AU2013370977B2 - Heterobicyclo-substituted-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with A2A antagonist properties - Google Patents

Heterobicyclo-substituted-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with A2A antagonist properties Download PDF

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Publication number
AU2013370977B2
AU2013370977B2 AU2013370977A AU2013370977A AU2013370977B2 AU 2013370977 B2 AU2013370977 B2 AU 2013370977B2 AU 2013370977 A AU2013370977 A AU 2013370977A AU 2013370977 A AU2013370977 A AU 2013370977A AU 2013370977 B2 AU2013370977 B2 AU 2013370977B2
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triazolo
quinazolin
amine
methoxy
ethyl
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Ceased
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AU2013370977A
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AU2013370977A1 (en
Inventor
Amjad Ali
Christopher Boyce
Qiaolin Deng
Gioconda V. Gallo
Timothy J. Henderson
Xianhai Huang
Jae-Hun Kim
Rongze Kuang
Yeon-Hee Lim
Michael Man-Chu Lo
Edward Metzger
Andrew Stamford
Paul Tempest
Pauline Ting
Walter Won
Heping Wu
Dong Xiao
Younong Yu
Junying Zheng
Nicolas Zorn
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Assigned to MERCK SHARP & DOHME LLC reassignment MERCK SHARP & DOHME LLC Request to Amend Deed and Register Assignors: MERCK SHARP & DOHME CORP.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
AU2013370977A 2012-12-28 2013-12-20 Heterobicyclo-substituted-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with A2A antagonist properties Ceased AU2013370977B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPCT/CN2012/087865 2012-12-28
PCT/CN2012/087865 WO2014101120A1 (en) 2012-12-28 2012-12-28 Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
PCT/CN2013/076853 WO2014101373A1 (en) 2012-12-28 2013-06-06 Heterobicyclo-substituted-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds for treatment of central nervous system disorder
AUPCT/CN2013/076853 2013-06-06
PCT/US2013/076781 WO2014105666A1 (en) 2012-12-28 2013-12-20 Heterobicyclo-substituted-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties

Publications (2)

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AU2013370977A1 AU2013370977A1 (en) 2015-07-09
AU2013370977B2 true AU2013370977B2 (en) 2017-12-14

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AU2013370977A Ceased AU2013370977B2 (en) 2012-12-28 2013-12-20 Heterobicyclo-substituted-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with A2A antagonist properties

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US (2) US9708347B2 (enExample)
EP (1) EP2945632B1 (enExample)
JP (1) JP6306049B2 (enExample)
KR (1) KR102165113B1 (enExample)
AU (1) AU2013370977B2 (enExample)
BR (1) BR112015015468B8 (enExample)
CA (1) CA2896056C (enExample)
CY (1) CY1120258T1 (enExample)
DK (1) DK2945632T3 (enExample)
ES (1) ES2667477T3 (enExample)
HR (1) HRP20180678T1 (enExample)
HU (1) HUE037950T2 (enExample)
LT (1) LT2945632T (enExample)
ME (1) ME03034B (enExample)
MX (1) MX370017B (enExample)
NO (1) NO2945632T3 (enExample)
PL (1) PL2945632T3 (enExample)
PT (1) PT2945632T (enExample)
RS (1) RS57162B1 (enExample)
RU (2) RU2671628C2 (enExample)
SI (1) SI2945632T1 (enExample)
WO (3) WO2014101120A1 (enExample)

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KR20210093964A (ko) 2018-11-20 2021-07-28 머크 샤프 앤드 돔 코포레이션 치환된 아미노 트리아졸로피리미딘 및 아미노 트리아졸로피라진 아데노신 수용체 길항제, 제약 조성물 및 그의 용도
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NO2945632T3 (enExample) 2018-08-04
BR112015015468A2 (pt) 2017-07-11
WO2014101373A1 (en) 2014-07-03
RU2018136104A3 (enExample) 2022-04-05
ME03034B (me) 2018-10-20
KR20150100879A (ko) 2015-09-02
MX2015008481A (es) 2015-09-23
JP6306049B2 (ja) 2018-04-04
LT2945632T (lt) 2018-05-25
PL2945632T3 (pl) 2018-07-31
CA2896056A1 (en) 2014-07-03
KR102165113B1 (ko) 2020-10-13
RU2671628C2 (ru) 2018-11-06
ES2667477T3 (es) 2018-05-11
RU2015131148A (ru) 2017-02-03
EP2945632A4 (en) 2016-09-14
CY1120258T1 (el) 2019-07-10
RU2018136104A (ru) 2018-11-21
HUE037950T2 (hu) 2018-09-28
US20150361098A1 (en) 2015-12-17
EP2945632B1 (en) 2018-03-07
WO2014105666A1 (en) 2014-07-03
CA2896056C (en) 2020-11-10
US20170197991A1 (en) 2017-07-13
PT2945632T (pt) 2018-05-22
US9708347B2 (en) 2017-07-18
MX370017B (es) 2019-11-28
JP2016504363A (ja) 2016-02-12
DK2945632T3 (en) 2018-05-22
EP2945632A1 (en) 2015-11-25
AU2013370977A1 (en) 2015-07-09
WO2014101120A1 (en) 2014-07-03
SI2945632T1 (en) 2018-05-31
RS57162B1 (sr) 2018-07-31
BR112015015468B1 (pt) 2021-10-26
HRP20180678T1 (hr) 2018-06-01
BR112015015468B8 (pt) 2023-04-25
US10011615B2 (en) 2018-07-03

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