一类1,5‑二苯基吡唑‑3‑羧酸类化合物及其应用
KR20180041677A (ko) 2015-08-28 2018-04-24 노파르티스 아게 Mdm2 억제제 및 그의 조합물
WO2020024834A1 (en) 2018-07-31 2020-02-06 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
CN110772521A (zh) 2018-07-31 2020-02-11 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
MX2020009757A (es) * 2018-07-31 2020-10-08 Ascentage Pharma Suzhou Co Ltd Producto combinado de inhibidor de bcl-2 e inhibidor de mdm2 y uso de este en la prevencion y/o tratamiento de enfermedades.
CN110772640B (zh) 2018-07-31 2023-02-03 苏州亚盛药业有限公司 Bcl-2抑制剂与利妥昔单抗和/或苯达莫司汀或与CHOP联合的协同抗肿瘤作用
US20210275522A1 (en) * 2018-11-23 2021-09-09 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical compositions and use thereof
TWI770503B (zh) * 2019-05-13 2022-07-11 大陸商蘇州亞盛藥業有限公司 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物
WO2021110097A1 (en) * 2019-12-03 2021-06-10 Ascentage Pharma (Suzhou) Co., Ltd. N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
CN112168830B (zh) * 2019-07-02 2022-01-25 苏州亚盛药业有限公司 一种含有mTOR抑制剂的药物组合及其应用
TW202114664A (zh) * 2019-07-31 2021-04-16 大陸商蘇州亞盛藥業有限公司 Bcl-2/Bcl-xL抑制劑與化療藥的組合產品及其在預防和/或治療疾病中的用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018027097A1 (en) * 2016-08-05 2018-02-08 The Regents Of The University Of Michigan N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ZELENETZ P.et al., "Results of a Phase Ib Study of Venetoclax Plus R- or G-CHOP in Patients with B-Cell Non-Hodgkin Lymphoma", Blood, (2016-12-02), vol. 128, no. 22, doi:20191009104926, pages 3032 - 3032 *
ZINZANI P.et al., Blood, (2016-12-02), vol. 128, no. 22, doi:20191010155508X, pages 617 - 617 *

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