TW201904993A - IL-1β 結合抗體之用途 - Google Patents
IL-1β 結合抗體之用途Info
- Publication number
- TW201904993A TW201904993A TW107115136A TW107115136A TW201904993A TW 201904993 A TW201904993 A TW 201904993A TW 107115136 A TW107115136 A TW 107115136A TW 107115136 A TW107115136 A TW 107115136A TW 201904993 A TW201904993 A TW 201904993A
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- cancer
- functional fragment
- patient
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- A61K31/28—Compounds containing heavy metals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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| PCT/IB2018/054637 WO2018235056A1 (en) | 2017-06-22 | 2018-06-22 | Il-1beta binding antibodies for use in treating cancer |
| KR1020207001676A KR20200021086A (ko) | 2017-06-22 | 2018-06-22 | 암 치료에 사용하기 위한 il-1베타 결합 항체 |
| JP2019571038A JP2020524698A (ja) | 2017-06-22 | 2018-06-22 | がんの処置における使用のためのIL−1β結合性抗体 |
| PH1/2019/502857A PH12019502857A1 (en) | 2017-06-22 | 2018-06-22 | Il-1 beta binding antibodies for use in treating cancer |
| EP18749503.1A EP3642234A1 (en) | 2017-06-22 | 2018-06-22 | Il-1beta binding antibodies for use in treating cancer |
| SG11201911283UA SG11201911283UA (en) | 2017-06-22 | 2018-06-22 | Il-1beta binding antibodies for use in treating cancer |
| US16/624,130 US20230220063A1 (en) | 2017-06-22 | 2018-06-22 | Il-1beta binding antibodies for use in treating cancer |
| MX2019015516A MX2019015516A (es) | 2017-06-22 | 2018-06-22 | Anticuerpos de union a il-1beta para el uso en el tratamiento del cancer. |
| AU2018288060A AU2018288060B2 (en) | 2017-06-22 | 2018-06-22 | IL-1beta binding antibodies for use in treating cancer |
| RU2020102237A RU2020102237A (ru) | 2017-06-22 | 2018-06-22 | Связывающие il-1-бета антитела для применения в лечении рака |
| BR112019027558-4A BR112019027558A2 (pt) | 2017-06-22 | 2018-06-22 | anticorpos de ligação à il-1beta para uso no tratamento de câncer |
| JOP/2019/0292A JOP20190292A1 (ar) | 2017-06-22 | 2018-12-22 | استخدام الأجسام المضادة لربط il-1? في علاج السرطان |
| IL271221A IL271221A (en) | 2017-06-22 | 2019-12-05 | Antibodies that bind il-1beta for use in cancer therapy |
| CONC2019/0014433A CO2019014433A2 (es) | 2017-06-22 | 2019-12-19 | Anticuerpos de unión a il–1beta para el uso en el tratamiento del cáncer |
| CL2019003799A CL2019003799A1 (es) | 2017-06-22 | 2019-12-20 | Anticuerpos de unión a il–1beta para el uso en el tratamiento del cáncer. |
| AU2021245184A AU2021245184A1 (en) | 2017-06-22 | 2021-10-07 | Il-1beta binding antibodies for use in treating cancer |
| JP2023014125A JP2023071657A (ja) | 2017-06-22 | 2023-02-01 | がんの処置における使用のためのIL-1β結合性抗体 |
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Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105431452B (zh) | 2012-02-13 | 2019-12-31 | 新加坡科技研究局 | 中和IL-1β的人单克隆抗体 |
| AU2018287519B2 (en) * | 2017-06-22 | 2021-07-22 | Novartis Ag | IL-1beta binding antibodies for use in treating cancer |
| CN119746057A (zh) * | 2018-05-09 | 2025-04-04 | 诺华股份有限公司 | 卡那吉努单抗的用途 |
| EP3898674A1 (en) * | 2018-12-21 | 2021-10-27 | Novartis AG | Use of il-1beta binding antibodies |
| TW202102539A (zh) * | 2019-04-01 | 2021-01-16 | 美商伊梅塔斯科學療法公司 | 結合蛋白、其製備方法、其組合物、其用途、編碼其之核酸分子及包含核酸分子之宿主細胞 |
| CA3142662A1 (en) * | 2019-06-06 | 2020-12-10 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
| KR20220032076A (ko) * | 2019-07-09 | 2022-03-15 | 타보텍 바이오테라퓨틱스 (홍콩) 리미티드 | Tnf-알파 및 il-1베타에 대한 이중특이적 항체 및 이의 용도 |
| WO2021182573A1 (ja) * | 2020-03-12 | 2021-09-16 | 東レ株式会社 | 癌の治療及び/又は予防のための医薬品 |
| RU2745814C1 (ru) * | 2020-06-05 | 2021-04-01 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция левилимаба и ее применение |
| EP3970727A1 (en) * | 2020-09-16 | 2022-03-23 | Johann Wolfgang Goethe-Universität Frankfurt | Means for reducing radiotherapy resistance and adverse effects |
