AU2014368874B2 - Trans-spinal direct current modulation systems - Google Patents

Trans-spinal direct current modulation systems Download PDF

Info

Publication number
AU2014368874B2
AU2014368874B2 AU2014368874A AU2014368874A AU2014368874B2 AU 2014368874 B2 AU2014368874 B2 AU 2014368874B2 AU 2014368874 A AU2014368874 A AU 2014368874A AU 2014368874 A AU2014368874 A AU 2014368874A AU 2014368874 B2 AU2014368874 B2 AU 2014368874B2
Authority
AU
Australia
Prior art keywords
stimulation
spinal
nerve
neural
electrodes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2014368874A
Other languages
English (en)
Other versions
AU2014368874A1 (en
Inventor
Zaghloul Ahmed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of City University of New York
Original Assignee
Research Foundation of City University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of City University of New York filed Critical Research Foundation of City University of New York
Publication of AU2014368874A1 publication Critical patent/AU2014368874A1/en
Application granted granted Critical
Publication of AU2014368874B2 publication Critical patent/AU2014368874B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36003—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36062—Spinal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/3616—Voltage density or current density

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Electrotherapy Devices (AREA)
  • Magnetic Treatment Devices (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Amplifiers (AREA)
  • Amplitude Modulation (AREA)
  • Stabilization Of Oscillater, Synchronisation, Frequency Synthesizers (AREA)
  • Steroid Compounds (AREA)
AU2014368874A 2013-12-22 2014-12-22 Trans-spinal direct current modulation systems Active AU2014368874B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361919806P 2013-12-22 2013-12-22
US61/919,806 2013-12-22
US201461925423P 2014-01-09 2014-01-09
US61/925,423 2014-01-09
US201462092214P 2014-12-15 2014-12-15
US62/092,214 2014-12-15
PCT/US2014/071959 WO2015095880A2 (en) 2013-12-22 2014-12-22 Trans-spinal direct current modulation systems

Publications (2)

Publication Number Publication Date
AU2014368874A1 AU2014368874A1 (en) 2016-07-07
AU2014368874B2 true AU2014368874B2 (en) 2019-07-11

Family

ID=53403908

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014368874A Active AU2014368874B2 (en) 2013-12-22 2014-12-22 Trans-spinal direct current modulation systems

Country Status (20)

Country Link
US (3) US9283391B2 (enExample)
EP (2) EP3082947B1 (enExample)
JP (1) JP6518251B2 (enExample)
KR (2) KR102431161B1 (enExample)
CN (2) CN109432596B (enExample)
AU (1) AU2014368874B2 (enExample)
CA (1) CA2932000C (enExample)
CY (1) CY1122116T1 (enExample)
DK (1) DK3082947T3 (enExample)
ES (2) ES2889099T3 (enExample)
HR (1) HRP20191032T1 (enExample)
HU (1) HUE045175T2 (enExample)
IL (1) IL246430B (enExample)
LT (1) LT3082947T (enExample)
MX (1) MX366919B (enExample)
PL (1) PL3082947T3 (enExample)
PT (1) PT3082947T (enExample)
SG (1) SG11201604288WA (enExample)
SI (1) SI3082947T1 (enExample)
WO (1) WO2015095880A2 (enExample)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
WO2014169145A1 (en) 2013-04-10 2014-10-16 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
EP2661307A4 (en) 2011-01-03 2014-08-06 Univ California HIGH-DENSITY EPIDURAL STIMULATION TO FACILITATE MOVEMENTS, ATTACHMENTS, ARBITRARY MOVEMENTS AND RECOVERY OF AUTONOMIC, SEXUAL, VASOMOTORIC AND COGNITIVE FUNCTIONS AFTER NEUROLOGICAL INJURIES
US12172017B2 (en) 2011-05-09 2024-12-24 Setpoint Medical Corporation Vagus nerve stimulation to treat neurodegenerative disorders
EP2776119B1 (en) 2011-11-11 2019-02-06 The Regents of The University of California Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry
AU2013230776B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Immune system neuromodulation and associated systems and methods
US10195434B2 (en) 2012-06-15 2019-02-05 Case Western Reserve University Treatment of pain using electrical nerve conduction block
EP2861296A1 (en) 2012-06-15 2015-04-22 Case Western Reserve University Therapy delivery devices and methods for non-damaging neural tissue conduction block
US12453853B2 (en) 2013-01-21 2025-10-28 Cala Health, Inc. Multi-modal stimulation for treating tremor
CN114768089A (zh) 2013-01-21 2022-07-22 卡拉健康公司 用于控制震颤的设备和方法
WO2014144785A1 (en) 2013-03-15 2014-09-18 The Regents Of The University Of California Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion
US20150238764A1 (en) 2013-05-10 2015-08-27 Case Western Reserve University Systems and methods for preventing noise in an electric waveform for neural stimulation, block, or sensing
EP3441109A1 (en) 2013-05-30 2019-02-13 Graham H. Creasey Flexible dermal patch for a topical nerve stimulator system
US11229789B2 (en) 2013-05-30 2022-01-25 Neurostim Oab, Inc. Neuro activator with controller
JP6553623B2 (ja) 2013-09-16 2019-07-31 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 電磁エネルギー生成のための多素子カプラ
EP3782698A1 (en) 2013-09-27 2021-02-24 The Regents Of The University Of California Engaging the cervical spinal cord circuitry to re- enable volitional control of hand function in tetraplegic subjects
US9707391B2 (en) * 2013-12-22 2017-07-18 The Research Foundation Of The City University Of New York Method for modulation of effector organs
US9707390B2 (en) * 2013-12-22 2017-07-18 The Research Foundation Of The City University Of New York Apparatus for modulation of effector organs
WO2015095880A2 (en) * 2013-12-22 2015-06-25 Research Foundation Of The City University Of New York Trans-spinal direct current modulation systems
EP3753517B1 (en) 2014-05-18 2022-05-11 Neuspera Medical Inc. Midfield coupler
US20160336813A1 (en) 2015-05-15 2016-11-17 NeuSpera Medical Inc. Midfield coupler
JP2017516608A (ja) * 2014-05-23 2017-06-22 アルブレヒト モルスベアガーAlbrecht Molsberger 治療適用可能なマルチチャネル直流出力装置
BR112016025203B1 (pt) 2014-06-02 2022-09-06 Cala Health, Inc Sistema transcutâneo para tratar um paciente que sofre de tremor
CA2958924C (en) 2014-08-21 2023-09-12 The Regents Of The University Of California Regulation of autonomic control of bladder voiding after a complete spinal cord injury
AU2015308779B2 (en) 2014-08-27 2020-06-25 The Regents Of The University Of California Multi-electrode array for spinal cord epidural stimulation
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
AU2015358385B2 (en) 2014-12-03 2020-09-03 Medtronic Ireland Manufacturing Unlimited Company Systems and methods for modulating nerves or other tissue
US11077301B2 (en) 2015-02-21 2021-08-03 NeurostimOAB, Inc. Topical nerve stimulator and sensor for bladder control
CA2988586A1 (en) 2015-06-10 2016-12-15 Cala Health, Inc. Neuromodulation system for peripheral nerve stimulation with detachable therapy unit
US20200093400A1 (en) 2015-07-31 2020-03-26 Cala Health, Inc. Systems, devices, and method for the treatment of osteoarthritis
KR20180034653A (ko) * 2015-08-03 2018-04-04 갈바니 바이오일렉트로닉스 리미티드 신경조절 디바이스
WO2017031306A1 (en) * 2015-08-19 2017-02-23 University Of Louisville Research Foundation, Inc. Methods for providing optimized neurostimulation
