AU2017376441B2 - Oxazine derivatives as beta-secretase inhibitors and methods of use - Google Patents

Oxazine derivatives as beta-secretase inhibitors and methods of use Download PDF

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Publication number
AU2017376441B2
AU2017376441B2 AU2017376441A AU2017376441A AU2017376441B2 AU 2017376441 B2 AU2017376441 B2 AU 2017376441B2 AU 2017376441 A AU2017376441 A AU 2017376441A AU 2017376441 A AU2017376441 A AU 2017376441A AU 2017376441 B2 AU2017376441 B2 AU 2017376441B2
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Australia
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compound
tautomer
oxazin
dihydro
pharmaceutically acceptable
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AU2017376441A
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AU2017376441A1 (en
Inventor
Jennifer R. Allen
Matthew P. Bourbeau
Ning Chen
Michael J. Frohn
Paul E. Harrington
Qingyian Liu
Corey REEVES
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Amgen Inc
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2017376441A 2016-12-15 2017-12-13 Oxazine derivatives as beta-secretase inhibitors and methods of use Active AU2017376441B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662434711P 2016-12-15 2016-12-15
US62/434,711 2016-12-15
US201762570425P 2017-10-10 2017-10-10
US62/570,425 2017-10-10
PCT/US2017/066177 WO2018112081A1 (en) 2016-12-15 2017-12-13 Oxazine derivatives as beta-secretase inhibitors and methods of use

Publications (2)

Publication Number Publication Date
AU2017376441A1 AU2017376441A1 (en) 2019-07-04
AU2017376441B2 true AU2017376441B2 (en) 2021-10-14

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Family Applications (1)

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AU2017376441A Active AU2017376441B2 (en) 2016-12-15 2017-12-13 Oxazine derivatives as beta-secretase inhibitors and methods of use

Country Status (8)

Country Link
US (1) US10947223B2 (cg-RX-API-DMAC7.html)
EP (1) EP3555080B1 (cg-RX-API-DMAC7.html)
JP (1) JP7177773B2 (cg-RX-API-DMAC7.html)
AU (1) AU2017376441B2 (cg-RX-API-DMAC7.html)
CA (1) CA3047286A1 (cg-RX-API-DMAC7.html)
MA (1) MA52722A (cg-RX-API-DMAC7.html)
MX (1) MX388696B (cg-RX-API-DMAC7.html)
WO (1) WO2018112081A1 (cg-RX-API-DMAC7.html)

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US8999980B2 (en) † 2009-12-11 2015-04-07 Shionogi & Co., Ltd. Oxazine derivatives
US11548903B2 (en) 2016-12-15 2023-01-10 Amgen Inc. Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
EP3555084B1 (en) 2016-12-15 2022-03-16 Amgen Inc. Thiazine derivatives as beta-secretase inhibitors and methods of use
MA52722A (fr) 2016-12-15 2021-04-14 Amgen Inc Dérivés d'oxazine en tant qu'inhibiteurs de bêta-sécrétase et procédés d'utilisation
AU2017376446B2 (en) 2016-12-15 2021-10-14 Amgen Inc. 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
AU2017378316B2 (en) 2016-12-15 2021-04-01 Amgen Inc. Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
KR20210003872A (ko) 2018-04-27 2021-01-12 시오노기 앤드 컴파니, 리미티드 선택적 bace1 억제 활성을 갖는 테트라하이드로피라노옥사진 유도체

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Publication number Priority date Publication date Assignee Title
EP1942105A1 (en) * 2005-10-25 2008-07-09 Shionogi Co., Ltd. Aminodihydrothiazine derivative
EP2151435A1 (en) * 2007-04-24 2010-02-10 Shionogi&Co., Ltd. Pharmaceutical composition for treatment of alzheimer's disease
WO2013142613A1 (en) * 2012-03-20 2013-09-26 Elan Pharmaceuticals, Inc. Spirocyclic dihydro-thiazine and dihydro-oxazine bace inhibitors, and compositions and uses thereof
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Also Published As

Publication number Publication date
JP7177773B2 (ja) 2022-11-24
MX2019007101A (es) 2019-12-16
MA52722A (fr) 2021-04-14
JP2020503293A (ja) 2020-01-30
CA3047286A1 (en) 2018-06-21
US20200207747A1 (en) 2020-07-02
US10947223B2 (en) 2021-03-16
MX388696B (es) 2025-03-20
WO2018112081A1 (en) 2018-06-21
AU2017376441A1 (en) 2019-07-04
EP3555080B1 (en) 2023-09-20
EP3555080A1 (en) 2019-10-23

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