AU2014302028B2 - IL-21 binding proteins and uses thereof - Google Patents
IL-21 binding proteins and uses thereof Download PDFInfo
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- AU2014302028B2 AU2014302028B2 AU2014302028A AU2014302028A AU2014302028B2 AU 2014302028 B2 AU2014302028 B2 AU 2014302028B2 AU 2014302028 A AU2014302028 A AU 2014302028A AU 2014302028 A AU2014302028 A AU 2014302028A AU 2014302028 B2 AU2014302028 B2 AU 2014302028B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014302028A AU2014302028B2 (en) | 2013-06-27 | 2014-06-27 | IL-21 binding proteins and uses thereof |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013902377 | 2013-06-27 | ||
| AU2013902377A AU2013902377A0 (en) | 2013-06-27 | A super-agonist monoclonal antibody to human IL-21 and its application in immunomodulation | |
| AU2014302028A AU2014302028B2 (en) | 2013-06-27 | 2014-06-27 | IL-21 binding proteins and uses thereof |
| PCT/AU2014/000673 WO2014205501A1 (en) | 2013-06-27 | 2014-06-27 | Il-21 binding proteins and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014302028A1 AU2014302028A1 (en) | 2016-01-21 |
| AU2014302028B2 true AU2014302028B2 (en) | 2019-09-19 |
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| EP (1) | EP3013858B1 (enExample) |
| JP (1) | JP6563389B2 (enExample) |
| CN (1) | CN105579470B (enExample) |
| AU (1) | AU2014302028B2 (enExample) |
| CA (1) | CA2915882C (enExample) |
| ES (1) | ES2898650T3 (enExample) |
| WO (1) | WO2014205501A1 (enExample) |
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| WO2014205501A1 (en) | 2013-06-27 | 2014-12-31 | Monash University | Il-21 binding proteins and uses thereof |
| AU2015367224B2 (en) | 2014-12-19 | 2020-12-10 | Monash University | IL-21 antibodies |
| JP6872756B2 (ja) * | 2016-01-12 | 2021-05-19 | 国立大学法人千葉大学 | 抗Ｍｙｌ９抗体 |
| JP2020530454A (ja) | 2017-08-07 | 2020-10-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 安全な細胞治療薬を生成するためのプラットフォーム |
| WO2022117569A1 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer |
| EP4263600A1 (en) | 2020-12-18 | 2023-10-25 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| CN119290543B (zh) * | 2024-12-13 | 2025-03-21 | 天津医科大学总医院空港医院 | 一种同时检测淋巴组织中il-6、il-21与t细胞cd4表面分子的试剂盒及方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005112983A2 (en) * | 2004-05-19 | 2005-12-01 | Wyeth | Modulation of immunoglobulin production and atopic disorders |
| WO2006105538A2 (en) * | 2005-03-31 | 2006-10-05 | Centocor, Inc. | Methods and compositions for treating il-21 related pathologies |
| WO2008112543A2 (en) * | 2007-03-09 | 2008-09-18 | Wyeth | Rat, rabbit, and cynomolgus monkey il-21 and il-22 nucleotide and polypeptide sequences |
| US20090191214A1 (en) * | 2007-12-07 | 2009-07-30 | Jaspers Stephen R | Anti-human il-21 monoclonal antibodies |
| WO2009100035A2 (en) * | 2008-02-01 | 2009-08-13 | Wyeth | Interleukin-21 (il-21) and il-21 receptor (il-21r) modulation of regulatory t cells and forkhead box p3 (foxp3) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309636B1 (en) * | 1995-09-14 | 2001-10-30 | Cancer Research Institute Of Contra Costa | Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides |
| WO2005097184A2 (en) | 2004-03-26 | 2005-10-20 | Human Genome Sciences, Inc. | Antibodies against nogo receptor |
| ITRM20040586A1 (it) * | 2004-11-29 | 2005-02-28 | Giuliani Spa | Epitopi antigenici dell'interleuchina-21, anticorpi relativi e loro uso in campo medico. |
| JP5322653B2 (ja) | 2005-11-28 | 2013-10-23 | ザイモジェネティクス， インコーポレイテッド | Ｉｌ−２１アンタゴニスト |
| WO2007109742A2 (en) | 2006-03-21 | 2007-09-27 | Weaver David T | Methods for humanizing antibodies and humanized antibodies made thereby |
| CN103702721A (zh) * | 2011-05-31 | 2014-04-02 | 诺沃—诺迪斯克有限公司 | Il-21表位和il-21配体 |
| WO2014205501A1 (en) | 2013-06-27 | 2014-12-31 | Monash University | Il-21 binding proteins and uses thereof |
-
2014
- 2014-06-27 WO PCT/AU2014/000673 patent/WO2014205501A1/en not_active Ceased
- 2014-06-27 US US14/392,256 patent/US10077301B2/en active Active
- 2014-06-27 JP JP2016522133A patent/JP6563389B2/ja not_active Expired - Fee Related
- 2014-06-27 CN CN201480037182.8A patent/CN105579470B/zh not_active Expired - Fee Related
- 2014-06-27 AU AU2014302028A patent/AU2014302028B2/en not_active Ceased
- 2014-06-27 EP EP14817437.8A patent/EP3013858B1/en active Active
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- 2014-06-27 CA CA2915882A patent/CA2915882C/en active Active
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2018
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2020
- 2020-07-23 US US16/937,121 patent/US20210002362A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005112983A2 (en) * | 2004-05-19 | 2005-12-01 | Wyeth | Modulation of immunoglobulin production and atopic disorders |
| WO2006105538A2 (en) * | 2005-03-31 | 2006-10-05 | Centocor, Inc. | Methods and compositions for treating il-21 related pathologies |
| WO2008112543A2 (en) * | 2007-03-09 | 2008-09-18 | Wyeth | Rat, rabbit, and cynomolgus monkey il-21 and il-22 nucleotide and polypeptide sequences |
| US20090191214A1 (en) * | 2007-12-07 | 2009-07-30 | Jaspers Stephen R | Anti-human il-21 monoclonal antibodies |
| WO2009100035A2 (en) * | 2008-02-01 | 2009-08-13 | Wyeth | Interleukin-21 (il-21) and il-21 receptor (il-21r) modulation of regulatory t cells and forkhead box p3 (foxp3) |
Non-Patent Citations (1)
| Title |
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| SPOLSKI, R. ET AL., "The Yin and Yang of Interleukin-21 in Allergy, Autoimmunity and Cancer", CURRENT OPINION IN IMMUNOLOGY, (2008), vol. 20, no. 3, pages 295 - 301 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20210002362A1 (en) | 2021-01-07 |
| CN105579470A (zh) | 2016-05-11 |
| WO2014205501A1 (en) | 2014-12-31 |
| CA2915882C (en) | 2022-12-06 |
| US20190071497A1 (en) | 2019-03-07 |
| EP3013858A1 (en) | 2016-05-04 |
| AU2014302028A1 (en) | 2016-01-21 |
| US20160145332A1 (en) | 2016-05-26 |
| CA2915882A1 (en) | 2014-12-31 |
| CN105579470B (zh) | 2021-05-25 |
| JP2016529213A (ja) | 2016-09-23 |
| ES2898650T3 (es) | 2022-03-08 |
| EP3013858B1 (en) | 2021-07-28 |
| US10787510B2 (en) | 2020-09-29 |
| US10077301B2 (en) | 2018-09-18 |
| JP6563389B2 (ja) | 2019-08-21 |
| EP3013858A4 (en) | 2017-01-25 |
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