AU2018338178B2 - Glucagon-like peptide 1 receptor agonists and uses thereof - Google Patents

Glucagon-like peptide 1 receptor agonists and uses thereof Download PDF

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Publication number
AU2018338178B2
AU2018338178B2 AU2018338178A AU2018338178A AU2018338178B2 AU 2018338178 B2 AU2018338178 B2 AU 2018338178B2 AU 2018338178 A AU2018338178 A AU 2018338178A AU 2018338178 A AU2018338178 A AU 2018338178A AU 2018338178 B2 AU2018338178 B2 AU 2018338178B2
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glp1
ser
val
lys
gly
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AU2018338178A1 (en
Inventor
Samuel Davis
Jesper Gromada
Andrew J. Murphy
Haruka Okamoto
Yang Wei
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/082—Hepadnaviridae (F), e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
AU2018338178A 2017-09-22 2018-09-21 Glucagon-like peptide 1 receptor agonists and uses thereof Active AU2018338178B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023223010A AU2023223010B2 (en) 2017-09-22 2023-09-04 Glucagon-like peptide 1 receptor agonists and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762562283P 2017-09-22 2017-09-22
US62/562,283 2017-09-22
PCT/US2018/052110 WO2019060653A1 (en) 2017-09-22 2018-09-21 GLP-1 RECEPTOR AGONISTS (GLUCAGON-LIKE PEPTIDE 1) AND USES THEREOF

Related Child Applications (1)

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AU2023223010A Division AU2023223010B2 (en) 2017-09-22 2023-09-04 Glucagon-like peptide 1 receptor agonists and uses thereof

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AU2018338178A1 AU2018338178A1 (en) 2020-04-02
AU2018338178B2 true AU2018338178B2 (en) 2023-06-08

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US (4) US11045522B2 (enExample)
EP (1) EP3684793A1 (enExample)
JP (3) JP7239566B2 (enExample)
KR (1) KR102696518B1 (enExample)
CN (2) CN118955732A (enExample)
AU (2) AU2018338178B2 (enExample)
CA (1) CA3073964A1 (enExample)
EA (1) EA202090649A1 (enExample)
IL (2) IL304574B2 (enExample)
MX (1) MX2020002977A (enExample)
MY (2) MY200364A (enExample)
SG (1) SG11202001637PA (enExample)
WO (1) WO2019060653A1 (enExample)
ZA (1) ZA202001167B (enExample)

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EP3684793A1 (en) * 2017-09-22 2020-07-29 Regeneron Pharmaceuticals, Inc. Glucagon-like peptide 1 receptor agonists and uses thereof
US12122817B2 (en) * 2020-09-22 2024-10-22 Serpentide Inc. Long-lasting GLP1 analogue drug for type-2 diabetes
EP4257598A4 (en) * 2020-12-03 2024-10-30 Immunoforge Co., Ltd. FUSION PROTEIN COMPRISING A GLP-1 RECEPTOR AGONIST AND AN ANTI-OSCAR ANTIBODY, AND USE THEREOF
WO2022117044A1 (en) * 2020-12-03 2022-06-09 Sunshine Lake Pharma Co., Ltd. Glp-1/gcg dual receptor agonist polypeptide and fusion protein thereof
CN112716966B (zh) * 2021-02-03 2022-05-03 浙江诺得药业有限公司 一种恩格列净药用组合物及其制备方法
CN113461785B (zh) * 2021-04-13 2022-10-14 湖南中晟全肽生化有限公司 Glp-1受体激动剂及其应用
CN114874333B (zh) * 2021-10-18 2025-01-24 深圳科兴药业有限公司 一种生长激素融合蛋白及其应用
CN114788876B (zh) * 2022-02-24 2024-07-05 北京医院 治疗糖尿病的mRNA药物制剂及其制备方法与应用
KR20230156889A (ko) * 2022-05-04 2023-11-15 이뮤노포지 주식회사 GLP-1, 면역글로불린 Fc, 및 IGF-1을 포함하는 융합단백질 및 이의 용도
WO2024123812A1 (en) 2022-12-05 2024-06-13 Shattuck Labs, Inc. Fusion proteins for the treatment of cardiometabolic diseases
CN117143242B (zh) * 2023-10-30 2024-03-29 南京佰抗生物科技有限公司 抗Galectin-3蛋白的单克隆抗体组合物及应用
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
US20250270274A1 (en) * 2024-02-26 2025-08-28 Serpentide Inc. Super long-lasting glp1 or glp1/gip analogue drug for type-2 diabetes and obesity

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MY207828A (en) 2025-03-21
CA3073964A1 (en) 2019-03-28
US12090193B2 (en) 2024-09-17
JP2024178255A (ja) 2024-12-24
KR102696518B1 (ko) 2024-08-21
CN111108117B (zh) 2024-08-06
EP3684793A1 (en) 2020-07-29
US20250000949A1 (en) 2025-01-02
US20240024428A1 (en) 2024-01-25
EA202090649A1 (ru) 2020-06-29
JP2023071827A (ja) 2023-05-23
IL304574A (en) 2023-09-01
US11779633B2 (en) 2023-10-10
IL304574B2 (en) 2025-08-01
JP2020534016A (ja) 2020-11-26
AU2018338178A1 (en) 2020-04-02
CN111108117A (zh) 2020-05-05
MY200364A (en) 2023-12-21
JP7789871B2 (ja) 2025-12-22
US11045522B2 (en) 2021-06-29
MX2020002977A (es) 2020-11-06
IL273253B1 (en) 2024-03-01
AU2023223010A1 (en) 2023-11-09
KR20200054303A (ko) 2020-05-19
US20210283225A1 (en) 2021-09-16
SG11202001637PA (en) 2020-03-30
IL273253A (en) 2020-04-30
WO2019060653A1 (en) 2019-03-28
AU2023223010B2 (en) 2025-12-04
ZA202001167B (en) 2024-06-26
CN118955732A (zh) 2024-11-15
IL304574B1 (en) 2025-04-01
US20190091296A1 (en) 2019-03-28
IL273253B2 (en) 2024-07-01
JP7239566B2 (ja) 2023-03-14
JP7559112B2 (ja) 2024-10-01

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