AU2017253621A1 - Administration of a bispecific construct binding to CD33 and CD3 for use in a method for the treatment of myeloid leukemia - Google Patents
Administration of a bispecific construct binding to CD33 and CD3 for use in a method for the treatment of myeloid leukemia Download PDFInfo
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- AU2017253621A1 AU2017253621A1 AU2017253621A AU2017253621A AU2017253621A1 AU 2017253621 A1 AU2017253621 A1 AU 2017253621A1 AU 2017253621 A AU2017253621 A AU 2017253621A AU 2017253621 A AU2017253621 A AU 2017253621A AU 2017253621 A1 AU2017253621 A1 AU 2017253621A1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Oncology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US201662324451P | 2016-04-19 | 2016-04-19 | |
| US62/324,451 | 2016-04-19 | ||
| PCT/EP2017/059108 WO2017182427A1 (en) | 2016-04-19 | 2017-04-18 | Administration of a bispecific construct binding to cd33 and cd3 for use in a method for the treatment of myeloid leukemia |
Publications (1)
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|---|---|
| AU2017253621A1 true AU2017253621A1 (en) | 2018-10-18 |
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| AU2017253621A Abandoned AU2017253621A1 (en) | 2016-04-19 | 2017-04-18 | Administration of a bispecific construct binding to CD33 and CD3 for use in a method for the treatment of myeloid leukemia |
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| US (1) | US11053318B2 (enExample) |
| EP (1) | EP3445784B1 (enExample) |
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| EA (1) | EA038736B1 (enExample) |
| IL (1) | IL262423A (enExample) |
| JO (1) | JOP20170091B1 (enExample) |
| MA (1) | MA44726A (enExample) |
| MX (1) | MX390484B (enExample) |
| MY (1) | MY194062A (enExample) |
| PH (1) | PH12018502230A1 (enExample) |
| SG (1) | SG11201808656SA (enExample) |
| TW (1) | TWI752952B (enExample) |
| UA (1) | UA124732C2 (enExample) |
| WO (1) | WO2017182427A1 (enExample) |
| ZA (1) | ZA201806514B (enExample) |
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| JP2018516248A (ja) | 2015-05-29 | 2018-06-21 | アンフィヴェナ セラピューティクス，インク． | 二重特異性のｃｄ３３およびｃｄ３結合タンパク質を使用する方法 |
| EP3165536A1 (en) * | 2015-11-09 | 2017-05-10 | Ludwig-Maximilians-Universität München | Trispecific molecule combining specific tumor targeting and local immune checkpoint inhibition |
| EP3830121A1 (en) * | 2018-07-30 | 2021-06-09 | Amgen Research (Munich) GmbH | Prolonged administration of a bispecific antibody construct binding to cd33 and cd3 |
| CA3110750A1 (en) | 2018-09-10 | 2020-03-19 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies against cd33 and constructs thereof |
| US20210324076A1 (en) * | 2018-10-12 | 2021-10-21 | Amphivena Therapeutics Inc | Cd33×cd3 binding proteins for treating inflammatory conditions and diseases |
| US11873338B2 (en) | 2018-12-20 | 2024-01-16 | Merus N.V. | CLEC12AxCD3 bispecific antibodies and methods for the treatment of disease |
| US20220251192A1 (en) * | 2019-06-26 | 2022-08-11 | Memorial Sloan Kettering Cancer Center | Anti-cd33 antibodies for treating cancer |
| WO2021091906A1 (en) * | 2019-11-04 | 2021-05-14 | Amgen Inc. | Methods for treating leukemia |
| EP4084821A4 (en) * | 2020-01-03 | 2024-04-24 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
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-
2017
- 2017-04-16 JO JOP/2017/0091A patent/JOP20170091B1/ar active
- 2017-04-18 AU AU2017253621A patent/AU2017253621A1/en not_active Abandoned
- 2017-04-18 EP EP17721537.3A patent/EP3445784B1/en active Active
- 2017-04-18 JP JP2018554711A patent/JP2019514871A/ja active Pending
- 2017-04-18 MA MA044726A patent/MA44726A/fr unknown
- 2017-04-18 BR BR112018070946A patent/BR112018070946A2/pt not_active IP Right Cessation
- 2017-04-18 EA EA201892367A patent/EA038736B1/ru unknown
- 2017-04-18 SG SG11201808656SA patent/SG11201808656SA/en unknown
- 2017-04-18 US US16/094,172 patent/US11053318B2/en active Active
- 2017-04-18 MX MX2018012717A patent/MX390484B/es unknown
- 2017-04-18 MY MYPI2018703790A patent/MY194062A/en unknown
- 2017-04-18 UA UAA201811280A patent/UA124732C2/uk unknown
- 2017-04-18 CA CA3019740A patent/CA3019740A1/en not_active Abandoned
- 2017-04-18 WO PCT/EP2017/059108 patent/WO2017182427A1/en not_active Ceased
- 2017-04-19 TW TW106113102A patent/TWI752952B/zh not_active IP Right Cessation
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| BR112018070946A2 (pt) | 2019-02-26 |
| WO2017182427A1 (en) | 2017-10-26 |
| US11053318B2 (en) | 2021-07-06 |
| MX2018012717A (es) | 2019-05-15 |
| EP3445784B1 (en) | 2022-06-01 |
| MY194062A (en) | 2022-11-10 |
| JOP20170091B1 (ar) | 2021-08-17 |
| MX390484B (es) | 2025-03-20 |
| ZA201806514B (en) | 2019-06-26 |
| UA124732C2 (uk) | 2021-11-10 |
| MA44726A (fr) | 2019-02-27 |
| JP2019514871A (ja) | 2019-06-06 |
| PH12018502230A1 (en) | 2019-07-08 |
| CA3019740A1 (en) | 2017-10-26 |
| EA201892367A1 (ru) | 2019-04-30 |
| TW201741339A (zh) | 2017-12-01 |
| SG11201808656SA (en) | 2018-10-30 |
| EP3445784A1 (en) | 2019-02-27 |
| TWI752952B (zh) | 2022-01-21 |
| EA038736B1 (ru) | 2021-10-12 |
| IL262423A (en) | 2018-12-31 |
| US20190127465A1 (en) | 2019-05-02 |
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