AU2018286754A1 - Treatment of inflammatory diseases with inhibitors of C5A activity - Google Patents

Treatment of inflammatory diseases with inhibitors of C5A activity Download PDF

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Publication number
AU2018286754A1
AU2018286754A1 AU2018286754A AU2018286754A AU2018286754A1 AU 2018286754 A1 AU2018286754 A1 AU 2018286754A1 AU 2018286754 A AU2018286754 A AU 2018286754A AU 2018286754 A AU2018286754 A AU 2018286754A AU 2018286754 A1 AU2018286754 A1 AU 2018286754A1
Authority
AU
Australia
Prior art keywords
antibody
antigen
binding
compound
binding fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2018286754A
Other languages
English (en)
Inventor
Renfeng Guo
Niels R. Riedemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
InflaRx GmbH
Original Assignee
InflaRx GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by InflaRx GmbH filed Critical InflaRx GmbH
Publication of AU2018286754A1 publication Critical patent/AU2018286754A1/en
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2018286754A 2017-06-23 2018-06-13 Treatment of inflammatory diseases with inhibitors of C5A activity Pending AU2018286754A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17177657 2017-06-23
EP17177657.8 2017-06-23
EP17189938 2017-09-07
EP17189938.8 2017-09-07
PCT/EP2018/065676 WO2018234118A1 (fr) 2017-06-23 2018-06-13 Traitement de maladies inflammatoires par des inhibiteurs de l'activité de c5a

Publications (1)

Publication Number Publication Date
AU2018286754A1 true AU2018286754A1 (en) 2019-12-19

Family

ID=62636193

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018286754A Pending AU2018286754A1 (en) 2017-06-23 2018-06-13 Treatment of inflammatory diseases with inhibitors of C5A activity

Country Status (10)

Country Link
EP (1) EP3642230A1 (fr)
JP (1) JP7502865B2 (fr)
KR (1) KR20200020727A (fr)
CN (1) CN111201241A (fr)
AU (1) AU2018286754A1 (fr)
CA (1) CA3066689C (fr)
IL (1) IL271074A (fr)
SG (1) SG11201912882QA (fr)
TW (1) TWI786132B (fr)
WO (1) WO2018234118A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY196220A (en) 2016-06-14 2023-03-23 Regeneron Pharma Anti-C5 Antibodies and uses Thereof
WO2019118556A1 (fr) 2017-12-13 2019-06-20 Regeneron Pharmaceuticals, Inc. Associations d'anticorps anti-c5 et utilisations associées
TW202041535A (zh) * 2019-03-14 2020-11-16 德商莫菲西斯公司 靶向C5aR的抗體
TW202140553A (zh) 2020-01-13 2021-11-01 美商威特拉公司 C5ar1抗體分子及其用途
CN114364695A (zh) * 2020-06-24 2022-04-15 舒泰神(北京)生物制药股份有限公司 特异性识别c5a的抗体及其应用
CA3173944A1 (fr) 2021-01-13 2022-07-21 Visterra, Inc. Anticorps humanises anti-recepteur 1 du complement 5a et leurs methodes d'utilisation

Family Cites Families (24)

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US4704355A (en) 1985-03-27 1987-11-03 New Horizons Diagnostics Corporation Assay utilizing ATP encapsulated within liposome particles
WO1991004014A1 (fr) 1989-09-21 1991-04-04 Synergen, Inc. Procede de transport de compositions a travers la barriere hemato-encephalique
SG48759A1 (en) 1990-01-12 2002-07-23 Abgenix Inc Generation of xenogenic antibodies
AUPO755097A0 (en) 1997-06-25 1997-07-17 University Of Queensland, The Receptor agonist and antagonist
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
AUPR833401A0 (en) * 2001-10-17 2001-11-08 University Of Queensland, The G protein-coupled receptor antagonists
WO2005079363A2 (fr) 2004-02-12 2005-09-01 Archemix Corporation Agents therapeutiques a base d'aptameres utiles dans le traitement de troubles lies a un complement
KR20070036033A (ko) * 2004-03-26 2007-04-02 프로믹스 피티와이 리미티드 보체 C5a 수용체 조절제를 이용한 신경계 증상의치료방법
US20110301098A1 (en) 2006-07-21 2011-12-08 Quax Paul H A Treatment for intimal hyperplasia and related conditions
GB0617734D0 (en) 2006-09-08 2006-10-18 Evolutec Ltd Method of treating peripheral nerve disorders
PT3078658T (pt) * 2008-12-22 2019-07-16 Chemocentryx Inc Antagonistas do c5ar
GB0905790D0 (en) * 2009-04-03 2009-05-20 Alligator Bioscience Ab Novel polypeptides and use thereof
EP2327725A1 (fr) 2009-11-26 2011-06-01 InflaRx GmbH Groupes caractéristiques à liaison anti-C5a avec une activité à blocage élevé
ES2632975T3 (es) 2010-06-24 2017-09-18 Chemocentryx, Inc. Antagonistas de C5aR
MX366660B (es) * 2013-03-14 2019-07-18 Alnylam Pharmaceuticals Inc Composiciones de arni contra el componente c5 del complemento y métodos para su uso.
DK2994488T3 (da) * 2013-05-08 2022-10-03 Novo Nordisk As Anvendelse af c5ar-antagonister
MX2016011862A (es) * 2014-03-20 2016-12-05 Inflarx Gmbh Inhibidores de c5a para el tratamiento de la neumonia viral.
EP3194596A1 (fr) 2014-09-16 2017-07-26 Alnylam Pharmaceuticals, Inc. Compositions d'arni de composant du complément c5 et leurs procédés d'utilisation
WO2016061066A1 (fr) 2014-10-15 2016-04-21 Alexion Pharmaceuticals, Inc. Procedes de replication de culture cellulaire de production d'eculizumab a grande echelle
FR3030515B1 (fr) * 2014-12-23 2017-01-20 Galderma Res & Dev Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines
EP3313437A1 (fr) 2015-06-26 2018-05-02 Alexion Pharmaceuticals, Inc. Procédé de traitement d'un patient soumis à une vaccination avec l'éculizumab ou un variant de l'éculizumab
KR102395093B1 (ko) 2016-04-04 2022-05-04 케모센트릭스, 인크. 가용성 C5aR 길항제
WO2018184739A1 (fr) * 2017-04-03 2018-10-11 Inflarx Gmbh Traitement de maladies inflammatoires par des inhibiteurs de l'activité de c5a

Also Published As

Publication number Publication date
IL271074A (en) 2020-01-30
CA3066689C (fr) 2024-01-16
JP7502865B2 (ja) 2024-06-19
TW201904611A (zh) 2019-02-01
CA3066689A1 (fr) 2018-12-27
KR20200020727A (ko) 2020-02-26
SG11201912882QA (en) 2020-01-30
CN111201241A (zh) 2020-05-26
WO2018234118A1 (fr) 2018-12-27
EP3642230A1 (fr) 2020-04-29
TWI786132B (zh) 2022-12-11
JP2020524696A (ja) 2020-08-20

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