AU2015235979B2 - Celastrol and derivatives for the treatment of obesity - Google Patents

Celastrol and derivatives for the treatment of obesity Download PDF

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Publication number
AU2015235979B2
AU2015235979B2 AU2015235979A AU2015235979A AU2015235979B2 AU 2015235979 B2 AU2015235979 B2 AU 2015235979B2 AU 2015235979 A AU2015235979 A AU 2015235979A AU 2015235979 A AU2015235979 A AU 2015235979A AU 2015235979 B2 AU2015235979 B2 AU 2015235979B2
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AU
Australia
Prior art keywords
celastrol
obese
administered
formulation
mice
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AU2015235979A
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AU2015235979A1 (en
Inventor
Ralph Mazitschek
Umut Ozcan
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General Hospital Corp
Boston Children's Hospital
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General Hospital Corp
Boston Children's Hospital
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Publication of AU2015235979A1 publication Critical patent/AU2015235979A1/en
Priority to AU2019202601A priority Critical patent/AU2019202601A1/en
Application granted granted Critical
Publication of AU2015235979B2 publication Critical patent/AU2015235979B2/en
Assigned to THE GENERAL HOSPITAL CORPORATION, The Children’s Medical Center Corporation reassignment THE GENERAL HOSPITAL CORPORATION Request for Assignment Assignors: The Children’s Medical Center Corporation
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
AU2015235979A 2014-03-26 2015-03-26 Celastrol and derivatives for the treatment of obesity Active AU2015235979B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019202601A AU2019202601A1 (en) 2014-03-26 2019-04-15 Celastrol and derivatives for the treatment of obesity

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461970839P 2014-03-26 2014-03-26
US61/970,839 2014-03-26
PCT/US2015/022746 WO2015148802A1 (en) 2014-03-26 2015-03-26 Celastrol and derivatives for the treatment of obesity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019202601A Division AU2019202601A1 (en) 2014-03-26 2019-04-15 Celastrol and derivatives for the treatment of obesity

Publications (2)

Publication Number Publication Date
AU2015235979A1 AU2015235979A1 (en) 2016-10-20
AU2015235979B2 true AU2015235979B2 (en) 2019-05-02

Family

ID=52823863

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015235979A Active AU2015235979B2 (en) 2014-03-26 2015-03-26 Celastrol and derivatives for the treatment of obesity
AU2019202601A Abandoned AU2019202601A1 (en) 2014-03-26 2019-04-15 Celastrol and derivatives for the treatment of obesity

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2019202601A Abandoned AU2019202601A1 (en) 2014-03-26 2019-04-15 Celastrol and derivatives for the treatment of obesity

Country Status (10)

Country Link
US (3) US20150274634A1 (enExample)
EP (1) EP3122347B1 (enExample)
JP (1) JP2017513824A (enExample)
CN (2) CN107073016A (enExample)
AU (2) AU2015235979B2 (enExample)
BR (1) BR112016021985B1 (enExample)
CA (2) CA3044998A1 (enExample)
ES (1) ES2813424T3 (enExample)
RU (1) RU2706239C2 (enExample)
WO (1) WO2015148802A1 (enExample)

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EP2209911B1 (en) 2007-10-19 2013-10-16 The Trustees of Columbia University in the City of New York Dna sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators and a deoxyinosine analogue with a reversible terminator group
US20170209408A1 (en) * 2014-04-03 2017-07-27 The Children's Medical Center Corporation Hsp90 inhibitors for the treatment of obesity and methods of use thereof
CN119241632A (zh) * 2015-10-23 2025-01-03 Erx制药股份有限公司 雷公藤红素的类似物
US10053693B2 (en) 2016-01-19 2018-08-21 Mubin I. Syed Method for controlling obesity using minimally invasive means
WO2017214709A1 (en) 2016-06-15 2017-12-21 NOISEUX, Nicolas Reagents, compositions and methods for improving viability and function of cells, tissues and organs
CN108026142B (zh) * 2016-07-04 2022-07-08 艾凯奇（厦门）生物科技有限公司 孤儿核受体Nur77的配体及其用途
CN106243181A (zh) * 2016-07-29 2016-12-21 合肥中科玛卡生物技术有限公司 一种从苦瓜中提取雷公藤红素的方法
WO2018026810A1 (en) * 2016-08-03 2018-02-08 Vanderbilt University Treatment methods using celastrol
CN111821308B (zh) * 2019-04-15 2021-10-08 中国科学院上海药物研究所 雷藤舒在制备用于治疗非酒精性脂肪性肝病的药物中的应用
US12570687B2 (en) * 2019-09-12 2026-03-10 Nucmito Pharmaceuticals Co. Ltd. Triterpenoid compounds, pharmaceutical compositions thereof, and their use for treating a nuclear receptor subfamily 4 group a member 1-mediated disease
CN117860904B (zh) * 2024-01-10 2025-02-18 四川大学 一种四面体框架核酸-雷公藤红素复合物及其制备方法和应用

Citations (1)

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RU2379037C2 (ru) * 2005-09-30 2010-01-20 Моринага Милк Индастри Ко., Лтд. Средство для снижения резистентности к инсулину
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TWI576347B (zh) * 2012-01-20 2017-04-01 艾克泰聯製藥有限公司 作為ｐ２ｘ受體拮抗劑之雜環醯胺衍生物
CN111529535A (zh) * 2012-09-27 2020-08-14 儿童医学中心公司 用于治疗肥胖症的化合物和其使用方法
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Also Published As

Publication number Publication date
ES2813424T3 (es) 2021-03-23
RU2016141567A3 (enExample) 2018-04-27
US20190062254A1 (en) 2019-02-28
WO2015148802A1 (en) 2015-10-01
CA3044998A1 (en) 2015-10-01
RU2706239C2 (ru) 2019-11-15
JP2017513824A (ja) 2017-06-01
CN107073016A (zh) 2017-08-18
EP3122347A1 (en) 2017-02-01
CN117357538A (zh) 2024-01-09
BR112016021985B1 (pt) 2022-08-30
EP3122347B1 (en) 2020-06-03
US20180194709A1 (en) 2018-07-12
AU2015235979A1 (en) 2016-10-20
RU2016141567A (ru) 2018-04-27
US20150274634A1 (en) 2015-10-01
CA2944030C (en) 2019-06-04
CA2944030A1 (en) 2015-10-01
BR112016021985A2 (pt) 2017-08-15
BR112016021985A8 (pt) 2021-06-29
AU2019202601A1 (en) 2019-05-02

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Legal Events

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PC1 Assignment before grant (sect. 113)

Owner name: THE GENERAL HOSPITAL CORPORATION

Free format text: FORMER APPLICANT(S): THE CHILDREN'S MEDICAL CENTER CORPORATION

Owner name: THE CHILDREN'S MEDICAL CENTER CORPORATION

Free format text: FORMER APPLICANT(S): THE CHILDREN'S MEDICAL CENTER CORPORATION

FGA Letters patent sealed or granted (standard patent)