TW201904993A - IL-1β 結合抗體之用途 - Google Patents

IL-1β 結合抗體之用途

Info

Publication number
TW201904993A
TW201904993A TW107115136A TW107115136A TW201904993A TW 201904993 A TW201904993 A TW 201904993A TW 107115136 A TW107115136 A TW 107115136A TW 107115136 A TW107115136 A TW 107115136A TW 201904993 A TW201904993 A TW 201904993A
Authority
TW
Taiwan
Prior art keywords
cancer
functional fragment
patient
administered
weeks
Prior art date
Application number
TW107115136A
Other languages
English (en)
Chinese (zh)
Inventor
摩尼卡 里古羅絲-瑟藍
派翠絲 馬洽巴
湯姆 索倫
保羅 瑞德克
彼特 立比
佩妮羅普 D 奧特威爾
以揚 劉
瑪爾葛瑞特 都根
Original Assignee
瑞士商諾華公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 瑞士商諾華公司 filed Critical 瑞士商諾華公司
Priority to AU2018288060A priority Critical patent/AU2018288060B2/en
Priority to RU2020102237A priority patent/RU2020102237A/ru
Priority to KR1020207001676A priority patent/KR20200021086A/ko
Priority to CA3066045A priority patent/CA3066045A1/en
Priority to PH1/2019/502857A priority patent/PH12019502857A1/en
Priority to EP18749503.1A priority patent/EP3642234A1/en
Priority to SG11201911283UA priority patent/SG11201911283UA/en
Priority to US16/624,130 priority patent/US20230220063A1/en
Priority to PCT/IB2018/054637 priority patent/WO2018235056A1/en
Priority to MX2019015516A priority patent/MX2019015516A/es
Priority to JP2019571038A priority patent/JP2020524698A/ja
Priority to BR112019027558-4A priority patent/BR112019027558A2/pt
Priority to JOP/2019/0292A priority patent/JOP20190292A1/ar
Publication of TW201904993A publication Critical patent/TW201904993A/zh
Priority to IL271221A priority patent/IL271221A/en
Priority to CONC2019/0014433A priority patent/CO2019014433A2/es
Priority to CL2019003799A priority patent/CL2019003799A1/es
Priority to AU2021245184A priority patent/AU2021245184A1/en
Priority to JP2023014125A priority patent/JP2023071657A/ja

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/245IL-1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001136Cytokines
    • A61K39/00114Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57423Specifically defined cancers of lung
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/80Vaccine for a specifically defined cancer
    • A61K2039/82Colon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/80Vaccine for a specifically defined cancer
    • A61K2039/828Stomach
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/80Vaccine for a specifically defined cancer
    • A61K2039/836Intestine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/80Vaccine for a specifically defined cancer
    • A61K2039/86Lung
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/80Vaccine for a specifically defined cancer
    • A61K2039/868Vaccine for a specifically defined cancer kidney
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/282Platinum compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
TW107115136A 2017-06-22 2018-05-03 IL-1β 結合抗體之用途 TW201904993A (zh)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CA3066045A CA3066045A1 (en) 2017-06-22 2018-06-22 Il-1beta binding antibodies for use in treating cancer
PCT/IB2018/054637 WO2018235056A1 (en) 2017-06-22 2018-06-22 Il-1beta binding antibodies for use in treating cancer
KR1020207001676A KR20200021086A (ko) 2017-06-22 2018-06-22 암 치료에 사용하기 위한 il-1베타 결합 항체
JP2019571038A JP2020524698A (ja) 2017-06-22 2018-06-22 がんの処置における使用のためのIL−1β結合性抗体
PH1/2019/502857A PH12019502857A1 (en) 2017-06-22 2018-06-22 Il-1 beta binding antibodies for use in treating cancer
EP18749503.1A EP3642234A1 (en) 2017-06-22 2018-06-22 Il-1beta binding antibodies for use in treating cancer
SG11201911283UA SG11201911283UA (en) 2017-06-22 2018-06-22 Il-1beta binding antibodies for use in treating cancer
US16/624,130 US20230220063A1 (en) 2017-06-22 2018-06-22 Il-1beta binding antibodies for use in treating cancer
MX2019015516A MX2019015516A (es) 2017-06-22 2018-06-22 Anticuerpos de union a il-1beta para el uso en el tratamiento del cancer.
AU2018288060A AU2018288060B2 (en) 2017-06-22 2018-06-22 IL-1beta binding antibodies for use in treating cancer
RU2020102237A RU2020102237A (ru) 2017-06-22 2018-06-22 Связывающие il-1-бета антитела для применения в лечении рака
BR112019027558-4A BR112019027558A2 (pt) 2017-06-22 2018-06-22 anticorpos de ligação à il-1beta para uso no tratamento de câncer
JOP/2019/0292A JOP20190292A1 (ar) 2017-06-22 2018-12-22 استخدام الأجسام المضادة لربط il-1? في علاج السرطان
IL271221A IL271221A (en) 2017-06-22 2019-12-05 Antibodies that bind il-1beta for use in cancer therapy
CONC2019/0014433A CO2019014433A2 (es) 2017-06-22 2019-12-19 Anticuerpos de unión a il–1beta para el uso en el tratamiento del cáncer
CL2019003799A CL2019003799A1 (es) 2017-06-22 2019-12-20 Anticuerpos de unión a il–1beta para el uso en el tratamiento del cáncer.
AU2021245184A AU2021245184A1 (en) 2017-06-22 2021-10-07 Il-1beta binding antibodies for use in treating cancer
JP2023014125A JP2023071657A (ja) 2017-06-22 2023-02-01 がんの処置における使用のためのIL-1β結合性抗体

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US201762523458P 2017-06-22 2017-06-22
US62/523,458 2017-06-22
US201762529515P 2017-07-07 2017-07-07
US62/529,515 2017-07-07
US201762550307P 2017-08-25 2017-08-25
US201762550325P 2017-08-25 2017-08-25
US62/550,307 2017-08-25
US62/550,325 2017-08-25
US201762596054P 2017-12-07 2017-12-07
US62/596,054 2017-12-07
US201862649631P 2018-03-29 2018-03-29
US62/649,631 2018-03-29

Publications (1)

Publication Number Publication Date
TW201904993A true TW201904993A (zh) 2019-02-01

Family

ID=62530267

Family Applications (3)

Application Number Title Priority Date Filing Date
TW107115136A TW201904993A (zh) 2017-06-22 2018-05-03 IL-1β 結合抗體之用途
TW112108903A TW202400641A (zh) 2017-06-22 2018-06-22 IL-1β 結合抗體之用途
TW107121619A TW201904995A (zh) 2017-06-22 2018-06-22 IL-1β 結合抗體之用途

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW112108903A TW202400641A (zh) 2017-06-22 2018-06-22 IL-1β 結合抗體之用途
TW107121619A TW201904995A (zh) 2017-06-22 2018-06-22 IL-1β 結合抗體之用途

Country Status (18)

