KR102770289B1 - 플루오렌의 유도체를 이용하여 증대된 조혈 줄기 세포를 제조하는 조성물 및 방법 - Google Patents
플루오렌의 유도체를 이용하여 증대된 조혈 줄기 세포를 제조하는 조성물 및 방법 Download PDFInfo
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- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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| PCT/US2018/057783 WO2019084452A1 (en) | 2017-10-27 | 2018-10-26 | COMPOSITIONS AND METHODS FOR PRODUCING EXPANDED HEMATOPOIETIC STEM CELLS USING FLUORENE DERIVATIVES |
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| KR102488238B1 (ko) * | 2018-12-13 | 2023-01-13 | 동우 화인켐 주식회사 | 양자점, 이를 포함하는 양자점 발광다이오드, 양자점 필름, 광 변환 수지 조성물, 상기 광 변환 수지 조성물을 이용하여 형성되는 컬러필터, 광 변환 적층기재 및 상기 컬러필터 또는 상기 광 변환 적층기재를 포함하는 화상표시장치 |
| AU2020265737A1 (en) * | 2019-05-01 | 2021-12-02 | Immunebridge Inc. | Methods of making oligopotent and unipotent precursors |
| CA3138280A1 (en) * | 2019-05-01 | 2020-11-05 | Transfusion Health, Llc | Compositions and methods of making expanded hematopoietic stem cells using derivatives of carbazole |
| CN114787342A (zh) * | 2019-12-16 | 2022-07-22 | 广州辑因医疗科技有限公司 | 扩增造血干细胞的小分子化合物及其组合 |
| CN111019886B (zh) * | 2019-12-18 | 2023-02-03 | 卓越细胞工程(香港)有限公司 | 新的干性因子和其用于培养胚胎干细胞的方法或培养体系 |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994005276A1 (en) * | 1992-09-08 | 1994-03-17 | Morgan Lee R | Cytotoxic compounds |
| WO2005079845A1 (ja) * | 2004-02-20 | 2005-09-01 | Astellas Pharma Inc. | 片頭痛予防薬 |
| JP2008511156A (ja) * | 2004-09-24 | 2008-04-10 | エルジー・ケム・リミテッド | 新しい有機発光素子材料およびこれを用いた有機発光素子(7) |
| JP2010538968A (ja) * | 2007-06-01 | 2010-12-16 | ザ トラスティーズ オブ プリンストン ユニバーシティ | 宿主細胞代謝経路の調節によるウイルス感染治療 |
| CN103086859A (zh) * | 2011-11-08 | 2013-05-08 | 清华大学 | 2,4-二羟基-5,6-取代-1-卤代苯衍生物、其合成方法及其应用 |
| US20140135359A1 (en) * | 2012-11-12 | 2014-05-15 | Louis C. Martineau | Methods of designing, preparing, and using novel protonophores |
| CN104557862A (zh) * | 2014-12-15 | 2015-04-29 | 苏州云轩医药科技有限公司 | 具有Wnt信号通路抑制活性的杂环化合物 |
| JP2015515448A (ja) * | 2012-02-27 | 2015-05-28 | ブリティッシュ コロンビア キャンサー エイジェンシー ブランチBritish Columbia Cancer Agency Branch | 癌におけるエピジェネティックな欠陥を修復するためのエフェクタータンパク質相互作用のリプログラミング |
| JP2016538306A (ja) * | 2013-11-27 | 2016-12-08 | アメリカ合衆国 | 複素環化合物及びその使用方法 |
| JP2017513897A (ja) * | 2014-04-22 | 2017-06-01 | ウニヴェルシテ ド モントリオールUniversite De Montreal | 化合物および造血幹細胞および/または造血前駆細胞の増大におけるその使用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1120461A (en) * | 1964-07-06 | 1968-07-17 | Manuf Prod Pharma | Derivatives of fluoreno-[1,9-ef]1,4-diazepine-1-oxide |
| GB1314899A (en) * | 1970-07-28 | 1973-04-26 | Sterling Winthrop Group Ltd | Thiosemicarbazones processes for their preparations and compositions incorporating them |
| US3947593A (en) * | 1973-06-15 | 1976-03-30 | Richardson-Merrell Inc. | Pharmaceutically useful bis-amine derivatives |
| EP0005288A1 (en) * | 1978-04-21 | 1979-11-14 | Chimac Societe Anonyme | Derivatives of 1-amino-fluoren-9-one and their use as herbicides |
