AU2016305513A1 - Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals - Google Patents
Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals Download PDFInfo
- Publication number
- AU2016305513A1 AU2016305513A1 AU2016305513A AU2016305513A AU2016305513A1 AU 2016305513 A1 AU2016305513 A1 AU 2016305513A1 AU 2016305513 A AU2016305513 A AU 2016305513A AU 2016305513 A AU2016305513 A AU 2016305513A AU 2016305513 A1 AU2016305513 A1 AU 2016305513A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- alkyl
- cancer
- mmol
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 *CC(*(*)=*1*)=*(*)N(*)C1=O Chemical compound *CC(*(*)=*1*)=*(*)N(*)C1=O 0.000 description 5
- ZJTKSXUAVVEKPY-UHFFFAOYSA-N CC(c1cnccc1)Oc(cc(cc1CC2)Br)c1NC2=O Chemical compound CC(c1cnccc1)Oc(cc(cc1CC2)Br)c1NC2=O ZJTKSXUAVVEKPY-UHFFFAOYSA-N 0.000 description 1
- QAPJXXGCRDCITL-UHFFFAOYSA-N CC(c1cnccc1)Oc(cc(cc1CC2)C(C=C3C)=CN(C)C3=O)c1NC2=O Chemical compound CC(c1cnccc1)Oc(cc(cc1CC2)C(C=C3C)=CN(C)C3=O)c1NC2=O QAPJXXGCRDCITL-UHFFFAOYSA-N 0.000 description 1
- BSXYAFHIMFKOID-UHFFFAOYSA-N CC1=CC(c(cc2)c(COC3CCC3)c(CC3)c2NC3=O)=CN(C)C1=O Chemical compound CC1=CC(c(cc2)c(COC3CCC3)c(CC3)c2NC3=O)=CN(C)C1=O BSXYAFHIMFKOID-UHFFFAOYSA-N 0.000 description 1
- JPCNPDFLNPOVSU-UHFFFAOYSA-N CC1=CC(c(cc2)c(COC3CCCC3)c(CC3)c2NC3=O)=CN(C)C1=O Chemical compound CC1=CC(c(cc2)c(COC3CCCC3)c(CC3)c2NC3=O)=CN(C)C1=O JPCNPDFLNPOVSU-UHFFFAOYSA-N 0.000 description 1
- DYWQDGCGWPXKMH-UHFFFAOYSA-N CC1=CC(c(cc2)c(Cc(cc3)ccc3C#N)c(CC3)c2NC3=O)=CN(C)C1=O Chemical compound CC1=CC(c(cc2)c(Cc(cc3)ccc3C#N)c(CC3)c2NC3=O)=CN(C)C1=O DYWQDGCGWPXKMH-UHFFFAOYSA-N 0.000 description 1
- DCZGEAPKUREHOT-UHFFFAOYSA-N CC1=CC(c(cc2)c(Cc3ccncc3)c(CC3)c2NC3=O)=CN(C)C1=O Chemical compound CC1=CC(c(cc2)c(Cc3ccncc3)c(CC3)c2NC3=O)=CN(C)C1=O DCZGEAPKUREHOT-UHFFFAOYSA-N 0.000 description 1
- VXUZSBUPJIUMJE-UHFFFAOYSA-N CC1=CC(c(cc2CC3)c(COC4CCC4)cc2NC3=O)=CN(C)C1=O Chemical compound CC1=CC(c(cc2CC3)c(COC4CCC4)cc2NC3=O)=CN(C)C1=O VXUZSBUPJIUMJE-UHFFFAOYSA-N 0.000 description 1
- VIQFKZZEKXTOEL-UHFFFAOYSA-N CC1=CC(c(cc2CC3)c(Cc4cccnc4)cc2NC3=O)=CN(C)C1=O Chemical compound CC1=CC(c(cc2CC3)c(Cc4cccnc4)cc2NC3=O)=CN(C)C1=O VIQFKZZEKXTOEL-UHFFFAOYSA-N 0.000 description 1
- MSUCWVADGRZPTK-UHFFFAOYSA-N CC1=CC(c(cc2CC3)cc(OC4CCCCC4)c2NC3=O)=CN(C)C1=O Chemical compound CC1=CC(c(cc2CC3)cc(OC4CCCCC4)c2NC3=O)=CN(C)C1=O MSUCWVADGRZPTK-UHFFFAOYSA-N 0.000 description 1
- SJZHFMGDLZVPNY-UHFFFAOYSA-N CC1=CC(c(cc2CC3)cc(OCC4CCCCC4)c2NC3=O)=CN(C)C1=O Chemical compound CC1=CC(c(cc2CC3)cc(OCC4CCCCC4)c2NC3=O)=CN(C)C1=O SJZHFMGDLZVPNY-UHFFFAOYSA-N 0.000 description 1
- KSRCTRHGKKLDPX-UHFFFAOYSA-N CC1=CC(c(cc2CC3)cc(OCC4CCOCC4)c2NC3=O)=CN(C)C1=O Chemical compound CC1=CC(c(cc2CC3)cc(OCC4CCOCC4)c2NC3=O)=CN(C)C1=O KSRCTRHGKKLDPX-UHFFFAOYSA-N 0.000 description 1
- COYOQRPUZLFQEP-UHFFFAOYSA-N CC1=CC(c(cc2CC3)cc(OCc4c[o]cn4)c2NC3=O)=CN(C)C1=O Chemical compound CC1=CC(c(cc2CC3)cc(OCc4c[o]cn4)c2NC3=O)=CN(C)C1=O COYOQRPUZLFQEP-UHFFFAOYSA-N 0.000 description 1
- WRFYIYOXJWKONR-UHFFFAOYSA-N COc(cc(cc1)Br)c1N Chemical compound COc(cc(cc1)Br)c1N WRFYIYOXJWKONR-UHFFFAOYSA-N 0.000 description 1
- ODGDFYHIYZFQEV-UHFFFAOYSA-N COc(cc(cc1)Br)c1NC(CCCl)=O Chemical compound COc(cc(cc1)Br)c1NC(CCCl)=O ODGDFYHIYZFQEV-UHFFFAOYSA-N 0.000 description 1
- RUEAJFJUWRXYQL-UHFFFAOYSA-N O=C(CC1)Nc(cc2)c1c(Br)c2Cl Chemical compound O=C(CC1)Nc(cc2)c1c(Br)c2Cl RUEAJFJUWRXYQL-UHFFFAOYSA-N 0.000 description 1
- WXTGQHCUOMLSQB-UHFFFAOYSA-N O=C(CC1)Nc(cc2)c1c(Cl)c2Br Chemical compound O=C(CC1)Nc(cc2)c1c(Cl)c2Br WXTGQHCUOMLSQB-UHFFFAOYSA-N 0.000 description 1
- QOPFKGOBJUYBLM-UHFFFAOYSA-N O=C(CCCl)Nc(cc1)cc(Cl)c1Br Chemical compound O=C(CCCl)Nc(cc1)cc(Cl)c1Br QOPFKGOBJUYBLM-UHFFFAOYSA-N 0.000 description 1
- YQQIGFQNEAJXFW-UHFFFAOYSA-N O=C(CCCl)Nc(cc1Br)ccc1Cl Chemical compound O=C(CCCl)Nc(cc1Br)ccc1Cl YQQIGFQNEAJXFW-UHFFFAOYSA-N 0.000 description 1
- NHCWVYLTHOUUNE-UHFFFAOYSA-N O=C(CCc1c2)Nc1cc(Br)c2Cl Chemical compound O=C(CCc1c2)Nc1cc(Br)c2Cl NHCWVYLTHOUUNE-UHFFFAOYSA-N 0.000 description 1
- HGGUWHWVJPOCLK-UHFFFAOYSA-N O=C(CCc1c2)Nc1cc(Cl)c2Br Chemical compound O=C(CCc1c2)Nc1cc(Cl)c2Br HGGUWHWVJPOCLK-UHFFFAOYSA-N 0.000 description 1
- ZVXYIXSYYOVPOD-UHFFFAOYSA-N O=C(CCc1cc(Br)c2)Nc1c2OCC1COCCC1 Chemical compound O=C(CCc1cc(Br)c2)Nc1c2OCC1COCCC1 ZVXYIXSYYOVPOD-UHFFFAOYSA-N 0.000 description 1
- YWPJLDIAZYVZTB-UHFFFAOYSA-N Oc(cc(cc1CC2)Br)c1NC2=O Chemical compound Oc(cc(cc1CC2)Br)c1NC2=O YWPJLDIAZYVZTB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562203623P | 2015-08-11 | 2015-08-11 | |
| US62/203,623 | 2015-08-11 | ||
| US201662356579P | 2016-06-30 | 2016-06-30 | |
| US62/356,579 | 2016-06-30 | ||
| PCT/CA2016/050943 WO2017024408A1 (en) | 2015-08-11 | 2016-08-11 | Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2016305513A1 true AU2016305513A1 (en) | 2018-03-08 |
Family
ID=57982883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016305513A Abandoned AU2016305513A1 (en) | 2015-08-11 | 2016-08-11 | Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10501438B2 (enExample) |
| EP (1) | EP3334717B1 (enExample) |
| JP (1) | JP2018527340A (enExample) |
| KR (1) | KR20180039117A (enExample) |
| CN (1) | CN108290856A (enExample) |
| AU (1) | AU2016305513A1 (enExample) |
| CA (1) | CA2994472A1 (enExample) |
| HK (1) | HK1256753A1 (enExample) |
| IL (1) | IL257347A (enExample) |
| MX (1) | MX2018001751A (enExample) |
| WO (1) | WO2017024408A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020093162A1 (en) * | 2018-11-07 | 2020-05-14 | Neomed Institute | Treatment of bet inhibitor-resistant cancers and other diseases responsive to dual bet and cbp/ep300 inhibition therapy |
| EP3938340B1 (en) * | 2019-03-11 | 2025-07-09 | Collaborative Medicinal Development, LLC | Heteroaromatic and heterobicyclic aromatic derivatives for the treatment of ferroptosis-related disorders |
