AU2014274703B2 - A biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases - Google Patents

A biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases Download PDF

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Publication number
AU2014274703B2
AU2014274703B2 AU2014274703A AU2014274703A AU2014274703B2 AU 2014274703 B2 AU2014274703 B2 AU 2014274703B2 AU 2014274703 A AU2014274703 A AU 2014274703A AU 2014274703 A AU2014274703 A AU 2014274703A AU 2014274703 B2 AU2014274703 B2 AU 2014274703B2
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Australia
Prior art keywords
peptide
seq
amino acid
angiogenesis
plga
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Ceased
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AU2014274703A
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English (en)
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AU2014274703A1 (en
Inventor
Jordan J. Green
Esak LEE
Niranjan B. Pandey
Aleksander S. Popel
Ron B. Shmueli
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Johns Hopkins University
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Johns Hopkins University
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Publication of AU2014274703B2 publication Critical patent/AU2014274703B2/en
Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
AU2014274703A 2013-06-07 2014-06-09 A biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases Ceased AU2014274703B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361832290P 2013-06-07 2013-06-07
US61/832,290 2013-06-07
PCT/US2014/041526 WO2014197892A1 (en) 2013-06-07 2014-06-09 A biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases

Publications (2)

Publication Number Publication Date
AU2014274703A1 AU2014274703A1 (en) 2015-12-10
AU2014274703B2 true AU2014274703B2 (en) 2019-07-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014274703A Ceased AU2014274703B2 (en) 2013-06-07 2014-06-09 A biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases

Country Status (11)

Country Link
US (4) US9802984B2 (OSRAM)
EP (2) EP3643318A1 (OSRAM)
JP (2) JP6470740B2 (OSRAM)
CN (2) CN105431162B (OSRAM)
AU (1) AU2014274703B2 (OSRAM)
CA (1) CA2914764C (OSRAM)
DK (1) DK3003343T3 (OSRAM)
ES (1) ES2774217T3 (OSRAM)
HU (1) HUE047735T2 (OSRAM)
IL (1) IL242760B (OSRAM)
WO (1) WO2014197892A1 (OSRAM)

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DK3003343T3 (da) * 2013-06-07 2020-02-03 Univ Johns Hopkins Biomimetisk peptid og bionedbrydelig leveringsplatform til behandling af angiogenese- og lymfangiogeneseafhængige sygdomme
US20170216363A1 (en) 2014-08-07 2017-08-03 The Johns Hopkins University Nanoparticle modification of human adipose-derived mesenchymal stem cells for treating brain cancer and other neurological diseases
KR101748120B1 (ko) * 2015-07-13 2017-06-16 서울대학교산학협력단 나노입자-유리체 기반 단백질 복합체를 유효성분으로 포함하는 혈관신생억제용 조성물 및 이의 용도
KR20180081608A (ko) * 2015-11-19 2018-07-16 아스클리픽스 테라퓨틱스, 엘엘씨. 항-혈관형성, 항-림프관신생, 및 항-부종성 특성을 가진 펩티드 및 나노입자 제제
KR20190066040A (ko) * 2016-10-04 2019-06-12 아스클리픽스 테라퓨틱스, 인크. Tie2 신호전달을 활성화시키기 위한 화합물 및 방법
AU2018266690A1 (en) * 2017-05-08 2019-12-12 Asclepix Therapeutics, Inc. Biodegradable microparticles for sustained delivery of anti-angiogenic peptide
WO2019028427A1 (en) * 2017-08-03 2019-02-07 Asclepix Therapeutics, Llc. METHODS OF IDENTIFYING AND PREPARING PHARMACEUTICAL AGENTS TO ACTIVATE TIE2 RECEPTOR
WO2019075056A1 (en) 2017-10-10 2019-04-18 The Johns Hopkins University BIODEGRADABLE BIOMIMETIC PARTICLES
US11697804B2 (en) 2018-10-01 2023-07-11 The Johns Hopkins University Transcriptionally targeted and CpG-free plasmid for theranostic gene therapy
EP3920894A4 (en) * 2019-02-06 2022-11-09 The University of North Carolina at Chapel Hill COMPOSITIONS AND METHODS TO INHIBIT POSTOPERATIVE ADHESIONS
JP7650074B2 (ja) * 2019-03-26 2025-03-24 アスクレピクス セラピューティクス インコーポレイテッド 眼疾患を治療するための組成物及び方法
CN113144213B (zh) * 2021-03-23 2023-04-07 西安交通大学医学院第一附属医院 一种多级pH响应基因-药物共递送的纳米药物、制备方法及其应用
WO2024044745A2 (en) * 2022-08-26 2024-02-29 Asclepix Therapeutics, Inc. Formulations for intraocular delivery of peptides derived from type iv collagen

Citations (1)

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US20120114759A1 (en) * 2009-05-15 2012-05-10 The Johns Hopkins University Peptide/particle delivery systems

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EP2015781A4 (en) 2005-09-12 2009-12-23 Univ Johns Hopkins COMPOSITIONS HAVING ANTIANGIOGENIC ACTIVITY AND USES THEREOF
JP2009522372A (ja) * 2006-01-09 2009-06-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ワクチンおよび腫瘍免疫療法のためのｔｎｆｒｓｆ、ｔｌｒ、ｎｌｒ、ｒｈｒ、プリン受容体、およびサイトカイン受容体アゴニストの組み合わせ免疫刺激剤
ITMI20060625A1 (it) 2006-03-31 2007-10-01 Istituto Naz Per La Ricerca Peptide antiangiogenico e suoi impieghi terapeutici
CA2666709A1 (en) * 2006-11-10 2008-05-29 Genentech, Inc. Method for treating age-related macular degeneration
WO2008085828A2 (en) 2007-01-03 2008-07-17 The Johns Hopkins University Peptide modulators of angiogenesis and use thereof
AU2009245785A1 (en) * 2008-05-06 2009-11-12 Glaxo Group Limited Encapsulation of biologically active agents
AU2009275135A1 (en) * 2008-07-21 2010-01-28 Compugen Ltd. Angiopoietin derived peptides
WO2011084620A2 (en) 2009-12-16 2011-07-14 Brigham And Women's Hospital, Inc. Particles for multiple agent delivery
US20120192339A1 (en) 2010-07-28 2012-08-02 Honeywell International Inc. Flexible Body Armor Vest with Breast Plate
US20120270770A1 (en) 2010-08-03 2012-10-25 Jesse Michael Jaynes Anti-angiogenic peptides and their uses
WO2012079088A2 (en) * 2010-12-10 2012-06-14 The Johns Hopkins University Mimetic peptides derived from collagen type iv and their use for treating angiogenesis- and lymphangiogenesis- dependent diseases
US8877827B2 (en) 2011-02-24 2014-11-04 Konica Minolta, Inc. Active ray-curable inkjet ink, and image formation method
US12371522B2 (en) 2011-10-12 2025-07-29 The Johns Hopkins University Bioreducible poly (beta-amino ester)s for siRNA delivery
WO2014066898A1 (en) 2012-10-26 2014-05-01 The Johns Hopkins University A layer-by-layer approach to co-deliver dna and sirna via aunps: a potential platform for modifying release kinetics
DK3003343T3 (da) * 2013-06-07 2020-02-03 Univ Johns Hopkins Biomimetisk peptid og bionedbrydelig leveringsplatform til behandling af angiogenese- og lymfangiogeneseafhængige sygdomme

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Also Published As

Publication number Publication date
US20200361993A1 (en) 2020-11-19
JP6931011B2 (ja) 2021-09-01
EP3643318A1 (en) 2020-04-29
DK3003343T3 (da) 2020-02-03
IL242760B (en) 2021-03-25
US9802984B2 (en) 2017-10-31
EP3003343B1 (en) 2019-10-23
US20160122390A1 (en) 2016-05-05
US11981754B2 (en) 2024-05-14
ES2774217T3 (es) 2020-07-17
HK1222542A1 (zh) 2017-07-07
CN110981941A (zh) 2020-04-10
US20240391957A1 (en) 2024-11-28
AU2014274703A1 (en) 2015-12-10
US20180134753A1 (en) 2018-05-17
US10774112B2 (en) 2020-09-15
JP2016521712A (ja) 2016-07-25
JP2019089790A (ja) 2019-06-13
WO2014197892A1 (en) 2014-12-11
CA2914764A1 (en) 2014-12-11
JP6470740B2 (ja) 2019-02-13
CN105431162A (zh) 2016-03-23
CA2914764C (en) 2021-10-26
HUE047735T2 (hu) 2020-05-28
EP3003343A1 (en) 2016-04-13
EP3003343A4 (en) 2016-11-30
CN105431162B (zh) 2019-12-10

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