| DK575387A (da) * | 1986-11-04 | 1988-05-05 | Otsuka Pharma Co Ltd | Hydrofluorenderivater, fremgangsmaade til fremstilling deraf og praeparater indeholdende saadanne forbindelser |
| JP2622197B2 (ja) * | 1990-03-01 | 1997-06-18 | 三共株式会社 | 13−エーテル置換ミルベマイシン誘導体 |
| JP2807860B2 (ja) * | 1993-06-18 | 1998-10-08 | 大塚製薬株式会社 | フルオレノン誘導体 |
| AU700386B2 (en) * | 1995-10-16 | 1999-01-07 | Kyowa Hakko Kogyo Co. Ltd. | Triciclic compounds |
| CO5170528A1 (es) * | 1999-05-28 | 2002-06-27 | Smithkline Beecham Corp | Antagonistas de los receptores de la il-8 nistas del recpetor de la il-8 |
| US20020035104A1 (en) * | 2000-08-18 | 2002-03-21 | Genentech, Inc. | Integrin receptor inhibitors |
| BRPI0116728B1 (pt) * | 2001-01-05 | 2018-10-30 | Pfizer Inc. | anticorpos para receptor de fator de crescimento i semelhante à insulina |
| TW200413009A (en) * | 2002-10-04 | 2004-08-01 | Univ Pennsylvania | Biphenyls and fluorenes as imaging agents in alzheimer's disease |
| BRPI0410439A (pt) * | 2003-05-19 | 2006-06-06 | Irm Llc | compostos e composições imunossupressoras |
| WO2005032598A1 (en) * | 2003-10-02 | 2005-04-14 | The General Hospital Corporation | Polybiotin compounds for magnetic resonance imagining and drug delivery |
| EP1755574A4 (en) | 2004-04-06 | 2009-05-13 | Semafore Pharmaceuticals Inc | PTEN INHIBITORS |
| WO2007016762A1 (en) * | 2005-08-10 | 2007-02-15 | Quest Pharmatech Inc. | Perylenequinone derivatives and uses thereof |
| SI2032606T1 (sl) * | 2006-05-30 | 2014-02-28 | Genentech, Inc. | Protitelesa in imunokonjugati in njihove uporabe |
| CN101506154B (zh) * | 2006-08-21 | 2015-06-17 | 辛塔制药公司 | 用于治疗增生性疾病的化合物 |
| EP2148569B1 (en) * | 2007-04-23 | 2014-07-16 | Stowers Institute for Medical Research | Methods and compositions for hematopoeitic stem cell self-renewal |
| TW200916472A (en) * | 2007-06-20 | 2009-04-16 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
| JP5645658B2 (ja) * | 2007-07-10 | 2014-12-24 | カーネギー メロン ユニバーシティー | 核磁気共鳴技術のための細胞標識を製造するための組成物及び方法 |
| AU2008305581C1 (en) * | 2007-09-26 | 2014-12-11 | Celgene Corporation | 6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same |
| FR2929276B1 (fr) * | 2008-04-01 | 2010-04-23 | Servier Lab | Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN101418269B (zh) * | 2008-09-27 | 2010-12-01 | 大连理工大学 | 一种链霉菌及其在还原芳香酮中的应用 |
| US20100310456A1 (en) * | 2009-06-04 | 2010-12-09 | General Electric Company | Imaging of myelin basic protein |
| JP5761718B2 (ja) * | 2009-08-07 | 2015-08-12 | 国立大学法人東京農工大学 | 新規糖転移酵素、新規糖転移酵素遺伝子および新規糖供与体化合物 |
| JP5984217B2 (ja) | 2010-06-15 | 2016-09-06 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 少量の末梢血からの人工多能性幹細胞の作製 |
| MX344772B (es) * | 2011-01-28 | 2017-01-06 | Univ Kentucky Res Found | Analogos de estilbeno y metodos para tratar cancer. |
