AU2018392325A1 - Cyclohexyl acid triazole azoles as LPA antagonists - Google Patents
Cyclohexyl acid triazole azoles as LPA antagonists Download PDFInfo
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- AU2018392325A1 AU2018392325A1 AU2018392325A AU2018392325A AU2018392325A1 AU 2018392325 A1 AU2018392325 A1 AU 2018392325A1 AU 2018392325 A AU2018392325 A AU 2018392325A AU 2018392325 A AU2018392325 A AU 2018392325A AU 2018392325 A1 AU2018392325 A1 AU 2018392325A1
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- Prior art keywords
- alkyl
- lpa
- fibrosis
- haloalkyl
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2018/066123 WO2019126094A1 (en) | 2017-12-19 | 2018-12-18 | Cyclohexyl acid triazole azoles as lpa antagonists |
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| PE20210655A1 (es) | 2017-12-19 | 2021-03-31 | Bristol Myers Squibb Co | Carbamoil ciclohexil acidos ligados a n de triazol como antagonistas de lpa |
| WO2019126089A1 (en) * | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Cyclohexyl acid pyrazole azines as lpa antagonists |
| CN113260310A (zh) * | 2018-10-15 | 2021-08-13 | 百时美施贵宝公司 | 用于成像lpa1受体的放射性配体 |
| CN111434653A (zh) | 2019-01-15 | 2020-07-21 | 武汉朗来科技发展有限公司 | 三氮唑类化合物及其制备方法与用途 |
| EP3986553A1 (en) | 2019-06-18 | 2022-04-27 | Bristol-Myers Squibb Company | Cyclobutyl carboxylic acids as lpa antagonists |
| CN114728168B (zh) | 2019-11-15 | 2024-04-09 | 吉利德科学公司 | 三唑氨基甲酸酯吡啶基磺酰胺作为lpa受体拮抗剂及其用途 |
| AU2021282986B2 (en) | 2020-06-03 | 2024-03-07 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
| TWI838626B (zh) | 2020-06-03 | 2024-04-11 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| KR20240068583A (ko) * | 2020-08-11 | 2024-05-17 | 비바 스타 바이오사이언시스 리미티드 | Lpa 수용체 길항제로서의 트리아졸-피리디닐 치환된 아자시클로헥실 아세트산 화합물 |
| US20240018102A1 (en) * | 2020-10-22 | 2024-01-18 | Lhotse Bio, Inc | Compounds and compositions for treating conditions associated with lpa receptor activity |
| CN114621135B (zh) * | 2020-12-11 | 2024-01-30 | 上海拓界生物医药科技有限公司 | 一种lpa1小分子拮抗剂 |
| KR20240005892A (ko) | 2021-05-11 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제 및 이의 용도 |
| WO2023016521A1 (zh) * | 2021-08-12 | 2023-02-16 | 上海赛默罗生物科技有限公司 | 取代三唑类衍生物、其制备方法、药物组合物和用途 |
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| TW202342017A (zh) | 2022-02-25 | 2023-11-01 | 美商洛子峰生物有限公司 | 用於治療與ｌｐａ受體活性相關的病狀的化合物及組合物 |
| CN115785014B (zh) * | 2022-12-27 | 2025-01-24 | 瑞石生物医药有限公司 | 四唑衍生物及其用途 |
| US12359594B2 (en) | 2023-08-01 | 2025-07-15 | Discovery Energy, Llc | Convertible silencer |
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| DE60234318D1 (de) | 2001-02-08 | 2009-12-24 | Ono Pharmaceutical Co | Mittel zur behandlung von harnwegserkrankungen, umfassend mittel zur kontrolle des lpa-rezeptors |
| DE102004038403B4 (de) | 2004-08-07 | 2006-08-31 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 3-Hydroxycyclohexancarbonsäure-Derivaten |
| US20080186971A1 (en) | 2007-02-02 | 2008-08-07 | Tarari, Inc. | Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic |
| CA2720490A1 (en) * | 2008-04-04 | 2009-10-08 | Irm Llc | Compounds and compositions as itpkb inhibitors |
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| GB2474120B (en) | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
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| BR112013014019A2 (pt) | 2010-12-07 | 2016-09-13 | Amira Pharmaceuticals Inc | antagonistas do receptor do ácido lisofosfatídico e seus usos |
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| JP5976011B2 (ja) | 2011-04-05 | 2016-08-23 | 武田薬品工業株式会社 | スルホンアミド誘導体およびその用途 |
| WO2012138648A1 (en) * | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions and methods for modulating lpa receptors |
| MX356683B (es) * | 2011-09-27 | 2018-06-08 | Genfit | Derivados de triazolpiridazinas 6-sustituidas como agonistas rev-erb. |
| WO2013070879A1 (en) | 2011-11-10 | 2013-05-16 | Bristol-Myers Squibb Company | Methods for treating spinal cord injury with lpa receptor antagonists |
| US20140329871A1 (en) | 2011-12-04 | 2014-11-06 | Angion Biomedica Corp. | Small molecule anti-fibrotic compounds and uses thereof |
| US9187474B2 (en) | 2012-03-07 | 2015-11-17 | Deciphera Pharmaceuticals, Llc | Raf inhibitor compounds |
| EA201492285A1 (ru) * | 2012-06-20 | 2015-04-30 | Ф. Хоффманн-Ля Рош Аг | Соединения n-алкилтриазола в качестве антагонистов лизофосфатидной кислоты (lpar) |
| CA2869564A1 (en) | 2012-06-20 | 2013-12-27 | F. Hoffmann-La Roche Ag | N-aryltriazole compounds as lpar antagonists |
| JP6853619B2 (ja) * | 2015-01-16 | 2021-03-31 | 大塚製薬株式会社 | シアノトリアゾール化合物の医薬用途 |
| AR108838A1 (es) * | 2016-06-21 | 2018-10-03 | Bristol Myers Squibb Co | Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa |
| PE20210655A1 (es) | 2017-12-19 | 2021-03-31 | Bristol Myers Squibb Co | Carbamoil ciclohexil acidos ligados a n de triazol como antagonistas de lpa |
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| BR112020012177A2 (pt) | 2020-11-24 |
| US11319315B2 (en) | 2022-05-03 |
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| WO2019126094A1 (en) | 2019-06-27 |
| KR20200100713A (ko) | 2020-08-26 |
| US20210163470A1 (en) | 2021-06-03 |
| CA3085938A1 (en) | 2019-06-27 |
| JP7280881B2 (ja) | 2023-05-24 |
| EA202091505A1 (ru) | 2020-09-22 |
| IL275363A (en) | 2020-07-30 |
| ES2938863T3 (es) | 2023-04-17 |
| MX2020005818A (es) | 2020-08-20 |
| TW201927778A (zh) | 2019-07-16 |
| JP2021507900A (ja) | 2021-02-25 |
| CN111712492A (zh) | 2020-09-25 |
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