US11298533B2 (en) 2015-08-26 2022-04-12 The Regents Of The University Of California Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject
AU2016320803A1 (en) * 2015-09-08 2018-03-22 Case Western Reserve University Systems and methods for transcutaneous direct current block to alter nerve conduction
WO2017053847A1 (en) 2015-09-23 2017-03-30 Cala Health, Inc. Systems and methods for peripheral nerve stimulation in the finger or hand to treat hand tremors
JP6962909B2 (ja) 2015-10-06 2021-11-05 ケース ウェスタン リザーブ ユニバーシティCase Western Reserve University 直流電流神経伝導ブロックを伝えるための高電荷容量電極
US11097122B2 (en) 2015-11-04 2021-08-24 The Regents Of The University Of California Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel
US10864373B2 (en) 2015-12-15 2020-12-15 Case Western Reserve University Systems for treatment of a neurological disorder using electrical nerve conduction block
WO2017127756A1 (en) 2016-01-20 2017-07-27 Setpoint Medical Corporation Control of vagal stimulation
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
US11344722B2 (en) 2016-01-21 2022-05-31 Cala Health, Inc. Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
AU2017293799B2 (en) * 2016-07-08 2022-10-20 Cala Health, Inc. Systems and methods for stimulating n nerves with exactly n electrodes and improved dry electrodes
CA3033662A1 (en) 2016-08-25 2018-03-01 Cala Health, Inc. Systems and methods for treating cardiac dysfunction through peripheral nerve stimulation
AU2017251817A1 (en) * 2016-11-04 2018-05-24 Gimer Medical. Co. Ltd. Method for reducing overactive bladder syndrome and computer-readable medium thereof
AU2017254920B2 (en) * 2016-11-10 2019-04-04 Gimer Medical Co. Ltd. Method of reducing renal hypertension and computer-readable medium
EP4233999A3 (en) 2016-12-12 2023-11-22 The Regents of The University of California Implantable and non-invasive stimulators for gastrointestinal therapeutics
US11752328B2 (en) 2016-12-20 2023-09-12 Galvani Bioelectronics Limited Neuromodulation device
EP3565631B1 (en) 2017-01-05 2024-04-24 Noctrix Health, Inc. Restless leg syndrome or overactive nerve treatment
WO2021067751A1 (en) 2019-10-03 2021-04-08 Noctrix Health, Inc. Peripheral nerve stimulation for restless legs syndrome
EP4473909A3 (en) 2017-02-17 2025-01-29 The University of British Columbia Apparatus and methods for maintaining physiological functions
EP3606604A4 (en) 2017-04-03 2020-12-16 Cala Health, Inc. PERIPHERAL NEUROMODULATION SYSTEMS, METHODS AND DEVICES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH BLADDER HYPERACTIVITY
WO2018187237A1 (en) 2017-04-03 2018-10-11 Presidio Medical, Inc. Systems and methods for direct current nerve conduction block
US12434068B2 (en) 2017-05-23 2025-10-07 The Regents Of The University Of California Accessing spinal networks to address sexual dysfunction
EP3974021B1 (en) 2017-06-30 2023-06-14 ONWARD Medical N.V. A system for neuromodulation
US12090324B2 (en) * 2017-08-11 2024-09-17 Boston Scientific Neuromodulation Corporation Spinal cord stimulation for dorsal column recruitment or suppression using anodic and cathodic pulses
US11173307B2 (en) 2017-08-14 2021-11-16 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
EP3706856A4 (en) 2017-11-07 2021-08-18 Neurostim Oab, Inc. NON-INVASIVE NERVOUS ACTIVATOR WITH ADAPTIVE CIRCUIT
US11992684B2 (en) 2017-12-05 2024-05-28 Ecole Polytechnique Federale De Lausanne (Epfl) System for planning and/or providing neuromodulation
US12357828B2 (en) 2017-12-05 2025-07-15 Ecole Polytechnique Federale De Lausanne (Epfl) System for planning and/or providing neuromodulation
CN109999341A (zh) * 2018-01-04 2019-07-12 精能医学股份有限公司 电刺激器、制造电刺激器的方法及电刺激系统
CN110013605A (zh) * 2018-01-10 2019-07-16 精能医学股份有限公司 电刺激器、治疗方法及电刺激系统
WO2019143790A1 (en) 2018-01-17 2019-07-25 Cala Health, Inc. Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
EP3749194B1 (en) 2018-02-09 2025-09-03 Presidio Medical, Inc. Systems for cardiac conduction block
AU2019225810B2 (en) 2018-02-20 2024-11-14 Presidio Medical, Inc. Methods and systems for nerve conduction block
KR102141550B1 (ko) 2018-03-14 2020-08-05 이화여자대학교 산학협력단 비침습적 방광 배뇨 관리 시스템
US11986659B2 (en) * 2018-03-22 2024-05-21 Research Foundation Of The City University Of New York Modulation of neuronal NKCC1 as a therapeutic strategy for spasticity and related disorders
EP3793673B1 (en) * 2018-05-17 2023-07-26 Boston Scientific Scimed Inc. System for controlling blood pressure
EP4647113A1 (en) 2018-07-01 2025-11-12 Presidio Medical, Inc. Systems and methods for nerve conduction block
AU2019301128B2 (en) * 2018-07-11 2024-07-25 Dignify Therapeutics, Llc Method of treating voiding dysfunction
WO2020041502A1 (en) * 2018-08-21 2020-02-27 The Regents Of The University Of California Transcutaneous electrical and/or magnetic spinal stimulation for bladder or bowel control in subjects without cns injury
WO2020041633A1 (en) 2018-08-23 2020-02-27 The Regents Of The University Of California Non-invasive spinal cord stimulation for nerve root palsy, cauda equina syndrome, and restoration of upper extremity function
EP4137198B1 (en) * 2018-08-31 2026-01-07 Avation Medical, Inc. System and apparatus for applying transcutaneous electrical stimulation
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
CN109173056B (zh) * 2018-10-19 2022-03-22 南通大学 一种大鼠脊髓神经信号检测与评估系统及方法
US11602633B2 (en) * 2018-10-22 2023-03-14 Pathmaker Neurosystems Inc. Method and apparatus for controlling multi-site neurostimulation
DE18205821T1 (de) 2018-11-13 2020-12-24 Gtx Medical B.V. Steuerungssystem zur bewegungsrekonstruktion und/oder wiederherstellung für einen patienten
EP3695878B1 (en) 2019-02-12 2023-04-19 ONWARD Medical N.V. A system for neuromodulation
US11617884B2 (en) 2019-03-15 2023-04-04 Case Western Reserve University Electrically anesthetizing a peripheral nerve with on-demand electrical nerve block for chronic pain management
WO2020210786A1 (en) 2019-04-12 2020-10-15 Setpoint Medical Corporation Vagus nerve stimulation to treat neurodegenerative disorders
CN114144226A (zh) 2019-05-22 2022-03-04 加利福尼亚大学董事会 经皮脊髓电神经调制器及其用途
WO2020254796A1 (en) * 2019-06-19 2020-12-24 Galvani Bioelectronics Limited Neuromodulation device
US11458311B2 (en) 2019-06-26 2022-10-04 Neurostim Technologies Llc Non-invasive nerve activator patch with adaptive circuit
WO2021022020A1 (en) 2019-07-30 2021-02-04 Duke University Devices, systems, and methods for promoting voiding in subjects with underactive bladders
US12251560B1 (en) 2019-08-13 2025-03-18 Cala Health, Inc. Connection quality determination for wearable neurostimulation systems
US11890468B1 (en) 2019-10-03 2024-02-06 Cala Health, Inc. Neurostimulation systems with event pattern detection and classification
EP4041376A1 (en) 2019-10-03 2022-08-17 Noctrix Health, Inc. Peripheral nerve stimulation for restless legs syndrome
CN110585597B (zh) * 2019-10-21 2024-04-16 中南大学湘雅三医院 肠道蠕动智能调节系统
EP3824948A1 (en) 2019-11-19 2021-05-26 ONWARD Medical B.V. A planning and/or control system for a neuromodulation system
US11730964B2 (en) 2019-11-24 2023-08-22 Presidio Medical, Inc. Pulse generation and stimulation engine systems
WO2021102447A1 (en) 2019-11-24 2021-05-27 Presidio Medical, Inc. Current bias as a control mechanism for electrode operation
EP3827875B1 (en) 2019-11-27 2023-07-05 ONWARD Medical N.V. Neuromodulation system
DE19211698T1 (de) 2019-11-27 2021-09-02 Onward Medical B.V. Neuromodulation system
EP4017580A4 (en) 2019-12-16 2023-09-06 Neurostim Technologies LLC NON-INVASIVE NERVE ACTIVATOR WITH ENHANCED CHARGE DELIVERY
KR20230012585A (ko) 2020-05-21 2023-01-26 더 파인스타인 인스티튜츠 포 메디칼 리서치 미주 신경 자극을 위한 시스템들 및 방법들
US12208266B2 (en) 2020-05-26 2025-01-28 Research Foundation Of The City University Of New York Multi-site neuromodulation for treatment of ALS and related disorders
EP3915470A1 (en) * 2020-05-26 2021-12-01 ONWARD Medical B.V. Neuromodulation and/or neurostimulation system
KR102554540B1 (ko) * 2020-07-30 2023-07-12 재단법인대구경북과학기술원 맞춤형 전기 자극 제공 시스템 및 그 방법
IL305807A (en) 2021-03-12 2023-11-01 Amber Therapeutics Ltd Systems for controlling urinary incontinence
US12444497B2 (en) 2021-05-17 2025-10-14 Setpoint Medical Corporation Neurostimulation parameter authentication and expiration system for neurostimulation
US20250229086A1 (en) * 2022-01-20 2025-07-17 Setpoint Medical Corporation Treatment of inflammatory disorders
US12649059B2 (en) 2022-08-05 2026-06-09 The Feinstein Institutes For Medical Research Methods for reducing bleeding in hemophilia by vagus nerve stimulation to prime platelets
EP4694965A1 (en) * 2023-04-10 2026-02-18 The United States of America, as represented by the Secretary, Department of Health and Human Services Systems and methods for multichannel individualized stimulation therapy
WO2024231836A1 (en) * 2023-05-07 2024-11-14 Gerdcare Medical Ltd. Implantable device and method for treating gastro esophageal reflux disease (gerd) and the digestive system
US12623080B2 (en) 2023-06-21 2026-05-12 Onward Medical N.V. Neuromodulation system
AU2024290852A1 (en) * 2023-07-05 2026-01-15 Alphatec Spine, Inc. Intra-operative lower spine motor integrity monitoring through trans-spinal stimulation
WO2025081085A1 (en) * 2023-10-13 2025-04-17 Cionic, Inc. Alternating electrodes between measurement and intervention modes to address hyperexcitability
JPWO2025094661A1 (enExample) * 2023-11-02 2025-05-08
WO2025254758A1 (en) * 2024-06-05 2025-12-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Systems and methods for adjustable current individualized stimulation therapy

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040210261A1 (en) * 2003-04-21 2004-10-21 King Gary W. Neurostimulation to treat effects of sleep apnea
US20070073357A1 (en) * 2005-06-09 2007-03-29 Medtronic, Inc. Peripheral nerve field stimulation and spinal cord stimulation
WO2012129574A2 (en) * 2011-03-24 2012-09-27 California Institute Of Technology Neurostimulator
US20130072998A1 (en) * 2010-06-07 2013-03-21 Medtronic Parkway NE Stimulation therapy for bladder dysfunction
US8532779B2 (en) * 2008-10-31 2013-09-10 Medtronic, Inc. Implantable medical device crosstalk evaluation and mitigation

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5193539A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
US20060122660A1 (en) * 1998-10-26 2006-06-08 Boveja Birinder R Method and system for modulating sacral nerves and/or its branches in a patient to provide therapy for urological disorders and/or fecal incontinence, using rectangular and/or complex electrical pulses
US6366814B1 (en) * 1998-10-26 2002-04-02 Birinder R. Boveja External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders
US6353762B1 (en) * 1999-04-30 2002-03-05 Medtronic, Inc. Techniques for selective activation of neurons in the brain, spinal cord parenchyma or peripheral nerve
US20100016929A1 (en) * 2004-01-22 2010-01-21 Arthur Prochazka Method and system for controlled nerve ablation
US20080071321A1 (en) * 2004-06-10 2008-03-20 Ndi Medical, Inc. Systems and methods of neuromodulation stimulation for the restoration of sexual function
US9205261B2 (en) * 2004-09-08 2015-12-08 The Board Of Trustees Of The Leland Stanford Junior University Neurostimulation methods and systems
US7580753B2 (en) * 2004-09-08 2009-08-25 Spinal Modulation, Inc. Method and system for stimulating a dorsal root ganglion
CA2637851C (en) * 2006-01-23 2016-01-05 Rehabtronics Inc. Method of routing electrical current to bodily tissues via implanted passive conductors
US8612019B2 (en) * 2007-05-23 2013-12-17 Boston Scientific Neuromodulation Corporation Coupled monopolar and multipolar pulsing for conditioning and stimulation
US20090204173A1 (en) * 2007-11-05 2009-08-13 Zi-Ping Fang Multi-Frequency Neural Treatments and Associated Systems and Methods
US8996116B2 (en) * 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
US20130053922A1 (en) * 2009-10-22 2013-02-28 Zaghloul Ahmed Dipole electrical stimulation employing direct current for recovery from spinal cord injury
US20130035745A1 (en) * 2010-03-22 2013-02-07 Zaghloul Ahmed Charge-enhanced neural electric stimulation system
WO2012003451A2 (en) * 2010-07-01 2012-01-05 Stimdesigns Llc Universal closed-loop electrical stimulation system
WO2013036880A1 (en) * 2011-09-08 2013-03-14 Thacker James R Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods
US8880170B2 (en) * 2011-11-29 2014-11-04 Cardiac Pacemakers, Inc. Autonomic modulation using peripheral nerve field stimulation
US8706240B2 (en) * 2011-12-09 2014-04-22 Boston Scientific Neuromodulation Corporation Method for direct modulation of the spinothalamic tract
US9872992B2 (en) * 2012-03-16 2018-01-23 Boston Scientific Neuromodulation Corporation System and method for estimating location and depth of stimulation leads
AU2013232394B2 (en) * 2012-03-16 2015-06-11 Boston Scientific Neuromodulation Corporation Field augmented current steering using voltage sources
US20150073232A1 (en) * 2013-04-05 2015-03-12 Intelligent Widgets, Inc. Devices and methods for airflow diagnosis and restoration
US9707390B2 (en) * 2013-12-22 2017-07-18 The Research Foundation Of The City University Of New York Apparatus for modulation of effector organs
US9707391B2 (en) * 2013-12-22 2017-07-18 The Research Foundation Of The City University Of New York Method for modulation of effector organs
WO2015095880A2 (en) * 2013-12-22 2015-06-25 Research Foundation Of The City University Of New York Trans-spinal direct current modulation systems

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040210261A1 (en) * 2003-04-21 2004-10-21 King Gary W. Neurostimulation to treat effects of sleep apnea
US20070073357A1 (en) * 2005-06-09 2007-03-29 Medtronic, Inc. Peripheral nerve field stimulation and spinal cord stimulation
US8532779B2 (en) * 2008-10-31 2013-09-10 Medtronic, Inc. Implantable medical device crosstalk evaluation and mitigation
US20130072998A1 (en) * 2010-06-07 2013-03-21 Medtronic Parkway NE Stimulation therapy for bladder dysfunction
WO2012129574A2 (en) * 2011-03-24 2012-09-27 California Institute Of Technology Neurostimulator

Also Published As

Publication number Publication date
CA2932000A1 (en) 2015-06-25
WO2015095880A3 (en) 2015-12-23
EP3082947A2 (en) 2016-10-26
KR20160105822A (ko) 2016-09-07
CY1122116T1 (el) 2020-11-25
US20180071525A1 (en) 2018-03-15
EP3581239A1 (en) 2019-12-18
EP3082947A4 (en) 2018-08-22
US20160158542A1 (en) 2016-06-09
US9283391B2 (en) 2016-03-15
KR102431161B1 (ko) 2022-08-10
JP6518251B2 (ja) 2019-05-22
CN109432596B (zh) 2022-05-17
SI3082947T1 (sl) 2019-08-30
IL246430A0 (en) 2016-08-31
CA2932000C (en) 2023-08-22
LT3082947T (lt) 2019-07-10
KR20190140112A (ko) 2019-12-18
AU2014368874A1 (en) 2016-07-07
DK3082947T3 (da) 2019-06-17
US10493270B2 (en) 2019-12-03
MX366919B (es) 2019-07-30
IL246430B (en) 2020-06-30
ES2889099T3 (es) 2022-01-11
CN106029164B (zh) 2019-01-04
HUE045175T2 (hu) 2019-12-30
CN109432596A (zh) 2019-03-08
SG11201604288WA (en) 2016-07-28
MX2016007586A (es) 2016-12-12
WO2015095880A2 (en) 2015-06-25
HRP20191032T1 (hr) 2019-08-23
US20150196767A1 (en) 2015-07-16
JP2017503537A (ja) 2017-02-02
CN106029164A (zh) 2016-10-12
US9844668B2 (en) 2017-12-19
PT3082947T (pt) 2019-07-08
EP3581239B1 (en) 2021-05-05
PL3082947T3 (pl) 2019-10-31
ES2732734T3 (es) 2019-11-25
EP3082947B1 (en) 2019-03-13

Similar Documents

Publication Publication Date Title
US10493270B2 (en) Trans-spinal direct current modulation systems
US20250235694A1 (en) Transcutaneous electrical spinal cord neuromodulator and uses thereof
US9707390B2 (en) Apparatus for modulation of effector organs
US9707391B2 (en) Method for modulation of effector organs
JP6796089B2 (ja) 効果器を調節するための方法および装置
EP3993865A1 (en) Neural block by super-threshold low frequency electrical stimulation
Bruns et al. Variable patterned pudendal nerve stimuli improves reflex bladder activation
BR102013033095A2 (pt) equipamento para tratamento domiciliar da hiperatividade vesical e incontinência mista e de urgência e processo de tratamento da hiperatividade vesical e incontinência mista e de urgência empregando neuromodulação via estimulação tibial
CN101421003A (zh) 利用电信号来治疗肠梗阻状况的方法和装置
UA134741U (uk) Спосіб інвазивної електростимуляції спинного мозку

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)