AU2015317848B2 - Arginine deiminase with reduced cross-reactivity toward ADI - PEG 20 antibodies for cancer treatment - Google Patents

Arginine deiminase with reduced cross-reactivity toward ADI - PEG 20 antibodies for cancer treatment Download PDF

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Publication number
AU2015317848B2
AU2015317848B2 AU2015317848A AU2015317848A AU2015317848B2 AU 2015317848 B2 AU2015317848 B2 AU 2015317848B2 AU 2015317848 A AU2015317848 A AU 2015317848A AU 2015317848 A AU2015317848 A AU 2015317848A AU 2015317848 B2 AU2015317848 B2 AU 2015317848B2
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AU2015317848A1 (en
Inventor
Robert Almassy
Li-Chang Chen
Yang Lee
Wei-Jong SHIA
Richard Showalter
Wes SISSON
James A. Thomson
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Polaris Group Cayman Islands
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Polaris Group Cayman Islands
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Assigned to TDW GROUP reassignment TDW GROUP Request for Assignment Assignors: POLARIS GROUP
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03006—Arginine deiminase (3.5.3.6)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2015317848A 2014-09-16 2015-09-16 Arginine deiminase with reduced cross-reactivity toward ADI - PEG 20 antibodies for cancer treatment Active AU2015317848B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051182P 2014-09-16 2014-09-16
US62/051,182 2014-09-16
PCT/US2015/050354 WO2016044376A1 (en) 2014-09-16 2015-09-16 Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment

Publications (2)

Publication Number Publication Date
AU2015317848A1 AU2015317848A1 (en) 2017-04-20
AU2015317848B2 true AU2015317848B2 (en) 2021-04-22

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AU2015317848A Active AU2015317848B2 (en) 2014-09-16 2015-09-16 Arginine deiminase with reduced cross-reactivity toward ADI - PEG 20 antibodies for cancer treatment

Country Status (11)

Country Link
US (1) US9789170B2 (OSRAM)
EP (2) EP4104853A1 (OSRAM)
JP (2) JP6782230B2 (OSRAM)
KR (1) KR102730989B1 (OSRAM)
CN (2) CN114522225B (OSRAM)
AU (1) AU2015317848B2 (OSRAM)
CA (1) CA2961602A1 (OSRAM)
ES (1) ES2915382T3 (OSRAM)
SG (2) SG10202002557SA (OSRAM)
TW (2) TWI775160B (OSRAM)
WO (1) WO2016044376A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2015141932A (ru) 2013-03-15 2017-04-26 Поларис Груп Аргининдеиминаза с пониженной перекрестной реактивностью к антителам adi-peg 20 для лечения рака
CN106794229B (zh) 2014-03-18 2020-12-18 瑞华药业集团 工程化嵌合聚乙二醇化adi和使用方法
CA2961602A1 (en) 2014-09-16 2016-03-24 Polaris Group Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment
CN119950689A (zh) 2016-07-05 2025-05-09 北极星药业集团股份有限公司 使用精氨酸耗竭剂的组合癌症免疫疗法
EA201990491A1 (ru) 2016-08-18 2019-08-30 Мехарри Медикал Колледж Ингибиторы внутриклеточной инвазии
BR112019005935A2 (pt) * 2016-09-29 2019-06-11 Meharry Medical College inibidores bacterianos
EP3534963B1 (en) * 2016-11-02 2024-04-17 Polaris Group Formulations of pegylated arginine deiminase
US12344645B2 (en) 2017-03-29 2025-07-01 Polaris Group Protein conjugates

Citations (3)

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US20050129706A1 (en) * 1997-05-12 2005-06-16 Phoenix Pharmacologics, Inc. Modified arginine deiminase
US20120148559A1 (en) * 2010-12-01 2012-06-14 Board Of Regents The University Of Texas System Compositions and method for deimmunization of proteins
WO2014151982A2 (en) * 2013-03-15 2014-09-25 Polaris Group Arginine deiminase with reduced cross-reactivity toward adi – peg 20 antibodies for cancer treatment

