AU2014349246C1 - Pharmaceutical composition containing glutarimide derivatives, and application thereof for treating eosinophilic diseases - Google Patents

Pharmaceutical composition containing glutarimide derivatives, and application thereof for treating eosinophilic diseases Download PDF

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Publication number
AU2014349246C1
AU2014349246C1 AU2014349246A AU2014349246A AU2014349246C1 AU 2014349246 C1 AU2014349246 C1 AU 2014349246C1 AU 2014349246 A AU2014349246 A AU 2014349246A AU 2014349246 A AU2014349246 A AU 2014349246A AU 2014349246 C1 AU2014349246 C1 AU 2014349246C1
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AU
Australia
Prior art keywords
eosinophilic
diseases
compound
atopic dermatitis
bronchial asthma
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Ceased
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AU2014349246A
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English (en)
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AU2014349246A9 (en
AU2014349246B2 (en
AU2014349246A1 (en
Inventor
Alexander Grigorievich Chuchalin
Tatyana Alexandrovna Kromova
Vladimir Evgenievich Nebolsin
Anastasia Vladimirovna RYDLOVSKAYA
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Chemimmune Therapeutics LLC
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Chemimmune Therapeutics LLC
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Application filed by Chemimmune Therapeutics LLC filed Critical Chemimmune Therapeutics LLC
Publication of AU2014349246A1 publication Critical patent/AU2014349246A1/en
Publication of AU2014349246A9 publication Critical patent/AU2014349246A9/en
Application granted granted Critical
Publication of AU2014349246B2 publication Critical patent/AU2014349246B2/en
Priority to AU2018264084A priority Critical patent/AU2018264084C1/en
Publication of AU2014349246C1 publication Critical patent/AU2014349246C1/en
Assigned to “ChemImmune Therapeutics” Limited Liability Company reassignment “ChemImmune Therapeutics” Limited Liability Company Request for Assignment Assignors: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU "PHARMENTERPRISES"
Ceased legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2014349246A 2013-11-14 2014-11-12 Pharmaceutical composition containing glutarimide derivatives, and application thereof for treating eosinophilic diseases Ceased AU2014349246C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018264084A AU2018264084C1 (en) 2013-11-14 2018-11-15 Pharmaceutical composition comprising glutarimide derivatives, and application thereof for treating eosinophilic diseases

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2013150861/15A RU2552929C1 (ru) 2013-11-14 2013-11-14 Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний
RU2013150861 2013-11-14
PCT/RU2014/000855 WO2015072893A1 (ru) 2013-11-14 2014-11-12 Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018264084A Division AU2018264084C1 (en) 2013-11-14 2018-11-15 Pharmaceutical composition comprising glutarimide derivatives, and application thereof for treating eosinophilic diseases

Publications (4)

Publication Number Publication Date
AU2014349246A1 AU2014349246A1 (en) 2016-05-19
AU2014349246A9 AU2014349246A9 (en) 2018-09-20
AU2014349246B2 AU2014349246B2 (en) 2018-10-18
AU2014349246C1 true AU2014349246C1 (en) 2019-02-21

Family

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AU2014349246A Ceased AU2014349246C1 (en) 2013-11-14 2014-11-12 Pharmaceutical composition containing glutarimide derivatives, and application thereof for treating eosinophilic diseases
AU2018264084A Ceased AU2018264084C1 (en) 2013-11-14 2018-11-15 Pharmaceutical composition comprising glutarimide derivatives, and application thereof for treating eosinophilic diseases

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AU2018264084A Ceased AU2018264084C1 (en) 2013-11-14 2018-11-15 Pharmaceutical composition comprising glutarimide derivatives, and application thereof for treating eosinophilic diseases

Country Status (23)

Country Link
US (2) US9949962B2 (OSRAM)
EP (2) EP3069720B1 (OSRAM)
JP (4) JP2016540749A (OSRAM)
KR (2) KR102312013B1 (OSRAM)
CN (2) CN105722511B (OSRAM)
AU (2) AU2014349246C1 (OSRAM)
BR (1) BR112016010515B1 (OSRAM)
CA (1) CA2930231C (OSRAM)
CY (1) CY1122500T1 (OSRAM)
DK (1) DK3069720T3 (OSRAM)
EA (4) EA030961B1 (OSRAM)
ES (2) ES2836887T3 (OSRAM)
HU (1) HUE046671T2 (OSRAM)
IL (2) IL245429B (OSRAM)
LT (1) LT3069720T (OSRAM)
MX (2) MX386887B (OSRAM)
PL (2) PL3069720T3 (OSRAM)
PT (1) PT3069720T (OSRAM)
RU (1) RU2552929C1 (OSRAM)
SG (1) SG10201900504XA (OSRAM)
SI (1) SI3069720T1 (OSRAM)
UA (1) UA118687C2 (OSRAM)
WO (1) WO2015072893A1 (OSRAM)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
KR102576903B1 (ko) 2012-09-07 2023-09-13 리제너론 파아마슈티컬스, 인크. Il-4r 길항제 투여로 아토피성 피부염을 치료하는 방법
EP3725785B1 (en) * 2013-04-12 2024-04-10 Nebolsin, Vladimir Glutarimide derivative, use thereof, pharmaceutical composition based thereon and methods for producing the glutarimide derivative
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
KR102927870B1 (ko) 2014-02-28 2026-02-19 리제너론 파아마슈티컬스, 인크. Il-4r 길항제의 투여에 의한 피부 감염의 치료 방법
US11771743B2 (en) 2016-09-01 2023-10-03 Regeneron Pharmaceuticals, Inc. Methods for preventing or treating allergy by administering an IL-4R antagonist
CN106539792B (zh) * 2016-11-07 2017-08-25 王晓旭 一种治疗高血脂症的药物
GEP20227402B (en) * 2017-09-07 2022-08-10 Valenta Intellekt Ltd Use of glutarimide derivative to treat diseases related to aberrant activity of cytokines
RU2712281C1 (ru) * 2018-11-23 2020-01-28 Общество С Ограниченной Ответственностью "Хемиммьюн Терапьютикс" Применение производного глутаримида для преодоления резистентности к стероидам и терапии заболеваний, ассоциированных с аберрантным сигналингом интерферона гамма
SG11202109002XA (en) 2019-03-21 2021-09-29 Regeneron Pharma Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy
AU2020325021B2 (en) 2019-08-05 2024-05-30 Regeneron Pharmaceuticals, Inc. Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist
EP4010373A1 (en) 2019-08-05 2022-06-15 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r antagonist
EP4132571B1 (en) * 2020-04-07 2025-10-29 Hofseth Biocare ASA Salmonid oil compositions for use in the treatment of eosinophilic related inflammatory and respiratory conditions
MA58653B1 (fr) * 2020-06-26 2024-02-29 Valenta Intellekt Ltd Utilisation d'un dérivé de glutarimide pour traiter des maladies liées à l'activité aberrante d'interleukine-6
WO2023113650A1 (ru) * 2021-12-15 2023-06-22 Владимир Евгеньевич НЕБОЛЬСИН Фармацевтическая композиция 1-[2-(1-метилимидазол-4-ил)-этил]пергидроазин-2,6-дион для терапии заболеваний верхних дыхательных путей

