AU2015303641B2 - 2-(2,4,5-substituted aniline) pyrimidine derivative, pharmaceutical composition and use thereof - Google Patents

2-(2,4,5-substituted aniline) pyrimidine derivative, pharmaceutical composition and use thereof Download PDF

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Publication number
AU2015303641B2
AU2015303641B2 AU2015303641A AU2015303641A AU2015303641B2 AU 2015303641 B2 AU2015303641 B2 AU 2015303641B2 AU 2015303641 A AU2015303641 A AU 2015303641A AU 2015303641 A AU2015303641 A AU 2015303641A AU 2015303641 B2 AU2015303641 B2 AU 2015303641B2
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methyl
cancer
amino
methoxy
pharmaceutically acceptable
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AU2015303641A1 (en
Inventor
Aining Ji
Mingyu Jiang
Xiaoyun Zhu
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Nanjing Diansu Biological Technology Co Ltd
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Nanjing Diansu Biological Technology Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2015303641A 2014-08-15 2015-07-31 2-(2,4,5-substituted aniline) pyrimidine derivative, pharmaceutical composition and use thereof Active AU2015303641B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201410401604.7 2014-08-15
CN201410401604.7A CN104140418B (zh) 2014-08-15 2014-08-15 2-(2，4，5-取代苯胺)嘧啶衍生物及其用途
PCT/CN2015/085714 WO2016023422A1 (zh) 2014-08-15 2015-07-31 2-(2,4,5-取代苯胺)嘧啶衍生物、其药物组合物及其用途

Publications (2)

Publication Number Publication Date
AU2015303641A1 AU2015303641A1 (en) 2017-03-23
AU2015303641B2 true AU2015303641B2 (en) 2018-04-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015303641A Active AU2015303641B2 (en) 2014-08-15 2015-07-31 2-(2,4,5-substituted aniline) pyrimidine derivative, pharmaceutical composition and use thereof

Country Status (8)

Country Link
US (1) US10414756B2 (OSRAM)
EP (1) EP3181559B8 (OSRAM)
JP (1) JP6418622B2 (OSRAM)
KR (1) KR101937704B1 (OSRAM)
CN (1) CN104140418B (OSRAM)
AU (1) AU2015303641B2 (OSRAM)
CA (1) CA2958095C (OSRAM)
WO (1) WO2016023422A1 (OSRAM)

