AU2013271407B2 - Pyrimidinyl tyrosine kinase inhibitors - Google Patents

Pyrimidinyl tyrosine kinase inhibitors Download PDF

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Publication number
AU2013271407B2
AU2013271407B2 AU2013271407A AU2013271407A AU2013271407B2 AU 2013271407 B2 AU2013271407 B2 AU 2013271407B2 AU 2013271407 A AU2013271407 A AU 2013271407A AU 2013271407 A AU2013271407 A AU 2013271407A AU 2013271407 B2 AU2013271407 B2 AU 2013271407B2
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AU
Australia
Prior art keywords
compound
amino
chloro
mixture
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013271407A
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English (en)
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AU2013271407A1 (en
Inventor
Xiongwei Cai
Timothy R. CHAN
Patrick Conlon
Brian T. Hopkins
Michael Humora
Tracy J. Jenkins
Ross A. Miller
Xianglin Shi
Andrew Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen MA Inc
Viracta Therapeutics Inc
Original Assignee
Sunesis Pharmaceuticals Inc
Biogen MA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc, Biogen MA Inc filed Critical Sunesis Pharmaceuticals Inc
Publication of AU2013271407A1 publication Critical patent/AU2013271407A1/en
Assigned to BIOGEN MA INC., SUNESIS PHARMACEUTICALS, INC. reassignment BIOGEN MA INC. Amend patent request/document other than specification (104) Assignors: BIOGEN IDEC MA INC., SUNESIS PHARMACEUTICALS, INC.
Application granted granted Critical
Publication of AU2013271407B2 publication Critical patent/AU2013271407B2/en
Priority to AU2017201536A priority Critical patent/AU2017201536B2/en
Priority to AU2019203476A priority patent/AU2019203476B2/en
Priority to AU2021202412A priority patent/AU2021202412A1/en
Priority to AU2022275504A priority patent/AU2022275504A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AU2013271407A 2012-06-08 2013-06-07 Pyrimidinyl tyrosine kinase inhibitors Ceased AU2013271407B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2017201536A AU2017201536B2 (en) 2012-06-08 2017-03-07 Pyrimidinyl Tyrosine Kinase Inhibitors
AU2019203476A AU2019203476B2 (en) 2012-06-08 2019-05-17 Pyrimidinyl tyrosine kinase inhibitors
AU2021202412A AU2021202412A1 (en) 2012-06-08 2021-04-21 Pyrimidinyl tyrosine kinase inhibitors
AU2022275504A AU2022275504A1 (en) 2012-06-08 2022-11-25 Pyrimidinyl tyrosine kinase inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261657360P 2012-06-08 2012-06-08
US61/657,360 2012-06-08
PCT/US2013/044800 WO2013185084A1 (en) 2012-06-08 2013-06-07 Pyrimidinyl tyrosine kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017201536A Division AU2017201536B2 (en) 2012-06-08 2017-03-07 Pyrimidinyl Tyrosine Kinase Inhibitors

Publications (2)

Publication Number Publication Date
AU2013271407A1 AU2013271407A1 (en) 2015-01-22
AU2013271407B2 true AU2013271407B2 (en) 2016-12-08

Family

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Family Applications (5)

Application Number Title Priority Date Filing Date
AU2013271407A Ceased AU2013271407B2 (en) 2012-06-08 2013-06-07 Pyrimidinyl tyrosine kinase inhibitors
AU2017201536A Ceased AU2017201536B2 (en) 2012-06-08 2017-03-07 Pyrimidinyl Tyrosine Kinase Inhibitors
AU2019203476A Ceased AU2019203476B2 (en) 2012-06-08 2019-05-17 Pyrimidinyl tyrosine kinase inhibitors
AU2021202412A Abandoned AU2021202412A1 (en) 2012-06-08 2021-04-21 Pyrimidinyl tyrosine kinase inhibitors
AU2022275504A Abandoned AU2022275504A1 (en) 2012-06-08 2022-11-25 Pyrimidinyl tyrosine kinase inhibitors

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2017201536A Ceased AU2017201536B2 (en) 2012-06-08 2017-03-07 Pyrimidinyl Tyrosine Kinase Inhibitors
AU2019203476A Ceased AU2019203476B2 (en) 2012-06-08 2019-05-17 Pyrimidinyl tyrosine kinase inhibitors
AU2021202412A Abandoned AU2021202412A1 (en) 2012-06-08 2021-04-21 Pyrimidinyl tyrosine kinase inhibitors
AU2022275504A Abandoned AU2022275504A1 (en) 2012-06-08 2022-11-25 Pyrimidinyl tyrosine kinase inhibitors

Country Status (30)

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EP (3) EP2858499B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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HU (1) HUE039897T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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PL (1) PL2858499T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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SI (1) SI2858499T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SM (1) SMT201800442T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (3) TWI792158B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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ZA (1) ZA201409255B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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