| US20230382990A1 (en) | 2020-10-30 | 2023-11-30 | National Cerebral And Cardiovascular Center | Therapeutic agent for peripartum cardiomyopathy |
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| WO2023038619A1 (en) * | 2021-09-08 | 2023-03-16 | Board Of Regents, The University Of Texas System | USE OF IL-1β BINDING ANTIBODIES |
| CN115125303B (zh) * | 2022-06-07 | 2023-02-24 | 北京大学第一医院 | 阿帕替尼药敏标记物及其相关试剂的应用 |
| CN116139268A (zh) * | 2023-03-13 | 2023-05-23 | 上海交通大学医学院附属仁济医院 | 靶向IL-1β的抗体在制备治疗去势抵抗型前列腺癌中的用途 |
| CN116688130A (zh) * | 2023-06-08 | 2023-09-05 | 桂林医学院附属医院 | 靶向IL-1β/IL-1R1通路的拮抗剂在抑制肝癌肺转移前微环境或肺转移的药物中的应用 |
| WO2024258943A1 (en) * | 2023-06-13 | 2024-12-19 | Merck Sharp & Dohme Llc | Methods of using cyclic peptides for trapping interleukin-1 beta |
| WO2025235276A1 (en) * | 2024-05-06 | 2025-11-13 | Icahn School Of Medicine At Mount Sinai | Combination of il-1 receptor inhibitors, anti pd-1, and il-4 inhibitors in the treatment of cancer |
| WO2025242806A1 (en) | 2024-05-23 | 2025-11-27 | Universität Duisburg-Essen | A METHOD FOR PREDICTING THE RESPONSE OF A PATIENT WITH DLBCL TO ANTI-IL-1ß THERAPY |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1234031T (pt) | 1999-11-30 | 2017-06-26 | Mayo Foundation | B7-h1, uma nova molécula imunoregulatória |
| GB0020685D0 (en) | 2000-08-22 | 2000-10-11 | Novartis Ag | Organic compounds |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| AU2003281200A1 (en) | 2002-07-03 | 2004-01-23 | Tasuku Honjo | Immunopotentiating compositions |
| CN101899114A (zh) | 2002-12-23 | 2010-12-01 | 惠氏公司 | 抗pd-1抗体及其用途 |
| ES2657443T3 (es) | 2005-03-25 | 2018-03-05 | Gitr, Inc. | Anticuerpos anti-GITR y usos de los mismos |
| CN101228188A (zh) | 2005-06-21 | 2008-07-23 | 佐马技术有限公司 | IL-1β结合抗体及其片段 |
| KR101411165B1 (ko) | 2005-07-01 | 2014-06-25 | 메다렉스, 엘.엘.시. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체 |
| CN101213474B (zh) | 2005-07-04 | 2012-06-13 | 株式会社尼康美景 | 距离测量设备 |
| JP5709356B2 (ja) | 2006-01-13 | 2015-04-30 | アメリカ合衆国 | 哺乳動物細胞における発現のためのコドン最適化IL−15およびIL−15R−α遺伝子 |
| CA2652976C (en) | 2006-06-02 | 2015-08-11 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human il-6 receptor |
| US9244059B2 (en) | 2007-04-30 | 2016-01-26 | Immutep Parc Club Orsay | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| CA2690825C (en) | 2007-05-11 | 2019-02-12 | Altor Bioscience Corporation | Fusion molecules and il-15 variants |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
| US20090258020A1 (en) * | 2008-01-07 | 2009-10-15 | Patrys Limited | Antibody designated barb3, barb3 related antibodies, and methods of making and using same |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| CA2735006A1 (en) | 2008-08-25 | 2010-03-11 | Amplimmune, Inc. | Pd-1 antagonists and methods of use thereof |
| EP2342229A1 (en) | 2008-09-12 | 2011-07-13 | ISIS Innovation Limited | Pd-1 specific antibodies and uses thereof |
| ES2592216T3 (es) | 2008-09-26 | 2016-11-28 | Dana-Farber Cancer Institute, Inc. | Anticuerpos anti-PD-1, PD-L1 y PD-L2 humanos y sus usos |
| WO2010077634A1 (en) | 2008-12-09 | 2010-07-08 | Genentech, Inc. | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| EP2196476A1 (en) * | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
| CA2772613C (en) | 2009-09-03 | 2020-03-10 | Schering Corporation | Anti-gitr antibodies |
| NZ599405A (en) | 2009-11-24 | 2014-09-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
| US20130017199A1 (en) | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
| EP2545078A1 (en) | 2010-03-11 | 2013-01-16 | UCB Pharma, S.A. | Pd-1 antibody |
| HUE040213T2 (hu) | 2010-06-11 | 2019-02-28 | Kyowa Hakko Kirin Co Ltd | Anti-TIM antitest |
