AU2018313253B2 - Truncated guinea pig L-asparaginase variants and methods of use - Google Patents

Truncated guinea pig L-asparaginase variants and methods of use Download PDF

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Publication number
AU2018313253B2
AU2018313253B2 AU2018313253A AU2018313253A AU2018313253B2 AU 2018313253 B2 AU2018313253 B2 AU 2018313253B2 AU 2018313253 A AU2018313253 A AU 2018313253A AU 2018313253 A AU2018313253 A AU 2018313253A AU 2018313253 B2 AU2018313253 B2 AU 2018313253B2
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seq
gpa
variant
asparaginase
truncated
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AU2018313253A
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AU2018313253A1 (en
Inventor
Arnon Lavie
Hien-Anh NGUYEN
Amanda SCHALK
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US Department of Veterans Affairs
University of Illinois System
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US Department of Veterans Affairs
University of Illinois at Urbana Champaign
University of Illinois System
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01001—Asparaginase (3.5.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2018313253A 2017-08-11 2018-08-10 Truncated guinea pig L-asparaginase variants and methods of use Active AU2018313253B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762544411P 2017-08-11 2017-08-11
US201762544396P 2017-08-11 2017-08-11
US62/544,396 2017-08-11
US62/544,411 2017-08-11
PCT/US2018/046196 WO2019032952A1 (en) 2017-08-11 2018-08-10 TRUNCATED VARIANTS OF INDIA PIG ASPARAGINASE AND METHODS OF USE

Publications (2)

Publication Number Publication Date
AU2018313253A1 AU2018313253A1 (en) 2020-02-27
AU2018313253B2 true AU2018313253B2 (en) 2024-09-26

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Family Applications (1)

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AU2018313253A Active AU2018313253B2 (en) 2017-08-11 2018-08-10 Truncated guinea pig L-asparaginase variants and methods of use

Country Status (8)

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US (1) US11578315B2 (https=)
EP (1) EP3664832B1 (https=)
JP (1) JP7744621B2 (https=)
CN (1) CN111050784B (https=)
AU (1) AU2018313253B2 (https=)
CA (1) CA3106549A1 (https=)
ES (1) ES2965372T3 (https=)
WO (1) WO2019032952A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114292853A (zh) * 2021-11-29 2022-04-08 国药集团动物保健股份有限公司 Sumo促溶表达标签及其应用、sumo促溶表达蛋白、重组菌株及蛋白的制备方法
CN114369173B (zh) * 2022-03-22 2022-07-08 中国农业科学院北京畜牧兽医研究所 一种利用融合蛋白标签促进人颗粒溶素及动物NK lysin在毕赤酵母中表达的方法
CN116459344B (zh) * 2023-04-28 2025-03-18 上海市生物医药技术研究院 一种MNSFβ/RC3H1 PPI干扰多肽的抗炎治疗应用
WO2025026424A1 (en) * 2023-08-02 2025-02-06 The Hong Kong Polytechnic University Bioengineered asparaginase fusion proteins
WO2025210068A1 (en) 2024-04-03 2025-10-09 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Activity-improved variants of human asparaginase 1

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0811687A2 (en) * 1996-06-07 1997-12-10 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Polypeptides having l-asparaginase activity
WO2012170640A1 (en) * 2011-06-07 2012-12-13 The Trustees Of Columbia University In The City Of New York Methods and compositions for trail-drug combination therapy

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US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US6267964B1 (en) 1989-08-01 2001-07-31 Affibody Technology Sweden Ab Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives
SE9002213D0 (sv) 1990-06-21 1990-06-21 Hightech Receptor Ab Albumin binding proteins
US5766897A (en) 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
US6565841B1 (en) 1991-03-15 2003-05-20 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
JP3721210B2 (ja) * 1995-02-08 2005-11-30 株式会社林原生物化学研究所 哺乳類のｌ−アスパラギナーゼをコードするｄｎａ
JP3819540B2 (ja) * 1996-06-07 2006-09-13 株式会社林原生物化学研究所 Ｌ−アスパラギナーゼ活性を有する哺乳類由来のポリペプチド
EP2180054A1 (en) 1999-12-24 2010-04-28 Genentech, Inc. Methods and compositions for prolonging elimination half-times of bioactive compounds
US20050287153A1 (en) 2002-06-28 2005-12-29 Genentech, Inc. Serum albumin binding peptides for tumor targeting
US20040001827A1 (en) 2002-06-28 2004-01-01 Dennis Mark S. Serum albumin binding peptides for tumor targeting
US20020065397A1 (en) 2000-10-12 2002-05-30 Joseph Roberts Protecting therapeutic compositions from host-mediated inactivation
WO2004112717A2 (en) * 2003-06-17 2004-12-29 Harrison Roger G Conjugate for the specific targeting of anticancer agents to cancer cells and production thereof
AU2004254600A1 (en) 2003-06-26 2005-01-13 Lifesensors, Inc. Methods and compositions for enhanced protein expression and purification
JP5634008B2 (ja) 2004-04-06 2014-12-03 アフィボディ・アーベー 新規の使用および方法
US7985548B2 (en) 2006-03-03 2011-07-26 The United States Of America As Represented By The Department Of Health And Human Services Materials and methods directed to asparagine synthetase and asparaginase therapies
EP1894940A1 (en) * 2006-08-28 2008-03-05 Apogenix GmbH TNF superfamily fusion proteins
WO2009002947A2 (en) 2007-06-22 2008-12-31 Affymax, Inc. Compounds and peptides that bind the trail receptor
BR112012003346A2 (pt) * 2009-08-15 2016-11-16 Genentech Inc metodo de tratamento de um paciente diagnostico com cancer de mama metastico previamente tratado kit para tratamento de cancer de mama metastatico previamente tratado em um paciente humano metodo para instruir um paciente humano com cancer metodo promocional e metodo comercial
WO2012075173A2 (en) * 2010-12-01 2012-06-07 Board Of Regents The University Of Texas System Compositions and method for deimmunization of proteins
CA2849705A1 (en) 2011-09-23 2013-03-28 Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa Modified albumin-binding domains and uses thereof to improve pharmacokinetics
CN103184209B (zh) * 2011-12-27 2015-09-16 拜奥生物科技（上海）有限公司 人精氨酸酶和聚乙二醇化人精氨酸酶及其应用
MX355041B (es) 2012-05-25 2018-03-28 Janssen Biotech Inc Dominios de union a albumina consenso no naturales.
NO2776305T3 (https=) * 2014-04-23 2018-01-27

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0811687A2 (en) * 1996-06-07 1997-12-10 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Polypeptides having l-asparaginase activity
WO2012170640A1 (en) * 2011-06-07 2012-12-13 The Trustees Of Columbia University In The City Of New York Methods and compositions for trail-drug combination therapy

Also Published As

Publication number Publication date
EP3664832B1 (en) 2023-10-18
WO2019032952A8 (en) 2019-07-25
JP2020530300A (ja) 2020-10-22
CN111050784B (zh) 2024-03-19
US20200239867A1 (en) 2020-07-30
JP7744621B2 (ja) 2025-09-26
EP3664832A1 (en) 2020-06-17
AU2018313253A1 (en) 2020-02-27
ES2965372T3 (es) 2024-04-15
EP3664832C0 (en) 2023-10-18
WO2019032952A1 (en) 2019-02-14
CA3106549A1 (en) 2019-02-14
US11578315B2 (en) 2023-02-14
CN111050784A (zh) 2020-04-21

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