AU2013259384B2 - Nuclear transport modulators and uses thereof - Google Patents

Nuclear transport modulators and uses thereof Download PDF

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Publication number
AU2013259384B2
AU2013259384B2 AU2013259384A AU2013259384A AU2013259384B2 AU 2013259384 B2 AU2013259384 B2 AU 2013259384B2 AU 2013259384 A AU2013259384 A AU 2013259384A AU 2013259384 A AU2013259384 A AU 2013259384A AU 2013259384 B2 AU2013259384 B2 AU 2013259384B2
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compound
alkyl
group
disorder
cancer
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AU2013259384A1 (en
Inventor
Erkan Baloglu
Dilara Mccauley
Vincent P. Sandanayaka
Sharon Shacham
Sharon Shechter
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Biogen MA Inc
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Biogen MA Inc
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Priority to AU2016222459A priority Critical patent/AU2016222459A1/en
Priority to AU2018201012A priority patent/AU2018201012B2/en
Assigned to BIOGEN MA INC. reassignment BIOGEN MA INC. Request for Assignment Assignors: KARYOPHARM THERAPEUTICS, INC.
Priority to AU2019272017A priority patent/AU2019272017B2/en
Priority to AU2021221398A priority patent/AU2021221398B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Pulmonology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
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AU2013259384A 2012-05-09 2013-05-09 Nuclear transport modulators and uses thereof Active AU2013259384B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2016222459A AU2016222459A1 (en) 2012-05-09 2016-09-01 Nuclear transport modulators and uses thereof
AU2018201012A AU2018201012B2 (en) 2012-05-09 2018-02-12 Nuclear transport modulators and uses thereof
AU2019272017A AU2019272017B2 (en) 2012-05-09 2019-11-28 Nuclear transport modulators and uses thereof
AU2021221398A AU2021221398B2 (en) 2012-05-09 2021-08-23 Nuclear transport modulators and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261644802P 2012-05-09 2012-05-09
US61/644,802 2012-05-09
US201361798188P 2013-03-15 2013-03-15
US61/798,188 2013-03-15
PCT/US2013/040404 WO2013170068A2 (en) 2012-05-09 2013-05-09 Nuclear transport modulators and uses thereof

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AU2016222459A Division AU2016222459A1 (en) 2012-05-09 2016-09-01 Nuclear transport modulators and uses thereof

Publications (2)

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AU2013259384A1 AU2013259384A1 (en) 2014-12-18
AU2013259384B2 true AU2013259384B2 (en) 2016-06-02

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AU2013259384A Active AU2013259384B2 (en) 2012-05-09 2013-05-09 Nuclear transport modulators and uses thereof
AU2016222459A Abandoned AU2016222459A1 (en) 2012-05-09 2016-09-01 Nuclear transport modulators and uses thereof
AU2018201012A Active AU2018201012B2 (en) 2012-05-09 2018-02-12 Nuclear transport modulators and uses thereof
AU2019272017A Active AU2019272017B2 (en) 2012-05-09 2019-11-28 Nuclear transport modulators and uses thereof
AU2021221398A Active AU2021221398B2 (en) 2012-05-09 2021-08-23 Nuclear transport modulators and uses thereof

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AU2018201012A Active AU2018201012B2 (en) 2012-05-09 2018-02-12 Nuclear transport modulators and uses thereof
AU2019272017A Active AU2019272017B2 (en) 2012-05-09 2019-11-28 Nuclear transport modulators and uses thereof
AU2021221398A Active AU2021221398B2 (en) 2012-05-09 2021-08-23 Nuclear transport modulators and uses thereof

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US (10) US9096543B2 (cg-RX-API-DMAC7.html)
EP (3) EP2858991B1 (cg-RX-API-DMAC7.html)
JP (5) JP6195909B2 (cg-RX-API-DMAC7.html)
KR (5) KR102163377B1 (cg-RX-API-DMAC7.html)
CN (1) CN104428295B (cg-RX-API-DMAC7.html)
AU (5) AU2013259384B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014027860B8 (cg-RX-API-DMAC7.html)
CA (1) CA2872190C (cg-RX-API-DMAC7.html)
CL (1) CL2014003054A1 (cg-RX-API-DMAC7.html)
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CY (2) CY1120832T1 (cg-RX-API-DMAC7.html)
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RS (2) RS58058B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201407268SA (cg-RX-API-DMAC7.html)
SI (2) SI2858991T1 (cg-RX-API-DMAC7.html)
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UA (2) UA124922C2 (cg-RX-API-DMAC7.html)
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UA115532C2 (uk) 2011-07-29 2017-11-27 Каріофарм Терапеутікс, Інк. Модулятори нуклеарного транспорту, що містять гідразид, і їхнє застосування
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TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
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