Country Link
US (3) US20190048072A1 (enExample)
EP (1) EP3642234A1 (enExample)
JP (4) JP2020524694A (enExample)
KR (2) KR20200019865A (enExample)
CN (1) CN110831967A (enExample)
AU (4) AU2018287519B2 (enExample)
BR (1) BR112019027558A2 (enExample)
CA (2) CA3061874A1 (enExample)
CL (1) CL2019003799A1 (enExample)
CO (1) CO2019014433A2 (enExample)
IL (1) IL271221A (enExample)
JO (1) JOP20190292A1 (enExample)
MX (1) MX2019015516A (enExample)
PH (1) PH12019502857A1 (enExample)
RU (1) RU2020102237A (enExample)
SG (1) SG11201911283UA (enExample)
TW (3) TW201904993A (enExample)
WO (1) WO2018234879A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105431452B (zh) 2012-02-13 2019-12-31 新加坡科技研究局 中和IL-1β的人单克隆抗体
AU2018287519B2 (en) * 2017-06-22 2021-07-22 Novartis Ag IL-1beta binding antibodies for use in treating cancer
CN119746057A (zh) * 2018-05-09 2025-04-04 诺华股份有限公司 卡那吉努单抗的用途
EP3898674A1 (en) * 2018-12-21 2021-10-27 Novartis AG Use of il-1beta binding antibodies
TW202102539A (zh) * 2019-04-01 2021-01-16 美商伊梅塔斯科學療法公司 結合蛋白、其製備方法、其組合物、其用途、編碼其之核酸分子及包含核酸分子之宿主細胞
CA3142662A1 (en) * 2019-06-06 2020-12-10 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
KR20220032076A (ko) * 2019-07-09 2022-03-15 타보텍 바이오테라퓨틱스 (홍콩) 리미티드 Tnf-알파 및 il-1베타에 대한 이중특이적 항체 및 이의 용도
WO2021182573A1 (ja) * 2020-03-12 2021-09-16 東レ株式会社 癌の治療及び/又は予防のための医薬品
RU2745814C1 (ru) * 2020-06-05 2021-04-01 Закрытое Акционерное Общество "Биокад" Водная фармацевтическая композиция левилимаба и ее применение
EP3970727A1 (en) * 2020-09-16 2022-03-23 Johann Wolfgang Goethe-Universität Frankfurt Means for reducing radiotherapy resistance and adverse effects
US20230382990A1 (en) 2020-10-30 2023-11-30 National Cerebral And Cardiovascular Center Therapeutic agent for peripartum cardiomyopathy
WO2022167916A1 (en) * 2021-02-03 2022-08-11 Novartis Ag Use of il-1b binding antibodies for treating neuroinflammatory disorders
WO2023038619A1 (en) * 2021-09-08 2023-03-16 Board Of Regents, The University Of Texas System USE OF IL-1β BINDING ANTIBODIES
CN115125303B (zh) * 2022-06-07 2023-02-24 北京大学第一医院 阿帕替尼药敏标记物及其相关试剂的应用
CN116139268A (zh) * 2023-03-13 2023-05-23 上海交通大学医学院附属仁济医院 靶向IL-1β的抗体在制备治疗去势抵抗型前列腺癌中的用途
CN116688130A (zh) * 2023-06-08 2023-09-05 桂林医学院附属医院 靶向IL-1β/IL-1R1通路的拮抗剂在抑制肝癌肺转移前微环境或肺转移的药物中的应用
WO2024258943A1 (en) * 2023-06-13 2024-12-19 Merck Sharp & Dohme Llc Methods of using cyclic peptides for trapping interleukin-1 beta
WO2025235276A1 (en) * 2024-05-06 2025-11-13 Icahn School Of Medicine At Mount Sinai Combination of il-1 receptor inhibitors, anti pd-1, and il-4 inhibitors in the treatment of cancer
WO2025242806A1 (en) 2024-05-23 2025-11-27 Universität Duisburg-Essen A METHOD FOR PREDICTING THE RESPONSE OF A PATIENT WITH DLBCL TO ANTI-IL-1ß THERAPY

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1234031T (pt) 1999-11-30 2017-06-26 Mayo Foundation B7-h1, uma nova molécula imunoregulatória
GB0020685D0 (en) 2000-08-22 2000-10-11 Novartis Ag Organic compounds
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
AU2003281200A1 (en) 2002-07-03 2004-01-23 Tasuku Honjo Immunopotentiating compositions
CN101899114A (zh) 2002-12-23 2010-12-01 惠氏公司 抗pd-1抗体及其用途
ES2657443T3 (es) 2005-03-25 2018-03-05 Gitr, Inc. Anticuerpos anti-GITR y usos de los mismos
CN101228188A (zh) 2005-06-21 2008-07-23 佐马技术有限公司 IL-1β结合抗体及其片段
KR101411165B1 (ko) 2005-07-01 2014-06-25 메다렉스, 엘.엘.시. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체
CN101213474B (zh) 2005-07-04 2012-06-13 株式会社尼康美景 距离测量设备
JP5709356B2 (ja) 2006-01-13 2015-04-30 アメリカ合衆国 哺乳動物細胞における発現のためのコドン最適化IL−15およびIL−15R−α遺伝子
CA2652976C (en) 2006-06-02 2015-08-11 Regeneron Pharmaceuticals, Inc. High affinity antibodies to human il-6 receptor
US9244059B2 (en) 2007-04-30 2016-01-26 Immutep Parc Club Orsay Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
CA2690825C (en) 2007-05-11 2019-02-12 Altor Bioscience Corporation Fusion molecules and il-15 variants
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
US20090258020A1 (en) * 2008-01-07 2009-10-15 Patrys Limited Antibody designated barb3, barb3 related antibodies, and methods of making and using same
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
CA2735006A1 (en) 2008-08-25 2010-03-11 Amplimmune, Inc. Pd-1 antagonists and methods of use thereof
EP2342229A1 (en) 2008-09-12 2011-07-13 ISIS Innovation Limited Pd-1 specific antibodies and uses thereof
ES2592216T3 (es) 2008-09-26 2016-11-28 Dana-Farber Cancer Institute, Inc. Anticuerpos anti-PD-1, PD-L1 y PD-L2 humanos y sus usos
WO2010077634A1 (en) 2008-12-09 2010-07-08 Genentech, Inc. Anti-pd-l1 antibodies and their use to enhance t-cell function
EP2196476A1 (en) * 2008-12-10 2010-06-16 Novartis Ag Antibody formulation
CA2772613C (en) 2009-09-03 2020-03-10 Schering Corporation Anti-gitr antibodies
NZ599405A (en) 2009-11-24 2014-09-26 Medimmune Ltd Targeted binding agents against b7-h1
US20130017199A1 (en) 2009-11-24 2013-01-17 AMPLIMMUNE ,Inc. a corporation Simultaneous inhibition of pd-l1/pd-l2
EP2545078A1 (en) 2010-03-11 2013-01-16 UCB Pharma, S.A. Pd-1 antibody
HUE040213T2 (hu) 2010-06-11 2019-02-28 Kyowa Hakko Kirin Co Ltd Anti-TIM antitest
US9163087B2 (en) 2010-06-18 2015-10-20 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions
US8907053B2 (en) 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
BR112013021863A2 (pt) 2011-03-03 2016-11-22 Apexigen Inc anticorpos anti-receptor il-6 e métodos de uso
WO2012121679A1 (en) * 2011-03-09 2012-09-13 Agency For Science, Technology And Research Method of modulating phenotype of a renal cell cancer-associated monocyte or macrophage
PL2699264T3 (pl) 2011-04-20 2018-08-31 Medimmune, Llc Przeciwciała i inne cząsteczki wiążące B7-H1 i PD-1
EP2537933A1 (en) 2011-06-24 2012-12-26 Institut National de la Santé et de la Recherche Médicale (INSERM) An IL-15 and IL-15Ralpha sushi domain based immunocytokines
US8841418B2 (en) 2011-07-01 2014-09-23 Cellerant Therapeutics, Inc. Antibodies that specifically bind to TIM3
EP2785375B1 (en) 2011-11-28 2020-07-22 Merck Patent GmbH Anti-pd-l1 antibodies and uses thereof
CN105431452B (zh) * 2012-02-13 2019-12-31 新加坡科技研究局 中和IL-1β的人单克隆抗体
CN104736168B (zh) 2012-05-31 2018-09-21 索伦托治疗有限公司 与pd-l1结合的抗原结合蛋白
JO3300B1 (ar) 2012-06-06 2018-09-16 Novartis Ag مركبات وتركيبات لتعديل نشاط egfr
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
US9845356B2 (en) 2012-08-03 2017-12-19 Dana-Farber Cancer Institute, Inc. Single agent anti-PD-L1 and PD-L2 dual binding antibodies and methods of use
JP6461800B2 (ja) 2012-10-04 2019-01-30 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド ヒトモノクローナル抗pd−l1抗体および使用方法
ES2747997T3 (es) 2012-10-24 2020-03-12 Novartis Ag Formas de IL-15R alfa, células que expresan formas de IL-15R alfa, y usos terapéuticos de IL-15R alfa y complejos IL-15/IL-15R alfa
AR093984A1 (es) 2012-12-21 2015-07-01 Merck Sharp & Dohme Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
SI2970464T1 (sl) 2013-03-15 2020-08-31 Glaxosmithkline Intellectual Propety Development Limited Anti-LAG-3 vezavni proteini
HRP20210122T1 (hr) 2013-05-02 2021-04-16 Anaptysbio, Inc. Protutijela usmjerena protiv programirane smrti-1 (pd-1)
CN111423511B (zh) 2013-05-31 2024-02-23 索伦托药业有限公司 与pd-1结合的抗原结合蛋白
WO2014209804A1 (en) 2013-06-24 2014-12-31 Biomed Valley Discoveries, Inc. Bispecific antibodies
AR097306A1 (es) 2013-08-20 2016-03-02 Merck Sharp & Dohme Modulación de la inmunidad tumoral
TW201605896A (zh) 2013-08-30 2016-02-16 安美基股份有限公司 Gitr抗原結合蛋白
ES2792183T3 (es) 2013-09-13 2020-11-10 Beigene Switzerland Gmbh Anticuerpos anti-PD1 y su uso como productos terapéuticos y de diagnóstico
US10202454B2 (en) 2013-10-25 2019-02-12 Dana-Farber Cancer Institute, Inc. Anti-PD-L1 monoclonal antibodies and fragments thereof
WO2015081158A1 (en) 2013-11-26 2015-06-04 Bristol-Myers Squibb Company Method of treating hiv by disrupting pd-1/pd-l1 signaling
WO2015083120A1 (en) * 2013-12-04 2015-06-11 Novartis Ag USE OF IL-1β BINDING ANTIBODIES
PE20160953A1 (es) 2013-12-12 2016-09-26 Shanghai hengrui pharmaceutical co ltd Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este
CN105263521B (zh) 2014-01-15 2021-06-29 卡德门企业有限公司 免疫调节剂
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
TWI680138B (zh) 2014-01-23 2019-12-21 美商再生元醫藥公司 抗pd-l1之人類抗體
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
SI3556775T1 (sl) 2014-01-28 2022-02-28 Bristol-Myers Squibb Company Protitelesa proti-LAG-3 za zdravljenje hematoloških malignosti
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
ME03558B (me) 2014-03-14 2020-07-20 Novartis Ag Molekuli anti-lag-3 antiтela i njihove upotrebe
SMT202100116T1 (it) 2014-05-28 2021-05-07 Agenus Inc Anticorpi anti-gitr e metodi di utilizzo degli stessi
US9885721B2 (en) 2014-05-29 2018-02-06 Spring Bioscience Corporation PD-L1 antibodies and uses thereof
DK3151921T3 (da) 2014-06-06 2019-12-02 Bristol Myers Squibb Co Antistoffer mod glucocorticoid-induceret tumornekrosefaktor- receptorer (gitr) og anvendelser deraf
WO2015195163A1 (en) 2014-06-20 2015-12-23 R-Pharm Overseas, Inc. Pd-l1 antagonist fully human antibody
TWI693232B (zh) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
CN106604742B (zh) 2014-07-03 2019-01-11 百济神州有限公司 抗pd-l1抗体及其作为治疗剂及诊断剂的用途
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
JP2017531427A (ja) 2014-10-03 2017-10-26 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド グルココルチコイド誘導腫瘍壊死因子受容体(gitr)抗体およびその使用法
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
MX389663B (es) 2014-10-14 2025-03-20 Novartis Ag Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas.
CN107001475B (zh) 2014-11-06 2021-01-29 豪夫迈·罗氏有限公司 抗tim3抗体及使用方法
TWI595006B (zh) 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗pd-1抗體類和使用彼等之方法
WO2016111947A2 (en) 2015-01-05 2016-07-14 Jounce Therapeutics, Inc. Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
EP3265486A4 (en) 2015-03-06 2018-11-14 Sorrento Therapeutics, Inc. Antibody therapeutics that bind tim3
SG10201909173PA (en) 2015-04-01 2019-11-28 Anaptysbio Inc Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3)
AU2016261770B2 (en) * 2015-05-12 2022-06-02 Drexel University Compounds and compositions useful for treating or preventing cancer metastasis, and methods using same
CN107743586B (zh) 2015-06-03 2021-07-02 百时美施贵宝公司 用于癌症诊断的抗gitr抗体
CA2992298A1 (en) 2015-07-23 2017-01-26 Inhibrx Lp Multivalent and multispecific gitr-binding fusion proteins
US20180222982A1 (en) * 2015-07-29 2018-08-09 Novartis Ag Combination therapies comprising antibody molecules to pd-1
HK1250044A1 (zh) 2015-08-12 2018-11-23 Medimmune Limited Gitrl融合蛋白及其用途
AU2018287519B2 (en) * 2017-06-22 2021-07-22 Novartis Ag IL-1beta binding antibodies for use in treating cancer

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