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US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5804183A (en) 1997-01-31 1998-09-08 Enzon, Inc. Arginine deminase derived from mycoplasma arthritidis and polymer conjugates containing the same
US6635462B1 (en) 1997-05-12 2003-10-21 Phoenix Pharmacologies, Inc. Mutated form of arginine deiminase
US6180387B1 (en) 1997-08-11 2001-01-30 Smithkline Beecham Corporation Arginine deiminase
IT1298918B1 (it) 1998-02-20 2000-02-07 Mendes Srl Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche
AU2001275810A1 (en) 2000-07-27 2002-02-13 Angiolab, Inc. The pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis
KR20040004449A (ko) 2000-11-28 2004-01-13 휘닉스 파머컬러직스, 인크. 변형된 아르기닌 데이미나제
WO2004046309A2 (en) 2002-11-18 2004-06-03 Phoenix Pharmacologics, Inc. Methods for inhibiting viral replication in vivo
CN1536079A (zh) * 2003-04-09 2004-10-13 上海复旦张江生物医药股份有限公司 修饰的精氨酸脱亚氨酶
EP1629119A2 (en) 2003-04-29 2006-03-01 Wyeth Methods for diagnosing aml and mds by differential gene expression
WO2005052145A2 (en) 2003-10-07 2005-06-09 University Of Florida Recombinant alkaliizing bacteria
CN101002945B (zh) * 2006-01-20 2012-09-05 清华大学 一种用于肿瘤治疗的新型复合物
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US20090238813A1 (en) 2007-12-28 2009-09-24 Board Of Regents, The University Of Texas System Compositions And Methods For Engineered Human Arginine Deiminases
WO2010083312A2 (en) 2009-01-14 2010-07-22 The Trustees Of The University Of Pennsylvania Micro-rna biomarker in cancer
CN101591649B (zh) * 2009-07-10 2013-02-13 江苏泰康生物医药有限公司 甲氧基聚乙二醇修饰的精氨酸脱亚氨酶及其制备与应用
WO2011053871A2 (en) 2009-10-30 2011-05-05 Life Technologies Corporation Multi-primer assay for mycoplasma detection
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CN106794229B (zh) 2014-03-18 2020-12-18 瑞华药业集团 工程化嵌合聚乙二醇化adi和使用方法
CA2961602A1 (en) 2014-09-16 2016-03-24 Polaris Group Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050129706A1 (en) * 1997-05-12 2005-06-16 Phoenix Pharmacologics, Inc. Modified arginine deiminase
US20120148559A1 (en) * 2010-12-01 2012-06-14 Board Of Regents The University Of Texas System Compositions and method for deimmunization of proteins
WO2014151982A2 (en) * 2013-03-15 2014-09-25 Polaris Group Arginine deiminase with reduced cross-reactivity toward adi – peg 20 antibodies for cancer treatment

Also Published As

Publication number Publication date
KR20170104986A (ko) 2017-09-18
EP3193913A1 (en) 2017-07-26
JP2017529366A (ja) 2017-10-05
WO2016044376A1 (en) 2016-03-24
AU2015317848A1 (en) 2017-04-20
EP3193913A4 (en) 2018-07-18
CN114522225A (zh) 2022-05-24
EP3193913B1 (en) 2022-05-11
ES2915382T3 (es) 2022-06-22
SG11201702103XA (en) 2017-04-27
US9789170B2 (en) 2017-10-17
EP4104853A1 (en) 2022-12-21
US20160074487A1 (en) 2016-03-17
CN114522225B (zh) 2025-07-25
TWI775160B (zh) 2022-08-21
TW201625295A (zh) 2016-07-16
TW202103730A (zh) 2021-02-01
SG10202002557SA (en) 2020-04-29
TWI708612B (zh) 2020-11-01
JP2021004268A (ja) 2021-01-14
KR102730989B1 (ko) 2024-11-14
JP6961061B2 (ja) 2021-11-05
JP6782230B2 (ja) 2020-11-11
CA2961602A1 (en) 2016-03-24
CN107073085A (zh) 2017-08-18
CN107073085B (zh) 2022-02-18

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PC1 Assignment before grant (sect. 113)

Owner name: POLARIS GROUP

Free format text: FORMER APPLICANT(S): SHOWALTER, RICHARD; POLARIS GROUP

PC1 Assignment before grant (sect. 113)

Owner name: TDW GROUP

Free format text: FORMER APPLICANT(S): POLARIS GROUP

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PC Assignment registered

Owner name: POLARIS GROUP

Free format text: FORMER OWNER(S): TDW GROUP