AU2018378078A1 - IL-2 muteins and uses thereof - Google Patents
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- AU2018378078A1 AU2018378078A1 AU2018378078A AU2018378078A AU2018378078A1 AU 2018378078 A1 AU2018378078 A1 AU 2018378078A1 AU 2018378078 A AU2018378078 A AU 2018378078A AU 2018378078 A AU2018378078 A AU 2018378078A AU 2018378078 A1 AU2018378078 A1 AU 2018378078A1
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
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- Public Health (AREA)
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
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- Zoology (AREA)
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- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
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- Rheumatology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (11)
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| US201762595357P | 2017-12-06 | 2017-12-06 | |
| US62/595,357 | 2017-12-06 | ||
| US201862675972P | 2018-05-24 | 2018-05-24 | |
| US62/675,972 | 2018-05-24 | ||
| US201862721644P | 2018-08-23 | 2018-08-23 | |
| US62/721,644 | 2018-08-23 | ||
| US16/109,897 US10174092B1 (en) | 2017-12-06 | 2018-08-23 | IL-2 muteins |
| US16/109,897 | 2018-08-23 | ||
| US16/109,875 | 2018-08-23 | ||
| US16/109,875 US10174091B1 (en) | 2017-12-06 | 2018-08-23 | IL-2 muteins |
| PCT/US2018/062808 WO2019112854A1 (fr) | 2017-12-06 | 2018-11-28 | Mutéines d'il-2 et leurs utilisations |
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| EP (1) | EP3720470A4 (fr) |
| JP (1) | JP7250790B2 (fr) |
| KR (2) | KR20200097275A (fr) |
| CN (1) | CN111432831A (fr) |
| AU (1) | AU2018378078A1 (fr) |
| BR (1) | BR112020011343A2 (fr) |
| CA (1) | CA3083941A1 (fr) |
| IL (1) | IL274844A (fr) |
| MX (1) | MX2020005208A (fr) |
| SG (1) | SG11202003965VA (fr) |
| WO (1) | WO2019112854A1 (fr) |
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| CA3056630A1 (fr) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Immunotolerance ciblee |
| CA3064435A1 (fr) | 2017-05-24 | 2018-11-29 | Pandion Therapeutics, Inc. | Immunotolerance ciblee |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| BR112021023345A2 (pt) | 2019-05-20 | 2022-02-01 | Pandion Operations Inc | Imunotolerância com alvo em madcam |
| WO2021034890A1 (fr) * | 2019-08-19 | 2021-02-25 | Pandion Therapeutics, Inc. | Immunotolérance ciblée avec un agoniste de pd-1 |
| CN110642934B (zh) * | 2019-09-10 | 2022-08-23 | 中国医学科学院北京协和医院 | 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用 |
| WO2021076805A1 (fr) | 2019-10-15 | 2021-04-22 | Moderna TX, Inc. | Arnm codant des polypeptides de modulation immunitaire et leurs utilisations |
| CN112358540A (zh) * | 2020-11-03 | 2021-02-12 | 安徽环球基因科技有限公司 | 一种重组il2在毕赤酵母中的生产方法 |
| TW202345889A (zh) * | 2022-03-03 | 2023-12-01 | 大陸商海南先聲藥業有限公司 | ＩＬ２突變體－抗體Ｆｃ嵌段融合蛋白的藥物組合物及其應用 |
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| CN1007907B (zh) * | 1985-04-30 | 1990-05-09 | 弗·哈夫曼-拉罗彻有限公司 | 重组人类白细胞介素-2的提纯 |
| WO2005007121A2 (fr) * | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Polypeptides de l'interleukine-2(il-2) mutante |
| US9428567B2 (en) * | 2010-12-22 | 2016-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Antagonists of interleukin-2 receptor |
| US20140170153A1 (en) * | 2011-05-31 | 2014-06-19 | Novo Nordisk A/S | Il-21 epitope and il-21 ligands |
| US9546203B2 (en) * | 2013-03-14 | 2017-01-17 | Amgen Inc. | Aglycosylated Fc-containing polypeptides with cysteine substitutions |
| SG10202010158TA (en) * | 2014-07-21 | 2020-11-27 | Delinia Inc | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| KR20180133198A (ko) * | 2016-05-04 | 2018-12-13 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
| WO2018184965A1 (fr) * | 2017-04-03 | 2018-10-11 | F. Hoffmann-La Roche Ag | Immunoconjugués d'il-2 avec un anticorps bispécifique anti-pd-1 et tim-3 |
| CA3064435A1 (fr) * | 2017-05-24 | 2018-11-29 | Pandion Therapeutics, Inc. | Immunotolerance ciblee |
| WO2019112852A1 (fr) * | 2017-12-06 | 2019-06-13 | Pandion Therapeutics, Inc. | Immunotolérance ciblée |
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2018
- 2018-11-28 SG SG11202003965VA patent/SG11202003965VA/en unknown
- 2018-11-28 WO PCT/US2018/062808 patent/WO2019112854A1/fr unknown
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- 2018-11-28 BR BR112020011343-3A patent/BR112020011343A2/pt unknown
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| Publication number | Publication date |
|---|---|
| WO2019112854A1 (fr) | 2019-06-13 |
| EP3720470A4 (fr) | 2021-09-15 |
| CN111432831A (zh) | 2020-07-17 |
| JP2021507690A (ja) | 2021-02-25 |
| BR112020011343A2 (pt) | 2020-11-17 |
| MX2020005208A (es) | 2020-08-20 |
| KR20200097275A (ko) | 2020-08-18 |
| KR20240039201A (ko) | 2024-03-26 |
| IL274844A (en) | 2020-07-30 |
| SG11202003965VA (en) | 2020-06-29 |
| EP3720470A1 (fr) | 2020-10-14 |
| CA3083941A1 (fr) | 2019-06-13 |
| JP7250790B2 (ja) | 2023-04-03 |
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| HB | Alteration of name in register |
Owner name: PANDION OPERATIONS, INC. Free format text: FORMER NAME(S): PANDION THERAPEUTICS, INC. |