AU2017294551B2 - Soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides and uses thereof - Google Patents

Soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides and uses thereof Download PDF

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Publication number
AU2017294551B2
AU2017294551B2 AU2017294551A AU2017294551A AU2017294551B2 AU 2017294551 B2 AU2017294551 B2 AU 2017294551B2 AU 2017294551 A AU2017294551 A AU 2017294551A AU 2017294551 A AU2017294551 A AU 2017294551A AU 2017294551 B2 AU2017294551 B2 AU 2017294551B2
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sfgfr3
gly
val
leu
ser
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AU2017294551A
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AU2017294551A1 (en
Inventor
Stéphanie GARCIA
Elvire Gouze
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Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Nice Sophia Antipolis UNSA
Pfizer Inc
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Nice Sophia Antipolis UNSA
Pfizer Inc
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Assigned to PFIZER INC., INSERM (Institut National de la Santé et de la Recherche Médicale), Université Côte d'Azur reassignment PFIZER INC. Request for Assignment Assignors: INSERM (Institut National de la Santé et de la Recherche Médicale), THERACHON SAS, UNIVERSITÉ NICE SOPHIA ANTIPOLIS
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Priority to AU2022202906A priority Critical patent/AU2022202906A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2017294551A 2016-07-07 2017-07-07 Soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides and uses thereof Ceased AU2017294551B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022202906A AU2022202906A1 (en) 2016-07-07 2022-05-02 Soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662359607P 2016-07-07 2016-07-07
US62/359,607 2016-07-07
US201762467478P 2017-03-06 2017-03-06
US62/467,478 2017-03-06
PCT/EP2017/067119 WO2018007597A1 (en) 2016-07-07 2017-07-07 Soluble fibroblast growth factor receptor 3 (sfgfr3) polypeptides and uses thereof

Related Child Applications (1)

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AU2022202906A Division AU2022202906A1 (en) 2016-07-07 2022-05-02 Soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides and uses thereof

Publications (2)

Publication Number Publication Date
AU2017294551A1 AU2017294551A1 (en) 2019-01-31
AU2017294551B2 true AU2017294551B2 (en) 2022-03-03

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AU2017294551A Ceased AU2017294551B2 (en) 2016-07-07 2017-07-07 Soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides and uses thereof
AU2022202906A Abandoned AU2022202906A1 (en) 2016-07-07 2022-05-02 Soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides and uses thereof

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US (3) US10294289B2 (https=)
EP (2) EP3481859B1 (https=)
JP (2) JP7046903B2 (https=)
KR (2) KR20220122762A (https=)
CN (1) CN109715658B (https=)
AU (2) AU2017294551B2 (https=)
BR (1) BR112019000257A2 (https=)
CA (1) CA3029877C (https=)
DK (1) DK3481859T3 (https=)
ES (1) ES2912559T3 (https=)
HU (1) HUE058734T2 (https=)
IL (1) IL264030A (https=)
MX (1) MX2018016257A (https=)
PL (1) PL3481859T3 (https=)
PT (1) PT3481859T (https=)
RU (1) RU2751483C2 (https=)
SG (1) SG11201900074WA (https=)
SI (1) SI3481859T1 (https=)
WO (1) WO2018007597A1 (https=)
ZA (1) ZA201900507B (https=)

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EA201591324A1 (ru) 2013-01-16 2016-01-29 Инсерм (Энститю Насьональ Де Ля Сантэ Э Де Ля Решерш Медикаль) Полипептид растворимого рецептора 3 фактора роста фибробластов (fgr3) для применения с целью предотвращения или лечения нарушений, связанных с замедлением роста скелета
MX2018016257A (es) 2016-07-07 2019-11-21 Therachon Sas Polipéptidos del receptor 3 del factor de crecimiento de fibroblastos solubles (sfgfr3) y usos de los mismos.
JP7335247B2 (ja) * 2017-09-20 2023-08-29 ファイザー・インク 可溶性線維芽細胞増殖因子受容体３（ｓＦＧＦＲ３）ポリペプチドを使用した異常内臓脂肪蓄積の処置
WO2020243478A1 (en) * 2019-05-29 2020-12-03 Massachusetts Eye And Ear Infirmary Fibroblast growth factor 2 (fgf2) for treatment of human sensorineural hearing loss
US11625937B2 (en) * 2020-04-06 2023-04-11 Toyota Motor Engineering & Manufacturing North America, Inc. Methods and systems for monitoring human body weight with vehicle sensors and big data AI analytics
WO2022106976A1 (en) 2020-11-18 2022-05-27 Pfizer Inc. Stable pharmaceutical formulations of soluble fgfr3 decoys
WO2022254319A1 (en) 2021-06-01 2022-12-08 Pfizer Inc. Cell culture method for producing sfgfr3 polypeptide
WO2024104922A1 (en) 2022-11-14 2024-05-23 Ascendis Pharma Growth Disorders A/S Method of improving skeletal muscle function
AU2024240722A1 (en) 2023-03-20 2025-09-18 Ascendis Pharma Growth Disorders A/S Method of treatment of a thoracolumbar deformity in a human subject with achondroplasia
CN116284327A (zh) * 2023-03-28 2023-06-23 中国药科大学 一种靶向肿瘤的成纤维细胞生长因子19的重组蛋白及其应用

