TW201904993A - IL-1β 結合抗體之用途 - Google Patents

IL-1β 結合抗體之用途

Info

Publication number
TW201904993A
TW201904993A TW107115136A TW107115136A TW201904993A TW 201904993 A TW201904993 A TW 201904993A TW 107115136 A TW107115136 A TW 107115136A TW 107115136 A TW107115136 A TW 107115136A TW 201904993 A TW201904993 A TW 201904993A
Authority
TW
Taiwan
Prior art keywords
cancer
functional fragment
patient
administered
weeks
Prior art date
Application number
TW107115136A
Other languages
English (en)
Chinese (zh)
Inventor
摩尼卡 里古羅絲-瑟藍
派翠絲 馬洽巴
湯姆 索倫
保羅 瑞德克
彼特 立比
佩妮羅普 D 奧特威爾
以揚 劉
瑪爾葛瑞特 都根
Original Assignee
瑞士商諾華公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 瑞士商諾華公司 filed Critical 瑞士商諾華公司
Priority to AU2018288060A priority Critical patent/AU2018288060B2/en
Priority to JP2019571038A priority patent/JP2020524698A/ja
Priority to EP18749503.1A priority patent/EP3642234A1/en
Priority to CA3066045A priority patent/CA3066045A1/en
Priority to US16/624,130 priority patent/US20230220063A1/en
Priority to PCT/IB2018/054637 priority patent/WO2018235056A1/en
Priority to KR1020207001676A priority patent/KR20200021086A/ko
Priority to PH1/2019/502857A priority patent/PH12019502857A1/en
Priority to RU2020102237A priority patent/RU2020102237A/ru
Priority to SG11201911283UA priority patent/SG11201911283UA/en
Priority to BR112019027558-4A priority patent/BR112019027558A2/pt
Priority to MX2019015516A priority patent/MX2019015516A/es
Priority to JOP/2019/0292A priority patent/JOP20190292A1/ar
Publication of TW201904993A publication Critical patent/TW201904993A/zh
Priority to IL271221A priority patent/IL271221A/en
Priority to CONC2019/0014433A priority patent/CO2019014433A2/es
Priority to CL2019003799A priority patent/CL2019003799A1/es
Priority to AU2021245184A priority patent/AU2021245184A1/en
Priority to JP2023014125A priority patent/JP2023071657A/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
    • A61K39/00114—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
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    • A61K2039/836—Intestine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/868—Vaccine for a specifically defined cancer kidney
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW107115136A 2017-06-22 2018-05-03 IL-1β 結合抗體之用途 TW201904993A (zh)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CA3066045A CA3066045A1 (en) 2017-06-22 2018-06-22 Il-1beta binding antibodies for use in treating cancer
RU2020102237A RU2020102237A (ru) 2017-06-22 2018-06-22 Связывающие il-1-бета антитела для применения в лечении рака
EP18749503.1A EP3642234A1 (en) 2017-06-22 2018-06-22 Il-1beta binding antibodies for use in treating cancer
BR112019027558-4A BR112019027558A2 (pt) 2017-06-22 2018-06-22 anticorpos de ligação à il-1beta para uso no tratamento de câncer
US16/624,130 US20230220063A1 (en) 2017-06-22 2018-06-22 Il-1beta binding antibodies for use in treating cancer
PCT/IB2018/054637 WO2018235056A1 (en) 2017-06-22 2018-06-22 IL-1BETA BINDING ANTIBODIES FOR USE IN THE TREATMENT OF CANCER
KR1020207001676A KR20200021086A (ko) 2017-06-22 2018-06-22 암 치료에 사용하기 위한 il-1베타 결합 항체
PH1/2019/502857A PH12019502857A1 (en) 2017-06-22 2018-06-22 Il-1 beta binding antibodies for use in treating cancer
SG11201911283UA SG11201911283UA (en) 2017-06-22 2018-06-22 Il-1beta binding antibodies for use in treating cancer
AU2018288060A AU2018288060B2 (en) 2017-06-22 2018-06-22 IL-1beta binding antibodies for use in treating cancer
JP2019571038A JP2020524698A (ja) 2017-06-22 2018-06-22 がんの処置における使用のためのＩＬ−１β結合性抗体
MX2019015516A MX2019015516A (es) 2017-06-22 2018-06-22 Anticuerpos de union a il-1beta para el uso en el tratamiento del cancer.
JOP/2019/0292A JOP20190292A1 (ar) 2017-06-22 2018-12-22 استخدام الأجسام المضادة لربط il-1? في علاج السرطان
IL271221A IL271221A (en) 2017-06-22 2019-12-05 Antibodies that bind il-1beta for use in cancer therapy
CONC2019/0014433A CO2019014433A2 (es) 2017-06-22 2019-12-19 Anticuerpos de unión a il–1beta para el uso en el tratamiento del cáncer
CL2019003799A CL2019003799A1 (es) 2017-06-22 2019-12-20 Anticuerpos de unión a il–1beta para el uso en el tratamiento del cáncer.
AU2021245184A AU2021245184A1 (en) 2017-06-22 2021-10-07 Il-1beta binding antibodies for use in treating cancer
JP2023014125A JP2023071657A (ja) 2017-06-22 2023-02-01 がんの処置における使用のためのＩＬ－１β結合性抗体

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US201762523458P 2017-06-22 2017-06-22
US62/523,458 2017-06-22
US201762529515P 2017-07-07 2017-07-07
US62/529,515 2017-07-07
US201762550307P 2017-08-25 2017-08-25
US201762550325P 2017-08-25 2017-08-25
US62/550,307 2017-08-25
US62/550,325 2017-08-25
US201762596054P 2017-12-07 2017-12-07
US62/596,054 2017-12-07
US201862649631P 2018-03-29 2018-03-29
US62/649,631 2018-03-29

Publications (1)

Publication Number Publication Date
TW201904993A true TW201904993A (zh) 2019-02-01

Family

ID=62530267

Family Applications (3)

Application Number Title Priority Date Filing Date
TW107115136A TW201904993A (zh) 2017-06-22 2018-05-03 IL-1β 結合抗體之用途
TW107121619A TW201904995A (zh) 2017-06-22 2018-06-22 IL-1β 結合抗體之用途
TW112108903A TW202400641A (zh) 2017-06-22 2018-06-22 IL-1β 結合抗體之用途

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW107121619A TW201904995A (zh) 2017-06-22 2018-06-22 IL-1β 結合抗體之用途
TW112108903A TW202400641A (zh) 2017-06-22 2018-06-22 IL-1β 結合抗體之用途

Country Status (18)

Country Link
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