AU2018354418B2 - Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene - Google Patents
Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluoreneInfo
- Publication number
- AU2018354418B2 AU2018354418B2 AU2018354418A AU2018354418A AU2018354418B2 AU 2018354418 B2 AU2018354418 B2 AU 2018354418B2 AU 2018354418 A AU2018354418 A AU 2018354418A AU 2018354418 A AU2018354418 A AU 2018354418A AU 2018354418 B2 AU2018354418 B2 AU 2018354418B2
- Authority
- AU
- Australia
- Prior art keywords
- cells
- compound
- formula
- nrb
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/70—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/30—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/48—Halogenated derivatives
- C07C35/52—Alcohols with a condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
- C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
- C07C49/675—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having three rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/16—Acetic acid esters of dihydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/28—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/46—Amines, e.g. putrescine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762578297P | 2017-10-27 | 2017-10-27 | |
| US62/578,297 | 2017-10-27 | ||
| US201762583328P | 2017-11-08 | 2017-11-08 | |
| US62/583,328 | 2017-11-08 | ||
| PCT/US2018/057783 WO2019084452A1 (en) | 2017-10-27 | 2018-10-26 | COMPOSITIONS AND METHODS FOR PRODUCING EXPANDED HEMATOPOIETIC STEM CELLS USING FLUORENE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2018354418A1 AU2018354418A1 (en) | 2020-05-14 |
| AU2018354418B2 true AU2018354418B2 (en) | 2025-09-11 |
Family
ID=66247033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018354418A Active AU2018354418B2 (en) | 2017-10-27 | 2018-10-26 | Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11459293B2 (https=) |
| EP (1) | EP3700334B1 (https=) |
| JP (2) | JP2021501198A (https=) |
| KR (1) | KR102770289B1 (https=) |
| CN (1) | CN111885914B (https=) |
| AU (1) | AU2018354418B2 (https=) |
| CA (1) | CA3079959A1 (https=) |
| IL (1) | IL273978B2 (https=) |
| WO (1) | WO2019084452A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102488238B1 (ko) * | 2018-12-13 | 2023-01-13 | 동우 화인켐 주식회사 | 양자점, 이를 포함하는 양자점 발광다이오드, 양자점 필름, 광 변환 수지 조성물, 상기 광 변환 수지 조성물을 이용하여 형성되는 컬러필터, 광 변환 적층기재 및 상기 컬러필터 또는 상기 광 변환 적층기재를 포함하는 화상표시장치 |
| AU2020265737A1 (en) * | 2019-05-01 | 2021-12-02 | Immunebridge Inc. | Methods of making oligopotent and unipotent precursors |
| CA3138280A1 (en) * | 2019-05-01 | 2020-11-05 | Transfusion Health, Llc | Compositions and methods of making expanded hematopoietic stem cells using derivatives of carbazole |
| CN114787342A (zh) * | 2019-12-16 | 2022-07-22 | 广州辑因医疗科技有限公司 | 扩增造血干细胞的小分子化合物及其组合 |
| CN111019886B (zh) * | 2019-12-18 | 2023-02-03 | 卓越细胞工程(香港)有限公司 | 新的干性因子和其用于培养胚胎干细胞的方法或培养体系 |
Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3466274A (en) * | 1964-07-06 | 1969-09-09 | Manuf Prod Pharma | Fluoreno-(1,9-ef)-1,4-diazepine-1-oxides and 1,3-diazafluoranthene-1-oxides |
| GB1314899A (en) * | 1970-07-28 | 1973-04-26 | Sterling Winthrop Group Ltd | Thiosemicarbazones processes for their preparations and compositions incorporating them |
| EP0005288A1 (en) * | 1978-04-21 | 1979-11-14 | Chimac Societe Anonyme | Derivatives of 1-amino-fluoren-9-one and their use as herbicides |
| WO1994005276A1 (en) * | 1992-09-08 | 1994-03-17 | Morgan Lee R | Cytotoxic compounds |
