AU2013291943B2 - Method for the degradation of keratin and use of the keratin hydrolysate produced - Google Patents
Method for the degradation of keratin and use of the keratin hydrolysate produced Download PDFInfo
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- AU2013291943B2 AU2013291943B2 AU2013291943A AU2013291943A AU2013291943B2 AU 2013291943 B2 AU2013291943 B2 AU 2013291943B2 AU 2013291943 A AU2013291943 A AU 2013291943A AU 2013291943 A AU2013291943 A AU 2013291943A AU 2013291943 B2 AU2013291943 B2 AU 2013291943B2
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- keratin
- protease
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- keratin material
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- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010908 plant waste Substances 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920000656 polylysine Chemical group 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 229960002816 potassium chloride Drugs 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000013930 proline Nutrition 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000002708 random mutagenesis Methods 0.000 description 1
- 239000004456 rapeseed meal Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 235000013526 red clover Nutrition 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 229960001548 salinomycin Drugs 0.000 description 1
- 235000019378 salinomycin Nutrition 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- XOIQMTLWECTKJL-FBZUZRIGSA-M sodium;(2s,3r,4s)-4-[(2s,5r,7s,8r,9s)-2-[(2r,5s)-5-ethyl-5-[(2r,3s,5r)-5-[(2s,3s,5r,6r)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoate Chemical compound [Na+].C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C[C@@]21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)[C@H](C)C([O-])=O)O2 XOIQMTLWECTKJL-FBZUZRIGSA-M 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 239000010907 stover Substances 0.000 description 1
- 108010059339 submandibular proteinase A Proteins 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 229960003097 sulfaquinoxaline Drugs 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000012711 vitamin K3 Nutrition 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- RMRCNWBMXRMIRW-WYVZQNDMSA-L vitamin b12 Chemical compound N([C@@H]([C@@]1(C)[C@@](C)(CC(N)=O)[C@H](CCC(N)=O)\C(N1[Co+]C#N)=C(/C)\C1=N\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NCC(C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO RMRCNWBMXRMIRW-WYVZQNDMSA-L 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229940041603 vitamin k 3 Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4741—Keratin; Cytokeratin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
- A23K10/26—Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Wood Science & Technology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017206256A AU2017206256A1 (en) | 2012-07-20 | 2017-07-20 | Method for the degradation of keratin and use of the keratin hydrolysate produced |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1212937.5A GB201212937D0 (en) | 2012-07-20 | 2012-07-20 | Method |
| GB1212937.5 | 2012-07-20 | ||
| PCT/EP2013/065363 WO2014013081A2 (en) | 2012-07-20 | 2013-07-19 | Method |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017206256A Division AU2017206256A1 (en) | 2012-07-20 | 2017-07-20 | Method for the degradation of keratin and use of the keratin hydrolysate produced |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013291943A1 AU2013291943A1 (en) | 2015-01-22 |
| AU2013291943B2 true AU2013291943B2 (en) | 2017-05-11 |
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| AU2013291943A Ceased AU2013291943B2 (en) | 2012-07-20 | 2013-07-19 | Method for the degradation of keratin and use of the keratin hydrolysate produced |
| AU2017206256A Abandoned AU2017206256A1 (en) | 2012-07-20 | 2017-07-20 | Method for the degradation of keratin and use of the keratin hydrolysate produced |
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| AU2017206256A Abandoned AU2017206256A1 (en) | 2012-07-20 | 2017-07-20 | Method for the degradation of keratin and use of the keratin hydrolysate produced |
Country Status (11)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2018105352A (ru) | 2015-07-28 | 2019-08-29 | ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед | Производные бетулина для предупреждения или лечения ВИЧ-инфекций |
| CN108026140A (zh) | 2015-07-28 | 2018-05-11 | 葛兰素史克知识产权第二有限公司 | 用于预防或治疗hiv感染的白桦脂醇衍生物 |
