AU2016327930B2 - Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof - Google Patents
Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof Download PDFInfo
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- AU2016327930B2 AU2016327930B2 AU2016327930A AU2016327930A AU2016327930B2 AU 2016327930 B2 AU2016327930 B2 AU 2016327930B2 AU 2016327930 A AU2016327930 A AU 2016327930A AU 2016327930 A AU2016327930 A AU 2016327930A AU 2016327930 B2 AU2016327930 B2 AU 2016327930B2
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- liver
- mannitol
- pharmaceutically acceptable
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- 208000010706 fatty liver disease Diseases 0.000 title claims abstract description 67
- 206010019851 Hepatotoxicity Diseases 0.000 title claims abstract description 29
- 231100000304 hepatotoxicity Toxicity 0.000 title claims abstract description 27
- 230000007686 hepatotoxicity Effects 0.000 title claims abstract description 27
- 239000000594 mannitol Substances 0.000 claims description 97
- 210000004185 liver Anatomy 0.000 claims description 94
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- 235000010355 mannitol Nutrition 0.000 claims description 86
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 85
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- 208000004930 Fatty Liver Diseases 0.000 claims description 53
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- 206010019708 Hepatic steatosis Diseases 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 50
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- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C07C51/21—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen
- C07C51/215—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of saturated hydrocarbyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/42—Glutaric acid esters
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Urology & Nephrology (AREA)
Priority Applications (2)
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| AU2021205040A AU2021205040B2 (en) | 2015-09-24 | 2021-07-14 | Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof |
| AU2024200963A AU2024200963A1 (en) | 2015-09-24 | 2024-02-14 | Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US201562222959P | 2015-09-24 | 2015-09-24 | |
| US62/222,959 | 2015-09-24 | ||
| US201562257697P | 2015-11-19 | 2015-11-19 | |
| US62/257,697 | 2015-11-19 | ||
| AUPCT/CN2016/078039 | 2016-03-31 | ||
| PCT/CN2016/078039 WO2017084234A1 (zh) | 2015-11-19 | 2016-03-31 | 预防或治疗脂肪肝的药物组合物 |
| PCT/CN2016/100187 WO2017050298A1 (en) | 2015-09-24 | 2016-09-26 | Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof |
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| AU2021205040A Division AU2021205040B2 (en) | 2015-09-24 | 2021-07-14 | Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof |
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| AU2016327930A1 AU2016327930A1 (en) | 2018-05-10 |
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| AU2021205040A Active AU2021205040B2 (en) | 2015-09-24 | 2021-07-14 | Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof |
| AU2024200963A Pending AU2024200963A1 (en) | 2015-09-24 | 2024-02-14 | Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof |
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| AU2024200963A Pending AU2024200963A1 (en) | 2015-09-24 | 2024-02-14 | Compounds effective in treating hepatotoxicity and fatty liver diseases and uses thereof |
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| EP (2) | EP3991724A3 (es) |
| JP (2) | JP2018537517A (es) |
| KR (2) | KR20180058795A (es) |
| CN (1) | CN107614475A (es) |
| AU (3) | AU2016327930B2 (es) |
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| HK (1) | HK1244266A1 (es) |
