AU2019229978B2 - Arginase inhibitors - Google Patents

Arginase inhibitors Download PDF

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Publication number
AU2019229978B2
AU2019229978B2 AU2019229978A AU2019229978A AU2019229978B2 AU 2019229978 B2 AU2019229978 B2 AU 2019229978B2 AU 2019229978 A AU2019229978 A AU 2019229978A AU 2019229978 A AU2019229978 A AU 2019229978A AU 2019229978 B2 AU2019229978 B2 AU 2019229978B2
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AU
Australia
Prior art keywords
group
cancer
arginase
compound
agents
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AU2019229978A
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English (en)
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AU2019229978A1 (en
Inventor
Corinne Nicole FOLEY
Rebecca Louise Grange
Tezcan GUNEY
Jaroslaw Kalisiak
Eric Thomas NEWCOMB
Anh Thu TRAN
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Arcus Biosciences Inc
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Arcus Biosciences Inc
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Publication of AU2019229978A1 publication Critical patent/AU2019229978A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2019229978A 2018-03-05 2019-03-04 Arginase inhibitors Active AU2019229978B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862638412P 2018-03-05 2018-03-05
US62/638,412 2018-03-05
PCT/US2019/020507 WO2019173188A1 (en) 2018-03-05 2019-03-04 Arginase inhibitors

Publications (2)

Publication Number Publication Date
AU2019229978A1 AU2019229978A1 (en) 2020-10-15
AU2019229978B2 true AU2019229978B2 (en) 2024-05-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019229978A Active AU2019229978B2 (en) 2018-03-05 2019-03-04 Arginase inhibitors

Country Status (21)

Country Link
US (1) US12054500B2 (https=)
EP (1) EP3761992A4 (https=)
JP (1) JP7402167B2 (https=)
KR (1) KR102656571B1 (https=)
CN (1) CN111818928A (https=)
AU (1) AU2019229978B2 (https=)
BR (1) BR112020017604A2 (https=)
CA (1) CA3091805A1 (https=)
CL (1) CL2020002271A1 (https=)
CO (1) CO2020012060A2 (https=)
CR (1) CR20200445A (https=)
EA (1) EA202092086A1 (https=)
IL (1) IL276813B2 (https=)
MX (1) MX2020009290A (https=)
MY (1) MY205512A (https=)
PE (1) PE20210452A1 (https=)
PH (1) PH12020551352A1 (https=)
SG (1) SG11202008113RA (https=)
UA (1) UA127897C2 (https=)
WO (1) WO2019173188A1 (https=)
ZA (1) ZA202006006B (https=)

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EP3810615B1 (en) * 2018-06-20 2026-01-28 Merck Sharp & Dohme LLC Arginase inhibitors and methods of use
ES3034676T3 (en) 2018-11-16 2025-08-21 Arcus Biosciences Inc Inhibitors of arg1 and/or arg2
US12240867B2 (en) 2018-12-18 2025-03-04 Merck Sharp & Dohme Llc Arginase inhibitors and methods of use
AU2021292195A1 (en) 2020-06-17 2023-01-05 Arcus Biosciences, Inc. Crystalline forms of a CD73 inhibitor and uses thereof
TW202228720A (zh) 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 精胺酸酶抑制劑及其使用方法
WO2023077046A1 (en) 2021-10-29 2023-05-04 Arcus Biosciences, Inc. Inhibitors of hif-2alpha and methods of use thereof
CA3256561A1 (en) 2022-05-02 2023-11-09 Arcus Biosciences, Inc. Anti-tigit antibodies and their uses
EP4554680A1 (en) 2022-07-15 2025-05-21 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
US20260028336A1 (en) 2022-07-20 2026-01-29 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
CN119768155A (zh) 2022-09-14 2025-04-04 艾库斯生物科学有限公司 依曲地南的分散体
WO2024081385A1 (en) 2022-10-14 2024-04-18 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
EP4604920A1 (en) 2022-10-20 2025-08-27 Arcus Biosciences, Inc. Lyophilized formulations of cd73 compounds
EP4705292A1 (en) 2023-05-05 2026-03-11 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
US20250011318A1 (en) 2023-05-25 2025-01-09 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2025076299A1 (en) 2023-10-06 2025-04-10 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2025193759A1 (en) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Solid forms of an azolopyrimidine compound

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Also Published As

Publication number Publication date
PH12020551352A1 (en) 2021-06-21
ZA202006006B (en) 2025-02-26
PE20210452A1 (es) 2021-03-08
JP2021516237A (ja) 2021-07-01
JP7402167B2 (ja) 2023-12-20
CR20200445A (es) 2021-04-27
MY205512A (en) 2024-10-24
IL276813A (en) 2020-10-29
EP3761992A4 (en) 2021-11-24
CA3091805A1 (en) 2019-09-12
KR102656571B1 (ko) 2024-04-11
IL276813B1 (en) 2024-05-01
CO2020012060A2 (es) 2021-01-18
EP3761992A1 (en) 2021-01-13
AU2019229978A1 (en) 2020-10-15
US20210002306A1 (en) 2021-01-07
US12054500B2 (en) 2024-08-06
MX2020009290A (es) 2020-09-28
SG11202008113RA (en) 2020-09-29
BR112020017604A2 (pt) 2020-12-22
KR20200128117A (ko) 2020-11-11
CN111818928A (zh) 2020-10-23
IL276813B2 (en) 2024-09-01
EA202092086A1 (ru) 2021-02-09
CL2020002271A1 (es) 2021-04-09
WO2019173188A1 (en) 2019-09-12
UA127897C2 (uk) 2024-02-07

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