AU2016303614A1 - Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines - Google Patents
Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines Download PDFInfo
- Publication number
- AU2016303614A1 AU2016303614A1 AU2016303614A AU2016303614A AU2016303614A1 AU 2016303614 A1 AU2016303614 A1 AU 2016303614A1 AU 2016303614 A AU2016303614 A AU 2016303614A AU 2016303614 A AU2016303614 A AU 2016303614A AU 2016303614 A1 AU2016303614 A1 AU 2016303614A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- formula
- reacting
- pct
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- JBXAKQJKSGOFNP-UHFFFAOYSA-N O=C(NC(c1nc(C(F)(F)F)ccc1)=N1)NC1=O Chemical compound O=C(NC(c1nc(C(F)(F)F)ccc1)=N1)NC1=O JBXAKQJKSGOFNP-UHFFFAOYSA-N 0.000 description 2
- OHJMTUPIZMNBFR-UHFFFAOYSA-N NC(NC(N)=O)=O Chemical compound NC(NC(N)=O)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021200494A AU2021200494A1 (en) | 2015-08-05 | 2021-01-27 | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562201546P | 2015-08-05 | 2015-08-05 | |
| US62/201,546 | 2015-08-05 | ||
| PCT/US2016/045553 WO2017024134A1 (en) | 2015-08-05 | 2016-08-04 | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021200494A Division AU2021200494A1 (en) | 2015-08-05 | 2021-01-27 | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2016303614A1 true AU2016303614A1 (en) | 2018-02-15 |
Family
ID=56684781
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016303614A Abandoned AU2016303614A1 (en) | 2015-08-05 | 2016-08-04 | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
| AU2021200494A Abandoned AU2021200494A1 (en) | 2015-08-05 | 2021-01-27 | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021200494A Abandoned AU2021200494A1 (en) | 2015-08-05 | 2021-01-27 | Methods of preparing 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diols and 6-(aryl or heteroaryl)-1,3,5-triazine-2,4-diamines |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9751863B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3331866B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP6816106B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN108349933A (cg-RX-API-DMAC10.html) |
| AU (2) | AU2016303614A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2993615A1 (cg-RX-API-DMAC10.html) |
| MX (1) | MX365590B (cg-RX-API-DMAC10.html) |
| WO (1) | WO2017024134A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015324158A1 (en) | 2014-09-29 | 2017-04-13 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| EP3253746A1 (en) | 2015-02-04 | 2017-12-13 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CN108349933A (zh) * | 2015-08-05 | 2018-07-31 | 安吉奥斯医药品有限公司 | 制备6-(芳基或杂芳基)-1,3,5-三嗪-2,4-二醇和6-(芳基或杂芳基)-1,3,5-三嗪-2,4-二胺的方法 |
| JP2018534288A (ja) | 2015-10-15 | 2018-11-22 | アジオス ファーマシューティカルズ， インコーポレイテッド | 悪性腫瘍の治療のための併用療法 |
| CA3002029A1 (en) | 2015-10-15 | 2017-04-20 | Celgene Corporation | Combination therapy for treating malignancies |
| MA43374A (fr) | 2015-12-04 | 2018-10-10 | Agios Pharmaceuticals Inc | Méthodes de traitement de tumeurs malignes |
| CA3015753A1 (en) | 2016-02-26 | 2017-08-31 | Celgene Corporation | Idh2 inhibitors for the treatment of haematological maligancies and solid tumours |
| KR102498693B1 (ko) | 2016-09-07 | 2023-02-10 | 셀진 코포레이션 | 정제 조성물 |
| WO2018204787A1 (en) | 2017-05-05 | 2018-11-08 | Memorial Sloan Kettering Cancer Center | Methods of treatment of myeloproliferative neoplasm |
| WO2020092915A1 (en) | 2018-11-02 | 2020-05-07 | Celgene Corporation | Solid dispersions for treatment of cancer |
| WO2020092906A1 (en) | 2018-11-02 | 2020-05-07 | Celgene Corporation | Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof |
| WO2020092894A1 (en) | 2018-11-02 | 2020-05-07 | Celgene Corporation | Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl) pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol |
| US20220401450A1 (en) | 2019-11-14 | 2022-12-22 | Celgene Corporation | Pediatric formulations for treatment of cancer |
| CN111592524B (zh) * | 2020-05-20 | 2023-11-17 | 温州市天聚万迅信息科技有限公司 | 恩西德尼的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2390529A (en) | 1942-02-03 | 1945-12-11 | Ernst A H Friedheim | Hydrazino-1,3,5-triazino derivatives of substituted phenylarsenic compounds |
| JPS5170779A (ja) * | 1974-12-17 | 1976-06-18 | Nippon Shinyaku Co Ltd | Shinkinaguanamidoruino seiho |
| JPS58186682A (ja) | 1982-04-27 | 1983-10-31 | 日本化薬株式会社 | セルロ−ス又はセルロ−ス含有繊維材料の染色法 |
| DE3512630A1 (de) | 1985-04-06 | 1986-10-23 | Hoechst Ag, 6230 Frankfurt | Verfahren zum faerben oder bedrucken von cellulosefasern oder cellulosemischfasern |
| DE59106971D1 (de) | 1990-07-12 | 1996-01-11 | Ciba Geigy Ag | Verfahren zur photochemischen und thermischen Stabilisierung von Polyamid-Fasermaterialien. |
| JPH11158073A (ja) | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンａ３拮抗剤 |
| WO2000075129A1 (en) | 1999-06-07 | 2000-12-14 | Shire Biochem Inc. | Thiophene integrin inhibitors |
| SI2256108T1 (sl) | 2002-07-18 | 2016-05-31 | Janssen Pharmaceutica N.V. | Substituirani triazinski kinazni inhibitorji |
| WO2008131547A1 (en) | 2007-04-30 | 2008-11-06 | Prometic Biosciences Inc. | 'triazine derivatives, compositions containing such derivatives, and methods of treatment of cancer and autoimmune diseases using such derivatives' |
| GB0805477D0 (en) | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
| CA2764785C (en) | 2009-06-08 | 2015-10-27 | California Capital Equity, Llc | Triazine derivatives and their therapeutical applications |
| SMT201800334T1 (it) | 2012-01-06 | 2018-09-13 | Agios Pharmaceuticals Inc | Composti terapeuticamente attivi e loro metodi di utilizzo |
| CN104169260A (zh) | 2012-03-09 | 2014-11-26 | 卡尔那生物科学株式会社 | 新三嗪衍生物 |
| WO2015003360A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| MX375030B (es) | 2013-07-11 | 2025-03-06 | Agios Pharmaceuticals Inc | Compuestos de n,6-bis(aril o heteroaril)-1,3,5-triazin-2,4-diamina como inhibidores de idh2 mutantes para el tratamiento de cancer. |
| CN105916507A (zh) | 2013-08-02 | 2016-08-31 | 安吉奥斯医药品有限公司 | 治疗活性化合物及其使用方法 |
| AU2015324158A1 (en) | 2014-09-29 | 2017-04-13 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| EP3253746A1 (en) | 2015-02-04 | 2017-12-13 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CN108349933A (zh) * | 2015-08-05 | 2018-07-31 | 安吉奥斯医药品有限公司 | 制备6-(芳基或杂芳基)-1,3,5-三嗪-2,4-二醇和6-(芳基或杂芳基)-1,3,5-三嗪-2,4-二胺的方法 |
-
2016
- 2016-08-04 CN CN201680045391.6A patent/CN108349933A/zh active Pending
- 2016-08-04 CA CA2993615A patent/CA2993615A1/en not_active Abandoned
- 2016-08-04 EP EP16751449.6A patent/EP3331866B1/en active Active
- 2016-08-04 US US15/229,011 patent/US9751863B2/en active Active
- 2016-08-04 JP JP2018505739A patent/JP6816106B2/ja active Active
- 2016-08-04 MX MX2018001424A patent/MX365590B/es active IP Right Grant
- 2016-08-04 WO PCT/US2016/045553 patent/WO2017024134A1/en not_active Ceased
- 2016-08-04 AU AU2016303614A patent/AU2016303614A1/en not_active Abandoned
-
2020
- 2020-12-23 JP JP2020213670A patent/JP2021063097A/ja active Pending
-
2021
- 2021-01-27 AU AU2021200494A patent/AU2021200494A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US9751863B2 (en) | 2017-09-05 |
| JP2018528182A (ja) | 2018-09-27 |
| EP3331866A1 (en) | 2018-06-13 |
| MX2018001424A (es) | 2018-08-01 |
| US20170037031A1 (en) | 2017-02-09 |
| CA2993615A1 (en) | 2017-02-09 |
| MX365590B (es) | 2019-06-07 |
| EP3331866B1 (en) | 2023-07-26 |
| CN108349933A (zh) | 2018-07-31 |
| AU2021200494A1 (en) | 2021-03-11 |
| JP2021063097A (ja) | 2021-04-22 |
| JP6816106B2 (ja) | 2021-01-20 |
| WO2017024134A1 (en) | 2017-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9751863B2 (en) | Therapeutically active compounds and their methods of use | |
| AU2012269648B2 (en) | Therapeutically active compositions and their methods of use | |
| TWI759251B (zh) | 治療活性化合物及其使用方法 | |
| EP3019490B1 (en) | N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer | |
| JP7082256B1 (ja) | ５－ヘテロアリール－１ｈ－ピラゾール－３－アミン誘導体 | |
| TWI757312B (zh) | 作為異檸檬酸脫氫酶抑制劑的化合物及其應用 | |
| EP4056563A1 (en) | Compound as shp2 inhibitor and use thereof | |
| AU2014289745B2 (en) | Therapeutically active compounds and their methods of use | |
| KR20220118500A (ko) | 치환 직쇄 스피로 유도체 | |
| JP7207634B2 (ja) | Ｐ２ｘ３及び／又はｐ２ｘ２／３受容体アンタゴニスト、それを含む医薬組成物及びその使用 | |
| AU2013207289A1 (en) | Therapeutically active compounds and their methods of use | |
| AU2012298813A1 (en) | Inhibitors of Nedd8-activating enzyme | |
| JP2017057221A (ja) | 治療活性組成物およびそれらの使用方法 | |
| CN116783195A (zh) | N-苯基氨基羰基吡啶基-、嘧啶基和苯并-托烷作为gpr65的调节剂 | |
| KR102566237B1 (ko) | 사이클로올레핀 치환된 헤테로방향족 화합물 및 그의 용도 | |
| EP4105207A1 (en) | Quinolyl phosphine oxide compound, and composition and application thereof | |
| CN111377873B (zh) | 氨基嘧啶化合物及其制备方法和用途 | |
| JP2022528919A (ja) | Ｍａｌｔ１阻害剤としての尿素誘導体 | |
| TW202610644A (zh) | Cbl-b抑制劑的前藥化合物 | |
| HK40064179A (en) | Piperazine amide derivative, preparation method therefor, and use thereof in medicine | |
| EA044101B1 (ru) | Циклоолефиновые замещённые гетероароматические соединения и их применение | |
| HK40077066A (zh) | 喹啉基膦氧化合物及其组合物和用途 | |
| HK40027076A (en) | Cycloolefin substituted heteroaromatic compounds and their use | |
| NZ762447B2 (en) | Cycloolefin substituted heteroaromatic compounds and their use | |
| HK1224669A1 (en) | N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |