AU2013259892B2 - Permeable glycosidase inhibitors and uses thereof - Google Patents

Permeable glycosidase inhibitors and uses thereof Download PDF

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Publication number
AU2013259892B2
AU2013259892B2 AU2013259892A AU2013259892A AU2013259892B2 AU 2013259892 B2 AU2013259892 B2 AU 2013259892B2 AU 2013259892 A AU2013259892 A AU 2013259892A AU 2013259892 A AU2013259892 A AU 2013259892A AU 2013259892 B2 AU2013259892 B2 AU 2013259892B2
Authority
AU
Australia
Prior art keywords
tetrahydro
pyrano
thiazole
diol
dimethylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013259892A
Other languages
English (en)
Other versions
AU2013259892A1 (en
Inventor
Jiang Chang
Eric Hostetler
Wenping Li
Kun Liu
Ernest J. Mceachern
Changwei Mu
Harold G. Selnick
Yaode Wang
Zhongyong Wei
Yuanxi Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alectos Therapeutics Inc
Original Assignee
Alectos Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2012/075185 external-priority patent/WO2013166654A1/en
Application filed by Alectos Therapeutics Inc filed Critical Alectos Therapeutics Inc
Publication of AU2013259892A1 publication Critical patent/AU2013259892A1/en
Application granted granted Critical
Publication of AU2013259892B2 publication Critical patent/AU2013259892B2/en
Assigned to ALECTOS THERAPEUTICS INC., MERCK SHARP & DOHME LLC reassignment ALECTOS THERAPEUTICS INC. Request to Amend Deed and Register Assignors: ALECTOS THERAPEUTICS INC., MERCK SHARP & DOHME CORP.
Assigned to ALECTOS THERAPEUTICS INC. reassignment ALECTOS THERAPEUTICS INC. Request for Assignment Assignors: MERCK SHARP & DOHME LLC, ALECTOS THERAPEUTICS INC.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2013259892A 2012-05-08 2013-05-03 Permeable glycosidase inhibitors and uses thereof Ceased AU2013259892B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/CN2012/075185 WO2013166654A1 (en) 2012-05-08 2012-05-08 Permeable glycosidase inhibitors and uses thereof
AUPCT/CN2012/075185 2012-05-08
US201261655641P 2012-06-05 2012-06-05
US61/655,641 2012-06-05
PCT/US2013/039377 WO2013169576A1 (en) 2012-05-08 2013-05-03 Permeable glycosidase inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
AU2013259892A1 AU2013259892A1 (en) 2014-10-30
AU2013259892B2 true AU2013259892B2 (en) 2017-09-14

Family

ID=49551168

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013259892A Ceased AU2013259892B2 (en) 2012-05-08 2013-05-03 Permeable glycosidase inhibitors and uses thereof

Country Status (10)

Country Link
US (1) US9611275B2 (enExample)
EP (1) EP2847199B1 (enExample)
JP (1) JP6178843B2 (enExample)
KR (1) KR102108586B1 (enExample)
CN (1) CN104395323B (enExample)
AU (1) AU2013259892B2 (enExample)
BR (1) BR112014027724B1 (enExample)
CA (1) CA2871920C (enExample)
RU (1) RU2707292C2 (enExample)
WO (1) WO2013169576A1 (enExample)

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JP5687194B2 (ja) 2008-08-01 2015-03-18 サイモン フレイザー ユニバーシティ 選択的グリコシダーゼインヒビターおよびその使用
US9120781B2 (en) 2010-05-11 2015-09-01 Simon Fraser University Selective glycosidase inhibitors and uses thereof
WO2012061927A1 (en) 2010-11-08 2012-05-18 Alectos Therapeutics, Inc. Selective glycosidase inhibitors and uses thereof
BR112013016179A2 (pt) 2010-12-23 2018-07-10 Alectos Therapeutics Inc inibidores seletivos da glicosidase e usos dos mesmos.
WO2012126091A1 (en) 2011-03-24 2012-09-27 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
US9718854B2 (en) 2011-03-31 2017-08-01 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
MX364602B (es) 2011-06-27 2019-05-02 Alectos Therapeutics Inc Inhibidores selectivos de glicosidasa y usos de los mismos.
WO2013000085A1 (en) 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
WO2013000086A1 (en) 2011-06-27 2013-01-03 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
EP2890676B1 (en) 2012-08-31 2018-12-05 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
EP2890675A4 (en) 2012-08-31 2016-01-13 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
EP2914604A4 (en) 2012-10-31 2016-07-20 Alectos Therapeutics Inc GLYCOSIDASE INHIBITORS AND USES THEREOF
WO2014100934A1 (en) 2012-12-24 2014-07-03 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof
AU2014278178B2 (en) 2013-06-11 2021-01-21 President And Fellows Of Harvard College SC-beta cells and compositions and methods for generating the same
EP3215191B1 (en) 2014-11-05 2024-08-14 Voyager Therapeutics, Inc. Aadc polynucleotides for the treatment of parkinson's disease
KR20230145206A (ko) 2014-11-14 2023-10-17 보이저 테라퓨틱스, 인크. 조절성 폴리뉴클레오티드
US10584337B2 (en) 2016-05-18 2020-03-10 Voyager Therapeutics, Inc. Modulatory polynucleotides
IL297576B2 (en) 2016-05-18 2024-02-01 Voyager Therapeutics Inc Compositions and methods of treating huntington's disease
MX2019013172A (es) 2017-05-05 2020-09-07 Voyager Therapeutics Inc Composiciones y metodos para tratar la enfermedad de huntington.
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
CN112424359A (zh) 2018-05-15 2021-02-26 沃雅戈治疗公司 用于治疗帕金森氏病的组合物和方法
CN109160873A (zh) * 2018-08-14 2019-01-08 重庆市化工研究院 一种芳香族烯丙基醚及其合成方法和应用
US20230391796A1 (en) * 2020-09-25 2023-12-07 Universidad De Sevilla (Us) -University Of Seville (Us) Glycosidase inhibitors and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013025452A1 (en) * 2011-08-18 2013-02-21 Merck Sharp & Dohme Corp. Selective glycosidase inhibitors and uses thereof

Family Cites Families (12)

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SU1441749A1 (ru) * 1987-03-16 1996-01-10 Институт Тонкой Органической Химии Им.А.Л.Мнджояна 2-АМИНО-5,5-ДИМЕТИЛ-4,5-ДИГИДРО-7Н-ПИРАНО [4,3-d] ТИАЗОЛ, ОБЛАДАЮЩИЙ ТРАНКВИЛИЗИРУЮЩЕЙ АКТИВНОСТЬЮ
WO2006016904A2 (en) 2004-04-14 2006-02-16 Uab Research Foundation Activators of hexosamine biosynthesis as inhibitors of injury induced by ischemia or hemorrhagic shock
AU2006220187B2 (en) 2005-03-01 2012-11-08 Simon Fraser University Selective glycosidase inhibitors, methods of making inhibitors, and uses thereof
CN101595111A (zh) * 2006-08-31 2009-12-02 西蒙·弗雷瑟大学 选择性糖苷酶抑制剂及其用途
EP2057171A4 (en) * 2006-08-31 2010-04-21 Univ Fraser Simon SELECTIVE GLYCOSIDASE INHIBITORS AND APPLICATIONS THEREOF
JP5687194B2 (ja) 2008-08-01 2015-03-18 サイモン フレイザー ユニバーシティ 選択的グリコシダーゼインヒビターおよびその使用
WO2010012106A1 (en) 2008-08-01 2010-02-04 Simon Fraser University Selective glycosidase inhibitors and uses thereof
JP2012502884A (ja) 2008-09-16 2012-02-02 サイモン フレイザー ユニバーシティ 選択的グリコシダーゼ阻害剤およびその使用
US9120781B2 (en) * 2010-05-11 2015-09-01 Simon Fraser University Selective glycosidase inhibitors and uses thereof
WO2012061972A1 (en) 2010-11-08 2012-05-18 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof
TW201249848A (en) 2010-11-08 2012-12-16 Merck Sharp & Dohme Selective glycosidase inhibitors and uses thereof
WO2012159262A1 (en) * 2011-05-24 2012-11-29 Alectos Therapeutics Inc. Selective glycosidase inhibitors and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013025452A1 (en) * 2011-08-18 2013-02-21 Merck Sharp & Dohme Corp. Selective glycosidase inhibitors and uses thereof

Also Published As

Publication number Publication date
JP2015516420A (ja) 2015-06-11
US9611275B2 (en) 2017-04-04
RU2014149183A (ru) 2016-06-27
KR102108586B1 (ko) 2020-05-07
JP6178843B2 (ja) 2017-08-09
US20150152127A1 (en) 2015-06-04
CA2871920A1 (en) 2013-11-14
WO2013169576A1 (en) 2013-11-14
CA2871920C (en) 2021-03-09
EP2847199B1 (en) 2017-10-25
RU2707292C2 (ru) 2019-11-26
EP2847199A1 (en) 2015-03-18
CN104395323A (zh) 2015-03-04
BR112014027724B1 (pt) 2022-05-03
AU2013259892A1 (en) 2014-10-30
BR112014027724A2 (enExample) 2017-08-22
KR20150006841A (ko) 2015-01-19
EP2847199A4 (en) 2015-11-11
CN104395323B (zh) 2017-08-01

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
HB Alteration of name in register

Owner name: MERCK SHARP & DOHME LLC

Free format text: FORMER NAME(S): ALECTOS THERAPEUTICS INC.; MERCK SHARP & DOHME CORP.

Owner name: ALECTOS THERAPEUTICS INC.

Free format text: FORMER NAME(S): ALECTOS THERAPEUTICS INC.; MERCK SHARP & DOHME CORP.

PC Assignment registered

Owner name: ALECTOS THERAPEUTICS INC.

Free format text: FORMER OWNER(S): MERCK SHARP & DOHME LLC; ALECTOS THERAPEUTICS INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired