BR112018067538A2 - inibidores de ire1-alfa de pequenas moléculas - Google Patents
inibidores de ire1-alfa de pequenas moléculasInfo
- Publication number
- BR112018067538A2 BR112018067538A2 BR112018067538A BR112018067538A BR112018067538A2 BR 112018067538 A2 BR112018067538 A2 BR 112018067538A2 BR 112018067538 A BR112018067538 A BR 112018067538A BR 112018067538 A BR112018067538 A BR 112018067538A BR 112018067538 A2 BR112018067538 A2 BR 112018067538A2
- Authority
- BR
- Brazil
- Prior art keywords
- small molecule
- alpha inhibitors
- ire1
- inhibitors
- molecule ire1
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 150000003384 small molecules Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
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- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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Abstract
a presente invenção refere-se a inibidores de ire1alfa, composições contendo tais inibidores, e métodos de tratamento que incluem a administração de tais compostos. compostos exemplificativos são fornecidos ao longo deste pedido.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201662303236P | 2016-03-03 | 2016-03-03 | |
US201662303951P | 2016-03-04 | 2016-03-04 | |
PCT/US2017/020773 WO2017152117A1 (en) | 2016-03-03 | 2017-03-03 | Small molecule ire1-alpha inhibitors |
Publications (1)
Publication Number | Publication Date |
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BR112018067538A2 true BR112018067538A2 (pt) | 2019-02-05 |
Family
ID=58348003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BR112018067538A BR112018067538A2 (pt) | 2016-03-03 | 2017-03-03 | inibidores de ire1-alfa de pequenas moléculas |
Country Status (6)
Country | Link |
---|---|
US (4) | US20170252350A1 (pt) |
AU (2) | AU2017228405A1 (pt) |
BR (1) | BR112018067538A2 (pt) |
CA (2) | CA3016161A1 (pt) |
IL (2) | IL261385A (pt) |
WO (2) | WO2017152117A1 (pt) |
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-
2017
- 2017-03-03 US US15/449,610 patent/US20170252350A1/en not_active Abandoned
- 2017-03-03 AU AU2017228405A patent/AU2017228405A1/en not_active Abandoned
- 2017-03-03 BR BR112018067538A patent/BR112018067538A2/pt not_active IP Right Cessation
- 2017-03-03 US US15/449,547 patent/US10125123B2/en active Active
- 2017-03-03 CA CA3016161A patent/CA3016161A1/en not_active Abandoned
- 2017-03-03 CA CA3016196A patent/CA3016196A1/en not_active Abandoned
- 2017-03-03 WO PCT/US2017/020773 patent/WO2017152117A1/en active Application Filing
- 2017-03-03 AU AU2017228398A patent/AU2017228398A1/en not_active Abandoned
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2018
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- 2018-08-29 US US16/116,065 patent/US10988461B2/en active Active
- 2018-09-03 IL IL261557A patent/IL261557A/en unknown
-
2021
- 2021-03-30 US US17/217,599 patent/US20210238167A1/en not_active Abandoned
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US20170252350A1 (en) | 2017-09-07 |
CA3016196A1 (en) | 2017-09-08 |
US20170253590A1 (en) | 2017-09-07 |
IL261385A (en) | 2018-10-31 |
IL261557A (en) | 2018-10-31 |
US10125123B2 (en) | 2018-11-13 |
CA3016161A1 (en) | 2017-09-08 |
WO2017152126A1 (en) | 2017-09-08 |
US10988461B2 (en) | 2021-04-27 |
AU2017228405A1 (en) | 2018-10-18 |
AU2017228405A8 (en) | 2018-11-01 |
US20210238167A1 (en) | 2021-08-05 |
WO2017152117A1 (en) | 2017-09-08 |
AU2017228398A1 (en) | 2018-10-18 |
US20190016706A1 (en) | 2019-01-17 |
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