AU2015365602B2 - PARG inhibitory compounds - Google Patents
PARG inhibitory compounds Download PDFInfo
- Publication number
- AU2015365602B2 AU2015365602B2 AU2015365602A AU2015365602A AU2015365602B2 AU 2015365602 B2 AU2015365602 B2 AU 2015365602B2 AU 2015365602 A AU2015365602 A AU 2015365602A AU 2015365602 A AU2015365602 A AU 2015365602A AU 2015365602 B2 AU2015365602 B2 AU 2015365602B2
- Authority
- AU
- Australia
- Prior art keywords
- methyl
- methylcyclopropyl
- sulfonamide
- oxo
- benzimidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 *c(cc1[N+]([O-])=O)ccc1Cl Chemical compound *c(cc1[N+]([O-])=O)ccc1Cl 0.000 description 3
- DRRWQXDCWXWGNN-UHFFFAOYSA-N CC1(CC1)NS(c(cc1)cc([N+]([O-])=O)c1Cl)(=O)=O Chemical compound CC1(CC1)NS(c(cc1)cc([N+]([O-])=O)c1Cl)(=O)=O DRRWQXDCWXWGNN-UHFFFAOYSA-N 0.000 description 2
- UPKJZHJHTJZCCB-UHFFFAOYSA-N C#CCN(c(ccc(S(NC1(CF)CC1)(=O)=O)c1)c1N1c2nnc(C(F)F)[s]2)C1=O Chemical compound C#CCN(c(ccc(S(NC1(CF)CC1)(=O)=O)c1)c1N1c2nnc(C(F)F)[s]2)C1=O UPKJZHJHTJZCCB-UHFFFAOYSA-N 0.000 description 1
- CXVJKFUVGRNMBM-UHFFFAOYSA-N CC1(CC1)NS(c(cc(c(N1C)c2)N(C(SC)=N)C1=O)c2F)(=O)=O Chemical compound CC1(CC1)NS(c(cc(c(N1C)c2)N(C(SC)=N)C1=O)c2F)(=O)=O CXVJKFUVGRNMBM-UHFFFAOYSA-N 0.000 description 1
- OSCDNXGKRSZJCP-ONEGZZNKSA-N CC1(CC1)NS(c(cc1)cc(N2c3ccc(/C=C/C)[o]3)c1NC2=O)(=O)=O Chemical compound CC1(CC1)NS(c(cc1)cc(N2c3ccc(/C=C/C)[o]3)c1NC2=O)(=O)=O OSCDNXGKRSZJCP-ONEGZZNKSA-N 0.000 description 1
- RAPJRICLBGLPBZ-UHFFFAOYSA-N CC1(CC1)NS(c(cc1)cc2c1c(C(c(cc1)ccc1F)=O)c[nH]2)(=O)=O Chemical compound CC1(CC1)NS(c(cc1)cc2c1c(C(c(cc1)ccc1F)=O)c[nH]2)(=O)=O RAPJRICLBGLPBZ-UHFFFAOYSA-N 0.000 description 1
- BUTBPZJMPPIAHX-UHFFFAOYSA-N CC1(CC1)NS(c(cc1C(F)(F)F)cc(N2c3nnc(C)[s]3)c1N(C)C2=O)(=O)=O Chemical compound CC1(CC1)NS(c(cc1C(F)(F)F)cc(N2c3nnc(C)[s]3)c1N(C)C2=O)(=O)=O BUTBPZJMPPIAHX-UHFFFAOYSA-N 0.000 description 1
- BZNWVJWSXBOZCV-UHFFFAOYSA-N CC1(CC1)NS(c1cc([N+]([O-])=O)c(C)cc1)(=O)=O Chemical compound CC1(CC1)NS(c1cc([N+]([O-])=O)c(C)cc1)(=O)=O BZNWVJWSXBOZCV-UHFFFAOYSA-N 0.000 description 1
- XFQMTKCQALLPSF-UHFFFAOYSA-N CC1(CC1)NS(c1ccc(c(C(C2CC2)=O)c[n]2-c3nnc(C)[s]3)c2c1)(=O)=O Chemical compound CC1(CC1)NS(c1ccc(c(C(C2CC2)=O)c[n]2-c3nnc(C)[s]3)c2c1)(=O)=O XFQMTKCQALLPSF-UHFFFAOYSA-N 0.000 description 1
