AU2013276165B2 - Tricyclic compounds as KAT II inhibitors - Google Patents

Tricyclic compounds as KAT II inhibitors Download PDF

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Publication number
AU2013276165B2
AU2013276165B2 AU2013276165A AU2013276165A AU2013276165B2 AU 2013276165 B2 AU2013276165 B2 AU 2013276165B2 AU 2013276165 A AU2013276165 A AU 2013276165A AU 2013276165 A AU2013276165 A AU 2013276165A AU 2013276165 B2 AU2013276165 B2 AU 2013276165B2
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Australia
Prior art keywords
optionally substituted
halogen
pharmaceutically acceptable
acceptable salt
alkyl
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Expired - Fee Related
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AU2013276165A
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AU2013276165A1 (en
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Amy B. Dounay
Jamison B. Tuttle
Patrick R. Verhoest
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Pfizer Inc
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Pfizer Inc
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P25/00—Drugs for disorders of the nervous system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
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  • Psychology (AREA)
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  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
AU2013276165A 2012-06-15 2013-06-03 Tricyclic compounds as KAT II inhibitors Expired - Fee Related AU2013276165B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261660142P 2012-06-15 2012-06-15
US61/660,142 2012-06-15
PCT/IB2013/054570 WO2013186666A1 (en) 2012-06-15 2013-06-03 Tricyclic compounds as kat ii inhibitors

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AU2013276165A1 AU2013276165A1 (en) 2014-11-27
AU2013276165B2 true AU2013276165B2 (en) 2015-07-16

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AU2013276165A Expired - Fee Related AU2013276165B2 (en) 2012-06-15 2013-06-03 Tricyclic compounds as KAT II inhibitors

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US (1) US20150175603A1 (cg-RX-API-DMAC7.html)
EP (1) EP2861593A1 (cg-RX-API-DMAC7.html)
JP (1) JP2015523352A (cg-RX-API-DMAC7.html)
KR (1) KR20150007352A (cg-RX-API-DMAC7.html)
CN (1) CN104364253A (cg-RX-API-DMAC7.html)
AU (1) AU2013276165B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014030507A2 (cg-RX-API-DMAC7.html)
CA (1) CA2874400A1 (cg-RX-API-DMAC7.html)
HK (1) HK1206734A1 (cg-RX-API-DMAC7.html)
IL (1) IL236241A0 (cg-RX-API-DMAC7.html)
IN (1) IN2014DN09826A (cg-RX-API-DMAC7.html)
MX (1) MX2014014808A (cg-RX-API-DMAC7.html)
RU (1) RU2014146509A (cg-RX-API-DMAC7.html)
SG (1) SG11201407389QA (cg-RX-API-DMAC7.html)
WO (1) WO2013186666A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI693227B (zh) 2014-04-23 2020-05-11 日商田邊三菱製藥股份有限公司 新穎二環性或三環性雜環化合物
CN106349241B (zh) * 2015-07-15 2020-04-21 上海翰森生物医药科技有限公司 具有hsp90抑制活性的三唑衍生物及其制备方法和应用
EP3372601B1 (en) 2015-10-22 2022-09-21 Mitsubishi Tanabe Pharma Corporation Novel bicyclic heterocyclic compound
HRP20221020T1 (hr) 2018-07-20 2022-11-11 Grünenthal GmbH Supstituirani derivati triazolo kinoksalina
CN111196817B (zh) * 2018-11-19 2021-06-11 四川大学华西医院 作为brpf1抑制剂的三环化合物
TWI880049B (zh) * 2020-12-04 2025-04-11 美商美國禮來大藥廠 Kras g12c抑制劑

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120142729A1 (en) * 2010-12-01 2012-06-07 Pfizer Inc. KAT ll INHIBITORS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2316072B (en) * 1996-08-05 2000-05-10 Pharmacia Spa Pyrrolo[3,2-c]quinoline derivatives
JP5643818B2 (ja) * 2009-06-18 2014-12-17 ファイザー・インク Ｋａｔｉｉ阻害剤としての二環式および三環式化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120142729A1 (en) * 2010-12-01 2012-06-07 Pfizer Inc. KAT ll INHIBITORS

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Publication number Publication date
EP2861593A1 (en) 2015-04-22
BR112014030507A2 (pt) 2017-06-27
WO2013186666A1 (en) 2013-12-19
KR20150007352A (ko) 2015-01-20
HK1206734A1 (en) 2016-01-15
CN104364253A (zh) 2015-02-18
MX2014014808A (es) 2015-02-12
RU2014146509A (ru) 2016-08-10
US20150175603A1 (en) 2015-06-25
IN2014DN09826A (cg-RX-API-DMAC7.html) 2015-07-31
JP2015523352A (ja) 2015-08-13
CA2874400A1 (en) 2013-12-19
SG11201407389QA (en) 2015-02-27
AU2013276165A1 (en) 2014-11-27
IL236241A0 (en) 2015-02-01

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