AU2018331267B2 - Improved treatment of atopic dermatitis with tradipitant - Google Patents
Improved treatment of atopic dermatitis with tradipitant Download PDFInfo
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- AU2018331267B2 AU2018331267B2 AU2018331267A AU2018331267A AU2018331267B2 AU 2018331267 B2 AU2018331267 B2 AU 2018331267B2 AU 2018331267 A AU2018331267 A AU 2018331267A AU 2018331267 A AU2018331267 A AU 2018331267A AU 2018331267 B2 AU2018331267 B2 AU 2018331267B2
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- tradipitant
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- treatment
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US201762558303P | 2017-09-13 | 2017-09-13 | |
US62/558,303 | 2017-09-13 | ||
US201762572456P | 2017-10-14 | 2017-10-14 | |
US62/572,456 | 2017-10-14 | ||
PCT/US2018/048825 WO2019055225A1 (en) | 2017-09-13 | 2018-08-30 | ENHANCED TREATMENT OF ATOPIC DERMATITIS USING TRADIPITANT |
Publications (2)
Publication Number | Publication Date |
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AU2018331267A1 AU2018331267A1 (en) | 2020-04-16 |
AU2018331267B2 true AU2018331267B2 (en) | 2024-03-07 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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AU2018331267A Active AU2018331267B2 (en) | 2017-09-13 | 2018-08-30 | Improved treatment of atopic dermatitis with tradipitant |
Country Status (12)
Country | Link |
---|---|
US (1) | US11549147B2 (es) |
EP (1) | EP3681505A1 (es) |
JP (1) | JP7347743B2 (es) |
KR (1) | KR20200054232A (es) |
CN (1) | CN111093671A (es) |
AU (1) | AU2018331267B2 (es) |
BR (1) | BR112020004964A2 (es) |
CA (1) | CA3073998A1 (es) |
CL (1) | CL2020000655A1 (es) |
IL (1) | IL272949A (es) |
MX (1) | MX2020002852A (es) |
WO (1) | WO2019055225A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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BR112017018620A2 (pt) * | 2015-03-04 | 2018-04-17 | Vanda Pharmaceuticals Inc. | método de administração de tradipitanto, e, tradipitanto. |
US20210228555A1 (en) | 2018-06-08 | 2021-07-29 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
MX2022010437A (es) * | 2020-02-25 | 2022-09-07 | Vanda Pharmaceuticals Inc | Tratamiento mejorado de la dermatitis atopica con tradipitant. |
US20230145932A1 (en) | 2020-03-26 | 2023-05-11 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
US20220328808A1 (en) | 2020-05-07 | 2022-10-13 | Lg Energy Solution, Ltd. | High-nickel electrode sheet and method for manufacturing same |
WO2023034718A1 (en) | 2021-08-31 | 2023-03-09 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
Family Cites Families (15)
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---|---|---|---|---|
TW263498B (es) | 1993-11-10 | 1995-11-21 | Takeda Pharm Industry Co Ltd | |
CA2483159C (en) | 2002-04-26 | 2010-08-10 | Eli Lilly And Company | Triazole derivatives as tachykinin receptor antagonists |
BR0309486A (pt) | 2002-04-26 | 2005-02-09 | Lilly Co Eli | Composto ou um seu sal farmaceuticamente aceitável, composição farmacêutica, e, método para o tratamento de uma condição associada com um excesso de taquicininas |
JP2004250329A (ja) | 2002-12-26 | 2004-09-09 | Dainippon Pharmaceut Co Ltd | イサチン誘導体 |
US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
ES2340772T3 (es) | 2003-10-24 | 2010-06-09 | Eli Lilly And Company | Nuevas formas cristalinas (2-(1-(3,5-bis-trifluorometilbencil)-5-piridin-4-il-1h-(1,2,3)triazol-4-il)-piridin-3-il)-(2-clorofenil)-metadona. |
JP4673068B2 (ja) | 2005-01-19 | 2011-04-20 | 独立行政法人科学技術振興機構 | Th1型アレルギー疾患治療用組成物 |
DE102005006217B4 (de) | 2005-02-07 | 2007-08-16 | Universitätsklinikum Hamburg-Eppendorf | Diagnose von allergischen Erkrankungen und/oder atopischen Erkrankungen durch Nachweis von Autoantikörpern gegen CD28 in humanem Serum |
CA2643130A1 (en) | 2006-02-22 | 2007-08-30 | Valorisation Recherche Hscm, Limited Partnership | Compounds and methods of treating disorders associated with activation of metachromatic cells |
PT2121610E (pt) | 2006-12-20 | 2014-06-25 | Lilly Co Eli | Novos intermediários e processo útil para a preparação da {2-[1-(3,5-bis-trifluorometil-benzil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]-piridin-3-il}-(2-clorofenil)-metanona |
JP6644328B2 (ja) | 2013-02-28 | 2020-02-12 | ロート製薬株式会社 | アトピー性疾患の発症又は重症化リスクの評価法 |
US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
KR20160023692A (ko) | 2013-06-24 | 2016-03-03 | 타이거캣 파마, 인크. | 소양증에서의 nk-1 수용체 길항제 세를로피탄트의 용도 |
BR112017018620A2 (pt) * | 2015-03-04 | 2018-04-17 | Vanda Pharmaceuticals Inc. | método de administração de tradipitanto, e, tradipitanto. |
US10821099B2 (en) | 2018-09-28 | 2020-11-03 | Vanda Pharmaceuticals Inc. | Use of tradipitant in motion sickness |
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2018
- 2018-08-30 CN CN201880059276.3A patent/CN111093671A/zh active Pending
- 2018-08-30 KR KR1020207010029A patent/KR20200054232A/ko not_active Application Discontinuation
- 2018-08-30 US US16/644,567 patent/US11549147B2/en active Active
- 2018-08-30 EP EP18778635.5A patent/EP3681505A1/en active Pending
- 2018-08-30 MX MX2020002852A patent/MX2020002852A/es unknown
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2020
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- 2020-03-12 CL CL2020000655A patent/CL2020000655A1/es unknown
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US20210062262A1 (en) | 2021-03-04 |
JP7347743B2 (ja) | 2023-09-20 |
KR20200054232A (ko) | 2020-05-19 |
IL272949A (en) | 2020-04-30 |
BR112020004964A2 (pt) | 2020-09-15 |
RU2020112222A (ru) | 2021-10-13 |
MX2020002852A (es) | 2020-07-22 |
US11549147B2 (en) | 2023-01-10 |
EP3681505A1 (en) | 2020-07-22 |
JP2020533381A (ja) | 2020-11-19 |
WO2019055225A1 (en) | 2019-03-21 |
CL2020000655A1 (es) | 2020-10-09 |
CA3073998A1 (en) | 2019-03-21 |
CN111093671A (zh) | 2020-05-01 |
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