AU2017298251B2 - Bispecific anti-HER2 antibody - Google Patents

Bispecific anti-HER2 antibody Download PDF

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Publication number
AU2017298251B2
AU2017298251B2 AU2017298251A AU2017298251A AU2017298251B2 AU 2017298251 B2 AU2017298251 B2 AU 2017298251B2 AU 2017298251 A AU2017298251 A AU 2017298251A AU 2017298251 A AU2017298251 A AU 2017298251A AU 2017298251 B2 AU2017298251 B2 AU 2017298251B2
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AU
Australia
Prior art keywords
antibody
seq
amino acid
acid sequence
cancer
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Ceased
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AU2017298251A
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AU2017298251A1 (en
Inventor
Sijia Huang
Chunyang JIN
Feng Li
Pei Ye
Boyan Zhang
Jian Zhao
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Beijing Mabworks Biotech Co Ltd
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Beijing Mabworks Biotech Co Ltd
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Publication of AU2017298251A1 publication Critical patent/AU2017298251A1/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2017298251A 2016-07-22 2017-07-21 Bispecific anti-HER2 antibody Ceased AU2017298251B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201610584242.9 2016-07-22
CN201610584242.9A CN107446045A (zh) 2016-07-22 2016-07-22 一种抗her2的抗体、其药物组合物及用途
US15/461,732 2017-03-17
US15/461,732 US9745382B1 (en) 2016-07-22 2017-03-17 Bispecific anti-HER2 antibody
PCT/CN2017/093816 WO2018014864A1 (en) 2016-07-22 2017-07-21 Bispecific anti-her2 antibody

Publications (2)

Publication Number Publication Date
AU2017298251A1 AU2017298251A1 (en) 2019-02-14
AU2017298251B2 true AU2017298251B2 (en) 2020-02-06

Family

ID=59654118

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017298251A Ceased AU2017298251B2 (en) 2016-07-22 2017-07-21 Bispecific anti-HER2 antibody

Country Status (7)

Country Link
US (1) US9745382B1 (OSRAM)
EP (1) EP3487888A4 (OSRAM)
JP (1) JP6823175B2 (OSRAM)
CN (2) CN107446045A (OSRAM)
AU (1) AU2017298251B2 (OSRAM)
CA (1) CA3031330C (OSRAM)
WO (1) WO2018014864A1 (OSRAM)

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WO2019094608A1 (en) 2017-11-08 2019-05-16 Denali Therapeutics Inc. Anti-bace1 antibodies and methods of use thereof
KR20200131840A (ko) * 2018-03-13 2020-11-24 자임워크스 인코포레이티드 항-her2 2파라토프 항체-약물 접합체 및 이의 사용 방법
WO2020000458A1 (zh) * 2018-06-29 2020-01-02 深圳市博奥康生物科技有限公司 一种特异靶向人NGL基因的gRNA导向序列及其应用
WO2020000452A1 (zh) * 2018-06-29 2020-01-02 深圳市博奥康生物科技有限公司 一种靶向人NGL基因的新型RNAi干扰片段、RNAi载体及其制备方法和其应用
SG11202101436SA (en) * 2018-08-22 2021-03-30 Denali Therapeutics Inc Anti-her2 polypeptides and methods of use thereof
CN113166765B (zh) * 2018-08-29 2024-03-26 联合生物制药股份有限公司 去岩藻醣基化抗体及其制造
EP3988574A4 (en) * 2019-02-03 2022-10-12 Shanghai Bao Pharmaceuticals Co., Ltd. AGAINST HER2 BI-SPECIFIC ANTIBODIES AND THEIR USE
EP3842460A1 (en) * 2019-03-01 2021-06-30 RemeGen Co., Ltd. Antibody for her2 concomitant diagnosis immunohistochemical detection and application thereof
CN111848805B (zh) * 2019-04-30 2023-05-05 非同(成都)生物科技有限公司 用于肿瘤免疫治疗的具有双Her2位点的双特异性抗体
KR20230006823A (ko) * 2020-04-30 2023-01-11 치아타이 티안큉 파마수티컬 그룹 주식회사 Her2를 표적화하는 항원 결합 구조체 및 이의 용도
AU2021284297A1 (en) * 2020-06-03 2023-02-02 Dana-Farber Cancer Institute, Inc. Antagonistic biparatopic antibodies that specifically bind fibroblast growth factor receptor 2 and methods of using same
EP4190818A4 (en) * 2020-07-28 2024-08-07 Bio-Thera Solutions, Ltd. ANTI-HER2 ANTIBODY AND ITS USE
CN114539413A (zh) * 2020-11-25 2022-05-27 三生国健药业(上海)股份有限公司 结合her2的多价双特异性抗体、其制备方法和用途
EP4386006A1 (en) * 2021-07-05 2024-06-19 Jiangsu Alphamab Biopharmaceuticals Co., Ltd. Antibody-drug conjugate and application thereof
CN113817065B (zh) * 2021-09-06 2023-04-18 深圳市乐土生物医药有限公司 一种抗her2的多肽及其用途
WO2024028732A1 (en) * 2022-08-05 2024-02-08 Janssen Biotech, Inc. Cd98 binding constructs for treating brain tumors
JP2025525959A (ja) * 2022-08-05 2025-08-07 ヤンセン バイオテツク,インコーポレーテツド 脳腫瘍を治療するためのトランスフェリン受容体結合タンパク質
EP4652204A2 (en) * 2023-01-20 2025-11-26 Washington University Lilrb4/ilt3 antagonist compositions and methods of use thereof
WO2024183622A1 (zh) * 2023-03-03 2024-09-12 盛禾(中国)生物制药有限公司 一种抗her2抗体在制备治疗癌症的药物中的用途
WO2024183623A1 (zh) * 2023-03-03 2024-09-12 盛禾(中国)生物制药有限公司 一种抗her2抗体在制备治疗癌症的药物中的用途
WO2025124463A1 (zh) * 2023-12-12 2025-06-19 上海宝济药业股份有限公司 抗her2的双特异性抗体及其应用
CN118206662A (zh) * 2024-05-14 2024-06-18 中国人民解放军军事科学院军事医学研究院 一种靶向Her2的新型单克隆抗体及其应用
CN119462959B (zh) * 2024-10-24 2025-12-19 南京元迈细胞生物科技有限公司 嵌合抗原受体及其修饰的细胞

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Also Published As

Publication number Publication date
JP2019528779A (ja) 2019-10-17
EP3487888A4 (en) 2020-04-01
CN107446045A (zh) 2017-12-08
CA3031330C (en) 2020-04-28
JP6823175B2 (ja) 2021-01-27
WO2018014864A1 (en) 2018-01-25
EP3487888A1 (en) 2019-05-29
AU2017298251A1 (en) 2019-02-14
US9745382B1 (en) 2017-08-29
CA3031330A1 (en) 2018-01-25
CN109715671A (zh) 2019-05-03
CN109715671B (zh) 2020-08-21

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