AU2014274844B2 - Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9 - Google Patents

Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9 Download PDF

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Publication number
AU2014274844B2
AU2014274844B2 AU2014274844A AU2014274844A AU2014274844B2 AU 2014274844 B2 AU2014274844 B2 AU 2014274844B2 AU 2014274844 A AU2014274844 A AU 2014274844A AU 2014274844 A AU2014274844 A AU 2014274844A AU 2014274844 B2 AU2014274844 B2 AU 2014274844B2
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AU
Australia
Prior art keywords
antibody
subject
antigen
binding fragment
pcsk9
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2014274844A
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English (en)
Other versions
AU2014274844A8 (en
AU2014274844A1 (en
Inventor
Viktoria Gusarova
Anusch Peyman
William J. Sasiela
Hans-Ludwig Schaefer
Uwe Schwahn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Biotechnology SAS
Regeneron Pharmaceuticals Inc
Original Assignee
Sanofi Biotechnology SAS
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP13305762.0A external-priority patent/EP2810955A1/en
Priority claimed from EP20130306436 external-priority patent/EP2862877A1/en
Application filed by Sanofi Biotechnology SAS, Regeneron Pharmaceuticals Inc filed Critical Sanofi Biotechnology SAS
Publication of AU2014274844A1 publication Critical patent/AU2014274844A1/en
Publication of AU2014274844A8 publication Critical patent/AU2014274844A8/en
Application granted granted Critical
Publication of AU2014274844B2 publication Critical patent/AU2014274844B2/en
Priority to AU2020201191A priority Critical patent/AU2020201191A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
AU2014274844A 2013-06-07 2014-06-06 Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9 Ceased AU2014274844B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020201191A AU2020201191A1 (en) 2013-06-07 2020-02-19 Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201361832459P 2013-06-07 2013-06-07
US61/832,459 2013-06-07
EP13305762.0 2013-06-07
EP13305762.0A EP2810955A1 (en) 2013-06-07 2013-06-07 Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9
US201361892215P 2013-10-17 2013-10-17
US61/892,215 2013-10-17
EP20130306436 EP2862877A1 (en) 2013-10-18 2013-10-18 Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9
EP13306436.0 2013-10-18
US201461944855P 2014-02-26 2014-02-26
US61/944,855 2014-02-26
US201462002508P 2014-05-23 2014-05-23
US62/002,508 2014-05-23
PCT/US2014/041204 WO2014197752A1 (en) 2013-06-07 2014-06-06 Methods fo inhibting atherosclerosis by administering an inhibitor of pcsk9

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020201191A Division AU2020201191A1 (en) 2013-06-07 2020-02-19 Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9

Publications (3)

Publication Number Publication Date
AU2014274844A1 AU2014274844A1 (en) 2016-01-21
AU2014274844A8 AU2014274844A8 (en) 2016-02-25
AU2014274844B2 true AU2014274844B2 (en) 2019-11-28

Family

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AU2014274844A Ceased AU2014274844B2 (en) 2013-06-07 2014-06-06 Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9
AU2020201191A Abandoned AU2020201191A1 (en) 2013-06-07 2020-02-19 Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020201191A Abandoned AU2020201191A1 (en) 2013-06-07 2020-02-19 Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9

Country Status (12)

Country Link
US (3) US10494442B2 (enExample)
EP (1) EP3004171B1 (enExample)
JP (1) JP2016523847A (enExample)
KR (1) KR20160024906A (enExample)
CN (2) CN105705521A (enExample)
AU (2) AU2014274844B2 (enExample)
CA (1) CA2914721A1 (enExample)
EA (1) EA201592267A1 (enExample)
HK (1) HK1222865A1 (enExample)
MX (1) MX2015016887A (enExample)
TW (2) TW201534324A (enExample)
WO (1) WO2014197752A1 (enExample)

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US10111953B2 (en) 2013-05-30 2018-10-30 Regeneron Pharmaceuticals, Inc. Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
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