| JPH0761949A (ja) * | 1993-06-18 | 1995-03-07 | Otsuka Pharmaceut Co Ltd | 中枢及び末梢神経変性修復又は保護剤 |
| WO2004032975A2 (en) * | 2002-10-04 | 2004-04-22 | The Trustees Of The University Of Pennsylvania | Biphenyls and fluorenes as imaging agents in alzheimer's disease |
| WO2005079845A1 (ja) * | 2004-02-20 | 2005-09-01 | Astellas Pharma Inc. | 片頭痛予防薬 |
| JP2008511156A (ja) * | 2004-09-24 | 2008-04-10 | エルジー・ケム・リミテッド | 新しい有機発光素子材料およびこれを用いた有機発光素子(7) |
| CN101418269A (zh) * | 2008-09-27 | 2009-04-29 | 大连理工大学 | 一种链霉菌及其在还原芳香酮中的应用 |
| JP2010538968A (ja) * | 2007-06-01 | 2010-12-16 | ザ トラスティーズ オブ プリンストン ユニバーシティ | 宿主細胞代謝経路の調節によるウイルス感染治療 |
| CN102174320A (zh) * | 2011-03-17 | 2011-09-07 | 上海大学 | 具有扭曲结构的蓝色电致发光材料及其制备方法 |
| CN103086859A (zh) * | 2011-11-08 | 2013-05-08 | 清华大学 | 2,4-二羟基-5,6-取代-1-卤代苯衍生物、其合成方法及其应用 |
| US20140135359A1 (en) * | 2012-11-12 | 2014-05-15 | Louis C. Martineau | Methods of designing, preparing, and using novel protonophores |
| CN104557862A (zh) * | 2014-12-15 | 2015-04-29 | 苏州云轩医药科技有限公司 | 具有Wnt信号通路抑制活性的杂环化合物 |
| JP2015515448A (ja) * | 2012-02-27 | 2015-05-28 | ブリティッシュ コロンビア キャンサー エイジェンシー ブランチBritish Columbia Cancer Agency Branch | 癌におけるエピジェネティックな欠陥を修復するためのエフェクタータンパク質相互作用のリプログラミング |
| JP2016538306A (ja) * | 2013-11-27 | 2016-12-08 | アメリカ合衆国 | 複素環化合物及びその使用方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947593A (en) * | 1973-06-15 | 1976-03-30 | Richardson-Merrell Inc. | Pharmaceutically useful bis-amine derivatives |
| DK575387A (da) * | 1986-11-04 | 1988-05-05 | Otsuka Pharma Co Ltd | Hydrofluorenderivater, fremgangsmaade til fremstilling deraf og praeparater indeholdende saadanne forbindelser |
| JP2622197B2 (ja) * | 1990-03-01 | 1997-06-18 | 三共株式会社 | 13−エーテル置換ミルベマイシン誘導体 |
| AU700386B2 (en) * | 1995-10-16 | 1999-01-07 | Kyowa Hakko Kogyo Co. Ltd. | Triciclic compounds |
| CO5170528A1 (es) * | 1999-05-28 | 2002-06-27 | Smithkline Beecham Corp | Antagonistas de los receptores de la il-8 nistas del recpetor de la il-8 |
| US20020035104A1 (en) * | 2000-08-18 | 2002-03-21 | Genentech, Inc. | Integrin receptor inhibitors |
| BRPI0116728B1 (pt) * | 2001-01-05 | 2018-10-30 | Pfizer Inc. | anticorpos para receptor de fator de crescimento i semelhante à insulina |
| BRPI0410439A (pt) * | 2003-05-19 | 2006-06-06 | Irm Llc | compostos e composições imunossupressoras |
| WO2005032598A1 (en) * | 2003-10-02 | 2005-04-14 | The General Hospital Corporation | Polybiotin compounds for magnetic resonance imagining and drug delivery |
| EP1755574A4 (en) | 2004-04-06 | 2009-05-13 | Semafore Pharmaceuticals Inc | PTEN INHIBITORS |
| WO2007016762A1 (en) * | 2005-08-10 | 2007-02-15 | Quest Pharmatech Inc. | Perylenequinone derivatives and uses thereof |
| SI2032606T1 (sl) * | 2006-05-30 | 2014-02-28 | Genentech, Inc. | Protitelesa in imunokonjugati in njihove uporabe |
| CN101506154B (zh) * | 2006-08-21 | 2015-06-17 | 辛塔制药公司 | 用于治疗增生性疾病的化合物 |
| EP2148569B1 (en) * | 2007-04-23 | 2014-07-16 | Stowers Institute for Medical Research | Methods and compositions for hematopoeitic stem cell self-renewal |
| TW200916472A (en) * | 2007-06-20 | 2009-04-16 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
| JP5645658B2 (ja) * | 2007-07-10 | 2014-12-24 | カーネギー メロン ユニバーシティー | 核磁気共鳴技術のための細胞標識を製造するための組成物及び方法 |
| AU2008305581C1 (en) * | 2007-09-26 | 2014-12-11 | Celgene Corporation | 6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same |
| FR2929276B1 (fr) * | 2008-04-01 | 2010-04-23 | Servier Lab | Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US20100310456A1 (en) * | 2009-06-04 | 2010-12-09 | General Electric Company | Imaging of myelin basic protein |
| JP5761718B2 (ja) * | 2009-08-07 | 2015-08-12 | 国立大学法人東京農工大学 | 新規糖転移酵素、新規糖転移酵素遺伝子および新規糖供与体化合物 |
| JP5984217B2 (ja) | 2010-06-15 | 2016-09-06 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 少量の末梢血からの人工多能性幹細胞の作製 |
| MX344772B (es) * | 2011-01-28 | 2017-01-06 | Univ Kentucky Res Found | Analogos de estilbeno y metodos para tratar cancer. |
| WO2013033206A2 (en) * | 2011-08-29 | 2013-03-07 | University Of Rochester | Compositions and methods for inhibiting ccl3 |
| CA2946446C (en) * | 2014-04-22 | 2020-11-03 | Universite De Montreal | Pyrido-pyrrolo-pyrimidine and pyrido-indole compounds, pharmaceutical compositions containing same and their use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells |
| US20200155609A1 (en) | 2017-05-22 | 2020-05-21 | Transfusion Health Llc | Compositions and methods of making expanded hematopoietic stem cells using pten inhibitors |
-
2018
- 2018-10-26 AU AU2018354418A patent/AU2018354418B2/en active Active
- 2018-10-26 CA CA3079959A patent/CA3079959A1/en active Pending
- 2018-10-26 JP JP2020543247A patent/JP2021501198A/ja active Pending
- 2018-10-26 EP EP18870471.2A patent/EP3700334B1/en active Active
- 2018-10-26 KR KR1020207014934A patent/KR102770289B1/ko active Active
- 2018-10-26 IL IL273978A patent/IL273978B2/en unknown
- 2018-10-26 WO PCT/US2018/057783 patent/WO2019084452A1/en not_active Ceased
- 2018-10-26 US US16/758,396 patent/US11459293B2/en active Active
- 2018-10-26 CN CN201880083616.6A patent/CN111885914B/zh active Active
-
2022
- 2022-08-18 US US17/820,874 patent/US20230112489A1/en active Pending
-
2023
- 2023-11-24 JP JP2023198957A patent/JP2024015035A/ja active Pending
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3466274A (en) * | 1964-07-06 | 1969-09-09 | Manuf Prod Pharma | Fluoreno-(1,9-ef)-1,4-diazepine-1-oxides and 1,3-diazafluoranthene-1-oxides |
| GB1314899A (en) * | 1970-07-28 | 1973-04-26 | Sterling Winthrop Group Ltd | Thiosemicarbazones processes for their preparations and compositions incorporating them |
| EP0005288A1 (en) * | 1978-04-21 | 1979-11-14 | Chimac Societe Anonyme | Derivatives of 1-amino-fluoren-9-one and their use as herbicides |
| WO1994005276A1 (en) * | 1992-09-08 | 1994-03-17 | Morgan Lee R | Cytotoxic compounds |
| JPH0761949A (ja) * | 1993-06-18 | 1995-03-07 | Otsuka Pharmaceut Co Ltd | 中枢及び末梢神経変性修復又は保護剤 |
| WO2004032975A2 (en) * | 2002-10-04 | 2004-04-22 | The Trustees Of The University Of Pennsylvania | Biphenyls and fluorenes as imaging agents in alzheimer's disease |
| WO2005079845A1 (ja) * | 2004-02-20 | 2005-09-01 | Astellas Pharma Inc. | 片頭痛予防薬 |
| JP2008511156A (ja) * | 2004-09-24 | 2008-04-10 | エルジー・ケム・リミテッド | 新しい有機発光素子材料およびこれを用いた有機発光素子(7) |
| JP2010538968A (ja) * | 2007-06-01 | 2010-12-16 | ザ トラスティーズ オブ プリンストン ユニバーシティ | 宿主細胞代謝経路の調節によるウイルス感染治療 |
| CN101418269A (zh) * | 2008-09-27 | 2009-04-29 | 大连理工大学 | 一种链霉菌及其在还原芳香酮中的应用 |
| CN102174320A (zh) * | 2011-03-17 | 2011-09-07 | 上海大学 | 具有扭曲结构的蓝色电致发光材料及其制备方法 |
| CN103086859A (zh) * | 2011-11-08 | 2013-05-08 | 清华大学 | 2,4-二羟基-5,6-取代-1-卤代苯衍生物、其合成方法及其应用 |
| JP2015515448A (ja) * | 2012-02-27 | 2015-05-28 | ブリティッシュ コロンビア キャンサー エイジェンシー ブランチBritish Columbia Cancer Agency Branch | 癌におけるエピジェネティックな欠陥を修復するためのエフェクタータンパク質相互作用のリプログラミング |
| US20140135359A1 (en) * | 2012-11-12 | 2014-05-15 | Louis C. Martineau | Methods of designing, preparing, and using novel protonophores |
| JP2016538306A (ja) * | 2013-11-27 | 2016-12-08 | アメリカ合衆国 | 複素環化合物及びその使用方法 |
| CN104557862A (zh) * | 2014-12-15 | 2015-04-29 | 苏州云轩医药科技有限公司 | 具有Wnt信号通路抑制活性的杂环化合物 |
Non-Patent Citations (12)
| Title |
|---|
| "RN 500538-48-7 REGISTRY", DATABASE REGISTRY [ONLINE] RETRIEVED FROM STN, JPN7022004895, 25 March 2003 (2003-03-25), pages 17 - 2022, ISSN: 0004898515 * |
| "RN 908823-02-9 REGISTRY", DATABASE REGISTRY [ONLINE] RETRIEVED FROM STN, JPN7022004896, 27 September 2006 (2006-09-27), pages 11 - 2022, ISSN: 0004898516 * |
| BICZOK, L. et al., Journal of Physical Chemistry A, 1999, Vol.103, No.20, p3837-3842 * |
| CAS Registry Entry Number 3096-50-2, 'Acetamide, N-(9-oxo-9H-fluoren-2-yl)-', Entry date 16 Nov 1984 * |
| DEI, S. et al., Bioorganic & Medicinal Chemistry, 2001 , Vol.9, No.10, p2673 - 2682 * |
| INAMI K. et al., 'Activation Mechanism of 2-Acetylamino-9-fluorenone as a Mutagen in Salmonella typhimurium', Genes and Environment, Vol. 30, No. 3 pp. 71-76 (2008) * |
| KEMNITZER, W. et al., Bioorganic & Medicinal Chemistry Letters, 2009 , Vol.19, No.11, p3045-3049 * |
| KUMAR, R. et al., Chemical Biology & Drug Design, 2016 , Vol.88, No.5, p730-739 * |
| LEE, S. et al., MedChemComm, 2015 , Vol.6, No.7, p1278-1284 * |
| LI, F. et al., Chemical Communications, 2006, Vol.8, p865-867 * |
| NISHIDA, S. et al., 'Oxidation of Secondary Benzylic Alcohols to Ketones and Benzylic Oxygenation of Alkylarenes with Hydrogen Peroxide in the Presence of Activated Carbon', Synlett 2012, vol. 23(11), pages 1683-1685 * |
| PAN, H-L. et al., Journal of Organic Chemistry ,1958 , Vol.23, No. 6, p799-803 * |
Also Published As
| Publication number | Publication date |
|---|---|
| IL273978B1 (en) | 2024-05-01 |
| CN111885914B (zh) | 2022-05-13 |
| IL273978B2 (en) | 2024-09-01 |
| KR20200094141A (ko) | 2020-08-06 |
| AU2018354418A1 (en) | 2020-05-14 |
| KR102770289B1 (ko) | 2025-02-19 |
| EP3700334A4 (en) | 2021-07-21 |
| US20200255371A1 (en) | 2020-08-13 |
| US20230112489A1 (en) | 2023-04-13 |
| EP3700334A1 (en) | 2020-09-02 |
| CN111885914A (zh) | 2020-11-03 |
| WO2019084452A1 (en) | 2019-05-02 |
| US11459293B2 (en) | 2022-10-04 |
| EP3700334B1 (en) | 2026-04-08 |
| CA3079959A1 (en) | 2018-10-26 |
| JP2021501198A (ja) | 2021-01-14 |
| IL273978A (en) | 2020-05-31 |
| JP2024015035A (ja) | 2024-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2018354418B2 (en) | Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene | |
| EP3609890B1 (en) | Aryl hydrocarbon receptor antagonists and uses thereof | |
| WO2008046072A2 (en) | Chemical inducers of neurogenesis | |
| CN111417640B (zh) | 化合物及其在干细胞和/或祖细胞扩增中的应用 | |
| AU2013212457A1 (en) | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells | |
| WO2018217567A1 (en) | Compositions and methods of making expanded hematopoietic stem cells using pten inhibitors | |
| KR20190039988A (ko) | 조혈 줄기 및 전구 세포의 생성, 증식 및 분화를 위한 치환된 아졸 유도체 | |
| CA3138280A1 (en) | Compositions and methods of making expanded hematopoietic stem cells using derivatives of carbazole | |
| US20220315895A1 (en) | Methods of making oligopotent and unipotent precursors | |
| KR101362639B1 (ko) | 중간엽 줄기세포의 연골 세포로의 분화 유도를 위한 화합물의 용도 | |
| CN120693400A (zh) | 自然杀伤细胞 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HB | Alteration of name in register |
Owner name: IMMUNEBRIDGE INC. Free format text: FORMER NAME(S): TRANSFUSION HEALTH, LLC |
|
| FGA | Letters patent sealed or granted (standard patent) |