AU2016208475B2 - Universal killer T-cell - Google Patents

Universal killer T-cell Download PDF

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Publication number
AU2016208475B2
AU2016208475B2 AU2016208475A AU2016208475A AU2016208475B2 AU 2016208475 B2 AU2016208475 B2 AU 2016208475B2 AU 2016208475 A AU2016208475 A AU 2016208475A AU 2016208475 A AU2016208475 A AU 2016208475A AU 2016208475 B2 AU2016208475 B2 AU 2016208475B2
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AU
Australia
Prior art keywords
cell
cells
tcr
modified
antigen
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AU2016208475A
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English (en)
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AU2016208475A1 (en
Inventor
Gustav Gaudernack
Gunnar Kvalheim
Else Marit Inderberg Suso
Sébastien WÄLCHLI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oslo Universitetssykehus hf
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Oslo Universitetssykehus hf
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Publication of AU2016208475B2 publication Critical patent/AU2016208475B2/en
Priority to AU2022200126A priority Critical patent/AU2022200126A1/en
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0646Natural killers cells [NK], NKT cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4613Natural-killer cells [NK or NK-T]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/463Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632T-cell receptors [TCR]; antibody T-cell receptor constructs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/46443Growth factors
    • A61K39/464434Transforming growth factor [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/464454Enzymes
    • A61K39/464457Telomerase or [telomerase reverse transcriptase [TERT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/46449Melanoma antigens
    • A61K39/464491Melan-A/MART
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/27Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by targeting or presenting multiple antigens
    • A61K2239/28Expressing multiple CARs, TCRs or antigens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/515CD3, T-cell receptor complex
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/99Coculture with; Conditioned medium produced by genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2016208475A 2015-01-23 2016-01-22 Universal killer T-cell Active AU2016208475B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022200126A AU2022200126A1 (en) 2015-01-23 2022-01-11 Universal killer T-cell

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1501175.2 2015-01-23
GBGB1501175.2A GB201501175D0 (en) 2015-01-23 2015-01-23 A universal T-cell for personalised medicine
PCT/EP2016/051344 WO2016116601A1 (en) 2015-01-23 2016-01-22 Universal killer t-cell

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022200126A Division AU2022200126A1 (en) 2015-01-23 2022-01-11 Universal killer T-cell

Publications (2)

Publication Number Publication Date
AU2016208475A1 AU2016208475A1 (en) 2017-08-03
AU2016208475B2 true AU2016208475B2 (en) 2021-10-14

Family

ID=52673865

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016208475A Active AU2016208475B2 (en) 2015-01-23 2016-01-22 Universal killer T-cell
AU2022200126A Abandoned AU2022200126A1 (en) 2015-01-23 2022-01-11 Universal killer T-cell

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022200126A Abandoned AU2022200126A1 (en) 2015-01-23 2022-01-11 Universal killer T-cell

Country Status (17)

Country Link
US (2) US11155786B2 (da)
EP (2) EP3247791B1 (da)
JP (1) JP6899333B2 (da)
KR (1) KR102479118B1 (da)
CN (1) CN107250351A (da)
AU (2) AU2016208475B2 (da)
CA (1) CA2973924A1 (da)
DK (1) DK3247791T3 (da)
EA (1) EA201791381A1 (da)
ES (1) ES2922231T3 (da)
GB (1) GB201501175D0 (da)
IL (1) IL253464B (da)
MX (1) MX2017009459A (da)
PL (1) PL3247791T3 (da)
PT (1) PT3247791T (da)
SG (1) SG11201705693XA (da)
WO (1) WO2016116601A1 (da)

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FI3298033T4 (fi) 2015-05-18 2023-09-22 Tcr2 Therapeutics Inc Koostumuksia ja lääkinnällisiä käyttöjä fuusioproteiineja käyttävälle tcr:n uudelleenohjelmoinnille
WO2017192440A1 (en) * 2016-05-02 2017-11-09 Cerus Corporation Compositions and methods for improved nk cell therapies
AU2017306432A1 (en) 2016-08-02 2019-03-21 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
AU2017341048A1 (en) 2016-10-07 2019-05-23 TCR2 Therapeutics Inc. Compositions and methods for T-cell receptors reprogramming using fusion proteins
US11851491B2 (en) 2016-11-22 2023-12-26 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
WO2018104473A1 (en) 2016-12-07 2018-06-14 Oslo Universitetssykehus Hf Compositions and methods for cell therapy
EP3565565A4 (en) * 2017-01-04 2020-12-09 Nova Southeastern University NATURAL KILLER CELLS (NK) FOR THE EXPRESSION OF AN ANTIGENS-SPECIFIC FUNCTIONAL T-CELL RECEPTOR (TCR) COMPLEX, METHOD FOR MANUFACTURING THEREOF AND METHOD FOR THERAPEUTIC USE THEREOF
CA3110946A1 (en) * 2018-08-31 2020-03-05 Invectys SA Method to assess car functionality
JP6977969B2 (ja) * 2019-03-22 2021-12-08 株式会社ガイアバイオメディシン 免疫細胞提供システム
EP3750547A1 (en) 2019-06-13 2020-12-16 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Modified nk-92 cells, and therapeutic and diagnostic uses thereof
CN111662871A (zh) * 2020-06-11 2020-09-15 福建医科大学孟超肝胆医院(福州市传染病医院) 一种核酸适体功能化nk细胞及其制备与应用
IL301543A (en) 2020-09-24 2023-05-01 Medigene Immunotherapies Gmbh PRAME-specific T-cell receptors and uses thereof
EP4240830A1 (en) * 2020-11-03 2023-09-13 Hangzhou Qihan Biotechnology Co., Ltd. Systems and methods for enhanced immunotherapies
GB202017873D0 (en) 2020-11-12 2020-12-30 Olso Unversitetssykehus Hf Method of determining DLBCL prognosis
WO2022250312A1 (ko) * 2021-05-27 2022-12-01 (주)에스엠티바이오 신경내분비종양의 치료용 자연살해세포
WO2023047089A1 (en) 2021-09-21 2023-03-30 Oslo Universitetssykehus Hf Binding proteins for terminal deoxynucleotidyl transferase (tdt)
WO2023078287A1 (en) * 2021-11-03 2023-05-11 Hangzhou Qihan Biotechnology Co., Ltd. Systems and methods for enhanced immunotherapies
WO2024020537A2 (en) * 2022-07-22 2024-01-25 Board Of Regents, The University Of Texas System Cd3-expressing natural killer cells with enhanced function for adoptive immunotherapy

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Also Published As

Publication number Publication date
JP6899333B2 (ja) 2021-07-07
WO2016116601A1 (en) 2016-07-28
PT3247791T (pt) 2022-07-20
ES2922231T3 (es) 2022-09-12
US20220127574A1 (en) 2022-04-28
DK3247791T3 (da) 2022-07-11
EP3247791B1 (en) 2022-05-04
AU2016208475A1 (en) 2017-08-03
SG11201705693XA (en) 2017-08-30
EP4095239A1 (en) 2022-11-30
CA2973924A1 (en) 2016-07-28
AU2022200126A1 (en) 2022-02-10
NZ733855A (en) 2023-10-27
EP3247791A1 (en) 2017-11-29
MX2017009459A (es) 2018-04-11
PL3247791T3 (pl) 2022-09-05
CN107250351A (zh) 2017-10-13
GB201501175D0 (en) 2015-03-11
KR102479118B1 (ko) 2022-12-16
IL253464A0 (en) 2017-09-28
KR20170121178A (ko) 2017-11-01
BR112017015631A2 (pt) 2018-03-13
US20180010097A1 (en) 2018-01-11
JP2018512047A (ja) 2018-05-10
US11155786B2 (en) 2021-10-26
EA201791381A1 (ru) 2018-02-28
IL253464B (en) 2022-04-01

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