AU2017344882A1 - Combinations comprising an SSAO/VAP-1 inhibitor and a SGLT2 inhibitor, uses thereof - Google Patents

Combinations comprising an SSAO/VAP-1 inhibitor and a SGLT2 inhibitor, uses thereof Download PDF

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Publication number
AU2017344882A1
AU2017344882A1 AU2017344882A AU2017344882A AU2017344882A1 AU 2017344882 A1 AU2017344882 A1 AU 2017344882A1 AU 2017344882 A AU2017344882 A AU 2017344882A AU 2017344882 A AU2017344882 A AU 2017344882A AU 2017344882 A1 AU2017344882 A1 AU 2017344882A1
Authority
AU
Australia
Prior art keywords
inhibitor
aminomethyl
group
fluoroallyloxy
ssao
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2017344882A
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English (en)
Inventor
Thomas Klein
Michael Mark
Eric Williams Mayoux
Joerg Rippmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of AU2017344882A1 publication Critical patent/AU2017344882A1/en
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2017344882A 2016-10-19 2017-10-16 Combinations comprising an SSAO/VAP-1 inhibitor and a SGLT2 inhibitor, uses thereof Abandoned AU2017344882A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16194572 2016-10-19
EP16194572.0 2016-10-19
PCT/EP2017/076300 WO2018073154A1 (en) 2016-10-19 2017-10-16 Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof

Publications (1)

Publication Number Publication Date
AU2017344882A1 true AU2017344882A1 (en) 2019-03-28

Family

ID=57178303

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017344882A Abandoned AU2017344882A1 (en) 2016-10-19 2017-10-16 Combinations comprising an SSAO/VAP-1 inhibitor and a SGLT2 inhibitor, uses thereof

Country Status (14)

Country Link
US (1) US20210212968A1 (OSRAM)
EP (1) EP3528800A1 (OSRAM)
JP (1) JP2019531320A (OSRAM)
KR (1) KR20190070956A (OSRAM)
CN (1) CN109843279A (OSRAM)
AU (1) AU2017344882A1 (OSRAM)
BR (1) BR112019005930A2 (OSRAM)
CA (1) CA3041169A1 (OSRAM)
CL (1) CL2019000935A1 (OSRAM)
EA (1) EA201990951A1 (OSRAM)
IL (1) IL265989A (OSRAM)
MX (1) MX2019004549A (OSRAM)
PH (1) PH12019500845A1 (OSRAM)
WO (1) WO2018073154A1 (OSRAM)

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KR20190110740A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
AU2019351122A1 (en) 2018-09-28 2021-05-20 Acucela Inc. Inhibitors of VAP-1
US12037334B2 (en) 2018-09-28 2024-07-16 Acucela Inc. Inhibitors of VAP-1
JP7414230B2 (ja) * 2018-11-09 2024-01-16 国立大学法人 琉球大学 抗血液悪性腫瘍薬
CN121081472A (zh) 2018-12-13 2025-12-09 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
TW202039486A (zh) 2018-12-14 2020-11-01 南韓商柳韓洋行股份有限公司 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物
TWI835945B (zh) * 2018-12-14 2024-03-21 南韓商柳韓洋行股份有限公司 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物
CA3154391A1 (en) 2019-09-12 2021-03-18 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
AU2020377093A1 (en) 2019-10-29 2022-05-12 Eccogene Inc. SSAO inhibitors and use thereof
CN115666577A (zh) * 2020-03-25 2023-01-31 拓臻股份有限公司 呼吸道病症的治疗
IL298145A (en) * 2020-05-13 2023-01-01 Terns Pharmaceuticals Inc Combined treatment of liver disorders
CN113893256A (zh) * 2020-07-06 2022-01-07 诺未科技(北京)有限公司 化合物或其可药用盐、二聚体或三聚体在制备治疗癌症的药物中的应用
IL300853A (en) 2020-08-25 2023-04-01 Lilly Co Eli Polymorphs of an ssao inhibitor
US20240148767A1 (en) * 2021-03-04 2024-05-09 The Governors Of The University Of Alberta The use of empagliflozin for the treatment of ulcerative colitis and crohn's disease
TW202327589A (zh) * 2021-11-11 2023-07-16 美商拓臻製藥公司 肝病之組合療法
US20230181583A1 (en) * 2021-11-11 2023-06-15 Terns Pharmaceuticals, Inc. Treating liver disorders with an ssao inhibitor

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PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
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Also Published As

Publication number Publication date
MX2019004549A (es) 2019-06-12
IL265989A (en) 2019-06-30
CN109843279A (zh) 2019-06-04
BR112019005930A2 (pt) 2019-06-11
EP3528800A1 (en) 2019-08-28
JP2019531320A (ja) 2019-10-31
CL2019000935A1 (es) 2019-08-09
KR20190070956A (ko) 2019-06-21
CA3041169A1 (en) 2018-04-26
EA201990951A1 (ru) 2019-11-29
WO2018073154A1 (en) 2018-04-26
PH12019500845A1 (en) 2019-12-02
US20210212968A1 (en) 2021-07-15

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Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period