| CN102174320A (zh) * | 2011-03-17 | 2011-09-07 | 上海大学 | 具有扭曲结构的蓝色电致发光材料及其制备方法 |
| WO2013033206A2 (en) * | 2011-08-29 | 2013-03-07 | University Of Rochester | Compositions and methods for inhibiting ccl3 |
| US20200155609A1 (en) | 2017-05-22 | 2020-05-21 | Transfusion Health Llc | Compositions and methods of making expanded hematopoietic stem cells using pten inhibitors |
-
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- 2023-11-24 JP JP2023198957A patent/JP2024015035A/ja active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994005276A1 (en) * | 1992-09-08 | 1994-03-17 | Morgan Lee R | Cytotoxic compounds |
| WO2005079845A1 (ja) * | 2004-02-20 | 2005-09-01 | Astellas Pharma Inc. | 片頭痛予防薬 |
| JP2008511156A (ja) * | 2004-09-24 | 2008-04-10 | エルジー・ケム・リミテッド | 新しい有機発光素子材料およびこれを用いた有機発光素子(7) |
| JP2010538968A (ja) * | 2007-06-01 | 2010-12-16 | ザ トラスティーズ オブ プリンストン ユニバーシティ | 宿主細胞代謝経路の調節によるウイルス感染治療 |
| CN103086859A (zh) * | 2011-11-08 | 2013-05-08 | 清华大学 | 2,4-二羟基-5,6-取代-1-卤代苯衍生物、其合成方法及其应用 |
| JP2015515448A (ja) * | 2012-02-27 | 2015-05-28 | ブリティッシュ コロンビア キャンサー エイジェンシー ブランチBritish Columbia Cancer Agency Branch | 癌におけるエピジェネティックな欠陥を修復するためのエフェクタータンパク質相互作用のリプログラミング |
| US20140135359A1 (en) * | 2012-11-12 | 2014-05-15 | Louis C. Martineau | Methods of designing, preparing, and using novel protonophores |
| JP2016538306A (ja) * | 2013-11-27 | 2016-12-08 | アメリカ合衆国 | 複素環化合物及びその使用方法 |
| JP2017513897A (ja) * | 2014-04-22 | 2017-06-01 | ウニヴェルシテ ド モントリオールUniversite De Montreal | 化合物および造血幹細胞および/または造血前駆細胞の増大におけるその使用 |
| CN104557862A (zh) * | 2014-12-15 | 2015-04-29 | 苏州云轩医药科技有限公司 | 具有Wnt信号通路抑制活性的杂环化合物 |
Non-Patent Citations (8)
| Title |
|---|
| - Bioorganic & Medicinal Chemistry Letters, 2009, 19, 11, 3045-3049* |
| - Bioorganic & medicinal Chemistry, 2001, 9, 10, 2673-2682* |
| - Chemical Biology & Drug design, 2016, 88, 5, 730-739* |
| - DATABASE REGISTRY on STN, 2003년, RN 500538-48-7* |
| - DATABASE REGISTRY on STN, 2006년, RN 908823-02-9* |
| - Journal of organic chemistry, 1958, 23, 799-803* |
| - Journal of Physical Chemistry A, 1999, 103, 20, 3837-3842* |
| - MedChemComm, 2015, 6, 7, 1278-1284* |
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| AU2018354418B2 (en) | 2025-09-11 |
| IL273978B1 (en) | 2024-05-01 |
| CN111885914B (zh) | 2022-05-13 |
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| KR20200094141A (ko) | 2020-08-06 |
| AU2018354418A1 (en) | 2020-05-14 |
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| US20200255371A1 (en) | 2020-08-13 |
| US20230112489A1 (en) | 2023-04-13 |
| EP3700334A1 (en) | 2020-09-02 |
| CN111885914A (zh) | 2020-11-03 |
| WO2019084452A1 (en) | 2019-05-02 |
| US11459293B2 (en) | 2022-10-04 |
| EP3700334B1 (en) | 2026-04-08 |
| CA3079959A1 (en) | 2018-10-26 |
| JP2021501198A (ja) | 2021-01-14 |
| IL273978A (en) | 2020-05-31 |
| JP2024015035A (ja) | 2024-02-01 |
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