AU2014318579A1 - Modified therapeutic agents and compositions thereof - Google Patents
Modified therapeutic agents and compositions thereof Download PDFInfo
- Publication number
- AU2014318579A1 AU2014318579A1 AU2014318579A AU2014318579A AU2014318579A1 AU 2014318579 A1 AU2014318579 A1 AU 2014318579A1 AU 2014318579 A AU2014318579 A AU 2014318579A AU 2014318579 A AU2014318579 A AU 2014318579A AU 2014318579 A1 AU2014318579 A1 AU 2014318579A1
- Authority
- AU
- Australia
- Prior art keywords
- amino acid
- peptide
- acid sequence
- therapeutic agent
- relaxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Landscapes
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| JP6822839B2 (ja) | 2013-09-13 | 2021-01-27 | ザ・スクリップス・リサーチ・インスティテュート | 修飾された治療剤、及びその組成物 |
| US10039809B2 (en) | 2013-12-18 | 2018-08-07 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| US20160151511A1 (en) | 2014-12-02 | 2016-06-02 | Antriabio, Inc. | Proteins and protein conjugates with increased hydrophobicity |
| CN107743494B (zh) | 2015-06-02 | 2022-04-29 | 诺和诺德股份有限公司 | 具有极性重组延伸体的胰岛素 |
| CA2981501A1 (en) | 2015-06-04 | 2016-12-08 | Antriabio, Inc. | Amine pegylation methods for the preparation of site-specific protein conjugates |
| EP3310376A4 (en) | 2015-06-17 | 2019-01-23 | The California Institute for Biomedical Research | MODIFIED THERAPEUTIC AGENTS AND COMPOSITIONS THEREOF |
| CN106554404B (zh) * | 2015-09-25 | 2020-11-20 | 博瑞生物医药（苏州）股份有限公司 | 艾塞那肽修饰物及其用途 |
| MA43348A (fr) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | Conjugués de protéines |
| KR102668200B1 (ko) * | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| KR102670157B1 (ko) | 2015-10-28 | 2024-05-29 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
| JP7026044B2 (ja) | 2015-12-23 | 2022-02-25 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 神経性状態および神経変性状態の治療としての長時間作用型ＧＬＰ－１ｒアゴニスト |
| CN109111517B (zh) * | 2016-06-28 | 2022-12-20 | 江苏豪思生物科技有限公司 | 一种经修饰的生长分化因子及其制备方法和应用 |
| CN106361405B (zh) * | 2016-10-09 | 2017-07-28 | 上海岐华医疗科技有限公司 | 改进的超声外科手术系统 |
| EP3526242A1 (en) | 2016-10-12 | 2019-08-21 | University of Copenhagen | Peptide dual agonists of gipr and glp2r |
| BR112019009581A2 (pt) | 2016-11-10 | 2019-10-08 | Yuhan Corp | composição farmacêutica para evitar ou tratar hepatite, fibrose hepática, e cirrose hepática que compreende proteínas de fusão |
| CN106432471B (zh) * | 2016-12-14 | 2019-12-03 | 江苏师范大学 | 一种新型非洲爪蟾胰高血糖素样肽-1(glp-1)缀合肽及其应用 |
| CN108299553B (zh) * | 2017-01-13 | 2021-07-16 | 博瑞生物医药（苏州）股份有限公司 | 胃泌酸调节素修饰物 |
| WO2018148419A1 (en) | 2017-02-08 | 2018-08-16 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| CN108619490A (zh) * | 2017-03-22 | 2018-10-09 | 天士力医药集团股份有限公司 | 一种长效化突变的人源成纤维生长因子的新用途 |
| SG11201908771YA (en) * | 2017-03-22 | 2019-10-30 | Univ California | Modified oligonucleotides and therapeutic uses thereof |
| JP2020513019A (ja) | 2017-04-05 | 2020-04-30 | ノヴォ ノルディスク アー／エス | オリゴマー伸長インスリン−Ｆｃコンジュゲート |
| JP7191850B2 (ja) | 2017-04-21 | 2022-12-19 | ユーハン・コーポレイション | デュアル機能タンパク質およびその誘導体を生産するための方法 |
| EP3694537A1 (en) | 2017-10-12 | 2020-08-19 | University of Copenhagen | Combination therapy for treatment of bone disorders |
| CN111372945B (zh) * | 2017-11-06 | 2024-02-02 | 中山大学 | 基于胃泌酸调节素类似物glp-1r/gcgr双靶点激动剂多肽治疗特发性肺间质纤维化 |
| CA3089657A1 (en) * | 2018-01-31 | 2019-08-08 | Sanofi | Modified lipidated relaxin b chain peptides and their therapeutic use |
| CN110568112A (zh) * | 2018-06-05 | 2019-12-13 | 北京华金瑞清生物医药技术有限公司 | 一种直接检测艾塞那肽融合蛋白的方法 |
| CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
| CN118388627A (zh) * | 2019-03-05 | 2024-07-26 | 广东东阳光药业股份有限公司 | 一种多肽分子及其应用 |
| WO2020181130A2 (en) * | 2019-03-05 | 2020-09-10 | MiRagen Therapeutics, Inc. | Polynucleotide conjugates and uses thereof |
| EP3819307A1 (en) * | 2019-11-07 | 2021-05-12 | CytoKi Pharma ApS | Therapeutic derivatives of interleukin-22 |
| MX2022006861A (es) * | 2019-12-04 | 2022-07-11 | Scripps Research Inst | Agonistas del receptor glp2 y metodos de uso. |
| CN113366024B (zh) * | 2020-01-08 | 2024-11-05 | 上海翰森生物医药科技有限公司 | Fgf21突变体蛋白及其融合蛋白 |
| WO2021149925A1 (ko) * | 2020-01-20 | 2021-07-29 | 루다큐어 주식회사 | Trpv1 활성 매개 질환 치료용 약학적 조성물 |
| AU2021268355A1 (en) * | 2020-05-08 | 2022-11-24 | President And Fellows Of Harvard College | Engineered relaxins and methods of use thereof |
| CN114075276A (zh) * | 2020-08-17 | 2022-02-22 | 成都奥达生物科技有限公司 | 一种长效松弛素2类似物 |
| CN114478709A (zh) * | 2020-11-13 | 2022-05-13 | 成都奥达生物科技有限公司 | 一种长效肝炎病毒进入抑制剂 |
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| CN105792851B (zh) | 2023-10-10 |
| EP3043824A1 (en) | 2016-07-20 |
| JP6822839B2 (ja) | 2021-01-27 |
| EP3043824A4 (en) | 2017-10-25 |
| KR102302634B1 (ko) | 2021-09-14 |
| JP2020063249A (ja) | 2020-04-23 |
| KR20160079776A (ko) | 2016-07-06 |
| WO2015038938A1 (en) | 2015-03-19 |
| US20160287713A1 (en) | 2016-10-06 |
| ES2927607T3 (es) | 2022-11-08 |
| US20190328888A1 (en) | 2019-10-31 |
| EP3043824B1 (en) | 2022-07-06 |
| CA2924109A1 (en) | 2015-03-19 |
| US10286078B2 (en) | 2019-05-14 |
| JP2016531156A (ja) | 2016-10-06 |
| US10987427B2 (en) | 2021-04-27 |
| HK1226301A1 (zh) | 2017-09-29 |
| CN105792851A (zh) | 2016-07-20 |
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