| CN112239456B (zh) * | 2020-06-09 | 2021-09-07 | 浙江理工大学 | 一种取代2，3-二氢喹诺酮化合物的制备方法 |
| CN114276333B (zh) * | 2020-09-28 | 2023-05-09 | 中国科学院上海药物研究所 | 二氢喹喔啉类溴结构域二价抑制剂 |
| WO2024222147A1 (zh) * | 2023-04-23 | 2024-10-31 | 信义核新(北京)生物科技有限公司 | 喹诺酮类似物及其用途 |
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| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| DE4237656A1 (de) | 1992-06-13 | 1993-12-16 | Merck Patent Gmbh | Benzimidazolderivate |
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| JP6525437B2 (ja) | 2014-04-02 | 2019-06-05 | インターミューン， インコーポレイテッド | 抗線維性ピリジノン |
| KR102702503B1 (ko) * | 2014-04-23 | 2024-09-05 | 인사이트 홀딩스 코포레이션 | BET 단백질의 저해제로서의 1H-피롤로[2,3-c]피리딘-7(6H)-온 및 피라졸로[3,4-c]피리딘-7(6H)-온 |
| WO2016077656A2 (en) | 2014-11-13 | 2016-05-19 | Convergene Llc | Methods and compositions for inhibition of bromodomain and extraterminal proteins |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| WO2016097870A1 (en) | 2014-12-17 | 2016-06-23 | Zenith Epigenetics Corp. | Substituted bicyclic compounds as bromodomain inhibitors |
| US10231953B2 (en) | 2014-12-17 | 2019-03-19 | Zenith Epigenetics Ltd. | Inhibitors of bromodomains |
| GB201503720D0 (en) | 2015-03-05 | 2015-04-22 | Glaxosmithkline Ip No 2 Ltd | Chemical compound |
| GB201504689D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| US10501459B2 (en) | 2015-10-21 | 2019-12-10 | Neomed Institute | Substituted imidazo[1,2-a]pyridines as bromodomain inhibitors |
-
2016
- 2016-08-11 AU AU2016305513A patent/AU2016305513A1/en not_active Abandoned
- 2016-08-11 US US15/751,800 patent/US10501438B2/en active Active
- 2016-08-11 CN CN201680058648.1A patent/CN108290856A/zh active Pending
- 2016-08-11 EP EP16834368.9A patent/EP3334717B1/en active Active
- 2016-08-11 KR KR1020187006580A patent/KR20180039117A/ko not_active Withdrawn
- 2016-08-11 JP JP2018506998A patent/JP2018527340A/ja active Pending
- 2016-08-11 MX MX2018001751A patent/MX2018001751A/es unknown
- 2016-08-11 HK HK18115833.9A patent/HK1256753A1/zh unknown
- 2016-08-11 CA CA2994472A patent/CA2994472A1/en not_active Abandoned
- 2016-08-11 WO PCT/CA2016/050943 patent/WO2017024408A1/en not_active Ceased
-
2018
- 2018-02-04 IL IL257347A patent/IL257347A/en unknown
-
2019
- 2019-10-28 US US16/665,198 patent/US20200299262A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3334717A1 (en) | 2018-06-20 |
| CN108290856A (zh) | 2018-07-17 |
| HK1256753A1 (zh) | 2019-10-04 |
| US10501438B2 (en) | 2019-12-10 |
| EP3334717B1 (en) | 2020-07-01 |
| US20200299262A1 (en) | 2020-09-24 |
| US20180230130A1 (en) | 2018-08-16 |
| WO2017024408A1 (en) | 2017-02-16 |
| JP2018527340A (ja) | 2018-09-20 |
| KR20180039117A (ko) | 2018-04-17 |
| CA2994472A1 (en) | 2017-02-16 |
| IL257347A (en) | 2018-03-29 |
| EP3334717A4 (en) | 2019-02-13 |
| MX2018001751A (es) | 2018-08-01 |
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