AU2014269401A1 - Pharmaceutical combination comprising metformin and dihydroquercetin and its use for the treatment of cancer - Google Patents

Pharmaceutical combination comprising metformin and dihydroquercetin and its use for the treatment of cancer Download PDF

Info

Publication number
AU2014269401A1
AU2014269401A1 AU2014269401A AU2014269401A AU2014269401A1 AU 2014269401 A1 AU2014269401 A1 AU 2014269401A1 AU 2014269401 A AU2014269401 A AU 2014269401A AU 2014269401 A AU2014269401 A AU 2014269401A AU 2014269401 A1 AU2014269401 A1 AU 2014269401A1
Authority
AU
Australia
Prior art keywords
dihydroquercetin
cancer
pharmaceutically acceptable
acceptable salt
metformin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2014269401A
Other languages
English (en)
Inventor
Kunihiko Kiyono
Yasuharu NAGAHAMA
Kenji Onishi
Takashi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of AU2014269401A1 publication Critical patent/AU2014269401A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dermatology (AREA)
AU2014269401A 2013-05-24 2014-05-23 Pharmaceutical combination comprising metformin and dihydroquercetin and its use for the treatment of cancer Abandoned AU2014269401A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013-110278 2013-05-24
JP2013110278 2013-05-24
PCT/JP2014/064354 WO2014189152A1 (en) 2013-05-24 2014-05-23 Pharmaceutical combination comprising metformin and dihydroquercetin and its use for the treatment of cancer

Publications (1)

Publication Number Publication Date
AU2014269401A1 true AU2014269401A1 (en) 2016-01-21

Family

ID=50980347

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014269401A Abandoned AU2014269401A1 (en) 2013-05-24 2014-05-23 Pharmaceutical combination comprising metformin and dihydroquercetin and its use for the treatment of cancer

Country Status (14)

Country Link
US (4) US9808440B2 (enExample)
EP (1) EP3003296B1 (enExample)
JP (2) JP6440212B2 (enExample)
KR (1) KR102182946B1 (enExample)
CN (1) CN105263484B (enExample)
AR (1) AR096402A1 (enExample)
AU (1) AU2014269401A1 (enExample)
CA (1) CA2912881A1 (enExample)
HK (1) HK1223304A1 (enExample)
PH (1) PH12015502616A1 (enExample)
RU (2) RU2671488C2 (enExample)
SG (1) SG11201509555UA (enExample)
TW (2) TWI667021B (enExample)
WO (1) WO2014189152A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10468144B2 (en) 2014-08-19 2019-11-05 Nuscale Power, Llc Spent fuel storage rack
CN105330575A (zh) * 2015-10-14 2016-02-17 吉林海格力斯医药生物科技发展有限公司 一种用于治疗放疗、化疗引起的骨髓损伤的化合物
MX2019003725A (es) 2016-09-30 2019-08-12 Laboratorios Silanes S A De C V Glicinato de metformina, composiciones farmaceuticas que comprenden la misma, y metodos de uso de la misma.
CN108078938A (zh) * 2018-01-15 2018-05-29 栾晓民 一种二氢槲皮素制剂的制备方法及应用
WO2020033019A2 (en) 2018-04-25 2020-02-13 Charles R. Drew University Of Medicine And Science Novel mct4 inhibitors and uses thereof
KR102349477B1 (ko) * 2019-08-30 2022-01-10 (주)프론트바이오 바이구아나이드 계열 화합물 및 플라본, 하이드록시플라본, 플라바논, 플라본 유도체, 하이드록시플라본 유도체, 플라바논 유도체의 복합제를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물
HUE069002T2 (hu) * 2020-02-25 2025-02-28 Otsuka Pharma Co Ltd Decitabint és cedazuridint tartalmazó szilárd orális adagolási formák
CN111467332B (zh) * 2020-03-31 2021-08-24 中国科学院苏州生物医学工程技术研究所 低温等离子体与二甲双胍联用的应用
RU2740946C1 (ru) * 2020-06-30 2021-01-21 Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр фундаментальной и трансляционной медицины" (ФИЦ ФТМ) Средство для снижения патоморфологических изменений при гиперплазии предстательной железы
US20220409567A1 (en) * 2021-06-23 2022-12-29 Thomas Winston Adjuvant and complementary therapies for the treatment of cancer
CN115154458B (zh) * 2022-07-25 2023-11-10 天水师范学院 一种槲皮素-盐酸二甲双胍复合降糖药物的制备方法
WO2024233616A1 (en) * 2023-05-11 2024-11-14 Wainer Irving W Method for treating cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3523287B2 (ja) * 1993-02-26 2004-04-26 丸善製薬株式会社 発癌プロモーション抑制剤
US8178123B2 (en) 2001-08-29 2012-05-15 Femina Pharma Incorporated Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration
CN1320925C (zh) * 2005-03-30 2007-06-13 淮北市辉克药业有限公司 长期使用的治疗糖尿病的复方制剂
CA2606658A1 (en) 2006-10-13 2008-04-13 Mike Tyers Compositions and methods for treating neurological disorders or damage
DE102008029460A1 (de) 2008-06-20 2009-12-31 Otkrytoe Aktsionernoe Obschestvo Zavod Ekologicheskoy Tekhniki I Ekopitaniya 'diod' Taxifolinderivate zur Prophylaxe und Behandlung von neurologischen und psychiatrischen Störungen des zentralen Nervensystems
WO2010042886A2 (en) 2008-10-10 2010-04-15 Limerick Biopharma, Inc. Pyrone analogs for therapeutic treatment
AU2010292599A1 (en) * 2009-08-25 2012-03-15 President And Fellows Of Harvard College Use of metformin in cancer treatment and prevention
WO2012122295A2 (en) * 2011-03-07 2012-09-13 Ned Biosystems, Inc. Treatment for pancreatic adenocarcinoma and other cancers of epithelial origin
RU2451506C1 (ru) * 2011-06-02 2012-05-27 Сергей Юрьевич Лешков Комбинация для лечения сахарного диабета и его осложнений
JP5645796B2 (ja) 2011-11-21 2014-12-24 東京エレクトロン株式会社 液処理装置及び液処理方法

Also Published As

Publication number Publication date
PH12015502616A1 (en) 2016-02-29
US20160101082A1 (en) 2016-04-14
EP3003296B1 (en) 2018-10-10
CA2912881A1 (en) 2014-11-27
JP6754071B2 (ja) 2020-09-09
RU2015155283A (ru) 2017-06-29
JP6440212B2 (ja) 2018-12-19
SG11201509555UA (en) 2015-12-30
US9808440B2 (en) 2017-11-07
AR096402A1 (es) 2015-12-30
TWI688387B (zh) 2020-03-21
US10292962B2 (en) 2019-05-21
RU2018135973A (ru) 2018-11-14
KR20160013164A (ko) 2016-02-03
TW201536275A (zh) 2015-10-01
JP2016522202A (ja) 2016-07-28
HK1223304A1 (zh) 2017-07-28
CN105263484A (zh) 2016-01-20
WO2014189152A1 (en) 2014-11-27
US20180036280A1 (en) 2018-02-08
RU2018135973A3 (enExample) 2022-03-04
TWI667021B (zh) 2019-08-01
EP3003296A1 (en) 2016-04-13
US20180050014A1 (en) 2018-02-22
JP2019048850A (ja) 2019-03-28
RU2671488C2 (ru) 2018-11-01
KR102182946B1 (ko) 2020-11-25
US20180353466A1 (en) 2018-12-13
CN105263484B (zh) 2018-08-03
TW201906603A (zh) 2019-02-16

Similar Documents

Publication Publication Date Title
US10292962B2 (en) Pharmaceutical combination comprising metformin and dihydroquercetin and its use for the treatment of cancer
KR20130015669A (ko) 암의 재발 또는 전이의 억제용 약제학적 조성물
US9943537B2 (en) Antitumor agent and antitumor effect enhancer
EA033744B1 (ru) 7-бензил-4-(2-метилбензил)-2,4,6,7,8,9-гексагидроимидазо[1,2-a]пиридо[3,4-e]пиримидин-5(1h)-он, его соли и способы применения
JP2011520846A (ja) 多発性骨髄腫の治療
JP2025118615A (ja) Ｓｅｒｄ投薬レジメンの組み合わせを使用してがんを治療する方法
JP2010505745A (ja) 併用剤
KR20180088401A (ko) 3-(5-아미노-2-메틸-4-옥소-4h-퀴나졸린-3-일)-피페리딘-2,6-다이온을 사용한 주기 요법
EP3880207A1 (en) Combination of a mcl-1 inhibitor and midostaurin, uses and pharmaceutical compositions thereof
JP2022104746A (ja) 抗がん剤
JPWO2009110415A1 (ja) 併用剤
CN112999236B (zh) 乌本苷用于治疗脑干胶质瘤的用途
US20240342157A1 (en) Bak activators, pharmaceutical compositions, and uses in treating cancer
KR20250117425A (ko) 다발성 골수종의 치료를 위해 벨루모수딜을 투여하는 방법
NZ750260A (en) Antitumor agent and antitumor effect enhancer
TW200940546A (en) Combination drug

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period