AU2018287519B2 - IL-1beta binding antibodies for use in treating cancer - Google Patents

IL-1beta binding antibodies for use in treating cancer Download PDF

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Publication number
AU2018287519B2
AU2018287519B2 AU2018287519A AU2018287519A AU2018287519B2 AU 2018287519 B2 AU2018287519 B2 AU 2018287519B2 AU 2018287519 A AU2018287519 A AU 2018287519A AU 2018287519 A AU2018287519 A AU 2018287519A AU 2018287519 B2 AU2018287519 B2 AU 2018287519B2
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Australia
Prior art keywords
cancer
canakinumab
functional fragment
patient
weeks
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AU2018287519A
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AU2018287519A1 (en
Inventor
Margaret DUGAN
Yi Yang Lau
Peter Libby
Monica LIGUEROS-SAYLAN
Patrice MATCHABA
Penelope OTTEWELL
Paul Ridker
Tom Thuren
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Novartis AG
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Novartis AG
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Priority to AU2021254559A priority Critical patent/AU2021254559A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
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    • A61K31/282—Platinum compounds
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/00114—Interleukins [IL]
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2018287519A 2017-06-22 2018-05-03 IL-1beta binding antibodies for use in treating cancer Ceased AU2018287519B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021254559A AU2021254559A1 (en) 2017-06-22 2021-10-19 Il-1beta binding antibodies for use in treating cancer

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201762523458P 2017-06-22 2017-06-22
US62/523,458 2017-06-22
US201762529515P 2017-07-07 2017-07-07
US62/529,515 2017-07-07
US201762550307P 2017-08-25 2017-08-25
US201762550325P 2017-08-25 2017-08-25
US62/550,307 2017-08-25
US62/550,325 2017-08-25
US201762596054P 2017-12-07 2017-12-07
US62/596,054 2017-12-07
US201862649631P 2018-03-29 2018-03-29
US62/649,631 2018-03-29
PCT/IB2018/053096 WO2018234879A1 (en) 2017-06-22 2018-05-03 USE OF IL-1β BINDING ANTIBODIES IN THE TREATMENT OF CANCER

Related Child Applications (1)

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AU2021254559A Division AU2021254559A1 (en) 2017-06-22 2021-10-19 Il-1beta binding antibodies for use in treating cancer

Publications (2)

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AU2018287519A1 AU2018287519A1 (en) 2019-11-07
AU2018287519B2 true AU2018287519B2 (en) 2021-07-22

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AU2018287519A Ceased AU2018287519B2 (en) 2017-06-22 2018-05-03 IL-1beta binding antibodies for use in treating cancer
AU2018288060A Ceased AU2018288060B2 (en) 2017-06-22 2018-06-22 IL-1beta binding antibodies for use in treating cancer
AU2021245184A Abandoned AU2021245184A1 (en) 2017-06-22 2021-10-07 Il-1beta binding antibodies for use in treating cancer
AU2021254559A Abandoned AU2021254559A1 (en) 2017-06-22 2021-10-19 Il-1beta binding antibodies for use in treating cancer

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AU2021245184A Abandoned AU2021245184A1 (en) 2017-06-22 2021-10-07 Il-1beta binding antibodies for use in treating cancer
AU2021254559A Abandoned AU2021254559A1 (en) 2017-06-22 2021-10-19 Il-1beta binding antibodies for use in treating cancer

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US (3) US20190048072A1 (enExample)
EP (1) EP3642234A1 (enExample)
JP (4) JP2020524694A (enExample)
KR (2) KR20200019865A (enExample)
CN (1) CN110831967A (enExample)
AU (4) AU2018287519B2 (enExample)
BR (1) BR112019027558A2 (enExample)
CA (2) CA3061874A1 (enExample)
CL (1) CL2019003799A1 (enExample)
CO (1) CO2019014433A2 (enExample)
IL (1) IL271221A (enExample)
JO (1) JOP20190292A1 (enExample)
MX (1) MX2019015516A (enExample)
PH (1) PH12019502857A1 (enExample)
RU (1) RU2020102237A (enExample)
SG (1) SG11201911283UA (enExample)
TW (3) TW201904993A (enExample)
WO (2) WO2018234879A1 (enExample)

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SG10201708562VA (en) 2012-02-13 2017-12-28 Agency Science Tech & Res IL-1β Neutralizing Human Monoclonal Antibodies
WO2018234879A1 (en) * 2017-06-22 2018-12-27 Novartis Ag USE OF IL-1β BINDING ANTIBODIES IN THE TREATMENT OF CANCER
JP2021523894A (ja) * 2018-05-09 2021-09-09 ノバルティス アーゲー カナキヌマブの使用
WO2020039401A1 (en) * 2018-08-24 2020-02-27 Novartis Ag Treatment comprising il-1βeta binding antibodies and combinations thereof
US20220056123A1 (en) * 2018-12-21 2022-02-24 Novartis Ag Use of il-1beta binding antibodies
EP3947449A4 (en) * 2019-04-01 2022-09-07 Immetas Therapeutics, Inc. BISPECIFIC BINDING MOLECULES THAT TARGET THE TUMORS MICROENVIRONMENT AND AN IMMUNE CHECKPOINT PROTEIN
EP3980561A1 (en) * 2019-06-06 2022-04-13 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
WO2021007439A1 (en) * 2019-07-09 2021-01-14 Tavotek Biotherapeutics (Hong Kong) Limited Bispecific antibodies to tnf-alpha and il-1beta and uses thereof
CA3175127A1 (en) 2020-03-12 2021-09-16 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
JP7797875B2 (ja) * 2020-03-12 2026-01-14 東レ株式会社 癌の治療及び／又は予防のための医薬品
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