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WO2011084711A2 (en) * 2009-12-17 2011-07-14 Five Prime Therapeutics, Inc. Hair growth methods using fgfr3 extracellular domains
WO2014111467A1 (en) * 2013-01-16 2014-07-24 INSERM (Institut National de la Santé et de la Recherche Médicale) A soluble fibroblast growth factor receptor 3 (fgr3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders

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JP7335247B2 (ja) 2017-09-20 2023-08-29 ファイザー・インク 可溶性線維芽細胞増殖因子受容体３（ｓＦＧＦＲ３）ポリペプチドを使用した異常内臓脂肪蓄積の処置

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WO2010017198A2 (en) * 2008-08-04 2010-02-11 Five Prime Therapeutics, Inc. Fgfr extracellular domain acidic region muteins
WO2011084711A2 (en) * 2009-12-17 2011-07-14 Five Prime Therapeutics, Inc. Hair growth methods using fgfr3 extracellular domains
WO2014111467A1 (en) * 2013-01-16 2014-07-24 INSERM (Institut National de la Santé et de la Recherche Médicale) A soluble fibroblast growth factor receptor 3 (fgr3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders

Also Published As

Publication number Publication date
CN109715658A (zh) 2019-05-03
US20210309718A1 (en) 2021-10-07
KR20220122762A (ko) 2022-09-02
RU2019100381A (ru) 2020-08-11
SI3481859T1 (sl) 2022-07-29
HUE058734T2 (hu) 2022-09-28
EP4122955A1 (en) 2023-01-25
US11697678B2 (en) 2023-07-11
CN109715658B (zh) 2023-09-12
JP2019527053A (ja) 2019-09-26
MX2018016257A (es) 2019-11-21
ES2912559T3 (es) 2022-05-26
EP3481859A1 (en) 2019-05-15
ZA201900507B (en) 2023-04-26
RU2751483C2 (ru) 2021-07-14
AU2022202906A1 (en) 2022-05-26
PT3481859T (pt) 2022-05-23
WO2018007597A1 (en) 2018-01-11
CA3029877A1 (en) 2018-01-11
AU2017294551A1 (en) 2019-01-31
DK3481859T3 (da) 2022-04-25
RU2019100381A3 (https=) 2020-11-23
US20180230197A1 (en) 2018-08-16
JP7046903B2 (ja) 2022-04-04
SG11201900074WA (en) 2019-02-27
KR20190037240A (ko) 2019-04-05
BR112019000257A2 (pt) 2019-10-01
KR102432192B1 (ko) 2022-08-12
CA3029877C (en) 2023-07-25
JP7348980B2 (ja) 2023-09-21
US20200190162A1 (en) 2020-06-18
EP3481859B1 (en) 2022-04-13
US10294289B2 (en) 2019-05-21
US11021528B2 (en) 2021-06-01
PL3481859T3 (pl) 2022-07-11
IL264030A (en) 2019-01-31
JP2022096660A (ja) 2022-06-29

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Owner name: PFIZER INC.

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Owner name: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

Free format text: FORMER APPLICANT(S): THERACHON SAS; UNIVERSITE NICE SOPHIA ANTIPOLIS; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

Owner name: UNIVERSITE COTE D'AZUR

Free format text: FORMER APPLICANT(S): THERACHON SAS; UNIVERSITE NICE SOPHIA ANTIPOLIS; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

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