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AU9134191A (en) * 1990-12-24 1992-07-22 Merrell Dow Pharmaceuticals Inc. Use of certain glutarimide derivatives in the treatment of depression and mania
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ES2320638T3 (es) 2001-11-07 2009-05-27 Cytos Biotechnology Ag Disposicion ordenada de antigenos il-5, il-13 o eotasina, para el tratamiento de enfermedades alergicas con un componente eosinofilico.
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RU2406727C2 (ru) * 2008-02-13 2010-12-20 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Фармацевтическая композиция, содержащая n-ацильные производные аминокислот, и их применение в качестве противоаллергических, антианафилактических и противовоспалительных средств
RU2378284C2 (ru) * 2008-02-13 2010-01-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Способы получения n-ацильных производных аминокислот (варианты)
EP3725785B1 (en) 2013-04-12 2024-04-10 Nebolsin, Vladimir Glutarimide derivative, use thereof, pharmaceutical composition based thereon and methods for producing the glutarimide derivative

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Publication number Priority date Publication date Assignee Title
WO1994024133A1 (en) * 1993-04-09 1994-10-27 Cell Therapeutics, Inc. Ring-substituted cell signaling inhibitors

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Publication number Publication date
EA037447B1 (ru) 2021-03-30
EP3466425A1 (en) 2019-04-10
WO2015072893A1 (ru) 2015-05-21
HUE046671T2 (hu) 2020-03-30
AU2014349246A9 (en) 2018-09-20
EA030961B1 (ru) 2018-10-31
DK3069720T3 (da) 2019-11-25
PT3069720T (pt) 2019-12-02
US9949962B2 (en) 2018-04-24
EA032940B1 (ru) 2019-08-30
JP2020002152A (ja) 2020-01-09
SI3069720T1 (sl) 2020-02-28
MX2016006330A (es) 2016-09-06
EA201690798A1 (ru) 2016-08-31
CN105722511A (zh) 2016-06-29
EP3069720A8 (en) 2017-10-04
EA032955B3 (ru) 2020-02-27
KR102312013B1 (ko) 2021-10-15
ES2759530T3 (es) 2020-05-11
EA201990529A1 (ru) 2019-07-31
PL3466425T3 (pl) 2021-04-06
IL245429A0 (en) 2016-06-30
CN105722511B (zh) 2019-09-17
AU2014349246B2 (en) 2018-10-18
BR112016010515B1 (pt) 2022-09-27
JP6758677B2 (ja) 2020-09-23
LT3069720T (lt) 2020-01-10
JP2019214606A (ja) 2019-12-19
PL3069720T3 (pl) 2020-05-18
EP3069720A1 (en) 2016-09-21
AU2018264084B2 (en) 2020-05-14
KR20200053639A (ko) 2020-05-18
EA201891261A1 (ru) 2018-10-31
EP3069720A4 (en) 2017-06-21
ES2836887T3 (es) 2021-06-28
EA201891262A1 (ru) 2018-10-31
MX386887B (es) 2025-03-19
EP3069720B1 (en) 2019-10-30
AU2018264084C1 (en) 2020-08-27
UA118687C2 (uk) 2019-02-25
EA032955B1 (ru) 2019-08-30
JP2016540749A (ja) 2016-12-28
CA2930231A1 (en) 2015-05-21
US10220029B2 (en) 2019-03-05
MX365781B (es) 2019-06-13
MX2019006881A (es) 2019-08-01
RU2552929C1 (ru) 2015-06-10
KR20160078400A (ko) 2016-07-04
JP2019055953A (ja) 2019-04-11
RU2013150861A (ru) 2015-05-20
US20180104230A1 (en) 2018-04-19
IL271352A (en) 2020-01-30
IL271352B (en) 2021-04-29
AU2014349246A1 (en) 2016-05-19
AU2018264084A1 (en) 2018-12-06
CY1122500T1 (el) 2021-01-27
EP3466425B1 (en) 2020-10-07
JP6589251B2 (ja) 2019-10-16
IL245429B (en) 2020-02-27
KR102312294B1 (ko) 2021-10-15
SG10201900504XA (en) 2019-02-27
CN110200968A (zh) 2019-09-06
CA2930231C (en) 2022-06-14
US20160279114A1 (en) 2016-09-29
BR112016010515A2 (OSRAM) 2017-08-08

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