- LNIRWOHKBUGVTQ-UHFFFAOYSA-N CC1(CC1)NS(c1ccc(c(Cc(cc2)ccc2F)c[n]2-c3nnc(C)[s]3)c2c1)(=O)=O Chemical compound CC1(CC1)NS(c1ccc(c(Cc(cc2)ccc2F)c[n]2-c3nnc(C)[s]3)c2c1)(=O)=O LNIRWOHKBUGVTQ-UHFFFAOYSA-N 0.000 description 1
- VZNKRNHJZJFKLX-UHFFFAOYSA-N CCC1(CC1)NS(c(cc1)cc(N2c3nnc(C)[s]3)c1N(CCOC)C2=O)(=O)=O Chemical compound CCC1(CC1)NS(c(cc1)cc(N2c3nnc(C)[s]3)c1N(CCOC)C2=O)(=O)=O VZNKRNHJZJFKLX-UHFFFAOYSA-N 0.000 description 1
- GOYBCWBXXCBQEQ-UHFFFAOYSA-N CCCN(c(cc(c(S(NC1(C)CC1)(=O)=O)c1)F)c1N1c2nnc(C)[o]2)C1=O Chemical compound CCCN(c(cc(c(S(NC1(C)CC1)(=O)=O)c1)F)c1N1c2nnc(C)[o]2)C1=O GOYBCWBXXCBQEQ-UHFFFAOYSA-N 0.000 description 1
- AWJMAOMQVYVZLT-UHFFFAOYSA-N CCCN(c(cc(cc1)F)c1N1c2nnc(C(C)F)[s]2)C1=O Chemical compound CCCN(c(cc(cc1)F)c1N1c2nnc(C(C)F)[s]2)C1=O AWJMAOMQVYVZLT-UHFFFAOYSA-N 0.000 description 1
- HYTOPECXURUEDC-UHFFFAOYSA-N CCN(CCO1)C1=C Chemical compound CCN(CCO1)C1=C HYTOPECXURUEDC-UHFFFAOYSA-N 0.000 description 1
- DALUCNUGMDNXET-UHFFFAOYSA-N CCc1c(C)nc(C)[s]1 Chemical compound CCc1c(C)nc(C)[s]1 DALUCNUGMDNXET-UHFFFAOYSA-N 0.000 description 1
- UUVUHCAHXNGVLI-UHFFFAOYSA-N CN(c(cc(cc1)F)c1N1)C1=O Chemical compound CN(c(cc(cc1)F)c1N1)C1=O UUVUHCAHXNGVLI-UHFFFAOYSA-N 0.000 description 1
- BSVREEFIRRQEKK-UHFFFAOYSA-N Cc1n[s]c(N(c2cc(S(NC3(CF)CC3)(=O)=O)ccc2N2)C2=O)n1 Chemical compound Cc1n[s]c(N(c2cc(S(NC3(CF)CC3)(=O)=O)ccc2N2)C2=O)n1 BSVREEFIRRQEKK-UHFFFAOYSA-N 0.000 description 1
- CIYBHQVKZRLUSP-UHFFFAOYSA-N Cc1nnc(N(c2ccccc2N2)C2=O)[s]1 Chemical compound Cc1nnc(N(c2ccccc2N2)C2=O)[s]1 CIYBHQVKZRLUSP-UHFFFAOYSA-N 0.000 description 1
- DPIZKMGPXNXSGL-UHFFFAOYSA-N Nc(cc1)cc(N)c1[N+]([O-])=O Chemical compound Nc(cc1)cc(N)c1[N+]([O-])=O DPIZKMGPXNXSGL-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201422771 | 2014-12-19 | ||
| GB1422771.4 | 2014-12-19 | ||
| PCT/GB2015/054064 WO2016097749A1 (en) | 2014-12-19 | 2015-12-17 | Parg inhibitory compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015365602A1 AU2015365602A1 (en) | 2017-06-29 |
| AU2015365602B2 true AU2015365602B2 (en) | 2020-02-27 |
Family
ID=54937310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015365602A Active AU2015365602B2 (en) | 2014-12-19 | 2015-12-17 | PARG inhibitory compounds |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US10508086B2 (enExample) |
| EP (2) | EP3233845B1 (enExample) |
| JP (1) | JP6673920B2 (enExample) |
| KR (1) | KR102682782B1 (enExample) |
| CN (2) | CN107295799B (enExample) |
| AU (1) | AU2015365602B2 (enExample) |
| BR (1) | BR112017012707B1 (enExample) |
| CA (1) | CA2969298C (enExample) |
| ES (1) | ES2886471T3 (enExample) |
| IL (1) | IL252745B (enExample) |
| MA (1) | MA41179A (enExample) |
| MX (1) | MX380901B (enExample) |
| RU (1) | RU2017125520A (enExample) |
| SG (1) | SG11201704843QA (enExample) |
| WO (1) | WO2016097749A1 (enExample) |
| ZA (1) | ZA201704383B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA41140A (fr) | 2014-12-12 | 2017-10-17 | Cancer Research Tech Ltd | Dérivés de 2,4-dioxo-quinazoline-6-sulfonamide en tant qu'inhibiteurs de la parg |
| MA41179A (fr) | 2014-12-19 | 2017-10-24 | Cancer Research Tech Ltd | Composés inhibiteurs de parg |
| EP3947351A4 (en) | 2019-03-29 | 2022-12-07 | Board of Regents, The University of Texas System | SMALL MOLECULAR PARG INHIBITORS AND METHODS OF USE |
| EP4031249A1 (en) * | 2019-09-20 | 2022-07-27 | Ideaya Biosciences, Inc. | 4-substituted indole and indazole sulfonamido derivatives as parg inhibitors |
| WO2023057394A1 (en) | 2021-10-04 | 2023-04-13 | Forx Therapeutics Ag | N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer |
| CA3225500A1 (en) | 2021-10-04 | 2023-04-13 | Ulrich Luecking | Parg inhibitory compounds |
| EP4401721A4 (en) | 2021-10-17 | 2025-10-15 | Univ Of South Alabama Foundation For Research And Commercialization | CANCER TREATMENT |
| CA3251360A1 (en) | 2022-02-14 | 2023-08-17 | Arase Therapeutics Inc. | PARG INHIBITORS |
| WO2023165571A1 (zh) * | 2022-03-04 | 2023-09-07 | 上海璎黎药业有限公司 | 一种含五元杂芳环结构化合物、其药物组合物及应用 |
| WO2023175184A1 (en) | 2022-03-17 | 2023-09-21 | Forx Therapeutics Ag | 2,4-dioxo-1,4-dihydroquinazoline derivatives as parg inhibitors for the treatment of cancer |
| WO2023175185A1 (en) | 2022-03-17 | 2023-09-21 | Forx Therapeutics Ag | 2,4-dioxo-1,4-dihydroquinazoline derivatives as parg inhibitors for the treatment of cancer |
| CR20240391A (es) * | 2022-03-23 | 2024-11-05 | Ideaya Biosciences Inc | Compuestos de indazol sustituidos con piperazina como inhibidores de parg |
| CN114685283B (zh) * | 2022-04-06 | 2024-02-27 | 南京艾康生物科技有限公司 | 一种1-(氟甲基)环丙胺盐酸盐的制备方法 |
| WO2023205914A1 (en) * | 2022-04-28 | 2023-11-02 | Danatlas Pharmaceuticals Co., Ltd. | Tricyclic heterocyclic derivatives, compositions and uses thereof |
| CN117157299B (zh) * | 2022-04-28 | 2024-05-28 | 北京丹擎医药科技有限公司 | 三环杂环衍生物及其组合物和应用 |
| CA3251429A1 (en) | 2022-05-17 | 2023-11-23 | 858 Therapeutics, Inc. | PARG INHIBITORS |
| AU2023297713A1 (en) * | 2022-06-29 | 2025-02-13 | Hangzhou Synrx Therapeutics Biomedical Technology Co., Ltd. | Five-membered and six-membered nitrogen-containing compound, and intermediate, preparation method and use thereof |
| EP4559912A1 (en) * | 2022-07-19 | 2025-05-28 | Evopoint Biosciences Co., Ltd. | Sulfur-containing heteroaromatic ring compound, pharmaceutical composition thereof, and use thereof |
| EP4311829A1 (en) | 2022-07-28 | 2024-01-31 | Nodus Oncology Limited | Substituted bicyclic heteroaryl sulfonamide derivatives for the treatment of cancer |
| AU2023355735A1 (en) | 2022-10-03 | 2025-04-03 | Forx Therapeutics Ag | Parg inhibitory compound |
| WO2024080792A1 (en) * | 2022-10-13 | 2024-04-18 | Hanmi Pharm. Co., Ltd. | Novel heterobicyclic compound for inhibiting yap-tead interaction and pharmaceutical composition comprising same |
| WO2024120519A1 (zh) * | 2022-12-09 | 2024-06-13 | 捷思英达控股有限公司 | Tead抑制剂、其制备方法和在医学上的应用 |
| WO2024173234A1 (en) * | 2023-02-13 | 2024-08-22 | Arase Therapeutics Inc. | Inhibitors of parg |
| WO2024209035A1 (en) | 2023-04-05 | 2024-10-10 | Forx Therapeutics Ag | Parg inhibitory compounds |
| WO2024222842A1 (en) * | 2023-04-27 | 2024-10-31 | Danatlas Pharmaceuticals Co., Ltd. | Tricyclic heterocyclic derivatives, compositions and uses thereof |
| WO2024243304A2 (en) * | 2023-05-23 | 2024-11-28 | Quantx Biosciences Us, Inc. | Bicyclic heteroaryl compounds |
| WO2024254990A1 (zh) * | 2023-06-16 | 2024-12-19 | 上海璎黎药业有限公司 | 一种杂芳环结构化合物、其药物组合物及应用 |
| WO2025035108A2 (en) * | 2023-08-10 | 2025-02-13 | Arase Therapeutics Inc. | Inhibitors of parg |
| WO2025046148A1 (en) | 2023-09-01 | 2025-03-06 | Forx Therapeutics Ag | Novel parg inhibitors |
| WO2025073870A1 (en) | 2023-10-03 | 2025-04-10 | Forx Therapeutics Ag | Parg inhibitory compound |
| WO2025093755A1 (en) | 2023-11-01 | 2025-05-08 | Forx Therapeutics Ag | Novel parc inhibitors |
| WO2025098445A1 (zh) * | 2023-11-07 | 2025-05-15 | 南京同诺康医药科技有限公司 | Parg抑制剂及其制备方法和用途 |
| WO2025108225A1 (zh) * | 2023-11-20 | 2025-05-30 | 上海复星医药（集团）股份有限公司 | 作为parg抑制剂的含氮三环衍生物 |
| WO2025133396A1 (en) | 2023-12-22 | 2025-06-26 | Forx Therapeutics Ag | Novel bicyclo heteroaryl parg inhibitors |
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