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| WO (1) | WO2017050298A1 (es) |
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| LT3069733T (lt) * | 2013-11-13 | 2022-11-25 | National Defense Education And Research Foundation | Nauja acetaminofeno junginio sudėtis be šalutinio poveikio kepenims |
| JP2018537517A (ja) * | 2015-09-24 | 2018-12-20 | シニュー・ファーマ・インコーポレイテッドＳｉＮｅｗ Ｐｈａｒｍａ Ｉｎｃ． | 肝毒性および脂肪性肝疾患の処置に有効な化合物およびその使用 |
| JP2018534323A (ja) * | 2015-11-19 | 2018-11-22 | シニュー・ファーマ・インコーポレイテッドＳｉＮｅｗ Ｐｈａｒｍａ Ｉｎｃ． | 脂肪肝の予防または処置用医薬組成物 |
| AU2019220062A1 (en) * | 2018-02-14 | 2020-09-17 | Sinew Pharma Inc. | Methods and compositions for preventing, reducing or eradicating toxicity caused by acetaminophen (APAP) |
| CN110538187A (zh) * | 2018-05-28 | 2019-12-06 | 北京大学 | Cpt1激活剂 |
| KR102136326B1 (ko) * | 2018-09-06 | 2020-07-22 | 서울대학교산학협력단 | 가시박으로부터 분리한 플라보노이드 유도체를 유효성분으로 포함하는 간 질환 예방 또는 치료용 조성물 |
| TWI691719B (zh) * | 2018-10-19 | 2020-04-21 | 香港商阿瓦隆 海帕波有限公司 | 半乳糖快速定量檢測系統及其應用 |
| CN109920550A (zh) * | 2018-12-25 | 2019-06-21 | 天津大学 | 一种基于dMRI研究青少年肌阵挛性癫痫的方法 |
| CN110269855A (zh) * | 2019-07-19 | 2019-09-24 | 辽宁大学 | 黄酮类小分子化合物在制备抑制胰脂肪酶活性药物中的应用 |
| CN113999272A (zh) * | 2021-10-29 | 2022-02-01 | 广西医科大学 | 香蜂草苷的制备方法及其应用 |
| CN113875982A (zh) * | 2021-11-19 | 2022-01-04 | 武汉森澜生物科技有限公司 | 一种含二氢杨梅素的抗衰组合物及其应用 |
Citations (1)
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|---|---|---|---|---|
| US20140141082A1 (en) * | 2012-11-16 | 2014-05-22 | Song Gao | Compositions Containing Enriched Natural Crocin and/or Crocetin, and Their Therapeutic or Nutraceutical Uses |
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| US4661519A (en) * | 1983-04-12 | 1987-04-28 | Pola Chemical Industries Inc. | Method for dermatological application |
| CH664150A5 (de) * | 1985-01-15 | 1988-02-15 | Peter Paul Prof Dr Speiser | Fumarsaeureprodrug, verfahren zu seiner herstellung und dieses enthaltende darreichungsformen. |
| JP3916685B2 (ja) * | 1996-02-29 | 2007-05-16 | 第一製薬株式会社 | ガラクトース誘導体 |
| JP4677550B2 (ja) * | 2002-08-14 | 2011-04-27 | 独立行政法人産業技術総合研究所 | 環状エステル化合物 |
| TWI287990B (en) * | 2004-01-08 | 2007-10-11 | Nat Defense Medical Ct | Inhibitors and enhancers of uridine diphosphate-glucuronosyl transferase 2B (UGT2B) |
| US20070009441A1 (en) * | 2004-07-08 | 2007-01-11 | Molecular Therapeutics, Inc. | Biodegradable nanoparticles |
| CN1939929A (zh) * | 2005-09-29 | 2007-04-04 | 云南白药集团股份有限公司 | 一种偏诺皂苷类化合物酸式盐及制备方法 |
| CN103391781A (zh) * | 2011-04-20 | 2013-11-13 | 国防教育研究基金会 | 无/低副作用的抗结核病药物复方 |
| WO2014075051A1 (en) * | 2012-11-12 | 2014-05-15 | Segetis, Inc. | Crosslinkable polyketal esters, methods of manufacture and uses thereof |
| CN105143428B (zh) * | 2013-04-29 | 2017-08-25 | 哈沙·奇古鲁帕蒂 | 酒精饮料中降低的毒性 |
| TWI552748B (zh) | 2013-10-25 | 2016-10-11 | The use of a compound for the removal of hepatotoxicity against Acetaminophen (APAP) | |
| CN104623670A (zh) * | 2013-11-06 | 2015-05-20 | 高松 | 一种含西红花素的组合物及其应用 |
| LT3069733T (lt) * | 2013-11-13 | 2022-11-25 | National Defense Education And Research Foundation | Nauja acetaminofeno junginio sudėtis be šalutinio poveikio kepenims |
| CN104292289B (zh) * | 2014-07-10 | 2017-12-29 | 程怡 | 半乳糖配体及其在肝靶向脂质体中的应用 |
| JP2018537517A (ja) * | 2015-09-24 | 2018-12-20 | シニュー・ファーマ・インコーポレイテッドＳｉＮｅｗ Ｐｈａｒｍａ Ｉｎｃ． | 肝毒性および脂肪性肝疾患の処置に有効な化合物およびその使用 |
| JP2018534323A (ja) * | 2015-11-19 | 2018-11-22 | シニュー・ファーマ・インコーポレイテッドＳｉＮｅｗ Ｐｈａｒｍａ Ｉｎｃ． | 脂肪肝の予防または処置用医薬組成物 |
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2016
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| US20140141082A1 (en) * | 2012-11-16 | 2014-05-22 | Song Gao | Compositions Containing Enriched Natural Crocin and/or Crocetin, and Their Therapeutic or Nutraceutical Uses |
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