AU2013260005B2 - Solubilized capsule formulation of 1,1-dimethylethyl [(1S)-1-{[(2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate - Google Patents

Solubilized capsule formulation of 1,1-dimethylethyl [(1S)-1-{[(2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate Download PDF

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Publication number
AU2013260005B2
AU2013260005B2 AU2013260005A AU2013260005A AU2013260005B2 AU 2013260005 B2 AU2013260005 B2 AU 2013260005B2 AU 2013260005 A AU2013260005 A AU 2013260005A AU 2013260005 A AU2013260005 A AU 2013260005A AU 2013260005 B2 AU2013260005 B2 AU 2013260005B2
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formulation
compound
formula
capsule
day
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AU2013260005A
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AU2013260005A1 (en
Inventor
Robert Kevin Perrone
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Bristol Myers Squibb Holdings Ireland ULC
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Bristol Myers Squibb Holdings Ireland ULC
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Application filed by Bristol Myers Squibb Holdings Ireland ULC filed Critical Bristol Myers Squibb Holdings Ireland ULC
Publication of AU2013260005A1 publication Critical patent/AU2013260005A1/en
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Assigned to BRISTOL-MYERS SQUIBB HOLDINGS IRELAND UNLIMITED COMPANY reassignment BRISTOL-MYERS SQUIBB HOLDINGS IRELAND UNLIMITED COMPANY Request to Amend Deed and Register Assignors: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2013260005A 2012-05-07 2013-04-30 Solubilized capsule formulation of 1,1-dimethylethyl [(1S)-1-{[(2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate Ceased AU2013260005B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261643454P 2012-05-07 2012-05-07
US61/643,454 2012-05-07
PCT/US2013/038770 WO2013169520A1 (en) 2012-05-07 2013-04-30 Solubilized capsule formulation of 1,1-dimethylethyl [(1s)-1-{[(2s,4r)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1r,2s)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate

Publications (2)

Publication Number Publication Date
AU2013260005A1 AU2013260005A1 (en) 2015-01-15
AU2013260005B2 true AU2013260005B2 (en) 2017-07-13

Family

ID=48428670

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013260005A Ceased AU2013260005B2 (en) 2012-05-07 2013-04-30 Solubilized capsule formulation of 1,1-dimethylethyl [(1S)-1-{[(2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate

Country Status (33)

Country Link
US (1) US20130302414A1 (cg-RX-API-DMAC10.html)
EP (1) EP2846780B1 (cg-RX-API-DMAC10.html)
JP (1) JP6276756B2 (cg-RX-API-DMAC10.html)
KR (1) KR20150004921A (cg-RX-API-DMAC10.html)
CN (1) CN104363899A (cg-RX-API-DMAC10.html)
AR (1) AR090954A1 (cg-RX-API-DMAC10.html)
AU (1) AU2013260005B2 (cg-RX-API-DMAC10.html)
BR (1) BR112014027676A2 (cg-RX-API-DMAC10.html)
CA (1) CA2872765A1 (cg-RX-API-DMAC10.html)
CL (1) CL2014003012A1 (cg-RX-API-DMAC10.html)
CO (1) CO7141457A2 (cg-RX-API-DMAC10.html)
CY (1) CY1120756T1 (cg-RX-API-DMAC10.html)
DK (1) DK2846780T3 (cg-RX-API-DMAC10.html)
EA (1) EA028749B1 (cg-RX-API-DMAC10.html)
ES (1) ES2688817T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20181583T1 (cg-RX-API-DMAC10.html)
IL (1) IL235466B (cg-RX-API-DMAC10.html)
LT (1) LT2846780T (cg-RX-API-DMAC10.html)
MX (1) MX358545B (cg-RX-API-DMAC10.html)
MY (1) MY171378A (cg-RX-API-DMAC10.html)
NZ (1) NZ630248A (cg-RX-API-DMAC10.html)
PE (1) PE20142439A1 (cg-RX-API-DMAC10.html)
PH (1) PH12014502405A1 (cg-RX-API-DMAC10.html)
PL (1) PL2846780T3 (cg-RX-API-DMAC10.html)
PT (1) PT2846780T (cg-RX-API-DMAC10.html)
RS (1) RS57881B1 (cg-RX-API-DMAC10.html)
SG (1) SG11201406964QA (cg-RX-API-DMAC10.html)
SI (1) SI2846780T1 (cg-RX-API-DMAC10.html)
SM (1) SMT201800506T1 (cg-RX-API-DMAC10.html)
TW (1) TWI577392B (cg-RX-API-DMAC10.html)
UY (1) UY34785A (cg-RX-API-DMAC10.html)
WO (1) WO2013169520A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201408967B (cg-RX-API-DMAC10.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2673870T3 (es) * 2012-05-07 2018-06-26 Bristol-Myers Squibb Holdings Ireland Formulación de dosificación oral sólida de [(1S)-1-{[(2S,4R)-4-(7-cloro-4-metoxiisoquinolin-1-iloxi)-2-({(1R,2S)-1-[(ciclopropilsulfonil) carbamoil]-2-etenilciclopropil} carbamoil) pirrolidin-1-il] carbonil}-2,2-dimetil-propil] carbamato de 1,1-dimetiletilo
JP6154474B2 (ja) 2012-10-19 2017-06-28 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014071007A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2914613B1 (en) 2012-11-02 2017-11-22 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2964664B1 (en) 2013-03-07 2017-01-11 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2019130341A1 (en) * 2017-12-26 2019-07-04 Hetero Labs Limited Capsule compositions comprising lopinavir and ritonavir
EA202092131A1 (ru) 2018-03-14 2020-11-27 Кэнди Терапьютикс Лимитед Новый фармацевтический препарат, содержащий двойные антагонисты рецептора nk-1/nk-3
US12533358B1 (en) 2025-05-14 2026-01-27 Bayer Consumer Care Ag Methods of treatment with elinzanetant

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP1283041A1 (en) * 1996-11-21 2003-02-12 Abbott Laboratories Pharmaceutical compositions containing HIV-protease inhibitors

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ES2298286T3 (es) * 2000-10-31 2008-05-16 Boehringer Ingelheim Pharmaceuticals Inc. Formulaciones de dosis orales auto-emulsionantes de inhibidores de proteasa de piranona.
US6828301B2 (en) * 2002-02-07 2004-12-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for hepatitis C viral protease inhibitors
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
WO2010042834A1 (en) * 2008-10-09 2010-04-15 Anadys Pharmaceuticals, Inc. A method of inhibiting hepatitis c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds
US8252821B2 (en) * 2009-04-14 2012-08-28 Bristol-Myers Squibb Company Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1283041A1 (en) * 1996-11-21 2003-02-12 Abbott Laboratories Pharmaceutical compositions containing HIV-protease inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "A Multiple Ascending Dose Study of BMS-650032 in HCV Infected Subjects", CLINICALTRIALS.GOV, pages 1 - 3, XP002702909, Retrieved from the Internet <URL:http://clinicaltrials.gov/ct2/show/study/NCT00722358> [retrieved on 20130718] *
C Pasquinelle et al, Microbial Agents and Chemotherapy, vol 56, no 4, 1 April 2012, pages 1838-1844 *
Cole et al, Advanced Drug Delivery Reviews, vol 60, no 6, 21 December 2007, pages 747-756 *

Also Published As

Publication number Publication date
AR090954A1 (es) 2014-12-17
HK1204552A1 (en) 2015-11-27
SMT201800506T1 (it) 2018-11-09
PL2846780T3 (pl) 2018-11-30
NZ630248A (en) 2016-11-25
UY34785A (es) 2013-11-29
MY171378A (en) 2019-10-10
HRP20181583T1 (hr) 2018-11-30
ZA201408967B (en) 2016-10-26
EA201492039A1 (ru) 2015-02-27
RS57881B1 (sr) 2019-01-31
ES2688817T3 (es) 2018-11-07
KR20150004921A (ko) 2015-01-13
CN104363899A (zh) 2015-02-18
DK2846780T3 (en) 2018-09-17
IL235466B (en) 2019-03-31
EP2846780B1 (en) 2018-07-18
LT2846780T (lt) 2018-11-12
PH12014502405A1 (en) 2015-01-12
US20130302414A1 (en) 2013-11-14
TWI577392B (zh) 2017-04-11
JP2015516418A (ja) 2015-06-11
WO2013169520A1 (en) 2013-11-14
EA028749B1 (ru) 2017-12-29
PT2846780T (pt) 2018-10-26
MX358545B (es) 2018-08-24
CA2872765A1 (en) 2013-11-14
CY1120756T1 (el) 2019-12-11
PE20142439A1 (es) 2015-01-28
JP6276756B2 (ja) 2018-02-07
MX2014013220A (es) 2015-05-11
SI2846780T1 (sl) 2018-09-28
AU2013260005A1 (en) 2015-01-15
SG11201406964QA (en) 2014-11-27
EP2846780A1 (en) 2015-03-18
BR112014027676A2 (pt) 2017-06-27
TW201350145A (zh) 2013-12-16
CO7141457A2 (es) 2014-12-12
CL2014003012A1 (es) 2015-07-10

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HB Alteration of name in register

Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND UNLIMITED CO

Free format text: FORMER NAME(S): BRISTOL-MYERS SQUIBB HOLDINGS IRELAND

MK14 Patent ceased section 143(a) (annual fees not paid) or expired