| EP3353158A1 (en) | 2015-09-24 | 2018-08-01 | Glaxosmithkline Intellectual Property (No. 2) Limited | Compounds with hiv maturation inhibitory activity |
| CN105293599B (zh) * | 2015-10-10 | 2017-11-21 | 北海富安源生物科技有限公司 | 一种提高毛发水解合成率制备水生态保护剂的方法 |
| KR20180098675A (ko) | 2016-01-20 | 2018-09-04 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Hiv 성숙 억제 활성을 갖는 루판의 아민 유도체 |
| KR101859421B1 (ko) * | 2017-01-31 | 2018-05-21 | 주식회사 케라메딕스 | 탈모방지 또는 발모촉진용 주사용 조성물 |
| CN106867000A (zh) * | 2017-03-16 | 2017-06-20 | 苏州佰锐生物科技有限公司 | 一种促进角蛋白溶解及增强角蛋白材料强度的方法 |
| AU2018278219B2 (en) * | 2017-05-30 | 2024-03-07 | Mars, Incorporated | Methods for producing feather-based food products |
| FI127941B (en) | 2017-10-02 | 2019-05-31 | Hkscan Oyj | A method for converting feather-cracked material |
| PT3784349T (pt) | 2018-04-24 | 2024-01-22 | Viiv Healthcare Uk No 5 Ltd | Compostos com atividade inibidora de maturação do hiv |
| CN113307860A (zh) * | 2021-06-11 | 2021-08-27 | 四川大学 | 基于生物酶解作用从制革回收牛毛中提取角蛋白的方法 |
| CN113980943A (zh) * | 2021-12-18 | 2022-01-28 | 河北省微生物研究所有限公司 | 含胶原酶的复合酶制剂及其在处理皮革下脚料中的应用 |
| CN115011657B (zh) * | 2022-06-21 | 2024-05-31 | 岭南师范学院 | 一种高效酶解法水解虾壳蛋白的方法 |
| CN115261368A (zh) * | 2022-08-16 | 2022-11-01 | 北京思尔成生物技术有限公司 | 一种即用型胃蛋白酶工作液及其制备方法和应用 |
| PL443848A1 (pl) * | 2023-02-20 | 2024-08-26 | Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej Imienia Profesora Ignacego Mościckiego | Sposób jednoczesnego otrzymywania hydrolizatu keratyny i nierozpuszczalnej struktury keratynowej, hydrolizat keratyny oraz nierozpuszczalna struktura keratynowa |
| WO2025141023A1 (en) * | 2023-12-29 | 2025-07-03 | Basf Se | Methods for the production of protein hydrolysates with low levels of nitrosamines |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD244760A1 (de) * | 1985-12-23 | 1987-04-15 | Dessau Tornau Impfstoffwerk | Verfahren zur herstellung eines eiweisshydrolysates |
| WO1990001023A1 (en) * | 1988-07-19 | 1990-02-08 | American Biogenetics Corporation | Method for solubilizing keratinaceous materials using alkaline hydrogen peroxide solution |
| DE10054516A1 (de) * | 2000-11-03 | 2002-05-16 | Henkel Kgaa | Extrudiertes Proteinhydrolysat, Verfahren zu dessen Herstellung und dessen Verwendung |
| JP2005120286A (ja) * | 2003-10-17 | 2005-05-12 | Little Scientist:Kk | 羽毛ケラチン加水分解物またはその塩、及びこれらを含有する化粧料組成物、並びに羽毛ケラチン加水分解物またはその塩の製造方法 |
| AU2005300124A1 (en) * | 2004-10-28 | 2006-05-04 | Agresearch Limited | Production of fine particulates from keratin fibres |
| US9943089B2 (en) * | 2011-11-07 | 2018-04-17 | Mars, Incorporated | Food protein ingredient and methods for producing |
-
2012
- 2012-07-20 GB GBGB1212937.5A patent/GB201212937D0/en not_active Ceased
-
2013
- 2013-07-19 MX MX2015000749A patent/MX2015000749A/es unknown
- 2013-07-19 BR BR112015001226A patent/BR112015001226A2/pt not_active IP Right Cessation
- 2013-07-19 IN IN10709DEN2014 patent/IN2014DN10709A/en unknown
- 2013-07-19 US US14/415,564 patent/US20150152153A1/en not_active Abandoned
- 2013-07-19 WO PCT/EP2013/065363 patent/WO2014013081A2/en active Application Filing
- 2013-07-19 EP EP13739700.6A patent/EP2875144A2/en not_active Withdrawn
- 2013-07-19 CN CN201380038593.4A patent/CN104487588A/zh active Pending
- 2013-07-19 RU RU2015105827A patent/RU2015105827A/ru not_active Application Discontinuation
- 2013-07-19 AU AU2013291943A patent/AU2013291943B2/en not_active Ceased
-
2014
- 2014-12-10 PH PH12014502764A patent/PH12014502764A1/en unknown
-
2017
- 2017-07-20 AU AU2017206256A patent/AU2017206256A1/en not_active Abandoned
Non-Patent Citations (4)
| Title |
|---|
| D1 : WO 2002/036801 A2 (HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN) 10 May 2002 * |
| D2 : DD 244760 A1 (DESSAU TORNAU IMPFSTOFFWERK) 15 April 1987 * |
| D3 : JP 2005-120286 A (LITTLE SCIENTIST KK) 12 May 2005 * |
| D4 : WO 2013/070798 A2 (MARS, INCORPORATED) 16 May 2013 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015001226A2 (pt) | 2018-08-28 |
| AU2017206256A1 (en) | 2017-08-10 |
| US20150152153A1 (en) | 2015-06-04 |
| RU2015105827A (ru) | 2016-09-10 |
| IN2014DN10709A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-09-04 |
| PH12014502764A1 (en) | 2015-02-09 |
| AU2013291943A1 (en) | 2015-01-22 |
| GB201212937D0 (en) | 2012-09-05 |
| MX2015000749A (es) | 2015-04-14 |
| CN104487588A (zh) | 2015-04-01 |
| WO2014013081A2 (en) | 2014-01-23 |
| WO2014013081A3 (en) | 2014-04-10 |
| EP2875144A2 (en) | 2015-05-27 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |