AU2015206528B2 - NO-releasing nitrooxy-chromene conjugates - Google Patents
NO-releasing nitrooxy-chromene conjugates Download PDFInfo
- Publication number
- AU2015206528B2 AU2015206528B2 AU2015206528A AU2015206528A AU2015206528B2 AU 2015206528 B2 AU2015206528 B2 AU 2015206528B2 AU 2015206528 A AU2015206528 A AU 2015206528A AU 2015206528 A AU2015206528 A AU 2015206528A AU 2015206528 B2 AU2015206528 B2 AU 2015206528B2
- Authority
- AU
- Australia
- Prior art keywords
- chromene
- trifluoromethyl
- methyl
- ethyl
- nitrooxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *CCCCOC(C1=Cc(cc(c(Cc2ccccc2)c2)N)c2O[C@@]1*)=C Chemical compound *CCCCOC(C1=Cc(cc(c(Cc2ccccc2)c2)N)c2O[C@@]1*)=C 0.000 description 3
- YHKNIULYXYFUOG-QPKMRZHPSA-N CC(C)(C)c1c(C)cc(CC([C@@H](C(F)(F)F)O2)C(O[C@@H](CO[C@@H]34)[C@H]3OCC4O[NH+]([O-])[O-])=O)c2c1 Chemical compound CC(C)(C)c1c(C)cc(CC([C@@H](C(F)(F)F)O2)C(O[C@@H](CO[C@@H]34)[C@H]3OCC4O[NH+]([O-])[O-])=O)c2c1 YHKNIULYXYFUOG-QPKMRZHPSA-N 0.000 description 1
- KSOUUQFYSOZCKJ-UHFFFAOYSA-N CC(C)N(C(C)C)N=N Chemical compound CC(C)N(C(C)C)N=N KSOUUQFYSOZCKJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461927344P | 2014-01-14 | 2014-01-14 | |
| US61/927,344 | 2014-01-14 | ||
| PCT/US2015/011454 WO2015109011A1 (en) | 2014-01-14 | 2015-01-14 | No-releasing nitrooxy-chromene conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015206528A1 AU2015206528A1 (en) | 2016-08-04 |
| AU2015206528B2 true AU2015206528B2 (en) | 2019-04-18 |
Family
ID=53543408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015206528A Active AU2015206528B2 (en) | 2014-01-14 | 2015-01-14 | NO-releasing nitrooxy-chromene conjugates |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10266511B2 (https=) |
| EP (1) | EP3094333B1 (https=) |
| CN (1) | CN106102747A (https=) |
| AU (1) | AU2015206528B2 (https=) |
| BR (1) | BR112016016386B1 (https=) |
| CA (1) | CA2936952C (https=) |
| ES (1) | ES2836374T3 (https=) |
| IL (1) | IL246794B (https=) |
| MX (1) | MX369245B (https=) |
| WO (2) | WO2015109011A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105585547A (zh) * | 2016-03-09 | 2016-05-18 | 中国科学院广州生物医药与健康研究院 | 一种4-五氟化硫苯酚类化合物及制备方法以及五氟化硫取代苯并吡喃类化合物的制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060009431A1 (en) * | 2003-03-13 | 2006-01-12 | Nitromed, Inc. | Nitrosated and nitrosylated compounds, compositions and methods use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050101563A1 (en) | 2001-08-14 | 2005-05-12 | Pharmacia Corporation | Method and compositions for the treatment and prevention of pain and inflammation |
| ITMI20021391A1 (it) | 2002-06-25 | 2003-12-29 | Nicox Sa | Nitroderivati di inibitori della cicloossigenasi-2 |
| EP1562914A1 (en) | 2002-10-22 | 2005-08-17 | Merck Frosst Canada & Co. | Nitric oxide releasing selective cyclooxygenase-2 inhibitors |
| US7259266B2 (en) | 2003-03-31 | 2007-08-21 | Pharmacia Corporation | Benzopyran compounds useful for treating inflammatory conditions |
| US20050148627A1 (en) | 2003-03-31 | 2005-07-07 | Jeffery Carter | Benzopyran compounds for use in the treatment and prevention of inflammation related conditions |
| EP1692107A4 (en) * | 2003-12-10 | 2008-10-29 | Nitromed Inc | NITROGEN OXIDE-RELATED PYRUVATE COMPOUNDS, COMPOSITIONS AND USE METHOD |
| WO2006040646A1 (en) * | 2004-10-14 | 2006-04-20 | Pfizer, Inc. | Benzimidazole or indole amides as inhibitors of pin1 |
| WO2009009776A2 (en) | 2007-07-12 | 2009-01-15 | Tragara Pharmaceuticals, Inc. | Patient selection and therapeutic methods using markers of prostaglandin metabolism |
| CN103012350B (zh) * | 2012-12-07 | 2015-02-04 | 中国科学院广州生物医药与健康研究院 | 苯并吡喃类手性化合物的合成方法 |
-
2015
- 2015-01-14 WO PCT/US2015/011454 patent/WO2015109011A1/en not_active Ceased
- 2015-01-14 US US15/111,767 patent/US10266511B2/en active Active
- 2015-01-14 CN CN201580012500.XA patent/CN106102747A/zh active Pending
- 2015-01-14 WO PCT/US2015/011456 patent/WO2015109013A1/en not_active Ceased
- 2015-01-14 EP EP15737116.2A patent/EP3094333B1/en active Active
- 2015-01-14 ES ES15737116T patent/ES2836374T3/es active Active
- 2015-01-14 BR BR112016016386-9A patent/BR112016016386B1/pt active IP Right Grant
- 2015-01-14 AU AU2015206528A patent/AU2015206528B2/en active Active
- 2015-01-14 CA CA2936952A patent/CA2936952C/en active Active
- 2015-01-14 MX MX2016009222A patent/MX369245B/es active IP Right Grant
-
2016
- 2016-07-14 IL IL246794A patent/IL246794B/en active IP Right Grant
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060009431A1 (en) * | 2003-03-13 | 2006-01-12 | Nitromed, Inc. | Nitrosated and nitrosylated compounds, compositions and methods use |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3094333A4 (en) | 2017-09-06 |
| MX2016009222A (es) | 2017-03-06 |
| EP3094333B1 (en) | 2020-10-14 |
| CA2936952C (en) | 2023-01-24 |
| CN106102747A (zh) | 2016-11-09 |
| US20160340330A1 (en) | 2016-11-24 |
| WO2015109013A1 (en) | 2015-07-23 |
| CA2936952A1 (en) | 2015-07-23 |
| ES2836374T3 (es) | 2021-06-24 |
| BR112016016386B1 (pt) | 2023-02-23 |
| BR112016016386A2 (https=) | 2017-08-08 |
| MX369245B (es) | 2019-11-01 |
| WO2015109011A1 (en) | 2015-07-23 |
| IL246794A0 (en) | 2016-08-31 |
| IL246794B (en) | 2020-04-30 |
| EP3094333A1 (en) | 2016-11-23 |
| US10266511B2 (en) | 2019-04-23 |
| AU2015206528A1 (en) | 2016-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |