BR112019005935A2 - inibidores bacterianos - Google Patents

inibidores bacterianos

Info

Publication number
BR112019005935A2
BR112019005935A2 BR112019005935A BR112019005935A BR112019005935A2 BR 112019005935 A2 BR112019005935 A2 BR 112019005935A2 BR 112019005935 A BR112019005935 A BR 112019005935A BR 112019005935 A BR112019005935 A BR 112019005935A BR 112019005935 A2 BR112019005935 A2 BR 112019005935A2
Authority
BR
Brazil
Prior art keywords
peptides
gingivalis
bacterial inhibitors
virulence
disrupt
Prior art date
Application number
BR112019005935A
Other languages
English (en)
Inventor
Xie Hua
Original Assignee
Meharry Medical College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meharry Medical College filed Critical Meharry Medical College
Publication of BR112019005935A2 publication Critical patent/BR112019005935A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03006—Arginine deiminase (3.5.3.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03015—Protein-arginine deiminase (3.5.3.15)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)

Abstract

a presente invenção refere-se a peptídeos relacionados a determinadas porções da enzima arginina deiminase da bactéria streptococcus cristatus que interrompem a formação e composição de biofilmes contendo o patógeno oral porphyromonas gingivalis, e também modulam a virulência de p. gingivalis. composições farmacêuticas contendo tais peptídeos e método de uso dos mesmos são descritos.
BR112019005935A 2016-09-29 2017-09-13 inibidores bacterianos BR112019005935A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662401572P 2016-09-29 2016-09-29
US201662404690P 2016-10-05 2016-10-05
PCT/US2017/051352 WO2018063801A1 (en) 2016-09-29 2017-09-13 Bacterial inhibitors

Publications (1)

Publication Number Publication Date
BR112019005935A2 true BR112019005935A2 (pt) 2019-06-11

Family

ID=61760819

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019005935A BR112019005935A2 (pt) 2016-09-29 2017-09-13 inibidores bacterianos

Country Status (7)

Country Link
US (1) US11504414B2 (pt)
EP (1) EP3519429B1 (pt)
CN (1) CN110167955B (pt)
BR (1) BR112019005935A2 (pt)
ES (1) ES2905716T3 (pt)
MX (1) MX2019003475A (pt)
WO (1) WO2018063801A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0811530B1 (pt) 2007-05-14 2019-01-02 Research Foundation Of State Univ Of New York composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície
CN114469863B (zh) * 2021-11-26 2023-09-26 南方医科大学南方医院 甾醇脂质体作为牙髓和牙本质药物传递系统的应用
WO2023182185A1 (ja) * 2022-03-25 2023-09-28 メスキュージェナシス株式会社 ジンジパインに対して親和性及び／又は阻害能を有するペプチド及びその使用
CN116602951B (zh) * 2023-06-20 2024-08-30 华熙生物科技股份有限公司 γ-氨基丁酸在预防和/或减轻口腔炎症中的用途及实现该用途的方法
CN116622548B (zh) * 2023-03-31 2024-02-09 吉林农业大学 一株能够预防和或治疗牙周炎的嵴链球菌及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO652897A0 (en) * 1997-04-30 1997-05-29 University Of Melbourne, The Synthetic peptide constructs for the diagnosis and treatment of periodontitis
EP2264176A1 (en) * 1997-12-10 2010-12-22 CSL Limited Porphorymonas gingivalis polypeptides and polynucleotides
KR20040004449A (ko) * 2000-11-28 2004-01-13 휘닉스 파머컬러직스, 인크. 변형된 아르기닌 데이미나제
US20110250221A1 (en) * 2007-08-24 2011-10-13 University Of Wollongong Group A Streptococcus Pharmaceutical Compositions and Methods Thereof
EP2956130A4 (en) * 2013-02-14 2016-08-31 Univ Florida PROBIOTIC ARGINOLYTIC ORAL COMPOSITIONS AND METHOD FOR THE PREPARATION AND USE OF PROBIOTIC ARGINOLYTIC ORAL COMPOSITIONS
SG10202002557SA (en) * 2014-09-16 2020-04-29 Tdw Group Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment
CN110305193B (zh) * 2019-07-18 2021-10-08 河南科技大学 一种抗牙龈卟啉单胞菌多肽及应用

Also Published As

Publication number Publication date
ES2905716T3 (es) 2022-04-11
US20190209646A1 (en) 2019-07-11
EP3519429A4 (en) 2020-05-20
CN110167955B (zh) 2024-04-02
CN110167955A (zh) 2019-08-23
US11504414B2 (en) 2022-11-22
EP3519429A1 (en) 2019-08-07
MX2019003475A (es) 2019-11-28
EP3519429B1 (en) 2021-11-10
WO2018063801A1 (en) 2018-04-05

Similar Documents

Publication Publication Date Title
BR112019005935A2 (pt) inibidores bacterianos
BR112018067538A2 (pt) inibidores de ire1-alfa de pequenas moléculas
CL2018002928A1 (es) Compuestos arilo o heteroarilo sustituidos con amino como inhibidores de ehmt1 y ehmt2.
CY1125659T1 (el) Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη
BR112019007977A2 (pt) composto, composição farmacêutica, método de tratamento ou prevenção de câncer, e, uso de um composto
BR112015032595A2 (pt) inibidores de ido
MX2015011374A (es) Inhibidores de indolamina 2,3-dioxigenasa (ido).
BR112017017727A2 (pt) heterociclos bicíclicos como inibidores de fgfr4
MX2022004304A (es) Agentes inductores de apoptosis.
EA201891200A1 (ru) Композиции, содержащие бактериальные штаммы
EA033395B1 (ru) Ингибиторы индоламин-2,3-диоксигеназы и способы их применения
MX2019013735A (es) Antimitoscinas: inhibidores especificos de la biogenesis mitocondrial para erradicar celulas madre cancerosas.
CY1119489T1 (el) Υποκατεστημενη πιπεριδυλο-αιθυλο-πυριμιδινη ως αναστολεας της ο-ακυλο τρανσφερασης της γκρελινης
MX2016002075A (es) Inhibidores de indolamina 2,3-dioxigenasa (ido).
MX2021001376A (es) Carboxamidas como inhibidores de proteasa específicos de ubiquitina.
MX2019001011A (es) Compuestos farmaceuticos.
BR112018012304A2 (pt) composições e métodos para diminuir expressão de tau
PH12015502331A1 (en) Formulations of oxabicycloheptanes and oxabicycloheptenes
MX2017015923A (es) Inhibidores de indolamina-2,3-dioxigenasa (ido).
AU2017269673A1 (en) Pyridine dicarboxamide derivatives as bromodomain inhibitors
MX2022014007A (es) Compuestos como inhibidores de bcl-2.
BR112016001781A2 (pt) inibidores de rorc2 e métodos de uso dos mesmos
CY1122287T1 (el) Ενωσεις χρησιμες για την αναστολη toy ror-γαμμα-τ
NZ735398A (en) Novel n-acyl-arylsulfonamide derivatives as aminoacyl-trna synthetase inhibitors
BR112018071592A2 (pt) inibidores de erbb e usos dos mesmos

Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]