AU2013259779B2 - N-ethyl-4-hydroxyl-1-methyl-5- (methyl(2,3,4,5,6-pentahydroxyhexyl) amino) -2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide - Google Patents

N-ethyl-4-hydroxyl-1-methyl-5- (methyl(2,3,4,5,6-pentahydroxyhexyl) amino) -2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide Download PDF

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Publication number
AU2013259779B2
AU2013259779B2 AU2013259779A AU2013259779A AU2013259779B2 AU 2013259779 B2 AU2013259779 B2 AU 2013259779B2 AU 2013259779 A AU2013259779 A AU 2013259779A AU 2013259779 A AU2013259779 A AU 2013259779A AU 2013259779 B2 AU2013259779 B2 AU 2013259779B2
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AU
Australia
Prior art keywords
methyl
laquinimod
pharmaceutical composition
phenyl
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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AU2013259779A
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English (en)
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AU2013259779A1 (en
Inventor
Avital Laxer
Konstantin Ulanenko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
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Teva Pharmaceutical Industries Ltd
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Publication of AU2013259779A1 publication Critical patent/AU2013259779A1/en
Application granted granted Critical
Publication of AU2013259779B2 publication Critical patent/AU2013259779B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2013259779A 2012-05-08 2013-05-07 N-ethyl-4-hydroxyl-1-methyl-5- (methyl(2,3,4,5,6-pentahydroxyhexyl) amino) -2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide Expired - Fee Related AU2013259779B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261644054P 2012-05-08 2012-05-08
US61/644,054 2012-05-08
PCT/US2013/039911 WO2013169746A2 (en) 2012-05-08 2013-05-07 N-ethyl-4-hydroxyl-1-methyl-5-(methyl(2,3,4,5,6-pentahydroxyhexyl) amino)-2-oxo-n-phenyl-1,2-dihydroquinoline-3-carboxamide

Publications (2)

Publication Number Publication Date
AU2013259779A1 AU2013259779A1 (en) 2014-12-18
AU2013259779B2 true AU2013259779B2 (en) 2017-06-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013259779A Expired - Fee Related AU2013259779B2 (en) 2012-05-08 2013-05-07 N-ethyl-4-hydroxyl-1-methyl-5- (methyl(2,3,4,5,6-pentahydroxyhexyl) amino) -2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

Country Status (19)

Country Link
US (1) US8809537B2 (OSRAM)
EP (1) EP2697201A4 (OSRAM)
KR (1) KR20150022816A (OSRAM)
CN (1) CN104395291B (OSRAM)
AR (1) AR090975A1 (OSRAM)
AU (1) AU2013259779B2 (OSRAM)
BR (1) BR112014028121A2 (OSRAM)
CA (1) CA2873258A1 (OSRAM)
EA (1) EA201492029A1 (OSRAM)
HK (1) HK1207080A1 (OSRAM)
IL (1) IL235338A0 (OSRAM)
IN (1) IN2014MN02485A (OSRAM)
MX (1) MX2014013664A (OSRAM)
NZ (1) NZ630549A (OSRAM)
SG (1) SG11201407447XA (OSRAM)
TW (1) TW201350467A (OSRAM)
UY (1) UY34791A (OSRAM)
WO (1) WO2013169746A2 (OSRAM)
ZA (1) ZA201408825B (OSRAM)

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* Cited by examiner, † Cited by third party
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AR089862A1 (es) 2012-02-03 2014-09-24 Teva Pharma USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEA
MX2014009889A (es) 2012-02-16 2014-11-13 Teva Pharma N-etil-n-fenil-1,2-dihidro-4,5-di-hidroxi-1-metil-2-oxo-3-quinoli ncarboxamida, preparacion y usos de los mismos.
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
MX2015005632A (es) 2012-11-07 2016-02-05 Teva Pharma Sales de amina de laquinimod.
EP2970129A2 (en) 2013-03-14 2016-01-20 Teva Pharmaceutical Industries Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
KR20170005434A (ko) 2014-04-29 2017-01-13 테바 파마슈티컬 인더스트리즈 리미티드 높은 장애 상태를 갖는 재발-완화형 다발성 경화증(rrms) 환자 치료용 라퀴니모드

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2007146248A2 (en) * 2006-06-12 2007-12-21 Teva Pharmaceutical Industries, Ltd. Stable laquinimod preparations

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Also Published As

Publication number Publication date
TW201350467A (zh) 2013-12-16
US8809537B2 (en) 2014-08-19
EP2697201A4 (en) 2014-11-26
KR20150022816A (ko) 2015-03-04
AU2013259779A1 (en) 2014-12-18
CN104395291B (zh) 2017-07-28
AR090975A1 (es) 2014-12-17
WO2013169746A2 (en) 2013-11-14
IL235338A0 (en) 2014-12-31
ZA201408825B (en) 2016-07-27
CN104395291A (zh) 2015-03-04
HK1207080A1 (en) 2016-01-22
CA2873258A1 (en) 2013-11-14
WO2013169746A3 (en) 2013-12-05
EA201492029A1 (ru) 2015-06-30
MX2014013664A (es) 2015-04-17
US20130345256A1 (en) 2013-12-26
NZ630549A (en) 2016-01-29
UY34791A (es) 2013-11-29
SG11201407447XA (en) 2015-02-27
EP2697201A2 (en) 2014-02-19
IN2014MN02485A (OSRAM) 2015-07-17
BR112014028121A2 (pt) 2017-06-27

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