AU2018307479A1 - Organic compounds - Google Patents
Organic compounds Download PDFInfo
- Publication number
- AU2018307479A1 AU2018307479A1 AU2018307479A AU2018307479A AU2018307479A1 AU 2018307479 A1 AU2018307479 A1 AU 2018307479A1 AU 2018307479 A AU2018307479 A AU 2018307479A AU 2018307479 A AU2018307479 A AU 2018307479A AU 2018307479 A1 AU2018307479 A1 AU 2018307479A1
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- Australia
- Prior art keywords
- disorder
- compound
- alkyl
- compounds
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000002894 organic compounds Chemical class 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 221
- 150000003839 salts Chemical class 0.000 claims abstract description 131
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- 238000011282 treatment Methods 0.000 claims abstract description 77
- 201000010099 disease Diseases 0.000 claims abstract description 13
- 150000001875 compounds Chemical class 0.000 claims description 406
- 239000003814 drug Substances 0.000 claims description 103
- 239000000203 mixture Substances 0.000 claims description 90
- 230000000694 effects Effects 0.000 claims description 88
- 125000000217 alkyl group Chemical group 0.000 claims description 77
- 208000035475 disorder Diseases 0.000 claims description 72
- 229940127240 opiate Drugs 0.000 claims description 49
- 208000002193 Pain Diseases 0.000 claims description 45
- 239000000556 agonist Substances 0.000 claims description 38
- 239000003085 diluting agent Substances 0.000 claims description 34
- 230000036407 pain Effects 0.000 claims description 34
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims description 28
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- 239000011159 matrix material Substances 0.000 claims description 25
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
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- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims description 13
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- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 claims description 9
- 239000004031 partial agonist Substances 0.000 claims description 9
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 claims description 9
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- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims description 8
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- 125000003545 alkoxy group Chemical group 0.000 claims description 7
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- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 claims description 6
- 229960004606 clomipramine Drugs 0.000 claims description 6
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 6
- 229940125425 inverse agonist Drugs 0.000 claims description 6
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims description 6
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- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims description 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 5
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 claims description 5
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims description 5
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims description 5
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 claims description 5
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- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims description 5
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- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 claims description 5
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- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 claims description 5
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- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims description 5
- 229960002073 sertraline Drugs 0.000 claims description 5
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims description 5
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- GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 claims description 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 4
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Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| KR20180099905A (ko) | 2016-01-26 | 2018-09-05 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| WO2018071233A1 (en) | 2016-10-12 | 2018-04-19 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| AU2018240540B2 (en) | 2017-03-24 | 2021-09-23 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| JP7224333B2 (ja) | 2017-07-26 | 2023-02-17 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| CN112040940A (zh) | 2018-03-23 | 2020-12-04 | 细胞内治疗公司 | 有机化合物 |
| JP2021536453A (ja) * | 2018-08-31 | 2021-12-27 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規方法 |
| US10695345B2 (en) | 2018-08-31 | 2020-06-30 | Intra-Cellular Therapies, Inc. | Pharmaceutical capsule compositions comprising lumateperone mono-tosylate |
| AU2019403149A1 (en) * | 2018-12-17 | 2021-07-08 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| WO2020131911A1 (en) * | 2018-12-17 | 2020-06-25 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| US20220088014A1 (en) * | 2019-01-23 | 2022-03-24 | Intra-Cellular Therapies, Inc. | Methods of treating addiction |
| US20220362241A1 (en) * | 2019-09-25 | 2022-11-17 | Intra-Cellular Therapies, Inc. | Novel methods |
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| WO2022132182A1 (en) * | 2020-12-18 | 2022-06-23 | Hung, Shu-Mei | Feed pipe height adjustment mechanism for livestock feeding systems |
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| US2490813A (en) | 1944-11-29 | 1949-12-13 | Standard Oil Co | Continuous process for making aryl amines |
| US3299078A (en) | 1962-10-01 | 1967-01-17 | Smith Kline French Lab | Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines |
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- 2018-07-20 AU AU2018307479A patent/AU2018307479A1/en active Pending
- 2018-07-20 JP JP2020503842A patent/JP7223742B2/ja active Active
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- 2018-07-20 CA CA3071119A patent/CA3071119A1/en active Pending
- 2018-07-20 US US16/634,055 patent/US11376249B2/en active Active
- 2018-07-20 KR KR1020207005454A patent/KR20200033307A/ko not_active Application Discontinuation
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|---|---|
| BR112020001666A2 (pt) | 2020-07-21 |
| EP3658145A4 (en) | 2021-04-21 |
| US20220296591A1 (en) | 2022-09-22 |
| CA3071119A1 (en) | 2019-01-31 |
| RU2020107841A3 (es) | 2021-09-27 |
| IL272249B2 (en) | 2023-11-01 |
| US20210145829A1 (en) | 2021-05-20 |
| MX2020000968A (es) | 2020-09-28 |
| JP2020528431A (ja) | 2020-09-24 |
| CN111093665A (zh) | 2020-05-01 |
| JP7223742B2 (ja) | 2023-02-16 |
| RU2020107841A (ru) | 2021-08-26 |
| US11376249B2 (en) | 2022-07-05 |
| WO2019023062A1 (en) | 2019-01-31 |
| IL272249B1 (en) | 2023-07-01 |
| KR20200033307A (ko) | 2020-03-27 |
| EP3658145A1 (en) | 2020-06-03 |
| IL272249A (en) | 2020-03-31 |
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