AU2015349687B2 - Fused bicyclic compounds for the treatment of disease - Google Patents

Fused bicyclic compounds for the treatment of disease Download PDF

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Publication number
AU2015349687B2
AU2015349687B2 AU2015349687A AU2015349687A AU2015349687B2 AU 2015349687 B2 AU2015349687 B2 AU 2015349687B2 AU 2015349687 A AU2015349687 A AU 2015349687A AU 2015349687 A AU2015349687 A AU 2015349687A AU 2015349687 B2 AU2015349687 B2 AU 2015349687B2
Authority
AU
Australia
Prior art keywords
optionally substituted
compound
formula
aryl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2015349687A
Other languages
English (en)
Other versions
AU2015349687A1 (en
Inventor
Raju Mohan
Benjamin Anthony PRATT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akarna Therapeutics Ltd
Original Assignee
Akarna Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akarna Therapeutics Ltd filed Critical Akarna Therapeutics Ltd
Publication of AU2015349687A1 publication Critical patent/AU2015349687A1/en
Application granted granted Critical
Publication of AU2015349687B2 publication Critical patent/AU2015349687B2/en
Priority to AU2020250270A priority Critical patent/AU2020250270B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2015349687A 2014-11-21 2015-11-20 Fused bicyclic compounds for the treatment of disease Ceased AU2015349687B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020250270A AU2020250270B2 (en) 2014-11-21 2020-10-08 Fused bicyclic compounds for the treatment of disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462083031P 2014-11-21 2014-11-21
US62/083,031 2014-11-21
PCT/US2015/062017 WO2016081918A1 (en) 2014-11-21 2015-11-20 Fused bicyclic compounds for the treatment of disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020250270A Division AU2020250270B2 (en) 2014-11-21 2020-10-08 Fused bicyclic compounds for the treatment of disease

Publications (2)

Publication Number Publication Date
AU2015349687A1 AU2015349687A1 (en) 2017-06-29
AU2015349687B2 true AU2015349687B2 (en) 2020-07-09

Family

ID=56014622

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015349687A Ceased AU2015349687B2 (en) 2014-11-21 2015-11-20 Fused bicyclic compounds for the treatment of disease
AU2020250270A Ceased AU2020250270B2 (en) 2014-11-21 2020-10-08 Fused bicyclic compounds for the treatment of disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020250270A Ceased AU2020250270B2 (en) 2014-11-21 2020-10-08 Fused bicyclic compounds for the treatment of disease

Country Status (17)