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CN104140418B (zh) * 2014-08-15 2016-08-24 常州润诺生物科技有限公司 2-(2，4，5-取代苯胺)嘧啶衍生物及其用途
CN105237515B (zh) * 2014-10-10 2018-06-05 益方生物科技（上海）有限公司 氘代嘧啶类化合物、其制备方法、药物组合物和用途
CN111171000B (zh) * 2014-10-11 2023-09-01 上海翰森生物医药科技有限公司 Egfr抑制剂及其制备和应用
CN111170998B (zh) 2014-11-05 2023-04-11 益方生物科技(上海)股份有限公司 嘧啶或吡啶类化合物、其制备方法和医药用途
CN105712998B (zh) * 2014-12-05 2019-12-13 上海润诺生物科技有限公司 氮杂吲哚类衍生物、其制备方法及其在医药上的应用
CN105001208A (zh) * 2015-08-06 2015-10-28 南京雷科星生物技术有限公司 一种表皮生长因子受体egfr抑制剂及其制备方法与用途
CN105153122B (zh) * 2015-08-27 2018-07-20 上海圣考医药科技有限公司 [(吲哚-3-基)嘧啶-2-基]氨基苯基丙-2-烯酰胺衍生物及盐、制备方法、应用
JP6606278B2 (ja) * 2015-08-31 2019-11-13 ウーシー ショアンリャン バイオテクノロジー カンパニー，リミティド ２−アリールアミノピリジン、ピリミジン又はトリアジン誘導体及びその製造方法と使用
CN106478605A (zh) * 2015-09-02 2017-03-08 上海页岩科技有限公司 嘧啶类化合物、其制备方法和医药用途
WO2017117070A1 (en) * 2015-12-27 2017-07-06 NeuForm Pharmaceuticals, Inc. Deuterated compounds for treating cancer and related diseases and conditions, and compositions and methods thereof
CN108610331A (zh) * 2016-01-22 2018-10-02 焦玉奇 2-(2,4,5-取代苯胺)嘧啶衍生物
CN107043369A (zh) * 2016-02-06 2017-08-15 焦玉奇 2‑(2,4,5‑取代苯胺)嘧啶衍生物
AU2016399168B2 (en) * 2016-03-22 2021-01-21 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. EGFR inhibitor free base or acid salt polycrystalline form, preparation method therefor, and application
KR20220130249A (ko) 2016-05-26 2022-09-26 리커리엄 아이피 홀딩스, 엘엘씨 Egfr 억제제 화합물
US10654851B2 (en) * 2016-09-19 2020-05-19 Nanjing Chuangte Pharmaceutical Technology Co., Ltd. Deuterated 3-(4,5-substituted aminopyrimidine)phenyl derivatives and use thereof
CN108129342A (zh) * 2016-11-30 2018-06-08 浙江九洲药物科技有限公司 一种奥希替尼中间体及其制备方法
CN108047205B (zh) * 2016-12-14 2019-08-27 河南真实生物科技有限公司 2-(2，4，5-取代苯氨基)嘧啶衍生物、其制备方法及其在制备抗肿瘤药物中的应用
CN106957304B (zh) * 2017-04-25 2017-12-01 孔令廷 一种石墨烯负载FeCl3催化剂的制备方法及其在制备抗癌药物中间体的用途
CN107192773B (zh) * 2017-05-17 2019-09-27 张家港威胜生物医药有限公司 一种检测奥希替尼含量和有关物质的高效液相法
CN108929311B (zh) * 2017-05-22 2020-07-28 焦玉奇 2-(2,4,5-取代苯胺)嘧啶衍生物
JP6971390B2 (ja) * 2017-05-24 2021-11-24 ティーワイケー メディシンズ インコーポレーテッドTyk Medicines Inc. 重水素化ａｚｄ９２９１の結晶形、製造方法および使用
WO2019001425A1 (zh) * 2017-06-27 2019-01-03 浙江同源康医药股份有限公司 一种氘代奥斯替尼衍生物及其应用
TWI702205B (zh) * 2017-10-06 2020-08-21 俄羅斯聯邦商拜奧卡德聯合股份公司 表皮生長因子受體抑制劑
CN107954918B (zh) * 2017-11-30 2022-01-25 郑州泰基鸿诺医药股份有限公司 一种n-氘代甲基吲哚类化合物的合成方法
CN108047207A (zh) * 2018-01-30 2018-05-18 天津大学 N-[5-(嘧啶-2-氨基)-2,4-二取代苯基]-2-氟代丙烯酰胺氘代物及应用
CN110272420A (zh) * 2018-03-16 2019-09-24 江苏正大丰海制药有限公司 氘代3-(4,5-取代氨基嘧啶)苯基化合物单甲磺酸盐晶型及其制备方法
CN110950847B (zh) * 2018-09-27 2022-11-01 浙江同源康医药股份有限公司 氘代azd9291化合物的新晶型及其用途
CN110003183A (zh) * 2019-04-09 2019-07-12 河南真实生物科技有限公司 2-（2，4，5-取代苯氨基）嘧啶衍生物及其晶形b
CN111909135A (zh) * 2020-08-15 2020-11-10 天津大学 一种azd9291氘代物甲磺酸盐新盐型及其制备方法
UY39600A (es) * 2020-12-30 2022-05-31 Biocad Joint Stock Co Inhibidores del receptor del factor de crecimiento epidérmico
CN113387935B (zh) * 2021-07-23 2022-06-10 苏州雅深智慧科技有限公司 抑制三突变表皮生长因子受体酪氨酸激酶的化合物及用途
CN113582976B (zh) * 2021-08-24 2023-03-17 郑州大学 氘代2-取代苯胺-4-吲哚基嘧啶类衍生物及其制备方法和应用
WO2025092926A1 (zh) * 2023-10-31 2025-05-08 浙江同源康医药股份有限公司 一种嘧啶类衍生物的药物组合物

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WO2013014448A1 (en) * 2011-07-27 2013-01-31 Astrazeneca Ab 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer
CN104140418A (zh) * 2014-08-15 2014-11-12 朱孝云 新的2-(2,4,5-取代苯胺)嘧啶衍生物及其用途

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WO2010028015A2 (en) * 2008-09-03 2010-03-11 Auspex Pharmaceuticals, Inc 2-oxo-1,2-dihydro-quinoline modulators of immune function
CN101676266B (zh) * 2008-09-19 2011-10-26 苏州泽璟生物制药有限公司 氘代的ω-二苯基脲及衍生物以及包含该化合物的药物组合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013014448A1 (en) * 2011-07-27 2013-01-31 Astrazeneca Ab 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer
CN104140418A (zh) * 2014-08-15 2014-11-12 朱孝云 新的2-(2,4,5-取代苯胺)嘧啶衍生物及其用途

Also Published As

Publication number Publication date
US20180016258A1 (en) 2018-01-18
EP3181559B1 (en) 2018-10-03
US10414756B2 (en) 2019-09-17
CN104140418B (zh) 2016-08-24
JP2017523247A (ja) 2017-08-17
KR20170036107A (ko) 2017-03-31
EP3181559A1 (en) 2017-06-21
CA2958095C (en) 2023-09-26
CA2958095A1 (en) 2016-02-18
WO2016023422A1 (zh) 2016-02-18
CN104140418A (zh) 2014-11-12
EP3181559A4 (en) 2017-06-21
EP3181559B8 (en) 2018-11-14
AU2015303641A1 (en) 2017-03-23
JP6418622B2 (ja) 2018-11-07
KR101937704B1 (ko) 2019-01-14

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