AU2015394135B2 - Cancer treatments - Google Patents

Cancer treatments Download PDF

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Publication number
AU2015394135B2
AU2015394135B2 AU2015394135A AU2015394135A AU2015394135B2 AU 2015394135 B2 AU2015394135 B2 AU 2015394135B2 AU 2015394135 A AU2015394135 A AU 2015394135A AU 2015394135 A AU2015394135 A AU 2015394135A AU 2015394135 B2 AU2015394135 B2 AU 2015394135B2
Authority
AU
Australia
Prior art keywords
cancer
nuc
leukaemia
treatment
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2015394135A
Other languages
English (en)
Other versions
AU2015394135A1 (en
Inventor
Hugh GRIFFITH
Chris Mcguigan
Chris Pepper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nucana PLC
Original Assignee
Nucana PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53276184&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2015394135(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nucana PLC filed Critical Nucana PLC
Publication of AU2015394135A1 publication Critical patent/AU2015394135A1/en
Application granted granted Critical
Publication of AU2015394135B2 publication Critical patent/AU2015394135B2/en
Priority to AU2021277614A priority Critical patent/AU2021277614A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2015394135A 2015-05-14 2015-05-14 Cancer treatments Ceased AU2015394135B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021277614A AU2021277614A1 (en) 2015-05-14 2021-11-30 Cancer treatments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2015/051438 WO2016181093A1 (en) 2015-05-14 2015-05-14 Cancer treatments

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021277614A Division AU2021277614A1 (en) 2015-05-14 2021-11-30 Cancer treatments

Publications (2)

Publication Number Publication Date
AU2015394135A1 AU2015394135A1 (en) 2017-12-14
AU2015394135B2 true AU2015394135B2 (en) 2021-09-16

Family

ID=53276184

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015394135A Ceased AU2015394135B2 (en) 2015-05-14 2015-05-14 Cancer treatments
AU2021277614A Abandoned AU2021277614A1 (en) 2015-05-14 2021-11-30 Cancer treatments

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021277614A Abandoned AU2021277614A1 (en) 2015-05-14 2021-11-30 Cancer treatments

Country Status (26)

Country Link
US (3) US20180289733A1 (cg-RX-API-DMAC7.html)
EP (2) EP3197456B2 (cg-RX-API-DMAC7.html)
JP (1) JP6761852B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180021697A (cg-RX-API-DMAC7.html)
CN (2) CN115837028A (cg-RX-API-DMAC7.html)
AU (2) AU2015394135B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017024461B1 (cg-RX-API-DMAC7.html)
CA (1) CA2985540C (cg-RX-API-DMAC7.html)
CY (1) CY1120516T1 (cg-RX-API-DMAC7.html)
DK (1) DK3197456T3 (cg-RX-API-DMAC7.html)
EA (1) EA201792509A1 (cg-RX-API-DMAC7.html)
ES (1) ES2668377T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20180762T1 (cg-RX-API-DMAC7.html)
HU (1) HUE038541T2 (cg-RX-API-DMAC7.html)
IL (1) IL255591B (cg-RX-API-DMAC7.html)
LT (1) LT3197456T (cg-RX-API-DMAC7.html)
MX (2) MX390506B (cg-RX-API-DMAC7.html)
MY (1) MY192081A (cg-RX-API-DMAC7.html)
PH (1) PH12017502086B1 (cg-RX-API-DMAC7.html)
PL (1) PL3197456T3 (cg-RX-API-DMAC7.html)
PT (1) PT3197456T (cg-RX-API-DMAC7.html)
RS (1) RS57371B1 (cg-RX-API-DMAC7.html)
SI (1) SI3197456T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201800303T1 (cg-RX-API-DMAC7.html)
TR (1) TR201806642T4 (cg-RX-API-DMAC7.html)
WO (1) WO2016181093A1 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
DK3031812T3 (en) 2011-03-01 2018-09-17 NuCana plc CHEMICAL COMPOUNDS
SI3150616T1 (sl) 2012-11-16 2017-08-31 University College Cardiff Consultants Limited Mešanica rp/sp gemcitabin-(fenil-(benziloksi-l-alaninil))-fosfata
WO2015198059A1 (en) 2014-06-25 2015-12-30 Nucana Biomed Limited Formulation comprising a gemcitabine-prodrug
EP3160978B1 (en) 2014-06-25 2020-07-29 NuCana plc Gemcitabine prodrugs
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
LT3224268T (lt) 2014-11-28 2019-09-25 NuCana plc Naujieji 2` ir (arba) 5` aminorūgšties esterio fosforamidato 3`-deoksi adenozino dariniai, kaip priešvėžiniai junginiai
BR112018003594A2 (pt) 2015-09-25 2018-09-25 Hoffmann La Roche cadeia pesada de imunoglobulina recombinante, anticorpos, método de produção de conjugado e conjugados
PH12018500691B1 (en) 2015-10-05 2022-08-10 NuCana plc Combination therapy
RS62593B1 (sr) 2015-12-11 2021-12-31 NuCana plc Dijastereoselektivna sinteza derivata fosfata i proleka gemcitabina nuc-1031
HUE050290T2 (hu) * 2015-12-23 2020-11-30 NuCana plc Kombinált terápia
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
CA3008769A1 (en) * 2015-12-23 2017-06-29 NuCana plc Combination therapy comprising nuc-1031 and cisplatin
GB201609600D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201713916D0 (en) * 2017-08-30 2017-10-11 Nucana Biomed Ltd Treatment regimens
EP3863674A2 (en) 2018-10-12 2021-08-18 The Regents of the University of Colorado, a body corporate Compositions and methods for reducing cancer stem cells
CN117462555B (zh) * 2021-01-31 2025-12-30 兰州大学 6-巯基鸟嘌呤在制备预防和/或治疗酒精性胃溃疡药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012327A2 (en) * 2003-07-21 2005-02-10 University College Cardiff Consultants Limited Nucleotide phosphoramidates as anticancer agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20160625T1 (hr) * 2007-09-10 2016-08-12 Boston Biomedical, Inc. Novi inhibitori stat3 signalnog puta i inhibitori matičnih stanica raka
EP2274617A4 (en) * 2008-04-10 2011-11-09 Massachusetts Inst Technology METHOD OF DETECTING AND USING MEDIUM-TREATMENT AID ON CANCER STEM CELLS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012327A2 (en) * 2003-07-21 2005-02-10 University College Cardiff Consultants Limited Nucleotide phosphoramidates as anticancer agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GHAZALY, E. et al. "A Phase I/II study of a first-in-class nucleotide analogue Acelarin (NUC-1031) in patients with advanced solid tumors" 2014Retrieved from the internet:URL:http://www.nucanabiomed.com/downloads/Nucana2014ASCOPoster.pdf *
GHAZALY, E. et al. "Acelarin: A novel nucleotide analogue that overcomes the key cancer resistance mechanisms associated with poor survival" 2014Retrieved from the internet:URL:http://www.nucanabiomed.com/downloads/Nucana2014AACRPoster.pdf *
MCGUIGAN, C. et al. "A phosphoramidate ProTide (NUC-1031) and acquired and intrinsic resistance to gemcitabine" J. Clin. Oncol. (2011) vol. 29, E13540 *
SLUSARCZYK, M. et al. J. Med. Chem. (2014) vol. 157, pages 1531-1542 *
VENKATESHA, V. A. et al. "Sensitization of Pancreatic Cancer Stem Cells to Gemcitabine by Chk1 Inhibition" Neoplasia (2012) vol. 14, no. 6, pages 519-525 *

Also Published As

Publication number Publication date
WO2016181093A1 (en) 2016-11-17
JP2018515618A (ja) 2018-06-14
EP3197456B1 (en) 2018-04-04
HUE038541T2 (hu) 2018-10-29
EP3415149A1 (en) 2018-12-19
BR112017024461B1 (pt) 2023-04-04
AU2015394135A1 (en) 2017-12-14
BR112017024461A2 (pt) 2018-07-24
DK3197456T3 (en) 2018-06-06
MY192081A (en) 2022-07-26
US20230226092A1 (en) 2023-07-20
PL3197456T3 (pl) 2018-09-28
US20210100825A1 (en) 2021-04-08
IL255591A (en) 2018-01-31
JP6761852B2 (ja) 2020-09-30
KR20180021697A (ko) 2018-03-05
EP3197456B2 (en) 2023-10-11
SMT201800303T1 (it) 2018-07-17
CA2985540A1 (en) 2016-11-17
CY1120516T1 (el) 2019-07-10
EA201792509A1 (ru) 2018-05-31
US20180289733A1 (en) 2018-10-11
MX390506B (es) 2025-03-20
RS57371B1 (sr) 2018-08-31
CN115837028A (zh) 2023-03-24
PH12017502086B1 (en) 2022-12-09
TR201806642T4 (tr) 2018-06-21
MX2017014544A (es) 2018-09-26
PH12017502086A1 (en) 2018-04-30
SI3197456T1 (en) 2018-08-31
MX374946B (es) 2025-03-06
LT3197456T (lt) 2018-07-10
IL255591B (en) 2021-10-31
CA2985540C (en) 2021-08-24
CN107835687A (zh) 2018-03-23
EP3197456A1 (en) 2017-08-02
ES2668377T3 (es) 2018-05-17
MX2020009154A (es) 2022-03-08
HRP20180762T1 (hr) 2018-08-24
AU2021277614A1 (en) 2021-12-23
PT3197456T (pt) 2018-05-22

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired