CN111201241A - 用C5a活性抑制剂治疗炎性疾病 - Google Patents

用C5a活性抑制剂治疗炎性疾病 Download PDF

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Publication number
CN111201241A
CN111201241A CN201880041303.4A CN201880041303A CN111201241A CN 111201241 A CN111201241 A CN 111201241A CN 201880041303 A CN201880041303 A CN 201880041303A CN 111201241 A CN111201241 A CN 111201241A
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CN
China
Prior art keywords
antibody
antigen
binding
binding fragment
compound
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Pending
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CN201880041303.4A
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English (en)
Chinese (zh)
Inventor
郭仁峰
尼尔斯·R·里德曼
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InflaRx GmbH
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InflaRx GmbH
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Application filed by InflaRx GmbH filed Critical InflaRx GmbH
Publication of CN111201241A publication Critical patent/CN111201241A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
CN201880041303.4A 2017-06-23 2018-06-13 用C5a活性抑制剂治疗炎性疾病 Pending CN111201241A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17177657.8 2017-06-23
EP17177657 2017-06-23
EP17189938 2017-09-07
EP17189938.8 2017-09-07
PCT/EP2018/065676 WO2018234118A1 (fr) 2017-06-23 2018-06-13 Traitement de maladies inflammatoires par des inhibiteurs de l'activité de c5a

Publications (1)

Publication Number Publication Date
CN111201241A true CN111201241A (zh) 2020-05-26

Family

ID=62636193

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880041303.4A Pending CN111201241A (zh) 2017-06-23 2018-06-13 用C5a活性抑制剂治疗炎性疾病

Country Status (10)

Country Link
EP (1) EP3642230A1 (fr)
JP (1) JP2020524696A (fr)
KR (1) KR20200020727A (fr)
CN (1) CN111201241A (fr)
AU (1) AU2018286754A1 (fr)
CA (1) CA3066689C (fr)
IL (1) IL271074A (fr)
SG (1) SG11201912882QA (fr)
TW (1) TWI786132B (fr)
WO (1) WO2018234118A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114364695A (zh) * 2020-06-24 2022-04-15 舒泰神(北京)生物制药股份有限公司 特异性识别c5a的抗体及其应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017218515A1 (fr) 2016-06-14 2017-12-21 Regeneron Pharmaceuticals, Inc. Anticorps anti-c5 et leurs utilisations
CA3083113A1 (fr) 2017-12-13 2019-06-20 Regeneron Pharmaceuticals, Inc. Associations d'anticorps anti-c5 et utilisations associees
CA3132771A1 (fr) * 2019-03-14 2020-09-17 Morphosys Ag Anticorps ciblant c5ar
TW202140553A (zh) * 2020-01-13 2021-11-01 美商威特拉公司 C5ar1抗體分子及其用途
KR20230142831A (ko) 2021-01-13 2023-10-11 비스테라, 인크. 인간화된 보체 5a 수용체 1 항체 및 이의 사용 방법

Citations (6)

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CN1604909A (zh) * 2001-10-17 2005-04-06 昆士兰大学 作为g蛋白-偶联受体拮抗剂的环肽
CN1997384A (zh) * 2004-03-26 2007-07-11 普罗米克斯有限公司 使用补体C5a受体调节剂治疗神经系统病症
CN105392803A (zh) * 2013-05-08 2016-03-09 诺和诺德股份有限公司 C5aR拮抗剂的用途
WO2016102877A1 (fr) * 2014-12-23 2016-06-30 Galderma Research & Development Nouveaux composés antagonistes des récepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies médiées par des chimiokines
CN106132982A (zh) * 2014-03-20 2016-11-16 因弗拉克斯有限责任公司 用于治疗病毒性肺炎的C5a抑制剂
CN111108118A (zh) * 2017-04-03 2020-05-05 因弗拉克斯有限责任公司 用C5a活性抑制剂治疗炎性疾病

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US4704355A (en) 1985-03-27 1987-11-03 New Horizons Diagnostics Corporation Assay utilizing ATP encapsulated within liposome particles
CA2025907A1 (fr) 1989-09-21 1991-03-22 Franklin D. Collins Methode pour le transport de composes a travers la barriere hemato-encephalique
EP1690935A3 (fr) 1990-01-12 2008-07-30 Abgenix, Inc. Génération d'anticorps xenogéniques
AUPO755097A0 (en) 1997-06-25 1997-07-17 University Of Queensland, The Receptor agonist and antagonist
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
HUE038239T2 (hu) 2004-02-12 2018-10-29 Archemix Llc Komplementrendszerrel összefüggõ rendellenességek kezelésében alkalmazható aptamer terapeutikumok
EP2049141A4 (fr) * 2006-07-21 2011-10-26 Promics Pty Ltd Traitement de l'hyperplasie intimale et d'affections associées
GB0617734D0 (en) 2006-09-08 2006-10-18 Evolutec Ltd Method of treating peripheral nerve disorders
EP3078658B1 (fr) * 2008-12-22 2019-04-10 ChemoCentryx, Inc. Antagonistes de c5ar
GB0905790D0 (en) * 2009-04-03 2009-05-20 Alligator Bioscience Ab Novel polypeptides and use thereof
EP2327725A1 (fr) 2009-11-26 2011-06-01 InflaRx GmbH Groupes caractéristiques à liaison anti-C5a avec une activité à blocage élevé
DK2585064T3 (en) 2010-06-24 2017-07-24 Chemocentryx Inc C5aR antagonists
MX366660B (es) * 2013-03-14 2019-07-18 Alnylam Pharmaceuticals Inc Composiciones de arni contra el componente c5 del complemento y métodos para su uso.
WO2016044419A1 (fr) 2014-09-16 2016-03-24 Alnylam Pharmaceuticals, Inc. Compositions d'arni de composant du complément c5 et leurs procédés d'utilisation
ES2719876T3 (es) 2014-10-15 2019-07-16 Alexion Pharma Inc Métodos para replicar un cultivo celular de producción de eculizumab a gran escala
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CN1604909A (zh) * 2001-10-17 2005-04-06 昆士兰大学 作为g蛋白-偶联受体拮抗剂的环肽
CN1847261A (zh) * 2001-10-17 2006-10-18 昆士兰大学 作为g蛋白-偶联受体拮抗剂的环肽
CN1997384A (zh) * 2004-03-26 2007-07-11 普罗米克斯有限公司 使用补体C5a受体调节剂治疗神经系统病症
CN105392803A (zh) * 2013-05-08 2016-03-09 诺和诺德股份有限公司 C5aR拮抗剂的用途
CN106132982A (zh) * 2014-03-20 2016-11-16 因弗拉克斯有限责任公司 用于治疗病毒性肺炎的C5a抑制剂
WO2016102877A1 (fr) * 2014-12-23 2016-06-30 Galderma Research & Development Nouveaux composés antagonistes des récepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies médiées par des chimiokines
CN111108118A (zh) * 2017-04-03 2020-05-05 因弗拉克斯有限责任公司 用C5a活性抑制剂治疗炎性疾病

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"InflaRx initiates exploratory phase II trial with IFX-1, a first-in-class anti-complement C5a antibody, in patients with Hidradenitis Suppurativa", pages 1 - 2 *
AH-WENG A.等: "化脓性汗腺炎伴发坏疽性脓皮病", 世界核心医学期刊文摘·皮肤病学, vol. 2, no. 2, 28 February 2006 (2006-02-28), pages 46 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114364695A (zh) * 2020-06-24 2022-04-15 舒泰神(北京)生物制药股份有限公司 特异性识别c5a的抗体及其应用

Also Published As

Publication number Publication date
KR20200020727A (ko) 2020-02-26
TWI786132B (zh) 2022-12-11
TW201904611A (zh) 2019-02-01
WO2018234118A1 (fr) 2018-12-27
IL271074A (en) 2020-01-30
SG11201912882QA (en) 2020-01-30
CA3066689A1 (fr) 2018-12-27
CA3066689C (fr) 2024-01-16
JP2020524696A (ja) 2020-08-20
AU2018286754A1 (en) 2019-12-19
EP3642230A1 (fr) 2020-04-29

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