Country Link
US (5) US10233187B2 (https=)
EP (1) EP3221321B1 (https=)
JP (3) JP7224102B2 (https=)
KR (1) KR20170117020A (https=)
CN (2) CN111662297A (https=)
AU (2) AU2015349687B2 (https=)
CA (1) CA2968434A1 (https=)
CL (1) CL2017001289A1 (https=)
CO (1) CO2017005784A2 (https=)
ES (1) ES2911293T3 (https=)
IL (1) IL252309B (https=)
MX (1) MX370480B (https=)
MY (1) MY192927A (https=)
RU (1) RU2706007C2 (https=)
SA (1) SA517381566B1 (https=)
SG (2) SG10202010386PA (https=)
WO (1) WO2016081918A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
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EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
HRP20220522T1 (hr) 2014-08-04 2022-06-10 Nuevolution A/S Proizvoljno kondenzirani heterociklil-supstituirani derivati pirimidina koji su korisni za liječenje upalnih, metaboličkih, onkoloških i autoimunih bolesti
CA2968434A1 (en) * 2014-11-21 2016-05-26 Akarna Therapeutics, Ltd. Fused bicyclic compounds for the treatment of disease
AU2016238523A1 (en) * 2015-03-26 2017-11-09 Akarna Therapeutics, Ltd. Fused bicyclic compounds for the treatment of disease
BR112018073460A2 (pt) * 2016-05-25 2019-07-09 Akarna Therapeutics Ltd terapias combinadas usando moduladores do receptor farnesoide x (fxr)
CA3252823A1 (en) 2016-06-13 2025-02-25 Gilead Sciences, Inc. Substituted tert-butyl-3-(2-chloro-phenyl)-3-hydroxyazetidine-1-carboxylate compounds
MX385718B (es) 2016-06-13 2025-03-18 Gilead Sciences Inc Compuestos moduladores de fxr (nr1h4).
PT3600309T (pt) 2017-03-28 2022-10-03 Gilead Sciences Inc Combinações terapêuticas para o tratamento de doenças hepáticas
CN111542319A (zh) * 2017-06-02 2020-08-14 阿卡纳治疗学有限公司 稠合的双环化合物
EP3911647B1 (en) 2019-01-15 2023-12-13 Gilead Sciences, Inc. Isoxazole compound as fxr agonist and pharmaceutical compositions comprising same
CA3233305A1 (en) 2019-02-19 2020-08-27 Gilead Sciences, Inc. Solid forms of fxr agonists
CN111825653A (zh) * 2019-04-19 2020-10-27 安道麦马克西姆有限公司 取代吡唑类化合物的制备及其作为邻氨基苯甲酰胺前体的用途
KR20220038368A (ko) 2019-07-23 2022-03-28 노파르티스 아게 Fxr 작용제를 이용하는 간 질환의 병용 치료
WO2021014349A1 (en) 2019-07-23 2021-01-28 Novartis Ag Treatment comprising fxr agonists
JP7663559B2 (ja) 2019-09-03 2025-04-16 ノバルティス アーゲー Ａｃｔｒｉｉ受容体拮抗薬を含む肝疾患または肝臓障害の治療
CN114401745A (zh) 2019-09-19 2022-04-26 诺华股份有限公司 包含fxr激动剂的治疗
WO2021064575A1 (en) 2019-09-30 2021-04-08 Novartis Ag Treatment comprising the use of fxr agonists
MX2022007265A (es) 2019-12-20 2022-09-09 Nuevolution As Compuestos activos frente a receptores nucleares.
KR20220119424A (ko) 2019-12-20 2022-08-29 노파르티스 아게 인테그린 억제제를 사용한 간 질환의 조합 치료
US11685727B2 (en) 2019-12-20 2023-06-27 Nuevolution A/S Compounds active towards nuclear receptors
EP4126874A1 (en) 2020-03-31 2023-02-08 Nuevolution A/S Compounds active towards nuclear receptors
CA3174176A1 (en) 2020-03-31 2021-10-07 Sanne Schroder Glad Compounds active towards nuclear receptors
UY39391A (es) * 2020-08-24 2022-03-31 Adama Makhteshim Ltd Proceso para la preparación de pirazoles sustituidos
WO2022101853A1 (en) 2020-11-16 2022-05-19 Novartis Ag Method of determining liver fibrosis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070015746A1 (en) * 2003-07-23 2007-01-18 X-Ceptor Therapeutics Inc. Azepine derivaties as pharmaceutical agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7595311B2 (en) * 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
SI1668014T1 (sl) 2003-09-17 2009-06-30 Janssen Pharmaceutica Nv Kondenzirane heterociklične spojine kot modulatorji serotoninskih receptorjev
US20090137554A1 (en) * 2007-10-22 2009-05-28 Wyeth 1,4,5,6-TETRAHYDRO -PYRROLO[2,3-d]AZEPINES AND -IMIDAZO[4,5-d]AZEPINES AS MODULATORS OF NUCLEAR RECEPTOR ACTIVITY
US20090215748A1 (en) * 2007-12-20 2009-08-27 Wyeth FXR agonists for treating vitamin D associated diseases
WO2010036362A1 (en) 2008-09-26 2010-04-01 Wyeth 1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate nuclear receptor inhibitors
US8252826B2 (en) 2010-03-24 2012-08-28 Hoffmann-La Roche Inc. Cyclopentyl- and cycloheptylpyrazoles
CA2968434A1 (en) * 2014-11-21 2016-05-26 Akarna Therapeutics, Ltd. Fused bicyclic compounds for the treatment of disease
MX2018014034A (es) * 2016-05-25 2019-08-29 Akarna Therapeutics Ltd Compuestos bicíclicos fusionados para el tratamiento de enfermedades.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070015746A1 (en) * 2003-07-23 2007-01-18 X-Ceptor Therapeutics Inc. Azepine derivaties as pharmaceutical agents

Also Published As

Publication number Publication date
EP3221321A4 (en) 2018-04-25
SA517381566B1 (ar) 2021-05-16
RU2017121588A3 (https=) 2019-05-21
MX2017006694A (es) 2018-03-16
EP3221321A1 (en) 2017-09-27
MX370480B (es) 2019-12-16
JP2023011731A (ja) 2023-01-24
CO2017005784A2 (es) 2017-10-31
AU2015349687A1 (en) 2017-06-29
CN107207513A (zh) 2017-09-26
JP2017535614A (ja) 2017-11-30
MY192927A (en) 2022-09-15
JP2021011482A (ja) 2021-02-04
US20190308977A1 (en) 2019-10-10
IL252309B (en) 2021-01-31
RU2017121588A (ru) 2018-12-24
US20250171446A1 (en) 2025-05-29
BR112017010627A2 (pt) 2018-02-14
AU2020250270B2 (en) 2022-08-25
HK1244802A1 (zh) 2018-08-17
CN107207513B (zh) 2020-07-28
EP3221321B1 (en) 2021-12-15
US20210147426A1 (en) 2021-05-20
SG11201703953WA (en) 2017-06-29
US20170355699A1 (en) 2017-12-14
AU2020250270A1 (en) 2020-11-05
IL252309A0 (en) 2017-07-31
CL2017001289A1 (es) 2018-03-02
ES2911293T3 (es) 2022-05-18
RU2706007C2 (ru) 2019-11-13
WO2016081918A1 (en) 2016-05-26
US20230183247A1 (en) 2023-06-15
KR20170117020A (ko) 2017-10-20
US10233187B2 (en) 2019-03-19
CA2968434A1 (en) 2016-05-26
SG10202010386PA (en) 2020-11-27
JP7224102B2 (ja) 2023-02-17
CN111662297A (zh) 2020-09-15

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired