AU2019287437A1 - Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs - Google Patents

Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs Download PDF

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Publication number
AU2019287437A1
AU2019287437A1 AU2019287437A AU2019287437A AU2019287437A1 AU 2019287437 A1 AU2019287437 A1 AU 2019287437A1 AU 2019287437 A AU2019287437 A AU 2019287437A AU 2019287437 A AU2019287437 A AU 2019287437A AU 2019287437 A1 AU2019287437 A1 AU 2019287437A1
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AU
Australia
Prior art keywords
insulin
subject
liver
administering
analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2019287437A
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English (en)
Inventor
Jennifer L.R. Freeman
Maria Carmen Valcarce Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
vTv Therapeutics LLC
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vTv Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by vTv Therapeutics LLC filed Critical vTv Therapeutics LLC
Publication of AU2019287437A1 publication Critical patent/AU2019287437A1/en
Priority to AU2025203014A priority Critical patent/AU2025203014A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2019287437A 2018-06-12 2019-06-10 Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs Abandoned AU2019287437A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025203014A AU2025203014A1 (en) 2018-06-12 2025-04-29 Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862683772P 2018-06-12 2018-06-12
US62/683,772 2018-06-12
US201962857753P 2019-06-05 2019-06-05
US62/857,753 2019-06-05
PCT/US2019/036227 WO2019241089A1 (en) 2018-06-12 2019-06-10 Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025203014A Division AU2025203014A1 (en) 2018-06-12 2025-04-29 Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs

Publications (1)

Publication Number Publication Date
AU2019287437A1 true AU2019287437A1 (en) 2020-09-10

Family

ID=67297247

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2019287437A Abandoned AU2019287437A1 (en) 2018-06-12 2019-06-10 Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
AU2025203014A Pending AU2025203014A1 (en) 2018-06-12 2025-04-29 Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2025203014A Pending AU2025203014A1 (en) 2018-06-12 2025-04-29 Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs

Country Status (9)

Country Link
US (4) US10952993B2 (cg-RX-API-DMAC7.html)
EP (2) EP4487909A3 (cg-RX-API-DMAC7.html)
JP (2) JP2021526130A (cg-RX-API-DMAC7.html)
KR (1) KR20210020866A (cg-RX-API-DMAC7.html)
CN (3) CN112040945A (cg-RX-API-DMAC7.html)
AU (2) AU2019287437A1 (cg-RX-API-DMAC7.html)
CA (1) CA3093025A1 (cg-RX-API-DMAC7.html)
MX (2) MX2020008905A (cg-RX-API-DMAC7.html)
WO (1) WO2019241089A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112040945A (zh) 2018-06-12 2020-12-04 Vtv治疗有限责任公司 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途
US12391658B2 (en) 2020-02-18 2025-08-19 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
CA3181722A1 (en) 2020-06-08 2021-12-16 Jing TENG Salts or co-crystals of {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid and uses thereof

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