| US9163087B2 (en) | 2010-06-18 | 2015-10-20 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| BR112013021863A2 (pt) | 2011-03-03 | 2016-11-22 | Apexigen Inc | anticorpos anti-receptor il-6 e métodos de uso |
| WO2012121679A1 (en) * | 2011-03-09 | 2012-09-13 | Agency For Science, Technology And Research | Method of modulating phenotype of a renal cell cancer-associated monocyte or macrophage |
| PL2699264T3 (pl) | 2011-04-20 | 2018-08-31 | Medimmune, Llc | Przeciwciała i inne cząsteczki wiążące B7-H1 i PD-1 |
| EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| US8841418B2 (en) | 2011-07-01 | 2014-09-23 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to TIM3 |
| EP2785375B1 (en) | 2011-11-28 | 2020-07-22 | Merck Patent GmbH | Anti-pd-l1 antibodies and uses thereof |
| CN105431452B (zh) * | 2012-02-13 | 2019-12-31 | 新加坡科技研究局 | 中和IL-1β的人单克隆抗体 |
| CN104736168B (zh) | 2012-05-31 | 2018-09-21 | 索伦托治疗有限公司 | 与pd-l1结合的抗原结合蛋白 |
| JO3300B1 (ar) | 2012-06-06 | 2018-09-16 | Novartis Ag | مركبات وتركيبات لتعديل نشاط egfr |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| US9845356B2 (en) | 2012-08-03 | 2017-12-19 | Dana-Farber Cancer Institute, Inc. | Single agent anti-PD-L1 and PD-L2 dual binding antibodies and methods of use |
| JP6461800B2 (ja) | 2012-10-04 | 2019-01-30 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | ヒトモノクローナル抗pd−l1抗体および使用方法 |
| ES2747997T3 (es) | 2012-10-24 | 2020-03-12 | Novartis Ag | Formas de IL-15R alfa, células que expresan formas de IL-15R alfa, y usos terapéuticos de IL-15R alfa y complejos IL-15/IL-15R alfa |
| AR093984A1 (es) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
| SI2970464T1 (sl) | 2013-03-15 | 2020-08-31 | Glaxosmithkline Intellectual Propety Development Limited | Anti-LAG-3 vezavni proteini |
| HRP20210122T1 (hr) | 2013-05-02 | 2021-04-16 | Anaptysbio, Inc. | Protutijela usmjerena protiv programirane smrti-1 (pd-1) |
| CN111423511B (zh) | 2013-05-31 | 2024-02-23 | 索伦托药业有限公司 | 与pd-1结合的抗原结合蛋白 |
| WO2014209804A1 (en) | 2013-06-24 | 2014-12-31 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
| AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
| TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| ES2792183T3 (es) | 2013-09-13 | 2020-11-10 | Beigene Switzerland Gmbh | Anticuerpos anti-PD1 y su uso como productos terapéuticos y de diagnóstico |
| US10202454B2 (en) | 2013-10-25 | 2019-02-12 | Dana-Farber Cancer Institute, Inc. | Anti-PD-L1 monoclonal antibodies and fragments thereof |
| WO2015081158A1 (en) | 2013-11-26 | 2015-06-04 | Bristol-Myers Squibb Company | Method of treating hiv by disrupting pd-1/pd-l1 signaling |
| WO2015083120A1 (en) * | 2013-12-04 | 2015-06-11 | Novartis Ag | USE OF IL-1β BINDING ANTIBODIES |
| PE20160953A1 (es) | 2013-12-12 | 2016-09-26 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este |
| CN105263521B (zh) | 2014-01-15 | 2021-06-29 | 卡德门企业有限公司 | 免疫调节剂 |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| SI3556775T1 (sl) | 2014-01-28 | 2022-02-28 | Bristol-Myers Squibb Company | Protitelesa proti-LAG-3 za zdravljenje hematoloških malignosti |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| ME03558B (me) | 2014-03-14 | 2020-07-20 | Novartis Ag | Molekuli anti-lag-3 antiтela i njihove upotrebe |
| SMT202100116T1 (it) | 2014-05-28 | 2021-05-07 | Agenus Inc | Anticorpi anti-gitr e metodi di utilizzo degli stessi |
| US9885721B2 (en) | 2014-05-29 | 2018-02-06 | Spring Bioscience Corporation | PD-L1 antibodies and uses thereof |
| DK3151921T3 (da) | 2014-06-06 | 2019-12-02 | Bristol Myers Squibb Co | Antistoffer mod glucocorticoid-induceret tumornekrosefaktor- receptorer (gitr) og anvendelser deraf |
| WO2015195163A1 (en) | 2014-06-20 | 2015-12-23 | R-Pharm Overseas, Inc. | Pd-l1 antagonist fully human antibody |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| CN106604742B (zh) | 2014-07-03 | 2019-01-11 | 百济神州有限公司 | 抗pd-l1抗体及其作为治疗剂及诊断剂的用途 |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| JP2017531427A (ja) | 2014-10-03 | 2017-10-26 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | グルココルチコイド誘導腫瘍壊死因子受容体(gitr)抗体およびその使用法 |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| MX389663B (es) | 2014-10-14 | 2025-03-20 | Novartis Ag | Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas. |
| CN107001475B (zh) | 2014-11-06 | 2021-01-29 | 豪夫迈·罗氏有限公司 | 抗tim3抗体及使用方法 |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗pd-1抗體類和使用彼等之方法 |
| WO2016111947A2 (en) | 2015-01-05 | 2016-07-14 | Jounce Therapeutics, Inc. | Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof |
| EP3265486A4 (en) | 2015-03-06 | 2018-11-14 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind tim3 |
| SG10201909173PA (en) | 2015-04-01 | 2019-11-28 | Anaptysbio Inc | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
| AU2016261770B2 (en) * | 2015-05-12 | 2022-06-02 | Drexel University | Compounds and compositions useful for treating or preventing cancer metastasis, and methods using same |
| CN107743586B (zh) | 2015-06-03 | 2021-07-02 | 百时美施贵宝公司 | 用于癌症诊断的抗gitr抗体 |
| CA2992298A1 (en) | 2015-07-23 | 2017-01-26 | Inhibrx Lp | Multivalent and multispecific gitr-binding fusion proteins |
| US20180222982A1 (en) * | 2015-07-29 | 2018-08-09 | Novartis Ag | Combination therapies comprising antibody molecules to pd-1 |
| HK1250044A1 (zh) | 2015-08-12 | 2018-11-23 | Medimmune Limited | Gitrl融合蛋白及其用途 |
| AU2018287519B2 (en) * | 2017-06-22 | 2021-07-22 | Novartis Ag | IL-1beta binding antibodies for use in treating cancer |
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2018
- 2018-05-03 AU AU2018287519A patent/AU2018287519B2/en not_active Ceased
- 2018-05-03 WO PCT/IB2018/053096 patent/WO2018234879A1/en not_active Ceased
- 2018-05-03 KR KR1020197035726A patent/KR20200019865A/ko not_active Ceased
- 2018-05-03 JP JP2019570897A patent/JP2020524694A/ja not_active Withdrawn
- 2018-05-03 US US15/970,542 patent/US20190048072A1/en not_active Abandoned
- 2018-05-03 TW TW107115136A patent/TW201904993A/zh unknown
- 2018-05-03 CA CA3061874A patent/CA3061874A1/en active Pending
- 2018-06-22 TW TW112108903A patent/TW202400641A/zh unknown
- 2018-06-22 JP JP2019571038A patent/JP2020524698A/ja not_active Withdrawn
- 2018-06-22 TW TW107121619A patent/TW201904995A/zh unknown
- 2018-06-22 AU AU2018288060A patent/AU2018288060B2/en not_active Ceased
- 2018-06-22 EP EP18749503.1A patent/EP3642234A1/en not_active Withdrawn
- 2018-06-22 CA CA3066045A patent/CA3066045A1/en active Pending
- 2018-06-22 US US16/624,130 patent/US20230220063A1/en not_active Abandoned
- 2018-06-22 MX MX2019015516A patent/MX2019015516A/es unknown
- 2018-06-22 KR KR1020207001676A patent/KR20200021086A/ko not_active Ceased
- 2018-06-22 CN CN201880041546.8A patent/CN110831967A/zh active Pending
- 2018-06-22 RU RU2020102237A patent/RU2020102237A/ru unknown
- 2018-06-22 BR BR112019027558-4A patent/BR112019027558A2/pt not_active Application Discontinuation
- 2018-06-22 SG SG11201911283UA patent/SG11201911283UA/en unknown
- 2018-06-22 PH PH1/2019/502857A patent/PH12019502857A1/en unknown
- 2018-12-22 JO JOP/2019/0292A patent/JOP20190292A1/ar unknown
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2019
- 2019-12-05 IL IL271221A patent/IL271221A/en unknown
- 2019-12-19 CO CONC2019/0014433A patent/CO2019014433A2/es unknown
- 2019-12-20 CL CL2019003799A patent/CL2019003799A1/es unknown
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2021
- 2021-10-07 AU AU2021245184A patent/AU2021245184A1/en not_active Abandoned
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2022
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2023
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