AU2015340303B2 - Polyheteroaryl histone deacetylase inhibitors and their use in therapy - Google Patents

Polyheteroaryl histone deacetylase inhibitors and their use in therapy Download PDF

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Publication number
AU2015340303B2
AU2015340303B2 AU2015340303A AU2015340303A AU2015340303B2 AU 2015340303 B2 AU2015340303 B2 AU 2015340303B2 AU 2015340303 A AU2015340303 A AU 2015340303A AU 2015340303 A AU2015340303 A AU 2015340303A AU 2015340303 B2 AU2015340303 B2 AU 2015340303B2
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amino
alkyl
methyl
pyridin
pyrazin
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AU2015340303A
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AU2015340303A1 (en
Inventor
Alexander Richard Liam Cecil
Somhairle Maccormick
William John NODES
Stephen Joseph Shuttleworth
Franck Alexandre Silva
Cyrille Davy Tomassi
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Karus Therapeutics Ltd
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Karus Therapeutics Ltd
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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AU2015340303A 2014-10-29 2015-10-29 Polyheteroaryl histone deacetylase inhibitors and their use in therapy Withdrawn - After Issue AU2015340303B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1419264.5 2014-10-29
GBGB1419264.5A GB201419264D0 (en) 2014-10-29 2014-10-29 Compounds
PCT/GB2015/053256 WO2016067038A1 (en) 2014-10-29 2015-10-29 Polyheteroaryl histone deacetylase inhibitors and their use in therapy

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AU2015340303A1 AU2015340303A1 (en) 2017-05-18
AU2015340303B2 true AU2015340303B2 (en) 2020-01-16

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US (1) US10533003B2 (enExample)
EP (1) EP3212632A1 (enExample)
JP (1) JP2017532358A (enExample)
CN (1) CN107001333A (enExample)
AU (1) AU2015340303B2 (enExample)
CA (1) CA2966070A1 (enExample)
GB (1) GB201419264D0 (enExample)
IL (1) IL251861A0 (enExample)
MX (1) MX2017005423A (enExample)
WO (1) WO2016067038A1 (enExample)

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GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
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GB201609786D0 (en) * 2016-06-03 2016-07-20 Karus Therapeutics Ltd Compounds and method of use
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JP2022538284A (ja) 2019-06-27 2022-09-01 ザ ジョージ ワシントン ユニバーシティ， ア コングレッショナリー チャータード ノット－フォー－プロフィット コーポレイション Ｈｄａｃ６活性化マクロファージ、その組成物および使用
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